F. Hoffmann-La Roche AG


About Roche

Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible.

Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management.

Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. Thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Roche has been recognised as the Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry nine years in a row by the Dow Jones Sustainability Indices (DJSI).

The Roche Group, headquartered in Basel, Switzerland, is active in over 100 countries and in 2017 employed about 94,000 people worldwide. In 2017, Roche invested CHF 10.4 billion in R&D and posted sales of CHF 53.3 billion. Genentech, in the United States, is a wholly owned member of the Roche Group. Roche is the majority shareholder in Chugai Pharmaceutical, Japan. For more information, please visit www.roche.com.

Roche retains sole responsibility for content © 2018 F. Hoffmann-La Roche AG. All trademarks used or mentioned in this release are protected by law.

1 November 2017 - 31 October 2018

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for F. Hoffmann-La Roche AG published between 1 November 2017 - 31 October 2018 which are tracked by the Nature Index.

Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

127 51.94

Outputs by subject (FC)

Subject AC FC
Life Sciences 103 41
Chemistry 28 12.58
Physical Sciences 3 0.06

Highlight of the month

‘Exhausted’ cells may be invigorated against cancer



The best way to differentiate between cancer-fighting T cells in lung tumours may be to look at the number of immune-dampening ‘checkpoint’ molecules on the cell surface.

A team that included scientists from Roche’s Pharmaceutical Research and Early Development studied biopsy material from patients with advanced non-small cell lung cancer. To their surprise, they found that T cells crowded with PD-1 checkpoint proteins on their surfaces — usually a sign of immune ‘exhaustion’ — had the greatest capacity to recognize tumour tissue.

The PD-1–enriched T cells showed many signs of dysfunction, yet they expressed a key signalling molecule that recruited other immune cells to the tumour surroundings. This could explain why the presence of PD-1–elevated T cells was strongly predictive of how patients respond to cancer immunotherapy.

This unique T cell population thus offers a promising new biomarker for identifying patients most likely to benefit from the drug-treatment strategy.

Supported content

  1. Nature Medicine 24, 994–1004 (2018). doi: 10.1038/s41591-018-0057-z

View the article on the Nature Index

See more research highlights from F. Hoffmann-La Roche AG

More research highlights from F. Hoffmann-La Roche AG

1 November 2017 - 31 October 2018

International vs. domestic collaboration by FC

  • 9.11% Domestic
  • 90.89% International

Note: Hover over the graph to view the percentage of collaboration.

Note: Collaboration is determined by the fractional count (FC), which is listed in parentheses.

Affiliated joint institutions and consortia

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