F. Hoffmann-La Roche AG


About Roche

Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible.

Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management.

Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. More than thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Moreover, for the eleventh consecutive year, Roche has been recognised as one of the most sustainable companies in the Pharmaceuticals Industry by the Dow Jones Sustainability Indices (DJSI).

The Roche Group, headquartered in Basel, Switzerland, is active in over 100 countries and in 2019 employed about 98,000 people worldwide. In 2019, Roche invested CHF 11.7 billion in R&D and posted sales of CHF 61.5 billion. Genentech, in the United States, is a wholly owned member of the Roche Group. Roche is the majority shareholder in Chugai Pharmaceutical, Japan. For more information, please visit www.roche.com.

Roche retains sole responsibility for content © 2020 F. Hoffmann-La Roche AG. All trademarks used or mentioned in this release are protected by law.

1 July 2019 - 30 June 2020

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for F. Hoffmann-La Roche AG published between 1 July 2019 - 30 June 2020 which are tracked by the Nature Index.

Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

Count Share
158 61.90

Outputs by subject (Share)

Subject Count Share
Life Sciences 131 43.79
Chemistry 34 19.70
Physical Sciences 3 0.75
Earth & Environmental Sciences 1 0.50

Highlight of the month

Chemokine levels predict cancer immunotherapy success

© Douglas Sacha/Getty

© Douglas Sacha/Getty

Cancer patients with higher levels of an inflammatory signalling molecule in their bloodstream tend to respond worse to immune checkpoint-blocking drugs.

The finding — from a team led by scientists at Genentech, a Roche subsidiary — point to blood levels of this signalling molecule, a chemokine called interleukin 8 (IL-8), as an easily measurable biomarker for identifying patients most likely to benefit from immunotherapy. It also suggests that combining checkpoint inhibitors with agents that target IL-8 could boost response rates for many patients.

The researchers analysed blood and tumour samples from more than 1,400 patients with cancers of the kidney and bladder who had received atezolizumab, a Roche drug directed at an immunosuppressive molecule found on tumour cells.

The team also determined the source of the harmful molecule — a population of immune cells known as myeloid cells that both circulate in the blood and accumulate around tumours, where they create a microenvironment that suppresses the immune response.

Supported content

  1. Nature Medicine 26, 693–698 (2020). doi: 10.1038/s41591-020-0860-1

View the article on the Nature Index

See more research highlights from F. Hoffmann-La Roche AG

More research highlights from F. Hoffmann-La Roche AG

1 July 2019 - 30 June 2020

International vs. domestic collaboration by Share

  • 7.51% Domestic
  • 92.49% International

Note: Hover over the graph to view the percentage of collaboration.

Note: Collaboration is determined by the fractional count (Share), which is listed in parentheses.

Affiliated joint institutions and consortia

Return to institution outputs