F. Hoffmann-La Roche AG

Switzerland

About Roche

Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible.

Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management.

Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. Thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Roche has been recognised as the Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry nine years in a row by the Dow Jones Sustainability Indices (DJSI).

The Roche Group, headquartered in Basel, Switzerland, is active in over 100 countries and in 2017 employed about 94,000 people worldwide. In 2017, Roche invested CHF 10.4 billion in R&D and posted sales of CHF 53.3 billion. Genentech, in the United States, is a wholly owned member of the Roche Group. Roche is the majority shareholder in Chugai Pharmaceutical, Japan. For more information, please visit www.roche.com.

Roche retains sole responsibility for content © 2018 F. Hoffmann-La Roche AG. All trademarks used or mentioned in this release are protected by law.

1 July 2017 - 30 June 2018

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for F. Hoffmann-La Roche AG published between 1 July 2017 - 30 June 2018 which are tracked by the Nature Index.

Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

AC FC
122 55.49

Outputs by subject (FC)

Subject AC FC
Chemistry 31 18.48
Life Sciences 92 37.90
Physical Sciences 1 0.02

Highlight of the month

A look at how we see

© Monica Garcia-Salamon/EyeEm/Getty

© Monica Garcia-Salamon/EyeEm/Getty

Research into molecules able to rescue degenerating vision is yielding insights into the protein structures that enable us to see.

Retinitis pigmentosa is a degenerative eye disease arising from the incorrect maturation of the retinal rod cell protein opsin and its resulting instability. Now, a Swiss team led by Roche scientists has used computational modeling and in vitro screening techniques to discover molecules, such as S-RS1, capable of ‘rescuing’ opsin; stabilizing and moving it to its correct location within rod cells. In doing so, the team identified a previously-unknown physical conformation of the protein which may facilitate its binding to the light-sensing molecule retinal. Retinal bound to opsin forms rhodopsin, a crucial component of human sight.

In elucidating opsin’s structure, and how S-RS1 binds and modifies the protein, this research helps to deepen our understanding of the molecular biology underpinning degenerative eye conditions and helps to shed light on potential treatments.

Supported content

  1. Proceedings of the National Academy of Sciences of the USA 115, 3640–3645 (2018). doi: 10.1073/pnas.1718084115

View the article on the Nature Index

See more research highlights from F. Hoffmann-La Roche AG

More research highlights from F. Hoffmann-La Roche AG

1 July 2017 - 30 June 2018

International vs. domestic collaboration by FC

  • 8.58% Domestic
  • 91.42% International

Note: Hover over the graph to view the percentage of collaboration.

Note: Collaboration is determined by the fractional count (FC), which is listed in parentheses.

Affiliated joint institutions and consortia

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