F. Hoffmann-La Roche AG

Switzerland

About Roche

Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible.

Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management.

Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. Thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Roche has been recognised as the Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry nine years in a row by the Dow Jones Sustainability Indices (DJSI).

The Roche Group, headquartered in Basel, Switzerland, is active in over 100 countries and in 2017 employed about 94,000 people worldwide. In 2017, Roche invested CHF 10.4 billion in R&D and posted sales of CHF 53.3 billion. Genentech, in the United States, is a wholly owned member of the Roche Group. Roche is the majority shareholder in Chugai Pharmaceutical, Japan. For more information, please visit www.roche.com.

Roche retains sole responsibility for content © 2018 F. Hoffmann-La Roche AG. All trademarks used or mentioned in this release are protected by law.

1 August 2017 - 31 July 2018

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for F. Hoffmann-La Roche AG published between 1 August 2017 - 31 July 2018 which are tracked by the Nature Index.

Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

AC FC
123 54.03

Outputs by subject (FC)

Subject AC FC
Life Sciences 94 38.79
Chemistry 29 15.20
Physical Sciences 1 0.02

Highlight of the month

Mucking up the membrane

© KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty

© KATERYNA KON/SCIENCE PHOTO LIBRARY/Getty

Bacterial pathogens that shield their cellular insides with a double membrane have been notoriously difficult to kill using antibiotic agents. A team from Genentech, a subsidiary of Roche, has now discovered a drug that blocks the sugar-coated fat molecules that form the highly impermeable membrane from reaching their final destination on the outside of nasty ‘Gram-negative’ superbugs, such as Escherichia coli and Klebsiella pneumonia.

The researchers searched through a large chemical library for compounds capable of blocking MsbA, a bacterial enzyme involved in shuttling these membrane molecules, known as lipopolysaccharides, out of the cytoplasm. They found one such compound, which they optimized to have better properties. Structural analysis of this optimized drug in complex with MsbA revealed an unprecedented mechanism of action — a dual-mode inhibition of the target enzyme that could provide the playbook for designing other antibiotics.

This finding, reported in Nature, offers a promising new strategy for treating these types of infectious microbes, and could help inspire other efforts to discover drugs that work against similar vulnerabilities in bacterial defenses.


Supported content

  1. Nature 557, 196–201 (2018) doi: 10.1038/s41586-018-0083-5

View the article on the Nature Index

See more research highlights from F. Hoffmann-La Roche AG

More research highlights from F. Hoffmann-La Roche AG

1 August 2017 - 31 July 2018

International vs. domestic collaboration by FC

  • 10.19% Domestic
  • 89.81% International

Note: Hover over the graph to view the percentage of collaboration.

Note: Collaboration is determined by the fractional count (FC), which is listed in parentheses.

Affiliated joint institutions and consortia

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