F. Hoffmann-La Roche AG

Switzerland

About Roche

Roche is a global pioneer in pharmaceuticals and diagnostics focused on advancing science to improve people’s lives. The combined strengths of pharmaceuticals and diagnostics under one roof have made Roche the leader in personalised healthcare – a strategy that aims to fit the right treatment to each patient in the best way possible.

Roche is the world’s largest biotech company, with truly differentiated medicines in oncology, immunology, infectious diseases, ophthalmology and diseases of the central nervous system. Roche is also the world leader in in vitro diagnostics and tissue-based cancer diagnostics, and a frontrunner in diabetes management.

Founded in 1896, Roche continues to search for better ways to prevent, diagnose and treat diseases and make a sustainable contribution to society. The company also aims to improve patient access to medical innovations by working with all relevant stakeholders. Thirty medicines developed by Roche are included in the World Health Organization Model Lists of Essential Medicines, among them life-saving antibiotics, antimalarials and cancer medicines. Roche has been recognised as the Group Leader in sustainability within the Pharmaceuticals, Biotechnology & Life Sciences Industry nine years in a row by the Dow Jones Sustainability Indices (DJSI).

The Roche Group, headquartered in Basel, Switzerland, is active in over 100 countries and in 2017 employed about 94,000 people worldwide. In 2017, Roche invested CHF 10.4 billion in R&D and posted sales of CHF 53.3 billion. Genentech, in the United States, is a wholly owned member of the Roche Group. Roche is the majority shareholder in Chugai Pharmaceutical, Japan. For more information, please visit www.roche.com.

Roche retains sole responsibility for content © 2018 F. Hoffmann-La Roche AG. All trademarks used or mentioned in this release are protected by law.

1 January 2017 - 31 December 2017

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for F. Hoffmann-La Roche AG published between 1 January 2017 - 31 December 2017 which are tracked by the Nature Index.

Hover over the donut graph to view the WFC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

AC FC WFC
90 42.92 42.92

Outputs by subject (WFC)

Subject AC FC WFC
Chemistry 33 16.32 16.32
Life Sciences 62 29.40 29.40
Physical Sciences 2 0.14 0.14
Earth & Environmental Sciences 1 0.13 0.13

Highlight of the month

The root of stem cell regeneration

© Chad Baker/Photodisc/Getty

© Chad Baker/Photodisc/Getty

Stem cells help repair damaged tissue, but researchers are only now beginning to understand how stem cells themselves recover from damage.

A team of scientists at Genentech turned to hair follicles for an answer. Hair follicles include two groups of stem cells, known as Lgr5 and CD34 cells, essential for normal hair growth. By studying mice that had been engineered so that the Lgr5 cells were sensitive to a specific toxin, the team could kill the Lgr5 stem cells and observe how the stem cell population regenerated, reviving hair growth.

Their observations revealed that after the toxin treatment and the death of Lgr5 cells, inflammatory response genes were switched on in CD34 cells, followed by developmental genes which then transformed some of the CD34 cells into Lgr5 cells.

More investigation is needed to learn whether similar regeneration processes occur in other stem cell populations throughout the body.

Supported content

  1. Nature Cell Biology 19, 666-676 (2017). doi: 10.1038/ncb3535

View the article on the Nature Index

See more research highlights from F. Hoffmann-La Roche AG

More research highlights from F. Hoffmann-La Roche AG

1 January 2017 - 31 December 2017

International vs. domestic collaboration by WFC

  • 8.58% Domestic
  • 91.42% International

Note: Hover over the graph to view the percentage of collaboration.

Note: Collaboration is determined by the weighted fractional count (WFC), which is listed in parentheses.

Affiliated joint institutions and consortia

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