Spanish National Research Council (CSIC)
Consejo Superior de Investigaciones Científicas (CSIC)

Spain

The CSIC (Spanish National Research Council) is the largest and leading public research institution in Spain and the third in Europe due to the quality and quantity of its scientific production. It plays an essential role within the Spanish System for Science, Technology and Innovation and contributes to reinforce Spain’s position at the international level.

CSIC’s main aim is to develop and promote scientific studies to contribute to foster scientific and technological progress. CSIC's mission includes: 1) multidisciplinary scientific and technical research; 2) scientific and technical advice; 3) transferring results to the private sector; 4) contributing to the creation of technology-driven companies; 5) training specialised personnel; 6) management of infrastructure and large facilities; 7) promoting scientific culture. The CSIC is multidisciplinary, carrying out research in almost all fields of knowledge. Its activities encompass basic research all the way through to technological development.

The CSIC is present in all the autonomous regions through their centres across Spain. It comprises 120 centres spread across Spain, and is also present in Brussels and Rome. It is formed by employees with a wide range of academic qualifications and professional categories. The CSIC employs 11,000 people, of which 3.000 are researchers. In total, they represent the 6% of Spain’s R&D workforce and generate approximately the 20% of the country’s production. Likewise, the CSIC collaborates with other juridical entities such as consortia and trading companies.

1 August 2018 - 31 July 2019

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for Spanish National Research Council (CSIC) published between 1 August 2018 - 31 July 2019 which are tracked by the Nature Index.

Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

AC FC
1105 182.25

Outputs by subject (FC)

Subject AC FC
Earth & Environmental Sciences 107 21.66
Physical Sciences 564 74.41
Life Sciences 305 50.81
1 0
2 0.94
3 0.11
1 0.02
4 0.26
15 2.79
2 0.32
5 1.24
2 0.45
1 0
15 4.15
3 1.07
4 0.26
2 0.32
5 0.76
5 0.79
1 0.22
12 0.59
1 0.03
1 0.33
1 0.04
71 9.66
Recent trend reversal for declining European seagrass meadows
2019-07-26
0.07
Adaptive responses of animals to climate change are most likely insufficient
2019-07-23
0.03
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis
2019-07-16
0.01
Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification
2019-07-11
0.33
A practical guide for mutational signature analysis in hematological malignancies
2019-07-05
0.02
Global analysis reveals climatic controls on the oxygen isotope composition of cave drip water
2019-07-05
0.18
Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory
2019-07-04
0.36
Essentiality of sterol synthesis genes in the planctomycete bacterium
2019-07-02
0.13
Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly
2019-06-28
0.31
Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse
2019-06-28
0.03
The repressive role of Arabidopsis H2A.Z in transcriptional regulation depends on AtBMI1 activity
2019-06-27
0.50
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
2019-06-26
0.61
CD46 facilitates entry and dissemination of human cytomegalovirus
2019-06-20
0.03
Functional traits and phenotypic plasticity modulate species coexistence across contrasting climatic conditions
2019-06-11
0.17
LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8 T cell tumor-infiltration impairing anti-PD1 therapy
2019-06-11
0.04
Sfrp3 modulates stromal–epithelial crosstalk during mammary gland development by regulating Wnt levels
2019-06-06
0.55
Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B
2019-06-03
0.02
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
2019-05-29
0
Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in intestinal tumors
2019-05-24
0.06
Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines
2019-05-14
0.08
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
2019-05-13
0.06
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
2019-05-09
0.01
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease
2019-05-08
0.02
Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
2019-05-02
0.06
Palaeodemographic modelling supports a population bottleneck during the Pleistocene-Holocene transition in Iberia
2019-04-23
0.17
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis
2019-04-23
0.10
The extracellular matrix protects colonies from invasion and modulates plant co-colonization
2019-04-23
0.21
L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction
2019-04-18
0.08
Urbanity and the dynamics of language shift in Galicia
2019-04-11
0.06
Meta-analysis reveals that pollinator functional diversity and abundance enhance crop pollination and yield
2019-04-01
0.04
Myoglobinopathy is an adult-onset autosomal dominant myopathy with characteristic sarcoplasmic inclusions
2019-03-27
0.01
ZEB1 protects skeletal muscle from damage and is required for its regeneration
2019-03-25
0.22
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
2019-03-07
0.01
Role of carbonate burial in Blue Carbon budgets
2019-03-07
0.04
State-of-the-art global models underestimate impacts from climate extremes
2019-03-01
0.02
Man-made microbial resistances in built environments
2019-02-27
0.13
Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes
2019-02-27
0.06
Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response
2019-02-18
0.03
Recessive mutations in muscle-specific isoforms of cause congenital multi-minicore myopathy
2019-02-15
0.05
Ecosystem structural changes controlled by altered rainfall climatology in tropical savannas
2019-02-08
0.02
Approximate Bayesian computation with deep learning supports a third archaic introgression in Asia and Oceania
2019-01-16
0.17
Energetic equivalence underpins the size structure of tree and phytoplankton communities
2019-01-16
0.13
Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts
2019-01-10
0.01
Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions
2019-01-08
0.27
Selective single molecule sequencing and assembly of a human Y chromosome of African origin
2019-01-02
0.19
A virus-encoded type I interferon decoy receptor enables evasion of host immunity through cell-surface binding
2018-12-21
0.25
Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
2018-12-17
0.06
Functional biodiversity loss along natural CO gradients
2018-12-11
0.14
Transcription factor DUO1 generated by neo-functionalization is associated with evolution of sperm differentiation in plants
2018-12-11
0.08
Long distance electron transfer through the aqueous solution between redox partner proteins
2018-12-04
0.19
Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division
2018-11-30
0.38
A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25
2018-11-26
0.13
Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility
2018-11-16
0.02
A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity
2018-11-15
0.02
Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
2018-11-15
0.02
A common genetic mechanism underlies morphological diversity in fruits and other plant organs
2018-11-09
0.06
Overexpression of the vascular brassinosteroid receptor BRL3 confers drought resistance without penalizing plant growth
2018-11-08
0.32
Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity
2018-11-07
0.01
Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex
2018-10-31
0.04
3D virtual reconstruction of the Kebara 2 Neandertal thorax
2018-10-30
0.29
Mycoplasma genitalium adhesin P110 binds sialic-acid human receptors
2018-10-26
0.43
Structural basis for arginine glycosylation of host substrates by bacterial effector proteins
2018-10-16
0.04
Cortical population activity within a preserved neural manifold underlies multiple motor behaviors
2018-10-12
0.04
A rapid rate of sex-chromosome turnover and non-random transitions in true frogs
2018-10-05
0.05
Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder
2018-10-03
0.02
Intracellular nucleosomes constrain a DNA linking number difference of −1.26 that reconciles the Lk paradox
2018-09-28
1
A rationally designed JAZ subtype-selective agonist of jasmonate perception
2018-09-07
0.17
RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation
2018-09-05
0.16
The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function
2018-08-24
0.02
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
2018-08-24
0.01
Phylogenomics uncovers early hybridization and adaptive loci shaping the radiation of Lake Tanganyika cichlid fishes
2018-08-08
0.04
6 0.09
2 0.06
5 0.26
3 0.41
7 0.38
4 0.82
13 3.19
34 6.14
10 2.02
11 1.04
13 1.52
4 0.24
7 1.97
4 1.82
8 2.47
17 4
Chemistry 243 54.92

Highlight of the month

Alzheimer’s disrupts birth of new brain cells

© Viaframe/Getty

© Viaframe/Getty

Neuroscientists have found evidence that new brain cells are continually being formed in the brain region known as the hippocampus, but that Alzheimer’s disease disrupts this process. This finding could open up new ways to fight memory loss induced by the disease.

The hippocampus, situated squarely in the middle of your grey matter, is mainly associated with memory. Amazingly, it can grow new brain cells in a process called adult hippocampal neurogenesis (AHN).

Recently, researchers at the Spanish National Research Council used improved methods for visualizing immature neurons to show that the hippocampal neurons of healthy human brains are in varying stages of maturation, but that maturation of these cells declined with advancing Alzheimer’s.

Since the inhibition of AHN by Alzheimer’s may be connected with memory retention loss, further research could uncover ways to combat Alzheimer’s inhibition of AHN and thereby curb its destructive effects on memory retention.

Supported content

  1. Nature Medicine 25, 554–560 (2019). doi: 10.1038/s41591-019-0375-9

View the article on the Nature Index

See more research highlights from Spanish National Research Council (CSIC)

More research highlights from Spanish National Research Council (CSIC)

1 August 2018 - 31 July 2019

International vs. domestic collaboration by FC

  • 28.82% Domestic
  • 71.18% International

Note: Hover over the graph to view the percentage of collaboration.

Note: Collaboration is determined by the fractional count (FC), which is listed in parentheses.

Affiliated joint institutions and consortia

Return to institution outputs