Spanish National Research Council (CSIC)
Consejo Superior de Investigaciones Científicas (CSIC)

Spain

The CSIC (Spanish National Research Council) is the largest and leading public research institution in Spain and the third in Europe due to the quality and quantity of its scientific production. It plays an essential role within the Spanish System for Science, Technology and Innovation and contributes to reinforce Spain’s position at the international level.

CSIC’s main aim is to develop and promote scientific studies to contribute to foster scientific and technological progress. CSIC's mission includes:

  1. Multidisciplinary scientific and technical research
  2. Scientific and technical advice
  3. Transferring results to the private sector
  4. Contributing to the creation of technology-driven companies
  5. Training specialised personnel
  6. Management of infrastructure and large facilities
  7. Promoting scientific culture

The CSIC is multidisciplinary, carrying out research in almost all fields of knowledge. Its activities encompass basic research all the way through to technological development.

The CSIC is present in all the autonomous regions through their centres across Spain. It comprises 120 centres spread across Spain, and is also present in Brussels and Rome. It is formed by employees with a wide range of academic qualifications and professional categories. The CSIC employs 11,000 people, of which 3.000 are researchers. In total, they represent the 6% of Spain’s R&D workforce and generate approximately the 20% of the country’s production. Likewise, the CSIC collaborates with other juridical entities such as consortia and trading companies.

For more information on job opportunities at CSIC, please check our Nature Careers Employer Profile.

CSIC retains sole responsibility for content © 2021 Spanish National Research Council.

1 June 2020 - 31 May 2021

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for Spanish National Research Council (CSIC) published between 1 June 2020 - 31 May 2021 which are tracked by the Nature Index.

Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

Count Share
1267 226.83

Outputs by subject (Share)

Subject Count Share
Physical Sciences 617 99.77
Chemistry 286 60.54
Life Sciences 376 61.38
4 0.13
5 0.44
2 0.04
1 0.01
1 0.64
15 3.17
4 0.81
7 1.18
4 0.37
7 1.29
5 1.61
3 0.16
2 0.10
4 0.92
1 0.29
7 0.24
11 0.44
1 0
2 0.09
90 11.13
Restoration of energy homeostasis by SIRT6 extends healthy lifespan
2021-05-28
0.01
Spatially explicit analysis identifies significant potential for bioenergy with carbon capture and storage in China
2021-05-26
0.01
Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase
2021-05-25
0.03
Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures
2021-05-25
0.28
Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
2021-05-25
0.27
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology
2021-05-21
0
Plant DNA polymerases α and δ mediate replication of geminiviruses
2021-05-13
0.07
Feeding-induced resistance to acute lethal sepsis is dependent on hepatic BMAL1 and FXR signalling
2021-05-12
0.03
Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO
2021-05-11
0.01
Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections
2021-05-11
0.18
Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities
2021-05-11
0.04
Tracking the global reduction of marine traffic during the COVID-19 pandemic
2021-04-27
0.06
Non-structural carbohydrates mediate seasonal water stress across Amazon forests
2021-04-19
0
Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics
2021-04-14
0
Human-lineage-specific genomic elements are associated with neurodegenerative disease and transcript usage
2021-04-06
0.04
An ecological approach to structural flexibility in online communication systems
2021-03-29
0.14
A molecular timescale for eukaryote evolution with implications for the origin of red algal-derived plastids
2021-03-25
0.13
Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity
2021-03-25
0.03
Pili allow dominant marine cyanobacteria to avoid sinking and evade predation
2021-03-25
0.04
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease
2021-03-25
0.13
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
2021-03-22
0.11
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies
2021-03-17
0.22
Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment
2021-03-08
0.04
Flexible categorization in perceptual decision making
2021-02-24
0.13
Local computational methods to improve the interpretability and analysis of cryo-EM maps
2021-02-23
0.11
The evolution of critical thermal limits of life on Earth
2021-02-19
0.03
Fecal microbiota transplantation in HIV: A pilot placebo-controlled study
2021-02-18
0.01
Seasonal biological carryover dominates northern vegetation growth
2021-02-12
0.03
Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase
2021-02-11
0.35
Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
2021-02-11
0.22
Genetics of nodulation in uncovers mechanisms of the rhizobium–legume symbiosis
2021-02-05
0.06
Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
2021-01-28
0.12
A population-based controlled experiment assessing the epidemiological impact of digital contact tracing
2021-01-26
0.02
Sarcoma classification by DNA methylation profiling
2021-01-21
0
Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
2021-01-18
0.07
Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase
2021-01-15
0.04
Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice
2021-01-13
0.02
Contextual dependencies expand the re-usability of genetic inverters
2021-01-13
0.40
H2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspots
2021-01-12
0.11
Graphene active sensor arrays for long-term and wireless mapping of wide frequency band epicortical brain activity
2021-01-11
0.19
Earliest Olduvai hominins exploited unstable environments ~ 2 million years ago
2021-01-07
0.02
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
2021-01-04
0.39
In vivo diversification of target genomic sites using processive base deaminase fusions blocked by dCas9
2020-12-22
0.88
Quantifying and addressing the prevalence and bias of study designs in the environmental and social sciences
2020-12-11
0.05
Donkey genomes provide new insights into domestication and selection for coat color
2020-12-08
0
TGFβ promotes widespread enhancer chromatin opening and operates on genomic regulatory domains
2020-12-03
0.20
Dispersal-induced instability in complex ecosystems
2020-11-27
0.25
Large deep-sea zooplankton biomass mirrors primary production in the global ocean
2020-11-27
0.11
Viral Bcl2s’ transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis
2020-11-27
0.29
Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells
2020-11-25
0.11
Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain
2020-11-20
0.33
Consistent population declines but idiosyncratic range shifts in Alpine orchids under global change
2020-11-17
0.14
Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
2020-11-17
0.03
Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis
2020-11-16
0.14
Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
2020-11-12
0.19
Bryophytes are predicted to lag behind future climate change despite their high dispersal capacities
2020-11-05
0.10
Presence of low virulence chytrid fungi could protect European amphibians from more deadly strains
2020-10-26
0.02
Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells
2020-10-16
0.11
Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae
2020-10-14
0.24
Andean drought and glacial retreat tied to Greenland warming during the last glacial period
2020-10-12
0.08
Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies
2020-10-08
0.05
In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition
2020-10-07
0.08
Overestimation of the effect of climatic warming on spring phenology due to misrepresentation of chilling
2020-10-02
0.04
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
2020-10-02
0.03
Thioglycoligase derived from fungal GH3 β-xylosidase is a multi-glycoligase with broad acceptor tolerance
2020-09-25
0.83
VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
2020-09-22
0.27
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
2020-09-21
0
The influence of soil age on ecosystem structure and function across biomes
2020-09-18
0.07
Integrated microbiota and metabolite profiles link Crohn’s disease to sulfur metabolism
2020-08-28
0.04
Sex differences in oncogenic mutational processes
2020-08-28
0
Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
2020-08-25
0.26
An excess of niche differences maximizes ecosystem functioning
2020-08-21
0.13
An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
2020-08-20
0.03
A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
2020-08-12
0.06
Within-individual phenotypic plasticity in flowers fosters pollination niche shift
2020-08-11
0.31
Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis
2020-08-07
0.33
Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders
2020-08-06
0.06
Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton gradient and chromosome organization
2020-08-04
0.03
Ancient genomes in South Patagonia reveal population movements associated with technological shifts and geography
2020-08-03
0.04
Gradual polyploid genome evolution revealed by pan-genomic analysis of Brachypodium hybridum and its diploid progenitors
2020-07-29
0.02
Astrocytes modulate sensory-evoked neuronal network activity
2020-07-23
0.20
Coordinate β-adrenergic inhibition of mitochondrial activity and angiogenesis arrest tumor growth
2020-07-17
0.19
Pathways for horizontal gene transfer in bacteria revealed by a global map of their plasmids
2020-07-17
0.21
Meta-analysis of multidecadal biodiversity trends in Europe
2020-07-13
0.04
Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
2020-07-13
0.05
The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function
2020-07-13
0.01
IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
2020-07-07
0.12
Hydrolase–like catalysis and structural resolution of natural products by a metal–organic framework
2020-06-17
0.08
Ultrafast photochemistry produces superbright short-wave infrared dots for low-dose in vivo imaging
2020-06-10
0.05
Interpreting molecular similarity between patients as a determinant of disease comorbidity relationships
2020-06-05
0.05
5 0.37
4 0.03
3 0.91
1 0.03
9 1.89
13 3.55
46 6.12
14 3.88
16 1.07
31 7.93
4 0.21
12 2.91
10 2.74
5 2.12
27 4.58
Earth & Environmental Sciences 141 27.29

Highlight of the month

Astrocyte signalling linked to goal-directed behaviours

© JUAN GAERTNER/SCIENCE PHOTO LIBRARY/Getty Images

© JUAN GAERTNER/SCIENCE PHOTO LIBRARY/Getty Images

Support cells in the brain can affect goal-directed behaviours by interacting with inhibitory nerve cells, a finding that could lead to new treatments for neurological and psychiatric disorders.

Decision making during goal-directed behaviours involves weighing up the costs and benefits of each option. While various regions of the brain are involved in this assessment, the prefrontal provides critical support. The interplay between inhibitory and excitatory neurons in this region is well documented. But how astrocytes, a type of star-shaped supporting cell in the brain, interact with some of these same neurons was poorly understood.

Now, a mouse study led by scientists at the Spanish National Research Council has shown that receptors on astrocytes can sense neurotransmitters released by inhibitory neurons. The astrocytes, in turn, change the electrical firing properties of nearby excitatory neurons in the medial prefrontal cortex, altering brain waves that affect decision making and associated behaviours.

Supported content

  1. Nature Neuroscience 24, 82–92 (2021). doi: 10.1038/s41593-020-00752-x

View the article on the Nature Index

See more research highlights from Spanish National Research Council (CSIC)

More research highlights from Spanish National Research Council (CSIC)

1 June 2020 - 31 May 2021

International vs. domestic collaboration by Share

  • 41.96% Domestic
  • 58.04% International

Note: Hover over the graph to view the percentage of collaboration.

Top 10 domestic collaborators by Share (336 total)

  • Spanish National Research Council (CSIC), Spain
  • Domestic institution
  1. Autonomous University of Madrid (UAM), Spain (69.57)
    34.18
    35.39
  2. Institute for Corpuscular Physics (IFIC), Spain (57.86)
    19.97
    37.90
  3. University of Valencia (UV), Spain (54.53)
    26.65
    27.88
  4. Institute for Theoretical Physics (IFT), Spain (48.52)
    17.24
    31.28
  5. University of the Basque Country (UPV/EHU), Spain (39.27)
    13.21
    26.06
  6. University of Barcelona (UB), Spain (37.20)
    17.20
    19.99
  7. Complutense University of Madrid (UCM), Spain (32.81)
    17.36
    15.45
  8. Institute of Health Carlos III (ISCIII), Spain (27.09)
    13.50
    13.60
  9. University of Zaragoza (Unizar), Spain (24.89)
    14.04
    10.85
  10. Barcelona Institute of Science and Technology (BIST), Spain (24.23)
    10.75
    13.47

Note: Collaboration is determined by the fractional count (Share), which is listed in parentheses.

Affiliated joint institutions and consortia

Return to institution outputs