Spanish National Research Council (CSIC)
Consejo Superior de Investigaciones Científicas (CSIC)


The CSIC (Spanish National Research Council) is the largest and leading public research institution in Spain and the third in Europe due to the quality and quantity of its scientific production. It plays an essential role within the Spanish System for Science, Technology and Innovation and contributes to reinforce Spain’s position at the international level.

CSIC’s main aim is to develop and promote scientific studies to contribute to foster scientific and technological progress. CSIC's mission includes:

  1. Multidisciplinary scientific and technical research
  2. Scientific and technical advice
  3. Transferring results to the private sector
  4. Contributing to the creation of technology-driven companies
  5. Training specialised personnel
  6. Management of infrastructure and large facilities
  7. Promoting scientific culture

The CSIC is multidisciplinary, carrying out research in almost all fields of knowledge. Its activities encompass basic research all the way through to technological development.

The CSIC is present in all the autonomous regions through their centres across Spain. It comprises 120 centres spread across Spain, and is also present in Brussels and Rome. It is formed by employees with a wide range of academic qualifications and professional categories. The CSIC employs 11,000 people, of which 3.000 are researchers. In total, they represent the 6% of Spain’s R&D workforce and generate approximately the 20% of the country’s production. Likewise, the CSIC collaborates with other juridical entities such as consortia and trading companies.

For more information on job opportunities at CSIC, please check our Nature Careers Employer Profile.

CSIC retains sole responsibility for content © 2021 Spanish National Research Council.

1 May 2020 - 1 April 2021

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for Spanish National Research Council (CSIC) published between 1 May 2020 - 1 April 2021 which are tracked by the Nature Index.

Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

Count Share
1283 227.62

Outputs by subject (Share)

Subject Count Share
Physical Sciences 625 99.32
Earth & Environmental Sciences 146 27.45
Life Sciences 368 60.62
4 0.13
5 0.44
3 0.05
1 0.14
3 0.10
1 0.64
15 3.17
3 0.78
7 1.24
1 0.25
4 0.37
8 1.37
5 1.61
3 0.16
1 0.03
4 0.92
1 0.29
6 0.06
12 0.44
1 0
2 0.09
84 11.98
2 0.08
4 0.03
3 0.91
1 0.03
7 1.03
15 3.88
49 6.50
11 3.57
15 1.06
29 6.96
5 0.30
11 2.83
10 2.74
4 1.83
28 4.63
Chemistry 297 62.59

Highlight of the month

Prion-like protein forms fibrils in solution



An aggregate-forming protein implicated in various neurodegenerative diseases forms fibrils in solution, suggesting it has a natural tendency to arrange into fibrils over a wide range of conditions.

Many neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, involve aggregates such as fibrils formed by misfolded proteins known as prion-like proteins. These proteins can confer their abnormal structure to adjacent proteins, resulting in the spread of aggregates in the brain.

Now, a team led by scientists from the Spanish National Research Council has found that one such prion-like protein called TDP-43 forms droplets when put in a solution of pH 4. They also observed visual evidence for the formation of fibrils at the surfaces of these droplets but not in their interiors.

Since these observations were made in the absence of salts or RNAs, they suggest that TDP-43 can form aggregates over a wide range of conditions without any external inducement.

Supported content

  1. PLoS Biology 19, e3001198 (2021) doi: 10.1371/journal.pbio.3001198

View the article on the Nature Index

See more research highlights from Spanish National Research Council (CSIC)

More research highlights from Spanish National Research Council (CSIC)

1 May 2020 - 1 April 2021

International vs. domestic collaboration by Share

  • 41.83% Domestic
  • 58.17% International

Note: Hover over the graph to view the percentage of collaboration.

Top 10 domestic collaborators by Share (329 total)

  • Spanish National Research Council (CSIC), Spain
  • Domestic institution
  1. Autonomous University of Madrid (UAM), Spain (66.87)
  2. Institute for Corpuscular Physics (IFIC), Spain (61.16)
  3. University of Valencia (UV), Spain (56.88)
  4. Institute for Theoretical Physics (IFT), Spain (46.25)
  5. University of the Basque Country (UPV/EHU), Spain (41.37)
  6. University of Barcelona (UB), Spain (36.96)
  7. Complutense University of Madrid (UCM), Spain (35.03)
  8. Institute of Health Carlos III (ISCIII), Spain (26.34)
  9. University of Zaragoza (Unizar), Spain (26.06)
  10. Barcelona Institute of Science and Technology (BIST), Spain (24.39)

Note: Collaboration is determined by the fractional count (Share), which is listed in parentheses.

Affiliated joint institutions and consortia

Return to institution outputs