University of Cape Town (UCT)
Universiteit van Kaapstad
South Africa
Research Highlights and Innovations 2019-2020
The University of Cape Town’s (UCT) geographical vantage point at the tip of Africa offers an exhilarating research environment that combines excellence with impact.
As a leading research university, UCT is one of the best places in the world to research Africa-specific problems, from the chemistry of malarial drug discovery to the development of urban Africa. We have strong collaborative networks across the globe and often form a nexus of partnerships between researchers in the global north and global south, particularly Africa. UCT is the first university in Africa to join the International Alliance of Research Universities. It is therefore not surprising that we attract researchers — from postgraduates and postdoctoral fellows to leaders in their field — from all over the continent and the world.
Healthcare for Africa
In a country that faces four epidemics, where most countries only have one or two, UCT has developed expertise in addressing healthcare in Africa. The Institute of Infectious Disease and Molecular Medicine and the Drug Discovery and Development Centre have produced ground-breaking research, particularly in the areas of HIV, TB and malaria. The Wellcome Centre for Infectious Diseases Research in Africa is the first of its kind in Africa.
Climate and development
UCT has extensive interdisciplinary expertise in conservation, climate adaptation and community conflict. The AXA Research Fund awarded its first research chair in Africa to the director of the African Climate & Development Initiative, a leading research group. The Future Water Institute builds on UCT’s substantial research footprint in water and encompasses the skills and resources of departments across six faculties. UCT also hosts two Centres of Excellence under the African Research Universities Alliance, which draw together expertise from across the continent: the African Centre of Excellence for Inequalities Research and the Centre of Excellence in Climate and Development.
Experts in the southern skies
Through its global experts in the field, such as Professor George Ellis who co-wrote The Large Scale Structure of Space-Time with Stephen Hawking, and leading role in the Square Kilometre Array, UCT is a growing hub for astronomical and astrophysics research in Africa. Professor Russ Taylor is heading up the university’s involvement in the Square Kilometre Array project and the big-data challenges it brings.
UCT’s latest research
UCT’s research magazine, Research Highlights and Innovations 2019-2020, features research stories from across the university, as does its research and innovation news site.
University of Cape Town retains sole responsibility for content © 2021 University of Cape Town.
1 December 2019 - 30 November 2020
Region: Global
Subject/journal group: All
The table to the right includes counts of all research outputs for University of Cape Town (UCT) published between 1 December 2019 - 30 November 2020 which are tracked by the Nature Index.
Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.
Note: Articles may be assigned to more than one subject area.
Count | Share |
---|---|
165 | 17.06 |
Outputs by subject (Share)
Subject | Count | Share | |
---|---|---|---|
Life Sciences | 63 | 7.25 | |
Earth & Environmental Sciences | 30 | 5.44 | |
Physical Sciences | 84 | 3.59 | |
Chemistry | 9 | 2.84 | |
Angewandte Chemie International Edition | 1 | 0.04 | |
Inorganic Chemistry | 3 | 1.89 | |
Nature Communications | 5 | 0.91 |
Highlight of the month
Tuberculosis drug targets take shape
© STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY/Getty Images
The identification of essential genes in a tuberculosis-like bacterium could speed the development of new drugs for the deadly infectious disease.
Five researchers, all at the University of Cape Town, used microscopic imaging in combination with a CRISPR-based gene-perturbation technique to analyse several hundred genes of unknown function in a close relative of the bacterium that causes tuberculosis
The scientists found that many of these genes, when mutated, alter the shape and form of the bacteria in ways that cripple its growth. Computational methods allowed them to infer likely roles for the genes, any number of which could be targeted therapeutically.
Many of the same morphological defects observed in bacteria with perturbed genes were also seen in microbes exposed to pharmaceutical agents. The same approach now provides a comparative platform for exploring the mode of action of experimental tuberculosis treatments.
- eLife 9, e60083 (2020). doi: 10.7554/eLife.60083
See more research highlights from University of Cape Town (UCT)
More research highlights from University of Cape Town (UCT)
Top articles by Altmetric score in current window
Genome-wide analyses reveal drivers of penguin diversification.
Proceedings of the National Academy of Sciences of the United States of America
2020-08-17
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
Nature Communications
2020-09-04
1 December 2019 - 30 November 2020
International vs. domestic collaboration by Share
- 8.36% Domestic
- 91.64% International
Note: Hover over the graph to view the percentage of collaboration.
Top 10 domestic collaborators by Share (42 total)
- University of Cape Town (UCT), South Africa
- Domestic institution
-
University of the Witwatersrand, Johannesburg (Wits University), South Africa
(1.78)
-
National Health Laboratory Service (NHLS), South Africa
(1.71)
-
South African Medical Research Council (SAMRC), South Africa
(1.69)
-
Department of Science and Technology (DST), South Africa
(1.59)
-
NRF South African Environmental Observation Network (SAEON), South Africa
(1.46)
-
South African National Biodiversity Institute (SANBI), South Africa
(1.41)
-
Stellenbosch University (SU), South Africa
(1.15)
-
North-West University (NWU), South Africa
(1.13)
-
Nelson Mandela University (NMU), South Africa
(1.10)
-
South African Astronomical Observatory (SAAO), South Africa
(1.07)
Top 10 international collaborators by Share (2145 total)
- University of Cape Town (UCT), South Africa
- Foreign institution
-
National Institute for Nuclear Physics (INFN), Italy
(4.56)
-
The Hong Kong University of Science and Technology (HKUST), China
(4.49)
-
French National Centre for Scientific Research (CNRS), France
(3.59)
-
University of Washington (UW), United States of America (USA)
(3.04)
-
European Organization for Nuclear Research (CERN), Switzerland
(2.98)
-
University of Oxford, United Kingdom (UK)
(2.47)
-
Max Planck Society, Germany
(2.20)
-
National Institutes of Health (NIH), United States of America (USA)
(2.02)
-
UCL, United Kingdom (UK)
(1.95)
-
Helmholtz Association of German Research Centres, Germany
(1.90)
Note: Collaboration is determined by the fractional count (Share), which is listed in parentheses.
Affiliated joint institutions and consortia
- ALICE Collaboration, Switzerland
- Centre for the AIDS Programme of Research in South Africa (CAPRISA), South Africa
- Centre for the Study of Antimicrobial Resistance (CAMRA), South Africa
- Collaboration for AIDS Vaccine Discovery (CAVD), United States of America (USA)
- Comprehensive International Program of Research on AIDS (CIPRA), South Africa
- DST-NRF Centre of Excellence for Biomedical Tuberculosis Research (CBTBR), South Africa
- DST-NRF Centre of Excellence in Catalysis in South Africa (c*change), South Africa
- DST-NRF Centre of Excellence in Mathematical and Statistical Sciences (CoE-MaSS), South Africa
- DST-NRF Centre of Excellence in Palaeosciences (CoE-Pal), South Africa
- DST/NRF Centre of Excellence in Birds as Keys to Biodiversity Conservation, South Africa
- Functional Annotation of the Mammalian Genome (FANTOM), Japan
- Groote Schuur Hospital (GSH), South Africa
- International Centre for Education, Marine and Atmospheric Sciences over Africa (ICEMASA), South Africa
- MRC Unit on Risk and Resilience in Mental Disorders, South Africa
- MRC-UCT Gynecological Cancer Research Centre, South Africa
- More Medicines for Tuberculosis (MM4TB), Switzerland
- Nansen-Tutu Centre for Marine Environmental Research, South Africa
- Organization for Tropical Studies (OTS), United States of America (USA)
- SAMRC Risk and Resilience in Mental Disorders Research Unit, South Africa

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