Tokyo Medical and Dental University (TMDU)
東京医科歯科大学

Japan

With a history and track record of close coordination between the medical and dental fields as the cornerstone, TMDU contributes to human health and the well-being of society by fostering outstanding healthcare professionals with a humane and global outlook.

Tokyo Medical and Dental University was established as a national medical and dental educational institution on October 12, 1928, and currently located in the Yushima/Shoheizaka area of Tokyo, which is considered sacred ground for scholarship and learning in Japan. Since then, as Japan’s only comprehensive medical university and graduate school, TMDU has provided advanced medical treatment through a fusion of the medical and dental fields and worked to cultivate “professionals with knowledge and humanity,” thereby contributing to human health and the well-being of society. The “knowledge” referenced here includes learning, technology, and self-identity, while “humanity” means culture, sensitivity, and communication ability that accepts diversity. We believe that the fusion of these elements paves the way to becoming a true “professional.”

TMDU comprises the Faculty of Medicine, consisting of the School of Medicine and School of Health Care Sciences; the Faculty of Dentistry, consisting of the School of Dentistry and School of Oral Health Care Sciences; the College of Liberal Arts and Sciences; the Graduate School of Medical and Dental Sciences; the Graduate School of Health Care Sciences; the Institute of Biomaterials and Bioengineering; and the Medical Research Institute. TMDU aims to make wide-ranging contributions to society by training physicians, dentists, nurses, clinical laboratory technicians, dental hygienists, and dental technicians, who combine a desire to heal and a scientific outlook; working to nurture outstanding researchers and medical practitioners; and building research and academic systems in the medical and life science fields.

Medical technology is advancing rapidly, and TMDU, home to the oldest faculty of dentistry and the first school of health care sciences at a Japanese national university, has always been a pioneer in medical and dental education and research. Building on this experience, TMDU has assembled an outstanding faculty, unmatched facilities, and an excellent curriculum in the medical and dental fields, in order to train graduates who can flourish on the world stage through the combination of a broad education, a rich sensibility, high ethical standards, creativity and boldness to make their own decisions, an international outlook, and leadership ability.

The Tokyo Medical and Dental University retains sole responsibility for content. © 2018 Tokyo Medical and Dental University.

1 November 2017 - 31 October 2018

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for Tokyo Medical and Dental University (TMDU) published between 1 November 2017 - 31 October 2018 which are tracked by the Nature Index.

Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

AC FC
54 16.70

Outputs by subject (FC)

Subject AC FC
Life Sciences 43 10.32
Chemistry 10 6.11
3 2.94
5 2.53
1 0.04
1 0.60
Physical Sciences 3 0.53

Highlight of the month

How tumours keep their metabolic state

© E GSCHMEISSNER/Getty

© E GSCHMEISSNER/Getty

Tumours derive most of their energy by metabolizing sugar in a process called glycolysis, which healthy cells typically use only when oxygen levels are low. A team has shown that cancer cells silence a critical enzyme involved in the usual aerobic energy-producing pathway to help ensure glycolysis remains active all the time.

The team led by scientists from Tokyo Medical and Dental University found that breast cancer cells cultured for long periods in a state of reduced oxygen produced lower levels of a particular subunit of pyruvate dehydrogenase, an enzyme involved in kicking off aerobic metabolism. Levels of that subunit stayed down even after the cells returned to a normal oxygen environment, helping explain why cancers display this aberrant metabolic activity, known as the Warburg effect.

Surprisingly, however, experimentally blocking the subunit led to reduced cell progression, while elevating its expression promoted cancer growth in mice, casting doubt on the supposition that the Warburg effect always creates a favourable metabolic state for tumours.

Supported content

  1. Cancer Research 78, 1592–1603 (2018). doi: 10.1158/0008-5472.CAN-17-1751

View the article on the Nature Index

See more research highlights from Tokyo Medical and Dental University (TMDU)

More research highlights from Tokyo Medical and Dental University (TMDU)

1 November 2017 - 31 October 2018

International vs. domestic collaboration by FC

  • 73.11% Domestic
  • 26.89% International

Note: Hover over the graph to view the percentage of collaboration.

Top 10 domestic collaborators by FC (79 total)

  • Tokyo Medical and Dental University (TMDU), Japan
  • Domestic institution
  1. The University of Tokyo (UTokyo), Japan (10.78)
    3.03
    7.75
  2. RIKEN, Japan (5.58)
    2.84
    2.74
  3. Kyushu University, Japan (3.29)
    2.73
    0.56
  4. Kyoto University, Japan (2.88)
    1.65
    1.23
  5. Nagoya University, Japan (1.78)
    1.16
    0.62
  6. National Cancer Center (NCC), Japan (1.68)
    0.60
    1.08
  7. Keio University, Japan (1.64)
    0.65
    0.99
  8. National Institute of Advanced Industrial Science and Technology (AIST), Japan (1.50)
    1.08
    0.42
  9. Osaka University, Japan (1.46)
    0.56
    0.90
  10. Hiroshima University (HU), Japan (1.40)
    0.35
    1.05

Note: Collaboration is determined by the fractional count (FC), which is listed in parentheses.

Affiliated joint institutions and consortia

Return to institution outputs