Tokyo Medical and Dental University (TMDU)


With a history and track record of close coordination between the medical and dental fields as the cornerstone, TMDU contributes to human health and the well-being of society by fostering outstanding healthcare professionals with a humane and global outlook.

Tokyo Medical and Dental University was established as a national medical and dental educational institution on October 12, 1928, and currently located in the Yushima/Shoheizaka area of Tokyo, which is considered sacred ground for scholarship and learning in Japan. Since then, as Japan’s only comprehensive medical university and graduate school, TMDU has provided advanced medical treatment through a fusion of the medical and dental fields and worked to cultivate “professionals with knowledge and humanity,” thereby contributing to human health and the well-being of society. The “knowledge” referenced here includes learning, technology, and self-identity, while “humanity” means culture, sensitivity, and communication ability that accepts diversity. We believe that the fusion of these elements paves the way to becoming a true “professional.”

TMDU comprises the Faculty of Medicine, consisting of the School of Medicine and School of Health Care Sciences; the Faculty of Dentistry, consisting of the School of Dentistry and School of Oral Health Care Sciences; the College of Liberal Arts and Sciences; the Graduate School of Medical and Dental Sciences; the Graduate School of Health Care Sciences; the Institute of Biomaterials and Bioengineering; and the Medical Research Institute. TMDU aims to make wide-ranging contributions to society by training physicians, dentists, nurses, clinical laboratory technicians, dental hygienists, and dental technicians, who combine a desire to heal and a scientific outlook; working to nurture outstanding researchers and medical practitioners; and building research and academic systems in the medical and life science fields.

Medical technology is advancing rapidly, and TMDU, home to the oldest faculty of dentistry and the first school of health care sciences at a Japanese national university, has always been a pioneer in medical and dental education and research. Building on this experience, TMDU has assembled an outstanding faculty, unmatched facilities, and an excellent curriculum in the medical and dental fields, in order to train graduates who can flourish on the world stage through the combination of a broad education, a rich sensibility, high ethical standards, creativity and boldness to make their own decisions, an international outlook, and leadership ability.

The Tokyo Medical and Dental University retains sole responsibility for content. © 2018 Tokyo Medical and Dental University.

1 March 2017 - 28 February 2018

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for Tokyo Medical and Dental University (TMDU) published between 1 March 2017 - 28 February 2018 which are tracked by the Nature Index.

Hover over the donut graph to view the WFC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

49 16.46 16.46

Outputs by subject (WFC)

Subject AC FC WFC
Chemistry 12 8.24 8.24
Life Sciences 36 8.10 8.10
Physical Sciences 1 0.13 0.13

Highlight of the month

The toxic trail of tau

© Andrew Brookes/Cultura/Getty

© Andrew Brookes/Cultura/Getty

Only some people with frontotemporal dementia (FTD) have clumps of tau in their brains — but the toxic protein seems to help drive the disease even in the absence of tau tangles.

A Japanese team led by researchers at the Tokyo Medical and Dental University created a mouse model of FTD that doesn’t develop tau aggregates. Instead, because they lack a key gene called progranulin, these mice form brain deposits of another protein called TDP-43.

However, that gene, it turns out, is also needed for proper localization of tau in the brain.

Without progranulin, tau ends up in neuronal protrusions known as dendritic spines. This causes the spines to die off, leading to cognitive impairments that are independent of later TDP-43 aggregation. Blocking the signalling pathway that leads to tau mislocalization helped stop spine loss and reversed memory deficits.

Post-mortem brain tissue taken from people who had TDP-43–associated FTD also showed signs of tau accumulation in dendritic spines, indicating that a similar therapeutic strategy could help treat patients with the disease.

Supported content

  1. Nature Communications 9, 433 (2018). doi: 10.1038/s41467-018-02821-z

View the article on the Nature Index

See more research highlights from Tokyo Medical and Dental University (TMDU)

More research highlights from Tokyo Medical and Dental University (TMDU)

1 March 2017 - 28 February 2018

International vs. domestic collaboration by WFC

  • 70.26% Domestic
  • 29.74% International

Note: Hover over the graph to view the percentage of collaboration.

Top 10 domestic collaborators by WFC (72 total)

  • Tokyo Medical and Dental University (TMDU), Japan
  • Domestic institution
  1. The University of Tokyo (UTokyo), Japan (8.84)
  2. RIKEN, Japan (3.29)
  3. Kyushu University, Japan (2.94)
  4. Osaka University, Japan (2.26)
  5. Kyoto University, Japan (2.22)
  6. Nagoya City University, Japan (1.84)
  7. Keio University, Japan (1.55)
  8. Japanese Foundation for Cancer Research (JFCR), Japan (1.43)
  9. Tokyo University of Science (TUS), Japan (1.37)
  10. Nagoya University, Japan (1.11)

Note: Collaboration is determined by the weighted fractional count (WFC), which is listed in parentheses.

Affiliated joint institutions and consortia

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