The University of Wollongong (UOW)

Australia

At UOW we recognise that the search for solutions to the world’s challenges must be a global one. That’s why we have established an international network of campuses, partners and bright minds to foster a supportive research community that drives real change.

Our research priorities are working tirelessly to solve complex, real-world problems. We’ve discovered human ancestors, partnered with NASA to find clues to climate change, collaborated with Twitter to manage monsoon flooding, built a bionic bra from intelligent fabrics and invested in a Titan Krios cryo-electron microscope that will allow us to move from developing treatments to finding cures.

UOW’s strategic research initiative, the Global Challenges Program, provides a distinctive environment for collaborative challenge-led research to ultimately transform lives and regions. It encourages and develops creative and community-engaged research that helps drive social, economic and cultural change in our region, with the potential to be translatable across the globe.

UOW’s strong research partnerships with world-renowned organisations and industry work towards building a sustainable and equitable future for the 21st century. Through engagement, UOW builds bridges between academics, businesses and researchers and is working with our partners to grow the Illawarra’s innovation ecosystem and pursue the uptake of disruptive technologies that deliver positive economic impacts.

Our Innovation Campus (IC) is a world-class, award-winning research and commercial precinct, home to a number of UOW’s leading research institutes working on developing “intelligent” innovative materials; superconductors that make energy transmission more efficient, new techniques for sustainable building design and maritime law and security. IC is also home to iAccelerate, a purpose-built business incubator and accelerator, with its two-stream program being the first of its kind in Australia. iAccelerate supports students, staff and the greater Illawarra community by providing the infrastructure, mentoring and education programs for great ideas to grow and helps connect entrepreneurs with funding opportunities.

UOW is proud to be among the best modern universities in the world. Throughout our 42 years as an independent university, we’ve built an international reputation for world-class research and exceptional teaching quality. UOW is consistently ranked in the top 1% of universities in the world for the quality of our graduates, ranking 151-200 in the 2017 QS Graduate Employability Rankings. UOW is also ranked as the 17th best modern university in the world by QS Top 50 Under 50 2018.

UOW retains sole responsibility for content © 2017 University of Wollongong.

1 May 2017 - 30 April 2018

Region: Global
Subject/journal group: All

The table to the right includes counts of all research outputs for The University of Wollongong (UOW) published between 1 May 2017 - 30 April 2018 which are tracked by the Nature Index.

Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

AC FC
107 27.13

Outputs by subject (FC)

Subject AC FC
Chemistry 46 10.64
Life Sciences 18 5.66
Physical Sciences 58 14.80
Earth & Environmental Sciences 9 1.96

Highlight of the month

Putting a cap on neurodegenerative disease

©JUAN GAERTNER/SCIENCE PHOTO LIBRARY/Getty

©JUAN GAERTNER/SCIENCE PHOTO LIBRARY/Getty

The ‘heat shock protein’ Hsp27 combats neurodegenerative disease by binding to α-synuclein fibrils, fibrous protein structures associated with Alzheimer’s and Parkinson’s diseases, and halting their progression.

Wollongong University’s Heath Ecroyd and a team of Australian and UK scientists found that Hsp27 caps the ends of polymeric α-synuclein fibrils, preventing attachment of additional monomers, and that it binds to the surface of fibrils, reducing their ability to aggregate.

The team also found that Hsp27 binding reduced the cellular toxicity of α-synuclein fibrils, as evidenced by a reduction in reactive oxygen species — damaging, chemically reactive molecules that are implicated in neuronal toxicity.

During testing, Hsp27’s protective abilities failed when there was an overabundance of α-synuclein fibril ‘seeds’. This is an important finding since duplication or triplication of the gene encoding α-synuclein is associated with early onset Parkinson’s disease.

The mechanisms of Hsp27 may represent shared methods of heat shock protein action that may inform the development of future anti-neurodegenerative therapies.

Supported content

  1. Journal of Biological Chemistry 293, 4486–4497 (2018). doi: 10.1074/jbc.M117.813865

View the article on the Nature Index

See more research highlights from The University of Wollongong (UOW)

More research highlights from The University of Wollongong (UOW)

1 May 2017 - 30 April 2018

International vs. domestic collaboration by FC

  • 27.55% Domestic
  • 72.45% International

Note: Hover over the graph to view the percentage of collaboration.

Note: Collaboration is determined by the fractional count (FC), which is listed in parentheses.

Affiliated joint institutions and consortia

Return to institution outputs