United States of America (USA)

1 December 2019 - 30 November 2020

Subject/journal group: All

The table to the right includes counts of all research outputs for United States of America (USA) published between 1 December 2019 - 30 November 2020 which are tracked by the Nature Index.

Hover over the donut graph to view the FC output for each subject. Below, the same research outputs are grouped by subject. Click on the subject to drill-down into a list of articles organized by journal, and then by title.

Note: Articles may be assigned to more than one subject area.

Count Share
28986 20575.61

Outputs by subject (FC)

Subject Count Share
Life Sciences 12951 9608.83
113 68.86
92 74.32
263 209.84
286 222.26
98 73.98
93 64.78
102 81.37
1 1
290 206.53
119 97.31
70 44.50
1 0.44
72 61.25
98 69.18
88 68.97
789 660.54
Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance
2020-11-30
0.17
Biosynthesis of GlcNAc-rich N- and O-glycans in the Golgi apparatus does not require the nucleotide sugar transporter SLC35A3
2020-11-27
0.19
Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2
2020-11-27
1
Rate-limiting pyrophosphate release by hepatitis C virus polymerase NS5B improves fidelity
2020-11-27
1
The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription
2020-11-27
1
A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism
2020-11-26
1
A Second Mechanism Employed by Artemisinins to Suppress Plasmodium Falciparum Hinges on Inhibition of Hematin Crystallization
2020-11-25
1
An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14
2020-11-24
0.17
Deletion of bone marrow myeloperoxidase attenuates chronic kidney disease accelerated atherosclerosis
2020-11-24
1
Separable roles for RanGTP in nuclear and ciliary trafficking of a kinesin-2 subunit
2020-11-24
1
ppGalNAc-T4-catalyzed O-Glycosylation of TGF-β type Ⅱ receptor regulates breast cancer cells metastasis
2020-11-24
0.04
Comparison of human poly-N-acetyl-lactosamine synthase structure with GT-A fold glycosyltransferases supports a modular assembly of catalytic subsites
2020-11-23
1
Structural basis for multifunctional roles of human Ints3 C-terminal domain
2020-11-23
0.65
Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, disease, and mavacamten-treated cardiac systems
2020-11-23
1
RSU-1 interaction with prohibitin-2 links cell-extracellular matrix detachment to down-regulation of extracellular signal-regulated kinase signalling
2020-11-22
0.27
ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway
2020-11-20
1
E3 ubiquitin ligase PARK2, an inhibitor of melanoma cell growth, is repressed by the oncogenic ERK1/2-ELK1 transcriptional axis
2020-11-20
0.29
Metallo-β-Lactamase Domain-Containing Protein 2 (MBLAC2) is S-palmitoylated and exhibits acyl-CoA hydrolase activity
2020-11-20
1
The flexible N-terminus of BchL autoinhibits activity through interaction with its [4Fe-4S] cluster and relieved upon ATP binding
2020-11-20
1
To be there when the picture is being painted
2020-11-20
1
Rod photoreceptor clearance due to misfolded rhodopsin is linked to a DAMP-immune checkpoint switch
2020-11-19
0.76
SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles
2020-11-19
1
Comparative interactomes of HSF1 in stress and disease reveal a role for CTCF in HSF1-mediated gene regulation
2020-11-18
1
Identification of a druggable protein-protein interaction site between mutant p53 and its stabilizing chaperone DNAJA1
2020-11-18
1
Small molecule control of neurotransmitter sulfonation
2020-11-18
1
Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence
2020-11-18
1
Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis
2020-11-18
1
The role of cysteines in the structure and function of OGG1
2020-11-17
1
KCa3.1-dependent uptake of the cytotoxic DNA-binding dye Hoechst 33258 into cancerous but not healthy cervical cells
2020-11-16
1
Salivary complement inhibitors from mosquitoes: Structure and mechanism of action
2020-11-16
1
TET-mediated 5-methylcytosine oxidation in tRNA promotes translation
2020-11-16
1
TNF-α-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer’s disease pathology in young Trem2R47H rats
2020-11-16
0.71
The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades  doublecortin proteins to constrain neuronal dendritogenesis
2020-11-16
1
The phosphohistidine phosphatase SixA dephosphorylates the phosphocarrier NPr
2020-11-16
0.90
IQGAP1 binds AMPK and is required for maximum AMPK activation
2020-11-15
1
Crystal structures of glutathione- and inhibitor-bound human GGT1: Critical interactions within the cysteinylglycine binding site
2020-11-13
1
Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis
2020-11-13
0.87
Loss of versican and production of hyaluronan in lung epithelial cells are associated with airway inflammation during RSV infection
2020-11-13
1
Repurposing p97 inhibitors for chemical modulation of the bacterial ClpB/DnaK bi-chaperone system
2020-11-13
1
An autonomous, but INSIG-modulated, role for the Sterol Sensing Domain in mallostery-regulated ERAD of yeast HMG-CoA reductase
2020-11-12
1
Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells
2020-11-12
0.29
Molecular mechanisms of telomere biology disorders
2020-11-12
1
A Structural Basis for Lithium and Substrate Binding of an Inositide Phosphatase
2020-11-10
1
Agonist-independent Gαz activity negatively regulates β-cell compensation in a diet-induced obesity model of type 2 diabetes
2020-11-10
1
Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair  glutamatergic synaptic transmission
2020-11-10
1
Discovery of an ultra-specific triuret hydrolase (TrtA) establishes the triuret biodegradation pathway
2020-11-10
1
p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes
2020-11-10
1
A clinically-relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position
2020-11-09
1
Defining the divergent enzymatic properties of RNA polymerases I and II
2020-11-09
1
Maedi-visna virus Vif protein uses motifs distinct from HIV-1 Vif to bind zinc and cofactor required for A3 degradation
2020-11-09
0.71
PRAP1 is a novel lipid binding protein that promotes lipid absorption by facilitating MTTP-mediated lipid transport
2020-11-09
0.08
The 89-kDa PARP1 cleavage fragment serves as a cytoplasmic PAR carrier to induce AIF-mediated apoptosis
2020-11-09
0.21
The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice
2020-11-09
1
The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates
2020-11-09
0.08
HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo-electron and TIRF microscopy
2020-11-06
1
Structures and mechanism of human glycosyltransferase β1,3-N-acetylglucosaminyltransferase 2 (B3GNT2), an important player in immune homeostasis
2020-11-06
1
The nucleocytosolic O-fucosyltransferase Spindly affects protein expression and virulence in Toxoplasma gondii
2020-11-06
1
MpeV is a lyase isomerase that ligates a doubly-linked phycourobilin on the β-subunit of phycoerythrin I and II in marine Synechococcus
2020-11-05
0.67
Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells
2020-11-04
1
Heme oxygenase-1 affects cytochrome P450 function through the formation of heteromeric complexes: Interactions between CYP1A2 and heme oxygenase-1
2020-11-04
1
Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons
2020-11-04
1
Adaptation of Influenza Viruses to Human Airway Receptors
2020-11-03
1
DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs
2020-11-03
1
KIF3A accelerates KIF3C within the kinesin-2 heterodimer to generate symmetrical phosphate release rates for each processive step
2020-11-03
1
Misfolding, altered membrane distributions, and the unfolded protein response contribute to pathogenicity differences in Na,K-ATPase ATP1A3 mutations
2020-11-03
1
Ischemic stroke disrupts the endothelial glycocalyx through activation of proHPSE via acrolein exposure
2020-10-30
0.08
Structure, mechanism, and regulation of mitochondrial DNA transcription initiation
2020-10-30
0.80
A highly potent CD73 biparatopic antibody blocks organization of the enzyme active site through dual mechanisms
2020-10-29
0.94
High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity
2020-10-29
1
Ligand bias in receptor tyrosine kinase signaling
2020-10-29
1
Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding
2020-10-29
1
Nitro-fatty acids as activators of hSIRT6 deacetylase activity
2020-10-29
0.13
[4Fe-4S] cluster trafficking mediated by Arabidopsis mitochondrial ISCA and NFU proteins
2020-10-29
0.33
GUCY2D mutations in retinal guanylyl cyclase 1 provide biochemical reasons for dominant cone-rod dystrophy but not for stationary night blindness
2020-10-27
1
In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1
2020-10-27
0.75
Naturally-occurring hotspot cancer mutations in Gα13 promote oncogenic signaling
2020-10-27
1
Serum lipoprotein-derived fatty acids regulate hypoxia-inducible factor
2020-10-27
1
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)
2020-10-27
1
A Drug-Resistant β-lactamase Variant Changes the Conformation of Its Active Site Proton Shuttle to Alter Substrate Specificity and Inhibitor Potency
2020-10-26
1
Humanin selectively prevents the activation of pro-apoptotic protein BID by sequestering it into fibers
2020-10-26
1
Inhibition of oxidative metabolism by nitric oxide restricts EMCV replication selectively in pancreatic beta-cells
2020-10-25
1
BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells
2020-10-23
0.80
Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response
2020-10-23
1
Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function
2020-10-22
1
The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2
2020-10-22
0.80
Mycobacteria excises DNA damage in 12- or 13-nucleotide-long oligomers by prokaryotic-type dual incisions and performs transcription-coupled repair
2020-10-21
1
PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by Akt3 inhibition by promotion of PRC expression
2020-10-21
1
Solvent accessibility changes in a Na+-dependent C4-dicarboxylate transporter suggest differential substrate effects in a multistep mechanism.
2020-10-21
0.25
Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function
2020-10-21
1
A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominate one-head-bound state during its chemomechanical cycle
2020-10-20
1
AggreCount: An unbiased image analysis tool for identifying and quantifying cellular aggregates in a spatially-defined manner
2020-10-20
1
MicroRNA-98 reduces nerve growth factor expression in nicotine-induced airway remodeling
2020-10-20
1
Murine GFP-Mx1 forms nuclear condensates and associates with cytoplasmic intermediate filaments: novel antiviral activity against VSV
2020-10-19
0.83
Polymerase γ efficiently replicates through many natural template barriers but stalls at the HSP1 quadruplex
2020-10-19
1
Quantitative phosphoproteomic analysis reveals involvement of PD-1 in multiple T cell functions
2020-10-19
0.96
A structural and kinetic survey of GH5_4 endoglucanases reveals determinants of broad substrate specificity and opportunities for biomass hydrolysis
2020-10-16
0.89
Arid4b is critical for mouse embryonic stem cell differentiation towards mesoderm and endoderm, linking epigenetics to pluripotency exit
2020-10-15
0.43
Exofacial membrane composition and lipid metabolism regulates plasma membrane P4-ATPase substrate specificity
2020-10-15
1
Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways
2020-10-15
0.14
NETosis Occurs Independently of Neutrophil Serine Proteases
2020-10-15
0.50
Unusual zwitterionic catalytic site of SARS-CoV-2 main protease revealed by neutron crystallography
2020-10-15
1
FRET and optical trapping reveal mechanisms of actin-activation of the power stroke and phosphate-release in myosin V
2020-10-14
1
A heterologous in-cell assay for investigating intermicrovillar adhesion complex interactions reveals a novel protrusion length matching mechanism
2020-10-13
1
Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors
2020-10-13
1
Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity
2020-10-13
1
Heme oxygenase-2 is post-translationally regulated by heme occupancy in the catalytic site
2020-10-13
1
Hepatocyte nuclear factor 1β suppresses canonical Wnt signaling through transcriptional repression of lymphoid enhancer-binding factor 1
2020-10-13
1
Human trans-editing enzyme displays tRNA acceptor stem specificity and relaxed amino acid selectivity
2020-10-13
0.71
Identification of a domain critical for Staphylococcus aureus LukED receptor targeting and lysis of erythrocytes
2020-10-13
0.71
Kinetic investigation of the polymerase and exonuclease activities of human DNA polymerase epsilon holoenzyme
2020-10-13
1
Iron-mediated degradation of ribosomes under oxidative stress is attenuated by manganese.
2020-10-09
1
Leptin modulates pancreatic β-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors
2020-10-09
0.94
Potassium starvation induces autophagy in yeast
2020-10-09
1
Functional impact of a congenital stationary night blindness type 2 mutation depends on subunit composition of Cav1.4 Ca2+ channels
2020-10-08
1
Overlapping function of Hrd1 and Ste24 in translocon quality control provides robust channel surveillance
2020-10-08
1
Amyloid precursor protein is a restriction factor that protects against Zika virus infection in mammalian brains
2020-10-07
0.73
Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer
2020-10-07
1
Gαs directly drives PDZ-RhoGEF signaling to Cdc42
2020-10-06
0.13
Novel fluorescent GPCR biosensor detects retinal equilibrium binding to opsin and active G protein and arrestin signaling conformations
2020-10-06
1
M8R tropomyosin mutation disrupts actin-binding and filament regulation: the beginning affects the middle and end
2020-10-05
1
Optimized incorporation of an unnatural fluorescent amino acid affords measurement of conformational dynamics governinghigh-fidelity DNA replication
2020-10-05
1
Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing
2020-10-05
1
Shared requirements for key residues in the antibiotic resistance enzymes ErmC and ErmE suggest a common mode of RNA recognition
2020-10-05
1
Hdac3 regulates bone modeling by suppressing osteoclast responsiveness to RANKL
2020-10-04
1
Enhanced enzyme kinetics of reverse transcriptase variants cloned from animals infected with SIVmac239 lacking Viral Protein X
2020-10-02
0.80
Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6
2020-10-02
0.57
pH-dependent pyridoxine transport by SLC19A2 and SLC19A3: Implications for absorption in acidic microclimates
2020-10-02
0.25
Characterizing human α-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases
2020-10-01
0.86
Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting
2020-10-01
1
A physical basis for quantitative ChIP-sequencing
2020-09-29
1
A saturating mutagenesis CRISPR-Cas9 mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in murine ESCs
2020-09-29
0.27
Increasing kinase domain proximity promotes MST2 autophosphorylation during Hippo signaling
2020-09-29
1
Molecular basis for histone H3 “K4me3-K9me3/2” methylation pattern readout by Spindlin1
2020-09-29
0.22
A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins
2020-09-28
1
Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways
2020-09-28
0.10
Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation
2020-09-28
1
Functions of Gle1 are governed by two distinct modes of self-association
2020-09-27
1
Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes
2020-09-25
1
Calreticulin enhances the secretory trafficking of a misfolded alpha-1-antitrypsin
2020-09-25
1
Cell adhesion molecule IGPR-1 activates AMPK connecting cell adhesion to autophagy
2020-09-25
1
ERAD Deficiency Promotes Mitochondrial Dysfunction and Transcriptional Rewiring in Human Hepatic Cells
2020-09-25
0.29
N-Acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation
2020-09-25
0.48
Inhibition of mitochondrial oxidative metabolism attenuates EMCV replication and protects β-cells from virally mediated lysis
2020-09-24
1
Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling
2020-09-23
1
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
2020-09-23
0.38
Coupled intra- and interdomain dynamics support domain cross-talk in Pin1
2020-09-22
1
The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway
2020-09-21
1
Decrease of core-2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking
2020-09-14
0.13
Ferric uptake regulator (Fur) reversibly binds a [2Fe-2S] cluster to sense intracellular iron homeostasis in Escherichia coli
2020-09-14
1
Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages
2020-09-11
1
Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components
2020-09-11
1
Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2
2020-09-11
0.26
Gallic Acid is a Dual α/β-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice
2020-09-10
0.38
Histo-blood group antigens of glycosphingolipids predict susceptibility of human intestinal enteroids to norovirus infection
2020-09-10
0.46
Hoogsteen base pairs increase the susceptibility of double-stranded DNA to cytotoxic damage
2020-09-10
1
Mode of Targeting to the Proteasome Determines GFP Fate
2020-09-10
1
O-Fucosylation of ADAMTSL2 is required for secretion and is impacted by geleophysic dysplasia-causing mutations
2020-09-10
1
Pif1, RPA and FEN1 modulate the ability of DNA polymerase δ to overcome protein barriers during DNA synthesis
2020-09-10
1
Visualizing a viral genome with contrast variation small angle x-ray scattering
2020-09-10
1
An automated, high throughput methodology optimized for quantitative cell-free mitochondrial and nuclear DNA isolation from plasma
2020-09-08
1
Exploitation of DHODH and p53 activation as therapeutic targets - a case study in polypharmacology
2020-09-08
0.08
Mechanical contribution to muscle thin filament activation
2020-09-08
1
A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation
2020-09-06
0.86
Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity
2020-09-06
0.73
Polydisperse molecular architecture of connexin 26/30 heteromeric hemichannels revealed by AFM imaging
2020-09-04
0.29
SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells
2020-09-04
0.69
A blueprint for academic labs to produce SARS-CoV-2 RT-qPCR test kits
2020-09-03
1
Actin-binding protein Profilin1 promotes aggressiveness of clear cell renal cell carcinoma cells
2020-09-03
0.87
An autoinhibitory role for the GRF zinc finger domain of DNA glycosylase NEIL3
2020-09-02
1
C-terminal tail length guides insertion and assembly of membrane proteins
2020-09-02
1
Lysine Acetylation Regulates the Activity of Nuclear Pif1
2020-09-02
1
Mutant thermal proteome profiling for characterization of missense protein variants and their associated phenotypes within the proteome
2020-09-02
1
Structural basis for the interaction of Shiga toxin 2a with a C-terminal peptide of ribosomal P stalk proteins
2020-09-02
1
Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity
2020-09-01
1
Nef Homodimers Downregulate SERINC5 by AP-2-Mediated Endocytosis to Promote HIV-1 Infectivity
2020-09-01
1
Replication stress at microsatellites causes DNA double strand breaks and break induced replication
2020-09-01
0.78
The human mitochondrial enzyme BCO2 exhibits catalytic activity towards carotenoids and apocarotenoids
2020-09-01
1
Alternative signaling pathways from IGF1 or Insulin to Akt activation and Foxo1 nuclear efflux in adult skeletal muscle fibers
2020-08-31
1
G-protein coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts
2020-08-31
0.41
Receptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase signaling in cardiac myocytes by oxidizing agents
2020-08-31
0.06
Redesigning plant cell walls for the biomass-based bioeconomy
2020-08-31
1
A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by hetero-bifunctional ligands
2020-08-28
1
Asp22 drives the protonation state of the Staphylococcus epidermidis glucose/H+ symporter
2020-08-28
0.33
Computationally modeling mammalian succinate dehydrogenase kinetics identifies the origins and primary determinants of ROS production
2020-08-28
1
Exosite binding drives substrate affinity for the activation of coagulation factor X by the intrinsic Xase complex
2020-08-28
1
Solid-state NMR spectroscopy identifies three classes of lipids in C. neoformans melanized cell walls and whole fungal cells
2020-08-28
1
Artemisinins target the intermediate filament protein vimentin for human cytomegalovirus inhibition
2020-08-27
1
Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation
2020-08-27
0.60
Zymogen and activated protein C have similar structural architecture
2020-08-27
1
ATG16L1 autophagy pathway regulates BAX protein levels and programmed cell death
2020-08-26
1
The genetic Ca2+ sensor GCaMP3 reveals multiple Ca2+ stores differentially coupled to Ca2+ entry in the human malaria parasite Plasmodium falciparum
2020-08-26
0.58
A post-invasion role for Chlamydia type III effector TarP in modulating the dynamics and organization of host cell focal adhesions
2020-08-25
0.63
Regulation of the thrombin/protease-activated receptor 1 axis by chemokine (C-X-C motif) receptor 4
2020-08-24
1
Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide adenine dinucleotide cofactors
2020-08-23
0.67
Csx3 is a cyclic oligonucleotide phosphodiesterase associated with type-III CRISPR-Cas that degrades the second messenger cA4
2020-08-21
1
Global analysis of adenylate-forming enzymes reveals β-lactone biosynthesis pathway in pathogenic Nocardia
2020-08-21
0.43
ATP-dependent interactions of a cargo protein with the transmembrane domain of a polypeptide processing and secretion ABC transporter
2020-08-20
1
BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis
2020-08-20
1
CaV channels reject signaling from a second CaM in eliciting Ca2+-dependent feedback regulation
2020-08-20
1
Tandem sialoglycan-binding modules in a Streptococcus sanguinis serine-rich repeat adhesin create target dependent avidity effects
2020-08-20
1
Alternative N-terminal regions of Drosophila myosin heavy chain II regulate communication of the purine binding loop with the essential light chain
2020-08-19
0.50
Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2
2020-08-19
1
E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells
2020-08-19
1
Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite
2020-08-19
1
Increased surface charge in the protein chaperone Spy enhances its anti-aggregation activity
2020-08-17
0.50
A non-canonical role for the DNA glycosylase NEIL3 in suppressing APE1 endonuclease-mediated ssDNA damage
2020-08-14
1
Atypical TRAV1-2- T cell receptor recognition of the antigen-presenting molecule MR1
2020-08-14
0.36
Chemistry of Class 1 CRISPR-Cas effectors: binding, editing, and regulation
2020-08-14
1
Evaluation of active Rac1 levels in cancer cells: a case of misleading conclusions from immunofluorescence analysis
2020-08-14
1
Structural characterization of anti-CCL5 activity of the tick salivary protein Evasin-4
2020-08-14
0.11
HIV-1 Gag protein with or without p6 specifically dimerizes on the viral RNA packaging signal
2020-08-13
1
Human Ribosomal G-Quadruplexes Regulate Heme Bioavailability
2020-08-13
1
Sensitive quantification of α-glucans in mouse tissues, cell cultures, and human cerebrospinal fluid
2020-08-13
0.53
Tetramerizing tGCN4 Domain Facilitates Production of Influenza A H1N1 M2e Higher Order Soluble Oligomers that Show Enhanced Immunogenicity In vivo
2020-08-13
0.07
Tracking the carbons supplying gluconeogenesis
2020-08-13
1
Replication protein A binds RNA and promotes R-loop formation
2020-08-12
1
Sodium glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks
2020-08-12
1
The DUF328 family member YaaA is a DNA-binding protein with a novel fold
2020-08-12
1
The plant pathogen enzyme AldC is a long-chain aliphatic aldehyde dehydrogenase
2020-08-12
1
The ubiquitin system affects agronomic plant traits
2020-08-12
1
A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA Receptor
2020-08-11
1
Actin-binding compounds, previously discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle
2020-08-11
1
Caspases from Scleractinian Coral Show Unique Regulatory Features
2020-08-11
1
Intersection of the ATF6 and XBP1 ER stress pathways in mouse islet cells
2020-08-11
1
The African natural product knipholone anthrone and its analogue anthralin (dithranol) enhance HIV-1 latency reversal
2020-08-11
0.38
The chemokine X-factor: structure-function analysis of the CXC motif at CXCR4 and ACKR3
2020-08-11
1
The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin
2020-08-07
1
Acetylation modulates the Fanconi anemia pathway by protecting FAAP20 from ubiquitin-mediated proteasomal degradation
2020-08-06
1
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection
2020-08-06
1
Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover
2020-08-06
0.70
Point Mutations that Inactivate MGAT4D-L, an Inhibitor of MGAT1 and Complex N-Glycan Synthesis
2020-08-06
1
R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities
2020-08-06
1
FmhA and FmhC of Staphylococcus aureus incorporate serine residues into peptidoglycan crossbridges
2020-08-05
1
A non-GPCR binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling
2020-08-04
1
AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair
2020-08-04
0.33
Development of Noonan syndrome by deregulation of allosteric SOS autoactivation
2020-08-04
1
Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors
2020-08-03
0.06
Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure
2020-08-03
1
Cooperative dynamics across distinct structural elements regulate PTP1B activity
2020-07-31
1
High density lipoproteins are a potential therapeutic target for age-related macular degeneration
2020-07-31
1
Mechanistic Crosstalk between DNA/RNA Polymerase Enzyme Kinetics and Nucleotide Substrate Availability in Cells: Implications for Polymerase Inhibitor Discovery
2020-07-31
1
Modulating Disease-Relevant Tau Oligomeric Strains by Small Molecules
2020-07-31
0.75
Substrate recognition induces sequential electron transfer across subunits in the nitrogenase-like DPOR complex
2020-07-31
1
Truncation of tau selectively facilitates its pathological activities
2020-07-31
0.56
Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles
2020-07-30
1
Iron homeostasis and plant immune responses: recent insights and translational implications
2020-07-30
1
Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics
2020-07-30
0.99
Modification of lipid rafts by extracellular vesicles carrying HIV-1 protein Nef induces redistribution of APP and Tau causing neuronal dysfunction
2020-07-30
0.17
TGFb acts through PDGFRb to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression
2020-07-30
1
The insufficiency of ATG4A in macroautophagy
2020-07-30
0.89
Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity
2020-07-30
0.43
15-keto-PGE2acts as a biased/partial agonist to terminate PGE2-evoked signaling
2020-07-29
0.11
Cation channel conductance and pH gating of the innate immunity factor APOL1 is governed by pore lining residues within the C-terminal domain
2020-07-29
0.95
EGFR forms ligand-independent oligomers that are distinct from the active state
2020-07-29
1
Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction
2020-07-29
0.79
Applying gene editing to tailor precise genetic modifications in plants
2020-07-28
1
CHOP and c-JUN upregulate the mutant Z alpha-1 antitrypsin, exacerbating its aggregation and liver proteotoxicity.
2020-07-28
0.27
Catastrophic actin filament bursting by cofilin, Aip1, and coronin
2020-07-28
1
Intermittent enzyme replacement therapy prevents Neu1 deficiency
2020-07-28
1
Long-term Effects of the Proline-rich Antimicrobial Peptide Oncocin112 on the E. coli translation machinery
2020-07-28
1
Multimodal small-molecule screening for human prion protein binders
2020-07-28
0.92
Trapping conformational states of a flavin-dependent N-monooxygenase in crystallo reveals protein and flavin dynamics
2020-07-28
1
N6-Methyladenosine Modification of Hepatitis B and C Viral RNAs Attenuates Host Innate Immunity via RIG-I Signaling
2020-07-27
1
Evidence that polyphenols do not inhibit the phospholipid scramblase TMEM16F
2020-07-24
1
Regulation of eukaryotic translation initiation factor 6 dynamics through multisite phosphorylation by GSK3
2020-07-23
1
A Cytoskeletal Protein Complex is Essential for Division of Intracellular Amastigotes of Leishmania mexicana
2020-07-22
1
Brain cell somatic gene recombination and its phylogenetic foundations
2020-07-22
1
H2S and reactive sulfur signaling at the host bacterial pathogen interface
2020-07-22
1
Phase separation drives decision making in cell division
2020-07-22
0.15
A novel tumor suppressor ZBTB1 regulates tamoxifen resistance and aerobic glycolysis through suppressing HER2 expression in breast cancer
2020-07-20
0.09
Bile acid composition regulates the manganese transporter Slc30a10 in intestine
2020-07-20
1
Engineering Acyl-Homoserine Lactone-Interfering Enzymes Towards Bacterial Control
2020-07-20
0.17
Inhibitors of a Na+-pumping NADH-ubiquinone oxidoreductase play multiple roles to block enzyme function
2020-07-20
0.40
Ozone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors
2020-07-20
1
AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals
2020-07-18
1
Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology
2020-07-16
0.25
Maintenance of hook complex integrity and centrin arm assembly facilitates flagellum inheritance in Trypanosoma brucei
2020-07-16
1
PE5-PPE4-EspG3 heterotrimer structure from mycobacterial ESX-3 secretion system gives insight into cognate substrate recognition by ESX systems
2020-07-16
1
Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences
2020-07-15
1
Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease
2020-07-15
0.03
Ubiquitin ligase SMURF2 enhances epidermal growth factor receptor stability and tyrosine-kinase inhibitor resistance
2020-07-15
1
Structural features of bovine colostral immunoglobulin that confer proteolytic stability in a simulated intestinal fluid
2020-07-14
1
Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria
2020-07-14
1
The staphylococcal biofilm protein Aap forms a tetrameric species as a necessary intermediate before amyloidogenesis
2020-07-14
1
Spectroscopic evidence for direct flavin-flavin contact in a bifurcating electron transfer flavoprotein
2020-07-13
1
The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity andcontributes to membrane binding
2020-07-13
1
The molecular virology of Coronaviruses
2020-07-13
1
From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases
2020-07-10
1
Retromer forms low order oligomers on supported lipid bilayers
2020-07-10
0.94
A kinase cascade on the yeast lysosomal vacuole regulates its membrane dynamics: conserved kinase Env7 is phosphorylated by casein kinase Yck3
2020-07-09
1
Direct relationship between increased expression and mistrafficking of the Charcot–Marie–Tooth–associated protein PMP22
2020-07-09
1
Lysines in the lyase active site of DNA polymerase β destabilize nonspecific DNA binding, facilitating searching and DNA gap recognition
2020-07-09
1
Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination
2020-07-09
0.75
A functional role for eicosanoid-lysophospholipids in activating monocyte signaling
2020-07-08
1
Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase
2020-07-08
1
TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons
2020-07-07
0.25
The molecular basis for immune dysregulation by the hyperactivated E62K mutant of the GTPase RAC2
2020-07-07
1
Two highly related odorant receptors specifically detect α-bile acid pheromones in sea lamprey (Petromyzon marinus)
2020-07-07
0.50
A cryptic sequence targets the adhesion complex scaffold ANKS4B to apical microvilli to promote enterocyte brush border assembly
2020-07-06
1
Cardiolipin-deficient cells have decreased levels of the iron–sulfur biogenesis protein frataxin
2020-07-06
0.75
Phosphorylation on Ser-359 of the α2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses
2020-07-03
0.42
Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain
2020-07-02
0.06
Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation
2020-07-02
1
CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability
2020-07-01
0.80
Hairpin RNA-induced conformational change of a eukaryotic-specific lysyl-tRNA synthetase extension and role of adjacent anticodon-binding domain
2020-07-01
1
Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue
2020-07-01
1
The transcription factors aryl hydrocarbon receptor and MYC cooperate in the regulation of cellular metabolism
2020-07-01
1
A distinct talin2 structure directs isoform specificity in cell adhesion
2020-06-30
1
PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide–dependent biofilm formation
2020-06-29
0.13
Characterization of the nonheme iron center of cysteamine dioxygenase and its interaction with substrates
2020-06-28
1
SARS-CoV-2 (COVID-19) structural and evolutionary dynamicome: Insights into functional evolution and human genomics
2020-06-25
1
The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation
2020-06-25
1
Ubiquitination of interleukin-1α is associated with increased pro-inflammatory polarization of murine macrophages deficient in the E3 ligase ITCH
2020-06-25
1
High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins
2020-06-24
1
Muscarinic-dependent phosphorylation of the cardiac ryanodine receptor by protein kinase G is mediated by PI3K–AKT–nNOS signaling
2020-06-24
1
Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features
2020-06-23
1
The orphan receptor GPR139 signals via Gq/11 to oppose opioid effects
2020-06-23
1
The transcriptional repressor BCL11A promotes breast cancer metastasis
2020-06-23
1
5′-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs
2020-06-22
1
MtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase
2020-06-22
1
Runt-related transcription factor 1 is required for murine osteoblast differentiation and bone formation
2020-06-22
0.65
Structural and functional conservation of the programmed −1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)
2020-06-22
0.63
Structural insights into emergent signaling modes of G protein–coupled receptors
2020-06-22
1
The RNA-binding protein PTBP1 promotes ATPase-dependent dissociation of the RNA helicase UPF1 to protect transcripts from nonsense-mediated mRNA decay
2020-06-22
1
The bacterial copper resistance protein CopG contains a cysteine-bridged tetranuclear copper cluster
2020-06-22
1
Pterocarpan synthase (PTS) structures suggest a common quinone methide–stabilizing function in dirigent proteins and proteins with dirigent-like domains
2020-06-21
1
Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells
2020-06-18
0.92
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11
2020-06-18
0.60
Phosphorylation of cardiac myosin–binding protein-C contributes to calcium homeostasis
2020-06-18
1
The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice
2020-06-18
1
Two Caenorhabditis elegans calponin-related proteins have overlapping functions that maintain cytoskeletal integrity and are essential for reproduction
2020-06-18
1
Mechanistic insights into heme-mediated transcriptional regulation via a bacterial manganese-binding iron regulator, iron response regulator (Irr)
2020-06-17
0.20
Protein docking and steered molecular dynamics suggest alternative phospholamban-binding sites on the SERCA calcium transporter
2020-06-17
0.80
δ-Catenin engages the autophagy pathway to sculpt the developing dendritic arbor
2020-06-17
1
Differences in self-association between kindlin-2 and kindlin-3 are associated with differential integrin binding
2020-06-16
1
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
2020-06-16
0.07
Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity
2020-06-16
1
Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase
2020-06-15
1
Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice
2020-06-15
1
New analysis pipeline for high-throughput domain–peptide affinity experiments improves SH2 interaction data
2020-06-15
1
Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors
2020-06-15
1
The GTPase-activating protein p120RasGAP has an evolutionarily conserved “FLVR-unique” SH2 domain
2020-06-15
1
A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice
2020-06-12
1
A single von Willebrand factor C-domain protein acts as an extracellular pattern-recognition receptor in the river prawn Macrobrachium nipponense
2020-06-12
0.17
Phosphorylation of α-dystrobrevin is essential for αkap accumulation and acetylcholine receptor stability
2020-06-12
0.75
T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4
2020-06-12
0.10
A conserved evolutionary mechanism permits Δ9 desaturation of very-long-chain fatty acyl lipids
2020-06-11
1
A revolution in biochemistry and molecular biology education informed by basic research to meet the demands of 21st century career paths
2020-06-11
1
Post-translational modifications of Hsp90 and translating the chaperone code
2020-06-11
1
Structure and function of a flavin-dependent S-monooxygenase from garlic (Allium sativum)
2020-06-11
1
The Spo7 sequence LLI is required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid metabolism
2020-06-11
1
The folding and unfolding behavior of ribonuclease H on the ribosome
2020-06-11
0.60
Contributions of the heme coordinating ligands of the Pseudomonas aeruginosa outer membrane receptor HasR to extracellular heme sensing and transport
2020-06-10
1
A unique combination of glycoside hydrolases in Streptococcus suis specifically and sequentially acts on host-derived αGal-epitope glycans
2020-06-09
0.08
Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators
2020-06-09
1
Cytochrome c nitrite reductase from the bacterium Geobacter lovleyi represents a new NrfA subclass
2020-06-09
1
ETS variant transcription factor 5 and c-Myc cooperate in derepressing the human telomerase gene promoter via composite ETS/E-box motifs
2020-06-09
1
Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells
2020-06-09
1
Post-translational modifications of Hsp70 family proteins: Expanding the chaperone code
2020-06-09
1
Structural analysis of avibactam-mediated activation of the bla and mec divergons in methicillin-resistant Staphylococcus aureus
2020-06-09
0.29
The J-elongated conformation of β2-glycoprotein I predominates in solution: implications for our understanding of antiphospholipid syndrome
2020-06-09
0.67
The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice
2020-06-09
0.95
The serum protein transthyretin as a platform for dimerization and tetramerization of antibodies and Fab fragments to enable target clustering
2020-06-09
0.80
The yeast exoribonuclease Xrn1 and associated factors modulate RNA polymerase II processivity in 5' and 3' gene regions
2020-06-09
0.83
Translational regulation of environmental adaptation in bacteria
2020-06-09
1
Agonist binding directs dynamic competition among nuclear receptors for heterodimerization with retinoid X receptor
2020-06-08
0.05
CRISPR type II-A subgroups exhibit phylogenetically distinct mechanisms for prespacer insertion
2020-06-08
1
Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination
2020-06-08
1
Two components of DNA replication-dependent LexA cleavage
2020-06-08
1
A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP
2020-06-05
1
Characterization of SETD3 methyltransferase–mediated protein methionine methylation
2020-06-05
1
Iron alters the cell wall composition and intracellular lactate to affect Candida albicans susceptibility to antifungals and host immune response
2020-06-05
1
Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine
2020-06-05
1
Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis
2020-06-05
1
A requirement for an active proton delivery network supports a compound I-mediated C–C bond cleavage in CYP51 catalysis
2020-06-03
1
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease
2020-06-03
1
MicroRNA-223-3p promotes skeletal muscle regeneration by regulating inflammation in mice
2020-06-03
0.06
Picornaviral polymerase domain exchanges reveal a modular basis for distinct biochemical activities of viral RNA-dependent RNA polymerases
2020-06-03
0.80
The nonselective cation channel TRPV4 inhibits angiotensin II receptors
2020-06-03
1
Two clusters of surface-exposed amino acid residues enable high-affinity binding of retinal degeneration-3 (RD3) protein to retinal guanylyl cyclase
2020-06-03
1
Biochemical characterization of G protein coupling to calcitonin gene–related peptide and adrenomedullin receptors using a native PAGE assay
2020-06-02
1
Early cleavage of preimplantation embryos is regulated by tRNAGln-TTG–derived small RNAs present in mature spermatozoa
2020-06-02
0.06
Spontaneous and photosensitization-induced mutations in primary mouse cells transitioning through senescence and immortalization
2020-06-02
1
Transcription factors activated through RIP (regulated intramembrane proteolysis) and RAT (regulated alternative translocation)
2020-06-02
1
A-kinase-anchoring protein 1 (dAKAP1)-based signaling complexes coordinate local protein synthesis at the mitochondrial surface
2020-06-01
1
Elucidation of proteostasis defects caused by osteogenesis imperfecta mutations in the collagen-α2(I) C-propeptide domain
2020-06-01
1
Mechanisms of aortic carboxypeptidase-like protein secretion and identification of an intracellularly retained variant associated with Ehlers–Danlos syndrome
2020-06-01
1
Diabetes enhances translation of Cd40 mRNA in murine retinal Müller glia via a 4E-BP1/2–dependent mechanism
2020-05-31
1
Bacterial lyso-form lipoproteins are synthesized via an intramolecular acyl chain migration
2020-05-29
1
Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17
2020-05-29
1
An aberrantly sustained emergency granulopoiesis response accelerates postchemotherapy relapse in MLL1-rearranged acute myeloid leukemia in mice
2020-05-28
1
Combined p53- and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer
2020-05-28
1
Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1
2020-05-28
0.78
A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds
2020-05-27
0.25
Quantifying the strength of heterointeractions among receptor tyrosine kinases from different subfamilies: Implications for cell signaling
2020-05-27
1
The BADC and BCCP subunits of chloroplast acetyl-CoA carboxylase sense the pH changes of the light–dark cycle
2020-05-27
1
The urea transporter UT-A1 plays a predominant role in a urea-dependent urine-concentrating mechanism
2020-05-27
0.11
Regulation of poly(a)-specific ribonuclease activity by reversible lysine acetylation
2020-05-26
1
Resistance to excision determines efficiency of hepatitis C virus RNA-dependent RNA polymerase inhibition by nucleotide analogs
2020-05-26
1
The human B12 trafficking protein CblC processes nitrocobalamin
2020-05-26
1
Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization
2020-05-22
0.61
The BAR domain of the Arf GTPase-activating protein ASAP1 directly binds actin filaments
2020-05-22
1
The Cyt1Aa toxin from Bacillus thuringiensis inserts into target membranes via different mechanisms in insects, red blood cells, and lipid liposomes
2020-05-22
0.17
Hypoxia drives the assembly of the multienzyme purinosome complex
2020-05-21
0.33
Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes
2020-05-21
0.21
The N-terminal domain of the non-receptor tyrosine kinase ABL confers protein instability and suppresses tumorigenesis
2020-05-21
0.33
A bacterial biosynthetic pathway for methylated furan fatty acids
2020-05-20
1
The transcriptional corepressor CBFA2T3 inhibits all-trans-retinoic acid–induced myeloid gene expression and differentiation in acute myeloid leukemia
2020-05-20
1
An improved and highly selective fluorescence assay for measuring phosphatidylserine decarboxylase activity
2020-05-19
1
Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum
2020-05-19
1
Catalytically inactive T7 DNA polymerase imposes a lethal replication roadblock
2020-05-19
1
Mechanisms of evolved herbicide resistance
2020-05-19
0.86
Prochlorococcus phage ferredoxin: structural characterization and electron transfer to cyanobacterial sulfite reductases
2020-05-19
1
An atypical lipoteichoic acid from Clostridium perfringens elicits a broadly cross-reactive and protective immune response
2020-05-18
0.52
CofActor: A light- and stress-gated optogenetic clustering tool to study disease-associated cytoskeletal dynamics in living cells
2020-05-18
1
The emerging role of α-synuclein truncation in aggregation and disease
2020-05-18
1
A terminal α3-galactose modification regulates an E3 ubiquitin ligase subunit in Toxoplasma gondii
2020-05-15
1
Binding and allosteric transmission of histone H3 Lys-4 trimethylation to the recombinase RAG-1 are separable functions of the RAG-2 plant homeodomain finger
2020-05-15
1
Forcing the ribosome to change its message
2020-05-15
1
AKT Ser/Thr kinase increases V-ATPase–dependent lysosomal acidification in response to amino acid starvation in mammalian cells
2020-05-14
1
Structural basis for the binding of SNAREs to the multisubunit tethering complex Dsl1
2020-05-14
1
The structure and reactivity of the HoxEFU complex from the cyanobacterium Synechocystis sp. PCC 6803
2020-05-14
0.67
Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α
2020-05-13
1
A trimodular bacterial enzyme combining hydrolytic activity with oxidative glycosidic bond cleavage efficiently degrades chitin
2020-05-12
0.22
Novel role of ASH1L histone methyltransferase in anaplastic thyroid carcinoma
2020-05-12
1
Death by lipids: The role of small nucleolar RNAs in metabolic stress
2020-05-11
1
RAS internal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling
2020-05-11
1
The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription
2020-05-11
1
Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation
2020-05-08
0.67
The mRNA-binding protein IGF2BP1 maintains intestinal barrier function by up-regulating occludin expression
2020-05-08
1
Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of polymerase β-DNA complexes
2020-05-08
0.44
Ada protein– and sequence context–dependent mutagenesis of alkyl phosphotriester lesions in Escherichia coli cells
2020-05-07
1
Age-related changes in the physical properties, cross-linking, and glycation of collagen from mouse tail tendon
2020-05-07
0.29
Angiomotin regulates budding and spread of Ebola virus
2020-05-07
1
Neuroligin3 splice isoforms shape inhibitory synaptic function in the mouse hippocampus
2020-05-07
0.87
Androgen attenuates the inactivating phospho–Ser-127 modification of yes-associated protein 1 (YAP1) and promotes YAP1 nuclear abundance and activity
2020-05-06
1
Bacillus halodurans OapB forms a high-affinity complex with the P13 region of the noncoding RNA OLE
2020-05-06
1
Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant
2020-05-06
0.83
The RNA helicase DDX5 supports mitochondrial function in small cell lung cancer
2020-05-06
1
The post-synaptic scaffolding protein tamalin regulates ligand-mediated trafficking of metabotropic glutamate receptors
2020-05-06
0.14
The transcription factor GLI1 cooperates with the chromatin remodeler SMARCA2 to regulate chromatin accessibility at distal DNA regulatory elements
2020-05-06
1
An unexpected 2-histidine phosphoesterase activity of suppressor of T-cell receptor signaling protein 1 contributes to the suppression of cell signaling
2020-05-05
1
Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants
2020-05-05
1
Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling
2020-05-05
1
The human mitochondrial 12S rRNA m4C methyltransferase METTL15 is required for mitochondrial function
2020-05-05
1
The role of the histone H3 variant CENPA in prostate cancer
2020-05-05
1
The yeast Hrq1 helicase stimulates Pso2 translesion nuclease activity and thereby promotes DNA interstrand crosslink repair
2020-05-05
1
Histone acetyltransferase 1 is required for DNA replication fork function and stability
2020-05-04
1
Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function
2020-05-04
0.92
Malaria parasite plasmepsins: More than just plain old degradative pepsins
2020-05-04
1
Raffinose synthase enhances drought tolerance through raffinose synthesis or galactinol hydrolysis in maize and Arabidopsis plants
2020-05-04
0.17
19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2
2020-05-01
0.86
CRISPR-addressable yeast strains with applications in human G protein–coupled receptor profiling and synthetic biology
2020-05-01
1
Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts
2020-05-01
0.07
Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer
2020-05-01
1
Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly
2020-05-01
1
Transforming growth factor β (TGF-β) receptor signaling regulates kinase networks and phosphatidylinositol metabolism during T-cell activation
2020-05-01
1
Uptake of high-density lipoprotein by scavenger receptor class B type 1 is associated with prostate cancer proliferation and tumor progression in mice
2020-05-01
1
Correction of Niemann-Pick type C1 trafficking and activity with the histone deacetylase inhibitor valproic acid
2020-04-30
1
Estrogen receptor α (ERα)-binding super-enhancers drive key mediators that control uterine estrogen responses in mice
2020-04-30
1
GAPDH delivers heme to soluble guanylyl cyclase
2020-04-30
1
Purine-responsive expression of the Leishmania donovani NT3 purine nucleobase transporter is mediated by a conserved RNA stem–loop
2020-04-30
1
Structural basis for the hydrolytic dehalogenation of the fungicide chlorothalonil
2020-04-30
1
The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells
2020-04-30
1
Enigmatic MELK: The controversy surrounding its complex role in cancer
2020-04-29
1
Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1)
2020-04-29
0.25
Protein kinase Cι promotes UBF1–ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells
2020-04-29
1
The DNA-binding activity of USP1-associated factor 1 is required for efficient RAD51-mediated homologous DNA pairing and homology-directed DNA repair
2020-04-29
1
The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of α-synuclein
2020-04-29
1
The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development
2020-04-29
1
Diacylglycerol kinases regulate TRPV1 channel activity
2020-04-28
1
The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7
2020-04-28
1
A fluorescent timer reporter enables sorting of insulin secretory granules by age
2020-04-27
0.18
Host ESCRT factors are recruited during chikungunya virus infection and are required for the intracellular viral replication cycle
2020-04-27
0.04
Phosphatidylinositol 4,5-bisphosphate directly interacts with the β and γ subunits of the sodium channel ENaC
2020-04-27
1
Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
2020-04-27
0.25
The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms
2020-04-27
1
Chronic treatment with the complex I inhibitor MPP+ depletes endogenous PTEN-induced kinase 1(PINK1) via upregulation of BCL-2-associated athanogene 6
2020-04-24
1
Ethylene signalling in plants
2020-04-24
1
Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2
2020-04-24
0.74
Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor-mediated chemotaxis
2020-04-24
0.11
Mesencephalic astrocyte–derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart
2020-04-23
0.95
Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation
2020-04-23
0.88
Sphingosine kills bacteria by binding to cardiolipin
2020-04-23
0.38
Mechanism of allosteric inhibition in the Plasmodiumfalciparum cGMP-dependent protein kinase
2020-04-21
0.11
The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI)
2020-04-21
1
A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth 
2020-04-20
1
Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism
2020-04-20
0.98
The mRNA encoding the JUND tumor suppressor detains nuclear RNA-binding proteins to assemble polysomes that are unaffected by mTOR
2020-04-20
1
The mTOR Inhibitor Manassantin B Reveals A Crucial Role of mTORC2 Signaling in Epstein-Barr Virus Reactivation
2020-04-20
0.19
Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases
2020-04-17
0.50
Structure-function analyses of the G729R 2-oxoadipate dehydrogenase genetic variant associated with L-lysine metabolism disorder
2020-04-17
0.73
The circadian clock shapes the Arabidopsis transcriptome by regulating alternative splicing and alternative polyadenylation
2020-04-17
1
Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airway
2020-04-17
0.04
Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance
2020-04-16
1
Genome-wide single-nucleotide resolution of oxaliplatin–DNA adduct repair in drug-sensitive and -resistant colorectal cancer cell lines
2020-04-16
1
Inducible expression of a disease-associated ELANE mutation impairs granulocytic differentiation, without eliciting an unfolded protein response
2020-04-16
1
N-terminal protein acetylation by NatB modulates the levels of Nmnats, the NAD+ biosynthetic enzymes in Saccharomyces cerevisiae
2020-04-16
1
The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation
2020-04-15
1
The viral protein U (Vpu)-interacting host protein ATP6V0C down-regulates cell-surface expression of tetherin and thereby contributes to HIV-1 release
2020-04-14
1
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
2020-04-13
0.43
Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D
2020-04-13
1
Transient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB
2020-04-13
1
The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration
2020-04-12
0.79
Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17
2020-04-10
1
Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease
2020-04-10
1
The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1α in liver cancer cells
2020-04-10
0.09
Depletion of hepatic forkhead box O1 does not affect cholelithiasis in male and female mice
2020-04-09
0.72
Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions
2020-04-09
0.83
The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication
2020-04-09
1
The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action
2020-04-09
1
Deoxyribozyme-based method for absolute quantification of N6-methyladenosine fractions at specific sites of RNA
2020-04-08
1
Arachidonate 12-Lipoxygenase and 12-Hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer
2020-04-07
1
Knock-in rats with homozygous PSEN1L435F Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42, high Aβ43
2020-04-07
1
Mutations in penicillin-binding protein 2 from cephalosporin-resistant Neisseria gonorrhoeae hinder ceftriaxone acylation by restricting protein dynamics
2020-04-06
0.86
Crystallographic and kinetic analyses of the FdsBG subcomplex of the cytosolic formate dehydrogenase FdsABG from Cupriavidus necator
2020-04-05
1
One proline deletion in the fusion peptide of neurotropic mouse hepatitis virus (MHV) restricts retrograde axonal transport and neurodegeneration
2020-04-05
0.25
SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9 and PIAS2 and enhances its stability and function in cell proliferation
2020-04-05
0.08
The histone H4 basic patch regulates SAGA-mediated H2B deubiquitylation and histone acetylation
2020-04-03
1
The polymorphism rs975484 in the protein arginine methyltransferase-1 gene modulates expression of immune checkpoint genes in hepatocellular carcinoma
2020-04-03
1
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress
2020-04-03
1
Biosynthesis of the modified tetrapyrroles--the pigments of life
2020-04-02
0.33
Polarization of protease-activated receptor 2 (PAR-2) signaling is altered during airway epithelial remodeling and deciliation
2020-04-02
1
Sterile alpha motif domain requirement for cellular signaling and survival
2020-04-02
1
The C-terminal tails of the mitochondrial transcription factors Mtf1 and TFB2M are part of an auto-inhibitory mechanism that regulates DNA binding
2020-04-02
1
Thyrocyte cell survival and adaptation to chronic endoplasmic reticulum stress due to misfolded thyroglobulin
2020-04-02
0.92
An arrestin-1 surface opposite of its interface with photo-activated rhodopsin engages with enolase-1
2020-04-01
1
Non-photopic and photopic visual cycles differentially regulate immediate, early and late-phases of cone photoreceptor-mediated vision
2020-04-01
0.44
Quantification of the affinities of CRISPR-Cas9 nucleases for cognate protospacer adjacent motif (PAM) sequences
2020-04-01
0.83
A flexible network of Vimentin intermediate filaments promotes the migration of amoeboid cancer cells through confined environments
2020-03-31
1
Roles of active site residues in catalysis, substrate binding, cooperativity and the reaction mechanism of the quinoprotein glycine oxidase
2020-03-31
1
A Legionella effector kinase is activated by host inositol hexakisphosphate
2020-03-30
0.83
Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes
2020-03-30
1
The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal stimulated insulin secretion
2020-03-30
1
Zinc promotes liquid-liquid phase separation of tau protein
2020-03-30
1
It takes two (Las1 HEPN endoribonuclease Domains) to cut RNA correctly
2020-03-27
0.17
Tracking isotopically labeled oxidants using boronate-based redox probes
2020-03-26
0.50
Biophysical characterization of SARAH domain-mediated multimerization of Hippo pathway complexes in Drosophila
2020-03-25
1
Impact of 1,N6-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repair
2020-03-25
1
Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase
2020-03-25
1
Atomic force microscopy–based characterization of the interaction of PriA helicase with stalled DNA replication forks
2020-03-24
1
Catabolic degradation of endothelial VEGFA via autophagy
2020-03-24
1
Chemical roadblocking of DNA transcription for nascent RNA display
2020-03-24
1
The hibernating 100S complex is a target of ribosome-recycling factor and elongation factor G in Staphylococcus aureus
2020-03-24
1
The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex
2020-03-24
1
Transcriptional and translational S-box riboswitches differ in ligand-binding properties
2020-03-24
1
α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species
2020-03-24
0.33
5-Ethynyl-2’-deoxycytidine and 5-ethynyl-2’-deoxyuridine are differentially incorporated in cells infected with HSV-1, HCMV, and KSHV viruses
2020-03-23
1
A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning
2020-03-23
1
COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10
2020-03-23
0.73
Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells
2020-03-23
1
ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface
2020-03-19
1
Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications
2020-03-19
0.75
Deletion of Fatty Acid Transport Protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes
2020-03-18
1
Effects of deficiency in the RLBP1-encoded visual cycle protein CRALBP on visual dysfunction in humans and mice
2020-03-18
1
Mechanistic insights explain the transforming potential of the T507K substitution in the protein tyrosine phosphatase SHP2
2020-03-18
1
A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by ER aminopeptidase 1
2020-03-17
0.15
Glycation-mediated inter-protein crosslinking is promoted by chaperone-client complexes of α-crystallin: Implications for lens aging and presbyopia
2020-03-17
0.80
Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance
2020-03-17
1
Spectral and photochemical diversity of tandem cysteine cyanobacterial phytochromes
2020-03-17
0.17
The mRNA levels of heat shock factor-1 are regulated by thermogenic signals via the cAMP-dependent transcription factor ATF3
2020-03-17
1
ER stress increases store-operated Ca2+entry (SOCE) and augments basal insulin secretion in pancreatic β cells
2020-03-16
1
NFκB mediates lipopolysaccharide-induced alternative pre-mRNA splicing of MyD88 in mouse macrophages
2020-03-16
1
Structure-based discovery of a small-molecule inhibitor of methicillin-resistant Staphylococcus aureus virulence
2020-03-16
1
Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically relevant concentrations
2020-03-16
0.90
Cotranslational folding stimulates programmed ribosomal frameshifting in the alphavirus structural polyprotein
2020-03-13
1
Genetic evidence for reconfiguration of DNA polymerase θ active site for error-free translesion synthesis in human cells
2020-03-13
1
Nα-acetylation of the virulence factor EsxA is required for mycobacterial cytosolic translocation and virulence
2020-03-13
1
The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice
2020-03-13
0.67
Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization
2020-03-12
0.10
The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independently of its catalytic activity
2020-03-12
1
The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca2+-NFATC1 axis
2020-03-12
0.97
12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA2γ knockout
2020-03-11
1
A kainate receptor-selective RNA aptamer
2020-03-11
1
CRISPR-Cas12a has widespread off-target and dsDNA-nicking effects
2020-03-11
1
S-palmitoylation of the sodium channel Nav1.6 regulates its activity and neuronal excitability
2020-03-11
1
Reduction of protein phosphatase 2A (PP2A) complexity reveals cellular functions and dephosphorylation motifs of the PP2A/B’δ holoenzyme
2020-03-10
1
Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin
2020-03-10
0.94
Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability
2020-03-10
0.50
AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice
2020-03-09
1
The HIV-1 capsid–binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b
2020-03-09
0.98
The heme regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation
2020-03-09
1
Two and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils
2020-03-09
1
Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2
2020-03-06
1
HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane
2020-03-06
1
Substrate recognition and ATPase activity of the E. coli cysteine/cystine ABC transporter YecSC-FliY
2020-03-06
0.20
Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy
2020-03-05
1
Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7
2020-03-05
0.05
RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain
2020-03-05
1
Spatially remote motifs cooperatively affect substrate preference of a ruminal GH26-type endo-β-1,4-mannanase
2020-03-05
0.17
The dynein light chain 8 (LC8) binds “in-register” to multivalent intrinsically disordered partners
2020-03-05
1
Development of a novel β-1,6-glucan-specific detection system using functionally modified recombinant endo-β-1,6-glucanase
2020-03-04
0.28
Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact
2020-03-04
0.60
Nucleotides released from palmitate-activated murine macrophages attract neutrophils
2020-03-04
0.27
Development of cGAMP-Luc, a sensitive and precise coupled enzyme assay to measure cGAMP in complex biological samples
2020-03-03
1
SMAD7 enhances adult β cell proliferation without significantly affecting β cell function in mice
2020-03-02
1
A Kinesin adapter directly mediates dendritic mRNA localization during neural development in mice
2020-02-28
1
Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms.
2020-02-28
0.38
The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates α-tubulin
2020-02-28
0.86
Viruses go modular
2020-02-28
0.58
Emerging roles for R-loop structures in the management of topological stress
2020-02-27
1
Heparin inhibits pro-inflammatory and promotes anti-inflammatory macrophage polarization under hyperglycemic stress
2020-02-27
1
The luminescent HiBiT peptide enables selective quantitation of GPCR ligand engagement and internalization in living cells
2020-02-27
1
Duplication of leucyl-tRNA synthetase in an archaeal extremophile may play a role in adaptation to variable environmental conditions
2020-02-26
1
PKA phosphorylation potentiates CFTR gating by relieving auto-inhibition on the stimulatory C terminus of the regulatory domain
2020-02-26
0.50
Structural basis of cell surface signaling by a conserved sigma regulator in Gram-negative bacteria
2020-02-26
1
The biofilm adhesion protein Aap from Staphylococcus epidermidis forms zinc-dependent amyloid fibers
2020-02-26
1
Conformational rearrangements in the N-domain of Escherichia coli FepA during ferric enterobactin transport
2020-02-25
1
Site-specific 5-hydroxy-tryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high density lipoprotein biogenesis
2020-02-25
1
The roles of polymerases ν and θ in the replicative bypass of O6- and N2-alkyl-2'-deoxyguanosine lesions in human cells
2020-02-25
1
Structural asymmetry does not indicate hemi-phosphorylation in the bacterial histidine kinase CpxA
2020-02-24
1
The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
2020-02-24
0.40
Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages
2020-02-24
0.33
Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42
2020-02-24
1
Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I
2020-02-21
0.13
Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability
2020-02-21
0.75
A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2)
2020-02-20
1
Biochemical characterization of acyl activating enzymes for side chainmoieties of taxol and its analogs
2020-02-20
1
Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids
2020-02-20
0.09
Hepatic HAX-1 inactivation prevents metabolic diseases by enhancing mitochondrial activity and bile salt export
2020-02-20
1
Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel
2020-02-20
0.94
Bile Acid Sequestration Reverses Liver Injury and Prevents Progression of NASH in Western Diet-Fed Mice
2020-02-19
1
Competition for delivery of profilin-actin to barbed ends limits the rate of formin-mediated actin filament elongation
2020-02-19
1
Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1
2020-02-19
1
Regulation of gene expression during the fasting–feeding cycle of the liver displays mouse strain specificity
2020-02-19
1
Structural basis for specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015
2020-02-19
1
The intracellular domain of homomeric glycine receptors modulates agonist efficacy
2020-02-19
0.38
Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells
2020-02-18
1
Histone deacetylase 3 preferentially binds and collaborates with transcription factor RUNX1 to repress AML1-ETO-dependent transcription in t(8;21) AML
2020-02-18
1
Modulation of conformational equilibrium by phosphorylation underlies the activation of deubiquitinase A
2020-02-18
1
S-Acylation modulates the function of the apical sodium-dependent bile acid transporter in human cells
2020-02-18
1
The two splice variant forms of Cdc42 exert distinct and essential functions in neurogenesis
2020-02-18
1
Kelch-like protein 42 is a pro-fibrotic ubiquitin E3 ligase involved in in systemic sclerosis
2020-02-17
1
ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1)
2020-02-14
0.65
Extrahepatic deficiency of transferrin receptor 2 is associated with increased erythropoiesis independentof iron overload
2020-02-13
1
The hydrolysis mechanism of a GH45 cellulase and its potential relation to lytic transglycosylase and expansin function
2020-02-13
0.80
Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity
2020-02-11
1
Identification of a selective manganese ionophore that enables non-lethal quantification of cellular manganese
2020-02-11
1
Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids
2020-02-11
0.83
Sorting nexin 17 (SNX17) links endosomal sorting to Eps15 Homology Domain Protein 1 (EHD1)-mediated fission machinery
2020-02-10
1
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays
2020-02-07
0.75
A genome-wide CRISPR/Cas9 screen reveals that the aryl hydrocarbon receptor stimulates sphingolipid levels
2020-02-06
1
Pausing sites of RNA polymerase II on actively transcribed genes are enriched with DNA double-stranded breaks
2020-02-06
1
Structure-based group A streptococcal vaccine design: Helical wheel homology predicts antibody cross-reactivity among streptococcal M protein-derived peptides
2020-02-06
1
The glutamic acid-rich long C-terminal extension of troponin T has a critical role in insect muscle functions
2020-02-05
1
A specific amino acid context in EGFR and HER2 phosphorylation sites enables selective binding to the active site of Src homology phosphatase 2 (SHP2)
2020-02-04
1
Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKγ protein enhances the anticancer effect of chemotherapy
2020-02-04
0.80
Glutamine and asparagine activate mTORC1 independently of Rag GTPases
2020-02-04
1
Histone methyltransferase G9a diminishes expression of cannabinoid CB1 receptors in primary sensory neurons in neuropathic pain
2020-02-04
0.86
Pseudomonas aeruginosa exoenzyme Y directly bundles actin filaments
2020-02-04
1
Rational design, synthesis and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase
2020-02-04
1
A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry
2020-02-03
1
Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation
2020-02-03
0.50
Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode
2020-02-02
1
Tuning of pKa values activates substrates in flavin-dependent aromatic hydroxylases
2020-02-02
0.22
"Register-shift” insulin analogs uncover constraints of proteotoxicity in protein evolution
2020-01-31
0.84
Exploring Cryptococcus neoformans capsule structure and assembly with a hydroxylamine-armed fluorescent probe
2020-01-31
0.64
How and Why to Build a Mathematical Model: A Case Study Using Prion Aggregation
2020-01-31
1
Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12
2020-01-31
0.79
Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation
2020-01-31
0.88
Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease
2020-01-31
1
The DNA repair enzyme MUTYH potentiates cytotoxicity of the alkylating agent MNNG by interacting with abasic sites
2020-01-30
1
The GTPase KRAS suppresses the P53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells
2020-01-30
1
The transcription factor REST up-regulates tyrosine hydroxylase and antiapoptotic genes and protects dopaminergic neurons against manganese toxicity
2020-01-30
1
(R,R)-1,12-Dimethylspermine can mitigate abnormal spermidine accumulation in Snyder-Robinson syndrome
2020-01-29
0.80
A plant pentatricopeptide repeat protein with a DYW-deaminase domain is sufficient for catalyzing C-to-U RNA editing in vitro
2020-01-29
1
Antisense oligonucleotides targeting Notch2 ameliorate the osteopenic phenotype in a mouse model of Hajdu Cheney syndrome
2020-01-28
1
A nicotinamide phosphoribosyltransferase–GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus
2020-01-27
0.08
ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity
2020-01-27
1
Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4
2020-01-27
0.70
Human polymorphisms in Gsdmd alter the inflammatory response
2020-01-27
1
Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1
2020-01-27
1
The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter looping GLI1-STAT3 transcriptional complex
2020-01-27
1
Disruption of hepatic small heterodimer partner induces dissociation of steatosis and inflammation in experimental nonalcoholic steatohepatitis
2020-01-24
1
Improved workflow for mass spectrometry-based metabolomics analysis of the heart
2020-01-24
1
Infection-induced signals generated at the plasma membrane epigenetically regulate Wnt signaling in vitro and in vivo
2020-01-24
1
Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway
2020-01-24
0.19
Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex
2020-01-24
1
A synthetic heparinoid blocks tau aggregate cell uptake and amplification
2020-01-23
0.96
Intracellular vesicle clusters are organelles that synthesize extracellular vesicle-associated cargo proteins
2020-01-23
1
Optimization of sortase A ligation for flexible engineering of complex protein systems
2020-01-23
1
Pulse-chase SILAC–based analyses reveal selective over-synthesis and rapid turnover of mitochondrial protein components of respiratory complexes
2020-01-23
1
Uncovering the activities, biological roles, and regulation of bacterial cell wall hydrolases and tailoring enzymes
2020-01-23
1
Extracellular domains I-II of cell-surface glycoprotein CD44 mediate its trans-homophilic dimerization and tumor cluster aggregation
2020-01-22
0.93
HLA-DM catalytically enhances peptide dissociation by sensing peptide–MHC class II interactions throughout the peptide binding cleft
2020-01-22
1
A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation
2020-01-21
1
Mechanism underlying autoinducer recognition in the Vibrio cholerae DPO-VqmA quorum-sensing pathway
2020-01-21
1
Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin binding protein
2020-01-21
0.83
Hematopoietic progenitor kinase 1 down-regulates the oncogenic receptor tyrosine kinase AXL in pancreatic cancer
2020-01-20
1
A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors
2020-01-17
1
Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophyby forming a heterodimer with the transcriptional regulator C/EBPβ
2020-01-17
1
Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody
2020-01-17
1
The retina and retinal pigment epithelium differ in nitrogen metabolism and are metabolically connected
2020-01-17
0.54
The small molecule GAT1508 activates brain-specific GIRK1/2 channel heteromers and facilitates conditioned fear extinction in rodents
2020-01-17
1
DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gαi
2020-01-16
0.91
Interaction between the yeast RAVE complex and Vph1-containing Vo sectors is a central glucose-sensitive interaction required for V-ATPase reassembly
2020-01-15
1
Leukocyte-associated immunoglobulin-like receptor-1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway
2020-01-13
1
Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-kB and expression of the long-non coding RNA HAS2-AS1
2020-01-13
0.08
Steric constraints control processing of glycosylphosphatidylinositol anchors in Trypanosoma brucei
2020-01-13
1
A proteoliposome-based system reveals how lipids control photosynthetic light harvesting
2020-01-12
1
Analyses of the oncogenic BRAFD594G variant reveal a kinase-independent function of BRAF in activating MAPK signaling
2020-01-12
1
A fluorescence activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques
2020-01-09
0.60
Amelogenin phosphorylation regulates tooth enamel formation by stabilizing a transient amorphous mineral precursor
2020-01-09
1
The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells
2020-01-09
0.19
Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist
2020-01-08
1
First characterization of glucose flux through the hexosamine biosynthesis pathway (HBP) in ex vivo mouse heart
2020-01-08
0.60
Genome-wide analysis of targets of macrolide antibiotics in mammalian cells
2020-01-08
1
Mapping and engineering the interaction between adiponectin and T-cadherin
2020-01-08
1
PITHD1 is a proteasome-interacting protein essential for male fertilization
2020-01-08
0.13
The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation
2020-01-08
0.86
The location of sensing determines the pancreatic β cell response to the viral mimetic dsRNA
2020-01-08
1
An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation
2020-01-07
1
Cross-linking modifications of HDL apoproteins by oxidized phospholipids: Structural characterization, in vivo detection, and functional implications
2020-01-06
1
Granulins modulate liquid-liquid phase separation and aggregation of prion-like C-terminal domain of the neurodegeneration-associated protein TDP-43
2020-01-06
0.89
The bacterial deubiquitinase Ceg23 regulates the association of Lys-63-linked polyubiquitin molecules on the Legionella phagosome
2020-01-06
0.22
The plastidial Arabidopsis thaliana NFU1 protein binds and delivers [4Fe-4S] clusters to specific client proteins
2020-01-06
0.15
NOTCH3 is non-enzymatically fragmented in inherited cerebral small-vessel disease
2020-01-04
1
14-3-3 proteins protect AMPK-phosphorylated ten-eleven translocation-2 (TET2) from PP2A-mediated dephosphorylation
2020-01-03
1
Cryo-EM reveals the architecture of the dimeric cytochrome P450 CYP102A1 enzyme and conformational changes required for redox partner recognition
2020-01-03
1
Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization
2020-01-03
0.29
Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells
2020-01-02
1
Melanin deposition in two Cryptococcus species depends on cell-wall composition and flexibility
2020-01-02
0.94
RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules
2020-01-02
1
The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1
2020-01-02
1
Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning
2020-01-02
1
Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β
2019-12-31
1
A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation
2019-12-30
1
A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase
2019-12-30
1
A synthetic lethal drug combination mimics glucose deprivation-induced cancer cell death in the presence of glucose
2019-12-30
1
Motif V regulates energy transduction between the flavivirus NS3 ATPase and RNA-binding cleft
2019-12-30
1
Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity
2019-12-30
1
Processing and integration of functionally oriented prespacers in the E. coli CRISPR system depends on bacterial host exonucleases
2019-12-30
1
The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells
2019-12-30
1
Tyrosine Nitration on Calmodulin Enhances calcium-dependent association and activation of Nitric Oxide Synthase
2019-12-30
1
Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy
2019-12-27
0.03
Glucose stimulates microRNA-199 expression in murine pancreatic β-cells
2019-12-27
0.75
Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome
2019-12-27
0.67
Pulmonary Surfactant Lipids Inhibit Infections with the Pandemic H1N1 Influenza Virus in Several Animal Models
2019-12-27
0.90
Recognition of 1,N2-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active site residue
2019-12-27
1
Structural and mechanistic insights into Hsp104 function revealed by synchrotron x-ray footprinting
2019-12-27
1
The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals
2019-12-27
0.88
Transmembrane helix 6b links proton- and metal-release pathways and drives conformational change in an Nramp-family transition metal transporter
2019-12-27
1
Membrane receptor activation mechanisms and transmembrane peptide tools to elucidate them
2019-12-25
1
ACE over expression in myeloid cells increases oxidative metabolism and cellular ATP
2019-12-23
1
Comprehensive engineering of the tarantula venom peptide huwentoxin-IV to inhibit the human voltage-gated sodium channel hNav17
2019-12-23
1
The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled
2019-12-23
1
Identification of a truncated β1-chimaerin variant that inactivates nuclear Rac1
2019-12-22
0.14
The pentose phosphate pathway of cellulolytic clostridia relies on 6-phosphofructokinase instead of transaldolase
2019-12-22
0.60
FADS3 is a delta14Z sphingoid base desaturase that contributes to gender differences to the human plasma sphingolipidome
2019-12-20
0.38
JARID2 and the PRC2 complex regulate the cell cycle in skeletal muscle
2019-12-20
1
The mechanism of β-N-methylamino-L-alanine inhibition of tRNA aminoacylation and its impact on misincorporation
2019-12-20
1
Cl− and H+ coupling properties and subcellular localizations of wildtype and disease-associated variants of the voltage-gated Cl−/H+ exchanger ClC-5
2019-12-18
1
The InsP7 phosphatase Siw14 regulates inositol pyrophosphate levels to control localization of the general stress response transcription factor Msn2
2019-12-17
1
Downstream sequence-dependent RNA cleavage and pausing by RNA polymerase I
2019-12-16
1
The influenza NS1 protein modulates RIG-I activation via a strain-specific direct interaction with the second CARD of RIG-I
2019-12-16
1
Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer
2019-12-13
0.93
Changes in protein function underlie the disease spectrum in patients with CHIP mutations
2019-12-13
0.86
GAIN domain–mediated cleavage is required for activation of G protein–coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist
2019-12-13
1
A 49-residue sequence motif in the C-terminus of Nav1.9 regulates trafficking of the channel to the plasma membrane
2019-12-10
1
In vitro trackable assembly of RNA-specific nucleocapsids of the respiratory syncytial virus
2019-12-10
1
Mechanism of activation for the sirtuin 6 protein deacylase
2019-12-10
1
Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma
2019-12-10
0.86
Protein phosphatase 2A activation as a therapeutic strategy for managing MYC-driven cancers
2019-12-10
1
The protein tyrosine phosphatase RPTPζ/phosphacan is critical for perineuronal net structure
2019-12-10
0.80
The structure of the Thermococcus gammatolerans McrB N-terminal domain reveals a new mode of substrate recognition and specificity among McrB homologs
2019-12-10
1
Aberrant activation of hepatocyte growth factor/MET signaling promotes β-catenin–mediated prostatic tumorigenesis
2019-12-09
1
Antibody Validation for Western blot: By the User, for the User
2019-12-09
0.50
Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNAHis mutation
2019-12-09
0.09
PASylation of IL-1 Receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis
2019-12-09
0.55
Regulated protein stabilization underpins the functional interplay among basal body components in Trypanosoma brucei
2019-12-09
1
The human UDP-galactose 4’-epimerase (GALE) is required for cell-surface glycome structure and function
2019-12-09
1
Urokinase-type Plasminogen Activator (uPA) Regulates the Expression and Function of the Growth- associated Protein-43 (GAP-43) in the Synapse
2019-12-09
1
A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity
2019-12-06
1
ERAP1 enzyme-mediated trimming and structural analyses of MHC I–bound precursor peptides yield novel insights into antigen processing and presentation
2019-12-06
1
Mass cytometry–based single-cell analysis of human stem cell reprogramming uncovers differential regulation of specific pluripotency markers
2019-12-06
0.25
The host-defense peptide piscidin P1 reorganizes lipid domains in membranes and decreases activation energies in mechanosensitive ion channels
2019-12-06
1
The regulatory protein 14-3-3β binds to the IQ motifs of myosin-IC independently of phosphorylation
2019-12-06
1
Activity of the yeast cytoplasmic Hsp70 nucleotide exchange factor Fes1 is regulated by reversible methionine oxidation
2019-12-05
1
An unexpected second binding site for polypeptide substrates is essential for Hsp70 chaperone activity
2019-12-05
1
Copper-only superoxide dismutase enzymes and iron starvation stress in Candida fungal pathogens
2019-12-05
1
Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity
2019-12-05
1
Viral protein X Reduces the Incorporation of Mutagenic Noncanonical rNTPs during Lentivirus Reverse Transcription in Macrophages
2019-12-05
0.75
DNA polymerase β nucleotide-stabilized template misalignment fidelity depends on local sequence context
2019-12-04
1
Structural basis for shieldin complex subunit 3–mediated recruitment of the checkpoint protein REV7 during DNA double-strand break repair
2019-12-03
0.33
A capture-and-release method based on non-covalent ligand cross-linking and facile filtration for the purification of lectins and glycoproteins
2019-12-02
1
Comparative structure-function analysis of bromodomain and extraterminal motif (BET) proteins in a gene-complementation system
2019-12-02
0.80
High affinity binding of plasminogen-activator inhibitor 1-complexes to LDL receptor-related protein 1 requires lysines 80, 88 and 207
2019-12-02
1
PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response
2019-12-02
0.73
The Plasmodium falciparum circumsporozoite protein produced in Lactococcus lactis is a pure and stable
2019-12-02
0.25
139 109.68
370 282.30
123 83.23
416 350.22
180 140.73
162 112.95
477 328.90
99 78.77
72 51.49
109 84.90
2186 1421.72
92 55.28
1 0.83
78 51.61
153 105.50
74 60.03
108 85.85
81 64.61
213 182.14
156 106.03
284 216.28
1922 1480.98
265 182.56
328 233.82
699 499.53
217 169.33
99 47.48
118 85.79
71 40.81
1084 890.33
Earth & Environmental Sciences 4341 2853.57
Chemistry 7235 5250.77
Physical Sciences 8259 5364.59

1 December 2019 - 30 November 2020

View the connected world of international research collaboration. Visualize collaborations by subject or region.

Collaborations between countries

Percentage of collaboration by Share

Hover over the graph to view the percentage of collaboration.

Top 10 collaborators by Share

  • United States of America (USA)
  1. China (4420.77)
    2106.75
    2314.03
  2. 1144.34
    831.17
  3. Germany (1914.97)
    1082.34
    832.63
  4. Canada (1205.80)
    753.10
    452.71
  5. France (1078.91)
    656.65
    422.26
  6. Japan (974.94)
    598.68
    376.26
  7. Australia (712.66)
    427.56
    285.10
  8. Switzerland (698.47)
    414.10
    284.37
  9. South Korea (697.43)
    420.77
    276.66
  10. Italy (582.81)
    354.79
    228.01

Collaboration is determined by the combined fractional count (Share) of United States of America (USA) and the collaborating country.

Top 10 institutions from United States of America (USA)

Institution Count Share
1. Harvard University 2535 914
2. Stanford University 1694 647.18
3. Massachusetts Institute of Technology (MIT) 1828 528.46
4. National Institutes of Health (NIH) 1085 404.29
5. University of California, Berkeley (UC Berkeley) 1297 395.84
6. University of Michigan (U-M) 1010 391.33
7. Yale University 987 350.79
8. University of California, San Diego (UC San Diego) 1003 342.66
9. Columbia University in the City of New York (CU) 1027 327.89
10. University of California, Los Angeles (UCLA) 1114 327.29

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