M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's disease

Journal: eLife

Published: 2020-10-05

DOI: 10.7554/elife.57017

Affiliations: 8

Authors: 14

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Research Highlight

Mouse study suggests new therapy for Huntington’s disease

© Jonathan Kitchen/Getty

© Jonathan Kitchen/Getty

Therapies that stimulate information flow between the brain’s movement-command center and skill-learning hub could help correct movement and coordination problems associated with Huntington’s disease, a debilitating hereditary neurodegenerative disorder.

That’s according to a study by researchers in Spain, who scanned the brains of mice that had been genetically engineered to develop a Huntington’s-like condition. The team, which included scientists from the Spanish National Research Council, mapped the brain circuitry of the mice and discovered deficits in connectivity between the motor cortex, which controls movement, and the dorsolateral striatum, which affects habitual behaviours.

When the researchers selectively stimulated the pathway connecting these two brain regions using laser light, the mices’ motor skills and neuronal architectures of their brains both improved.

Drugs that have similar effects in the human brain could help ameliorate symptoms of Huntington’s in patients.

Supported content

  1. eLife 9, e57017 (2020). doi: 10.7554/eLife.57017
Institutions Share
August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Spain 0.40
University of Barcelona (UB), Spain 0.36
Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), Spain 0.14
Institute of Biomedical Research Barcelona (IIBB), CSIC, Spain 0.05
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Spain 0.05