miR‐200/375 control epithelial plasticity‐associated alternative splicing by repressing the RNA‐binding protein Quaking

Journal: The EMBO Journal

Published: 2018-06-05

DOI: 10.15252/embj.201899016

Affiliations: 8

Authors: 21

Go to article

Research Highlight

MicroRNAs leave cancer quaking

© KATERYNA KON/Science Photo Library/Getty

© KATERYNA KON/Science Photo Library/Getty

To prevent a cellular transition that promotes the spread of metastatic cancer, small regulatory RNA molecules are needed to quash the expression of a protein that would otherwise alter the processing of gene transcripts in a way that fuels tumour growth and aggressiveness.

A research team, led by scientists from the University of South Australia, searched for binding partners of a known tumour-suppressing short RNA called miR-200c. They found that the gene transcript encoding a protein called ‘Quaking’ was a direct target of this microRNA, and that miR-200c and another short regulatory RNA both suppressed the protein’s expression.

One particular form of Quaking normally stimulates metastasis in a range of cancers by modulating the splicing of coding and non-coding portions of numerous other genes. And both miR-200c and Quaking can alter the dynamic nature of structural filaments running through the cell to affect tumour spread.

Targeting this signalling pathway offering a promising strategy for limiting cancer progression.

Supported content

  1. The EMBO Journal 37, e99016 (2018). doi: 10.15252/embj.201899016
Institutions Share
Centre for Cancer Biology, Australia 0.67
Australian Prostate Cancer Research Centre - Queensland (APCRC - Q), Australia 0.10
Discipline of Medicine, Adelaide Uni, Australia 0.08
Dame Roma Mitchell Cancer Research Labs (DRMCRL), Adelaide Uni, Australia 0.03
Freemasons Foundation Centre for Men's Health, Adelaide Uni, Australia 0.03
Adelaide Medical School, Adelaide Uni, Australia 0.03
School of Biological Sciences, Adelaide Uni, Australia 0.03
Flinders Centre for Innovation in Cancer (FCIC), Flinders University, Australia 0.02