Journal: Journal of Neuroscience
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Synaptic changes explain genetic link to psychiatric disease
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A mouse study has revealed how a mutant gene linked to autism and other neuropsychiatric disorders alters synaptic activity in the brain.
Synaptic adhesion molecules regulate the development and function of synapses, which in turn govern the functions of neural circuits and the brain.
Now, a team led by researchers from the Institute for Basic Sciences created mice deficient in Lrfn2, a gene that encodes a synaptic adhesion molecule. These mice showed changes in both inhibitory and excitatory synaptic function, and displayed abnormal behaviours connected to social communication and startled responses.
The human version of Lrfn2 has been implicated in autism spectrum disorder, schizophrenia, working memory deficits and antisocial personality disorders. The findings reveal some of the neural impairments that likely underpin these neuropsychiatric problems — and suggest pathways that could be targeted therapeutically to correct synaptic defects.
- Journal of Neuroscience 38, 5872–5887 (2018). doi: 10.1523/JNEUROSCI.3321-17.2018