Prostaglandin transporter OATP2A1/SLCO2A1is essential for body temperature regulation during fever

Journal: Journal of Neuroscience

Published: 2018-06-13

DOI: 10.1523/jneurosci.3276-17.2018

Affiliations: 4

Authors: 10

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Research Highlight

Transport protein helps the brain run a fever

© Hiroshi Watanabe/Getty

© Hiroshi Watanabe/Getty

A protein involved in ferrying fever-inducing substances to and within the brain offers a promising therapeutic target for treating neuroinflammatory disorders.

Scientists from Kanazawa University and elsewhere in Japan studied mice with and without a working version of the Slco2a1 gene, which encodes the transport protein involved in the cellular uptake of prostaglandin E2 (PGE2), an important mediator of the body’s heat-generating response to fever-stimulating signals from pathogens.

By comparing febrile responses in these mouse models, they showed this protein mediates transport of PGE2 across the blood–brain barrier. It also helps secrete the hormone-like substance from the inside of particular brain cells in the hypothalamus to the surrounding space, thereby elevating the PGE2 concentration and triggering fever.

The findings help explain a certain kind of inflammatory response in the brain and suggest that blocking Slco2a1 or its protein product could help reduce neuroinflammation.

Supported content

  1. Journal of Neuroscience 38, 5584–5595 (2018). doi: 10.1523/JNEUROSCI.3276-17.2018
Institutions Share
Kanazawa University (KU), Japan 0.67
Teikyo University, Japan 0.30
Kindai University, Japan 0.03