Angiopoietin-1 is required for Schlemm’s canal development in mice and humans

Journal: Journal of Clinical Investigation

Published: 2017-11-06

DOI: 10.1172/jci95545

Affiliations: 17

Authors: 26

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Research Highlight

A closer look at a common eye disease

© Nastasic/E+/Getty

© Nastasic/E+/Getty

A genetic mutation that can cause glaucoma, a debilitating eye disease, has been identified. 

Glaucoma is a potentially blinding disease affecting more than 60 million people worldwide. The main cause is high fluid pressure inside the eye resulting from defects in its drainage system, which can develop before birth. 

A team including researchers from Flinders University bred mice without one or both of the genes Angpt1 and Angpt2. Previous research suggests these genes, usually responsible for growing new blood vessels, are involved in the development of the Schlemm’s canal — one of the eye’s main drainage routes. The team found that mice lacking both Angpt1 and Angpt2 did not develop a Schlemm’s canal at all, resulting in severe glaucoma, whereas mice lacking just Angpt1 developed an incomplete canal, resulting in raised fluid pressure in the eye, which could lead to glaucoma. 

These findings reveal a potential target for gene therapy to prevent or treat the condition.

Supported content

  1. Journal of Clinical Investigation 127, 4421-4436 (2017) doi: 10.1172/jci95545
Institutions FC
Department of Ophthalmology and Visual Sciences, UW-Madison, United States of America (USA) 0.15
Flinders Centre for Ophthalmology, Eye and Vision Research (FCOEVR), Flinders University, Australia 0.15
Feinberg Cardiovascular Research Institute (FCVRI), NU, United States of America (USA) 0.12
Division of Nephrology/Hypertension, NU, United States of America (USA) 0.12
The Jackson Laboratory, United States of America (USA) 0.08
Department of Ophthalmology, NU, United States of America (USA) 0.08
Harvard Department of Ophthalmology, United States of America (USA) 0.04
Institute of Human Genetics, FAU, Germany 0.04
Dean McGee Eye Institute (DMEI), United States of America (USA) 0.04
Harry Perkins Institute of Medical Research (HPIMR), Australia 0.03
Lions Eye Institute (LEI), UWA, Australia 0.03
Menzies Institute for Medical Research, UTAS, Australia 0.03
Centre for Medical Research (CMR), UWA, Australia 0.03
Hospital das Clínicas da FMUSP, Brazil 0.02
Department of Ophthalmology, Otolaryngology and Head and Neck Surgery, USP, Brazil 0.02
PathWest’s Diagnostic Genomics Laboratory, Australia 0.01
Centre for Eye Research Australia (CERA), Australia 0.01

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