Lung-restricted inhibition of Janus kinase 1 is effective in rodent models of asthma

Journal: Science Translational Medicine

Published: 2018-11-21

DOI: 10.1126/scitranslmed.aao2151

Affiliations: 9

Authors: 28

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Research Highlight

A new inhalable drug for asthma

© Karl Tapales/Getty

© Karl Tapales/Getty

An inhalable version of immune-suppressing drugs called JAK inhibitors helped improve symptoms of asthma in mouse and guinea pig models of the disease.

JAK inhibitors are already approved in pill form for treating rheumatoid arthritis, ulcerative colitis and other autoimmune disorders. In mouse models of asthma, these drugs have previously shown some therapeutic potential, but side effects precluded their further development for treating asthma in people.

Now, researchers at the Roche subsidiary Genentech have created a JAK inhibitor that can be administered as a dry powder through inhalation. This delivery system ensures that the drug stays in the lungs, with minimal systemic exposure to the rest of the body.

In the animal models, the drug reduced lung inflammation, improved allergen-induced airway hypersensitivity and exhibited better asthma control than standard corticosteroid therapy, with minimal toxicity.

The researchers conclude that human trials are now warranted.

Supported content

  1. Science Translational Medicine 10, eaao2151 (2018). doi: 10.1126/scitranslmed.aao2151
Institutions FC
Department of Translational Immunology, Genentech, Inc., United States of America (USA) 0.29
Department of Biochemical and Cellular Pharmacology, Genentech, Inc., United States of America (USA) 0.14
Charles River UK, Ltd., United Kingdom (UK) 0.14
Department of Drug Metabolism and Pharmacokinetics (DMPK), Genentech, Inc., United States of America (USA) 0.14
Department of Immunology, Genentech, Inc., United States of America (USA) 0.11
Department of Safety Assessment, Genentech, Inc., United States of America (USA) 0.07
Charles River Discovery Research Services Germany GmbH, Germany 0.07
Department of Discovery Chemistry, Genentech, Inc., United States of America (USA) 0.04

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