Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens

Journal: Science

Published: 2019-11-01

DOI: 10.1126/science.aay6485

Affiliations: 12

Authors: 15

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Research Highlight

Measles wipes out immune memory

© CHBD/Getty

© CHBD/Getty

Measles infections in children can destroy the immune system’s memory of prior exposure to other pathogens.

The finding — from a team that included scientists at Genentech, a Roche subsidiary — helps explain why youngsters recovering from measles are more susceptible to other infectious diseases. It also underscores the importance of vaccinating against the measles virus.

The researchers analysed blood samples from 77 unvaccinated Dutch children taken before and after a measles outbreak.

They found that the infection erased 11–73% of antibodies against other bacteria and viruses that were present before the children fell ill. Kids who were vaccinated against measles showed no such deficits in their antibody repertoires.

The researchers confirmed that measles induces a kind of immune amnesia by experimentally infecting monkeys with the virus and observing the same loss of pre-existing antibodies.

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  1. Science 366, 599–606 (2019). doi: 10.1126/science.aay6485
Institutions Share
Division of Genetics, BWH, United States of America (USA) 0.14
Harvard Department of Genetics, United States of America (USA) 0.14
Genentech, Inc., United States of America (USA) 0.13
W. Harry Feinstone Department of Molecular Microbiology and Immunology, JHU, United States of America (USA) 0.13
Department of Viroscience, Erasmus MC, Netherlands 0.07
Postgraduate School Molecular Medicine (Mol Med), Erasmus MC, Netherlands 0.07
HUCH Children's Hospital, Finland 0.07
Research Programs Unit (RPU), University of Helsinki, Finland 0.07
Barbara Davis Center for Childhood Diabetes (BDC), United States of America (USA) 0.07
Department of Pathology, JHU, United States of America (USA) 0.07
Department of Pathology, BWH, United States of America (USA) 0.02
Harvard Division of Medical Sciences (DMS), United States of America (USA) 0.02