Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses

Journal: Science

Published: 2019-08-16

DOI: 10.1126/science.aav0758

Affiliations: 5

Authors: 3

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Research Highlight

DNA sensor helps fight viruses in the nucleus

© SCIEPRO/SCIENCE PHOTO LIBRARY/Getty

© SCIEPRO/SCIENCE PHOTO LIBRARY/Getty

The nucleus — the inner sanctum of the cell — is not free of immune defenses, as long believed.

Unlike RNA viruses, DNA viruses direct their genomic DNA into the nuclei of host cells, but little is known about the surveillance mechanisms for detecting viral nucleic acids in the nucleus.

A Nankai University–led study has found that mammalian nuclei contain a protein that detects viral DNA and ships it off to the cell’s main compartment, the cytoplasm, for immune processing.

Importantly, this newly described DNA sensor helps initiate and amplify strong innate immune responses against viral pathogens residing in the nucleus without reacting against host DNA, which is packaged in tight coils and recognized as non-foreign.

The findings thus unveil a new facet of DNA recognition in the nucleus and provide a potential therapeutic target for treating viral infections.

Supported content

  1. Science 65, eaav0758 (2019). doi: 10.1126/science.aav0758
Institutions Share
National Key Laboratory of Medical Immunology, SMMU, China 0.51
State Key Laboratory of Medicinal Chemical Biology (SKLMCB), NKU, China 0.18
College of Life Sciences, NKU, China 0.18
State Key Laboratory of Medical Molecular Biology (SKLMMB), CAMS & PUMC, China 0.07
Department of Immunology, CAMS & PUMC, China 0.07

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