Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation

Journal: Science

Published: 2017-10-20

DOI: 10.1126/science.aan4526

Affiliations: 15

Authors: 26

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Research Highlight

Mouth bacteria upsets the bowels

© Burak Karademir/Moment/Getty

© Burak Karademir/Moment/Getty

Bacteria that live in your mouth could end up in the gut and trigger inflammatory bowel disease.

The average person swallows around 1.5 litres of saliva every day, sending a multitude of microbes through the body. Disturbances in gut flora, the gut’s microbial community, are thought to cause conditions such as inflammatory bowel disease (IBD), but tracing the source of inflammation has been difficult.

A team led by researchers from Keio University fed saliva from humans with IBD to healthy mice. After six weeks, they analysed the mice’s faeces and identified the presence of around 20 different human oral bacteria. There was a particular abundance of the Klebsiella — a harmless oral inhabitant when present in healthy humans. The team injected Klebsiella into a new batch of mice and found that it activated immune cells and triggered inflammation in the guts.

Additionally, Klebsiella triggered more inflammation in mice treated with antibiotics, suggesting that medicines that modify gut microbes could make patients more susceptible to bowel disease.

Supported content

  1. Science 358, 359-365 (2017). doi: 10.1126/science.aan4526
Institutions FC WFC
RIKEN Center for Integrative Medical Sciences (IMS), Japan 0.19 0.19
Department of Microbiology and Immunology, Keio University, Japan 0.13 0.13
Department of Immunology, WIS, Israel 0.08 0.08
RIKEN Center for Sustainable Resource Science (CSRS), Japan 0.08 0.08
NIH NHGRI Microbial Genomics Section (MGS), United States of America (USA) 0.08 0.08
UPMC CHP Richard King Mellon Foundation Institute for Pediatric Research (RKMFI), United States of America (USA) 0.08 0.08
Graduate School of Frontier Sciences (GSFS), UTokyo, Japan 0.07 0.07
Broad Institute of MIT and Harvard, United States of America (USA) 0.06 0.06
Graduate School of Advanced Science and Engineering / School of Advanced Science and Engineering (ASE), Waseda University, Japan 0.05 0.05
Graduate School and Faculty of Medicine, OCU, Japan 0.04 0.04
Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Singapore 0.04 0.04
Graduate School of Environmental and Life Science (GELS), Okayama University, Japan 0.04 0.04
Center for Computational and Integrative Biology (CCIB), MGH, United States of America (USA) 0.03 0.03
Harvard Medical School (HMS), United States of America (USA) 0.03 0.03
Faculty of Pharmacy, Mansoura University, Egypt 0.02 0.02

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