In situ measurements of intracellular thermal conductivity using heater-thermometer hybrid diamond nanosensors

Journal: Science Advances

Published: 2021-01-01

DOI: 10.1126/sciadv.abd7888

Affiliations: 7

Authors: 7

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Research Highlight

Nanodiamonds used to measure heat flow inside cells

© National Institutes of Health/Stocktrek Images/Getty Images

© National Institutes of Health/Stocktrek Images/Getty Images

Polymer-coated diamonds that act as both tiny heaters and thermometers have been used to measure heat flow inside living cells.

The knowledge of how heat flows within and between living cells is critical for thermal diagnostic techniques and therapies, amongst other applications. But there is a gaping gulf between temperatures predicted by theoretical models and those observed in experiments. One parameter that needs to be pinned down is the heat-transporting ability (thermal conductivity) in and between cells.

Now, a team led by researchers at Osaka University in Japan has measured this parameter inside breast-cancer cells by using nanoscale diamonds coated with a heat-releasing polymer as miniature heaters and thermometers.

Surprisingly, they found that the thermal conductivity inside cells is much closer to that of oil than that of water, which is the value used in most models.

Supported content

  1. Science Advances 7, eabd7888 (2021). doi: 10.1126/sciadv.abd7888
Institutions Share
Institute for Protein Research (IPR), Osaka University, Japan 0.50
Osaka University, Japan 0.21
National University of Singapore (NUS), Singapore 0.14
The University of Queensland (UQ), Australia 0.14
Japan Society for the Promotion of Science (JSPS), Japan 0
Japan Science and Technology Agency (JST), Japan 0