Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota

Journal: Science Advances

Published: 2019-05-01

DOI: 10.1126/sciadv.aaw1507

Affiliations: 4

Authors: 9

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Research Highlight

Gut microbes reduce levels of allergy-inducing antibody



Young mice lacking the right gut bacteria are sensitive to allergens in food. This suggests that there could be a connection between the gut microbiomes of infants and the development of food allergies early in life.

Recent research has consistently pointed to a link between gut bacteria and food allergies, but the details remain unclear.

Now, a team led by researchers at the Institute for Basic Science in the Republic of Korea has found that exposing young microbe-free mice to a normal diet caused them to produce elevated levels of immunoglobulin E—an antibody implicated in food allergies. In contrast, another group of microbe-free mice that were fed a diet free of anything capable of triggering the immune system did not have abnormal immunoglobulin E levels.

This raises the question of whether a diet free of food allergens may help to prevent the onset of allergies in young children who have been treated with antibiotics.

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  1. Science Advances 5, eaaw1507 (2019). doi: 10.1126/sciadv.aaw1507
Institutions Share
Division of Life Sciences, IBS, South Korea 0.61
Pohang University of Science and Technology (POSTECH), South Korea 0.28
Garvan Institute of Medical Research, Australia 0.06
University of New South Wales (UNSW Sydney), Australia 0.06