The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity

Journal: Journal of Biological Chemistry

Published: 2018-01-30

DOI: 10.1074/jbc.m117.813865

Affiliations: 4

Authors: 9

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Research Highlight

Putting a cap on neurodegenerative disease

©JUAN GAERTNER/SCIENCE PHOTO LIBRARY/Getty

©JUAN GAERTNER/SCIENCE PHOTO LIBRARY/Getty

The ‘heat shock protein’ Hsp27 combats neurodegenerative disease by binding to α-synuclein fibrils, fibrous protein structures associated with Alzheimer’s and Parkinson’s diseases, and halting their progression.

Wollongong University’s Heath Ecroyd and a team of Australian and UK scientists found that Hsp27 caps the ends of polymeric α-synuclein fibrils, preventing attachment of additional monomers, and that it binds to the surface of fibrils, reducing their ability to aggregate.

The team also found that Hsp27 binding reduced the cellular toxicity of α-synuclein fibrils, as evidenced by a reduction in reactive oxygen species — damaging, chemically reactive molecules that are implicated in neuronal toxicity.

During testing, Hsp27’s protective abilities failed when there was an overabundance of α-synuclein fibril ‘seeds’. This is an important finding since duplication or triplication of the gene encoding α-synuclein is associated with early onset Parkinson’s disease.

The mechanisms of Hsp27 may represent shared methods of heat shock protein action that may inform the development of future anti-neurodegenerative therapies.

Supported content

  1. Journal of Biological Chemistry 293, 4486–4497 (2018). doi: 10.1074/jbc.M117.813865
Institutions FC
Department of Chemistry, University of Cambridge, United Kingdom (UK) 0.43
Illawarra Health and Medical Research Institute (IHMRI), UOW, Australia 0.31
School of Biological Sciences, UOW, Australia 0.20
School of Chemistry, UOW, Australia 0.06

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