Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia

Journal: Nature Immunology

Published: 2018-09-24

DOI: 10.1038/s41590-018-0202-3

Affiliations: 12

Authors: 19

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Research Highlight

Red or white?

© Science Photo Library – SCIEPRO/Getty

© Science Photo Library – SCIEPRO/Getty

Infections disrupt the expression of a biological switch that determines whether immature blood-forming cells turn into red or white blood cells. This finding could lead to new drugs for treating blood diseases such as anaemia.

A team led by scientists from Tohoku University’s United Centers for Advanced Research and Translational Medicine have identified two regulatory proteins that promote the formation of oxygen-transporting red blood cells over infection-fighting white ones.

They found that exposure to a molecule found on the surface of bacteria leads to diminished levels of these proteins in progenitor blood-forming cells. The reduced activity then helps tip the balance towards the production of the white blood cells needed to fight off pathogens in the body.

But this also results in fewer red blood cells being made, which could explain why anaemia often accompanies infection and inflammation.

Supported content

  1. Nature Immunology 19, 1059–1070 (2018). doi: 10.1038/s41590-018-0202-3
Institutions FC
Department of Biochemistry, Tohoku University, Japan 0.40
Department of Hematology and Rheumatology, Tohoku University, Japan 0.15
Center for Regulatory Epigenome and Diseases (CRED), Tohoku University, Japan 0.11
Department of Pathology and Tumor Biology, Kyoto University, Japan 0.11
Department of Molecular Medicine, UNIPV, Italy 0.05
IRCCS Policlinico San Matteo, Italy 0.05
Japan Society for the Promotion of Science (JSPS), Japan 0.03
NIH NHLBI Laboratory of Molecular Immunology, United States of America (USA) 0.03
School of Medicine, SU, Japan 0.03
Graduate School of Medicine / School of Medicine, Tohoku University, Japan 0.02
Center for Regenerative Medicine (CRM), MGH, United States of America (USA) 0.02
RIKEN Laboratory for Human Disease Models, Japan 0.02

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