PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function

Journal: Nature Chemical Biology

Published: 2020-05-25

DOI: 10.1038/s41589-020-0553-6

Affiliations: 17

Authors: 25

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Research Highlight

Hormone-like substances could slow Parkinson’s disease



Two naturally occurring chemicals with hormone-like effects work together to maintain the health of dopamine-producing neurons in the brain. This finding could lead to new treatments for Parkinson’s disease.

Parkinson’s disease is an incurable neurodegenerative disorder that afflicts somewhere between 7 and 10 million people globally.

Now, a team co-led by scientists at Nanyang Technological University, Singapore, has found that two prostaglandin molecules, called PGE1 and PGA1, together bind and activate a protein called Nurr1 in brain cells. This interaction has neuroprotective effects that can guard cells against deadly neurotoxins and improve motor function in mouse models of Parkinson’s.

The researchers hope to use these insights to design a synthetic form of the prostaglandins as a potential drug that could slow, halt or even reverse neurodegenerative disease.

Supported content

  1. Nature Chemical Biology 16, 876–886 (2020). doi: 10.1038/s41589-020-0553-6
Institutions Share
School of Biological Sciences (SBS), NTU, Singapore 0.25
Molecular Neurobiology Laboratory, McLean Hospital, United States of America (USA) 0.16
Harvard Department of Psychiatry, United States of America (USA) 0.16
College of Bioscience and Biotechnology, Konkuk University, South Korea 0.08
National Neuroscience Institute (NNI), Singapore 0.06
Department of Anesthesiology, Perioperative and Pain Medicine, BWH, United States of America (USA) 0.04
Division of Chemistry and Biological Chemistry (CBC), NTU, Singapore 0.04
Experimental Drug Development Centre (EDDC), A*STAR, Singapore 0.04
Institute of Structural Biology (NISB), NTU, Singapore 0.04
Lee Kong Chian School of Medicine, Singapore 0.02
Ann Romney Center for Neurologic Diseases (CND), BWH, United States of America (USA) 0.02
Department of Neurology, BWH, United States of America (USA) 0.02
Graduate College, NTU, Singapore 0.01
Nanyang Institute of Technology in Health and Medicine (NITHM), NTU, Singapore 0.01
Paean Biotechnology Inc., South Korea 0.01
Department of Biomedical Engineering (BME), HYU, South Korea 0.01
Harvard Stem Cell Institute (HSCI), United States of America (USA) 0.01