Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor

Journal: Nature Chemical Biology

Published: 2019-05-17

DOI: 10.1038/s41589-019-0285-7

Affiliations: 14

Authors: 16

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Research Highlight

A novel peptide drug for cancer diagnosis and treatment

© BSIP/Getty

© BSIP/Getty

A short peptide drug that inhibits a growth factor implicated in cancer development has been discovered by researchers in Japan. The molecule could be useful for diagnostic tumour imaging and anti-cancer treatment.

A team co-led by Kanazawa University scientists identified a circular protein, just 12 amino acids around, that selectively binds to the activated form of hepatocyte growth factor (HGF) and prevents the growth factor from interacting with a cancer-associated protein to make tumours more aggressive.

The researchers showed that this peptide, known as HiP-8, could potently restrict the invasiveness of human cancer cell lines. They also used a fluorescently labelled version of HiP-8 to non-invasively visualize sites of HGF activity in a mouse model of lung cancer.

This kind of diagnostic information will help guide treatment decisions for cancer patients.

Supported content

  1. Nature Chemical Biology 15, 598–606 (2019). doi: 10.1038/s41589-019-0285-7
Institutions Share
RIKEN Center for Biosystems Dynamics Research (BDR), Japan 0.25
Department of Chemistry, UTokyo, Japan 0.16
WPI Nano Life Science Institute (NanoLSI), KU, Japan 0.15
Laboratory of Protein Synthesis and Expression, Osaka University, Japan 0.13
Division of Tumor Dynamics and Regulation, KU, Japan 0.08
Institute for Frontier Science Initiative (InFiniti), KU, Japan 0.05
School of Mathematics and Physics, KU, Japan 0.03
Graduate School of Natural Science and Technology, KU, Japan 0.03
Graduate School of Medicine / School of Medicine, Tohoku University, Japan 0.03
New Industry Creation Hatchery Center (NICHe), Tohoku University, Japan 0.03
Division of Medical Oncology, KU, Japan 0.03
The University of Sydney (USYD), Australia 0.03