A compendium of promoter-centered long-range chromatin interactions in the human genome

Journal: Nature Genetics

Published: 2019-09-09

DOI: 10.1038/s41588-019-0494-8

Affiliations: 18

Authors: 18

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Research Highlight

Map charts spatial contacts in DNA

© KTSDESIGN/SCIENCE PHOTO LIBRARY/Getty

© KTSDESIGN/SCIENCE PHOTO LIBRARY/Getty

A large-scale study of spatial contacts within the genomes of 27 human cell types and tissues has revealed the target genes of some 70,000 putative regulatory elements and more than 27,000 DNA variants linked to physiological traits and disease.

This ‘interactome’ map, generated by a team co-led by KAIST scientists, offers a window into the three-dimensional genomic architecture that shapes gene regulation throughout the human body — information that could lead to a better understanding of disease and provide leads for new treatment strategies.

Using a technique called capture Hi-C, the team detected regions of DNA that physically interact with gene-activating ‘promoter’ domains across a wide range of human cells and tissues. By first looking at well-annotated promoters, the researchers could infer the targets of other similar elements, allowing them to create a compendium of DNA interactions for future studies of regulatory pathways that go awry in various disease settings.

Supported content

  1. Nature Genetics 51, 1442–1449 (2019). doi: 10.1038/s41588-019-0494-8
Institutions Share
Ludwig Institute for Cancer Research Ltd. (LICR), United States of America (USA) 0.28
KAIST Department of Biological Sciences, South Korea 0.22
KAIST Department of Bio and Brain Engineering, South Korea 0.11
Department of Bioengineering (BE), UC San Diego, United States of America (USA) 0.06
University of California, San Francisco (UCSF), United States of America (USA) 0.06
Department of Neurosciences, UC San Diego, United States of America (USA) 0.05
NIH NIA Laboratory of Neurogenetics, United States of America (USA) 0.05
Biomedical Sciences Program, UC San Diego, United States of America (USA) 0.03
Krembil Research Institute, U of T, Canada 0.03
The Hospital for Sick Children (SickKids), U of T, Canada 0.03
Department of Pathology, UC San Diego, United States of America (USA) 0.02
Duke Department of Orthopaedic Surgery, United States of America (USA) 0.01
Duke Regeneration Next, United States of America (USA) 0.01
Duke Department of Cell Biology, United States of America (USA) 0.01
Department of Cellular and Molecular Medicine (CMM), UC San Diego, United States of America (USA) 0.01
Center for Epigenomics, UC San Diego, United States of America (USA) 0.01
Institute for Genomic Medicine (IGM), UC San Diego, United States of America (USA) 0.01
Moores Cancer Center, UC San Diego, United States of America (USA) 0.01

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