Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Journal: Nature Genetics

Published: 2019-02-28

DOI: 10.1038/s41588-019-0358-2

Affiliations: 348

Authors: 468

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Institutions FC
John P. Hussman Institute for Human Genomics (HIHG), United States of America (USA) 0.02
Penn Neurodegeneration Genomics Center (PNGC), Penn, United States of America (USA) 0.02
Laboratory of Excellence in Medical Genomics (LabEx GENMED), France 0.02
Department of Epidemiology, Erasmus MC, Netherlands 0.02
Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, United Kingdom (UK) 0.02
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG), Cardiff University, United Kingdom (UK) 0.02
Mayo Clinic Department of Neuroscience, Florida Campus, United States of America (USA) 0.01
Department of Biostatistics, BU, United States of America (USA) 0.01
Department of Psychiatry and Psychotherapy, UoC, Germany 0.01
IRCCS Santa Lucia Foundation, Italy 0.01
UCL Department of Neurodegenerative Disease, United Kingdom (UK) 0.01
School of Medicine, AUTH, Greece 0.01
Department of Basic and Clinical Neuroscience, KCL, United Kingdom (UK) 0.01
Department of Public Health and Caring Sciences (IFV), UU, Sweden 0.01
Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), Spain 0.01
USF Health Byrd Alzheimer's Institute, USF, United States of America (USA) 0.01
Centre for Public Health (CPH), QUB, United Kingdom (UK) 0.01
Department of Medicine, UW, United States of America (USA) 0.01
Hospital Universitario de Gran Canaria Doctor Negrín, Spain 0.01
Regional Neurogenetic Centre, ASPCZ, Italy 0.01
Institute for Computational Biology (ICB), United States of America (USA) 0.01
Department of Neurology, BU, United States of America (USA) 0.01
Mayo Clinic Department of Neurology, United States of America (USA) 0.01
Oxford Project to Investigate Memory and Ageing (OPTIMA), United Kingdom (UK) 0.01
Department of Pathology, UW, United States of America (USA) 0.01
Utah State University (USU), United States of America (USA) 0.01
UCSF Department of Neurology, United States of America (USA) 0.01
UCL Division of Psychiatry, United Kingdom (UK) 0.01
Department of Neurology, MGH, United States of America (USA) 0.01
UAB Department of Neurology, United States of America (USA) 0.01
Manchester Cancer Research Centre (MCRC), United Kingdom (UK) 0.01
Institute of Gerontology and Geriatrics, University of Perugia, Italy 0.01
Icelandic Heart Association (IHA), Iceland 0.01
Department of Psychiatry and Psychotherapy, Uni Bonn, Germany 0.01
Department of Neurology, CU, United States of America (USA) 0.01
Indiana Alzheimer Disease Center, IUPUI, United States of America (USA) 0.01
UK DRI at Cardiff (UK DRI Cardiff), United Kingdom (UK) 0.01
Department of Neurology, Emory University, United States of America (USA) 0.01
Department of Psychiatry and Behavioral Sciences, UW, United States of America (USA) 0.01
University Medical Center Hamburg-Eppendorf (UKE), UHH, Germany 0.01
USC Department of Neurology, United States of America (USA) 0.01
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, CU, United States of America (USA) 0.01
Institute of Psychiatry, Psychology and Neuroscience (IOPPN), KCL, United Kingdom (UK) 0.01
UCL Dementia Research Centre (DRC), United Kingdom (UK) 0
Queen's Medical Centre (QMC), NUH, United Kingdom (UK) 0
The University of Nottingham (UoN), United Kingdom (UK) 0
Department of Epidemiology, UW, United States of America (USA) 0
Centre Hospitalier Régional Universitaire de Lille (CHRU de Lille), France 0
Cardiovascular Health Research Unit (CHRU), United States of America (USA) 0
Section of Biomedical Genetics, BU, United States of America (USA) 0
Institut Pasteur de Lille (Pasteur-Lille), France 0
Risk Factors and Molecular Determinants of Aging-related Diseases (RID-AGE), France 0
Development of Innovative Strategies for a Transdisciplinary Approach to Alzheimer’s Disease (DISTALZ), France 0
Department of Neurology, IUPUI, United States of America (USA) 0
Department of Pathology and Laboratory Medicine, IUPUI, United States of America (USA) 0
Institute of Medical Computer Science, Biometry and Epidemiology (IMIBE), UDE, Germany 0
Faculty of Medicine, Soton, United Kingdom (UK) 0
Aging Research Center (ARC), Sweden 0
NIH National Institute on Aging (NIA), United States of America (USA) 0
Oxford Department of Psychiatry, United Kingdom (UK) 0
Institute of Biomedicine, UEF, Finland 0
Department of Psychiatry, Psychotherapy and Psychosomatics, MLU, Germany 0
Asturias Central University Hospital (HUCA), Spain 0
Department of Pathology and Laboratory Medicine, Penn, United States of America (USA) 0
Hospital Universitario Nuestra Señora de Valme, Spain 0
Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), UTHealth, United States of America (USA) 0
Swedish Medical Center, United States of America (USA) 0
Department of Biomedical Sciences (DiSB), UNICA, Italy 0
Institute of Neurology, UCSC, Italy 0
Wellcome Trust Sanger Institute, United Kingdom (UK) 0
KU Alzheimer's Disease Center (ADC), United States of America (USA) 0
Department of Psychiatry and Behavioral Sciences, UM, United States of America (USA) 0
UC Davis Department of Neurology, United States of America (USA) 0
UCL/MRC Prion Unit, United Kingdom (UK) 0
Genomic Medicine Group (GMX), Spain 0
University of Bari Aldo Moro (UniBA), Italy 0
Institute for Memory Impairments and Neurological Disorders (MIND), UCI, United States of America (USA) 0
Saul R. Korey Department of Neurology, Einstein, United States of America (USA) 0
Department of Neurology, Med Uni Graz, Austria 0
Department of Neurology, UCI, United States of America (USA) 0
Kuopio University Hospital (KUH), Finland 0
Department of Pharmacology and Neuroscience, UNT, United States of America (USA) 0
Department of Medicine, UW-Madison, United States of America (USA) 0
Universitat Internacional de Catalunya (UIC), Spain 0
Memory Clinic, ACE, Spain 0
Research Center, ACE, Spain 0
Institut Català de Neurociències Aplicades, ACE, Spain 0
Framingham Heart Study (FHS), United States of America (USA) 0
Rush Alzheimer’s Disease Center (RADC), United States of America (USA) 0
Rush Department of Neurological Sciences, United States of America (USA) 0
Hospital Universitario, Mútua Terrassa, Spain 0
Duke Department of Biology, United States of America (USA) 0
Tanz Centre for Research in Neurodegenerative Diseases (Tanz CRND), U of T, Canada 0
UCSF Weill Institute for Neurosciences, United States of America (USA) 0
Mesulam Center for Cognitive Neurology and Alzheimer's Disease, NU, United States of America (USA) 0
UCLA Department of Neurology, United States of America (USA) 0
Department of Neurosciences, UC San Diego, United States of America (USA) 0
Department of Pathology and Immunology, WUSTL, United States of America (USA) 0
Charité Department of Psychiatry and Psychotherapy, Germany 0
NYU Department of Psychiatry, United States of America (USA) 0
Mútua Terrassa, Spain 0
UAB Department of Pathology, United States of America (USA) 0
UK Sanders-Brown Center on Aging (SBCoA), United States of America (USA) 0
Department of Neurodegenerative Diseases and Geropsychiatry, Uni Bonn, Germany 0
Instituto de Investigación Marqués de Valdecilla (IDIVAL), HUMV, Spain 0
St. James's Hospital (SJH), TCD, Ireland 0
Mercer’s Institute for Successful Ageing (MISA), TCD, Ireland 0
Institute of Molecular Biology and Biochemistry (MBBC), Med Uni Graz, Austria 0
Brain and Spine Institute (ICM), France 0
AP-HP Pitié-Salpêtrière Hospital - Charles-Foix, France 0
UK DRI at UCL (UK DRI UCL), United Kingdom (UK) 0
Department of Psychiatry, WUSTL, United States of America (USA) 0
Department of Psychiatry, ISMMS, United States of America (USA) 0
Neurogenomics Division, TGen, United States of America (USA) 0
Kaiser Permanente Washington Health Research Institute (KPWHRI), United States of America (USA) 0
Institute of Epidemiology I (EPI I), HMGU, Germany 0
Department of Neurology and Memory Clinic, ZNA, Belgium 0
Functional Genomics Center Zurich (FGCZ), Switzerland 0
National Alzheimer's Coordinating Center (NACC), United States of America (USA) 0
IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Italy 0
Dino Ferrari Center, UNIMI, Italy 0
Department of Neurology and Neurosurgery, JHU, United States of America (USA) 0
Department of Neurology, UZ Leuven, Belgium 0
Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), WUSTL, United States of America (USA) 0
Cologne Center for Genomics (CCG), UoC, Germany 0
Civin Laboratory for Neuropathology, Banner Health, United States of America (USA) 0
Department of Psychiatry, UT Southwestern Medical Center, United States of America (USA) 0
Department of Pathology, Pitt, United States of America (USA) 0
Duke Department of Pathology, United States of America (USA) 0
Program in Medical and Population Genetics, Broad Institute, United States of America (USA) 0
Institute Born-Bunge, UA, Belgium 0
Department of Psychiatry and Psychotherapy, FAU, Germany 0
Department of Clinical and Experimental Medicine, UNIPI, Italy 0
IRCCS Oasi Maria Santissima, Italy 0
Somerset Partnership NHS Foundation Trust, United Kingdom (UK) 0
Memory Resource and Research Center (CMRR), IMNC, France 0
VIB-UAntwerp Center for Molecular Neurology (CMN), Belgium 0
Laboratory of Neurogenetics, UA, Belgium 0
Gertrude H. Sergievsky Center, CU, United States of America (USA) 0
Wien Center for Alzheimer's Disease and Memory Disorders, MSMC, United States of America (USA) 0
Institute of Psychiatry and Neuroscience of Paris (IPNP), France 0
Southmead Hospital, United Kingdom (UK) 0
Bristol Medical School, UoB, United Kingdom (UK) 0
School of Biotechnology, DCU, Ireland 0
BYU Department of Biology, United States of America (USA) 0
Institute of Biomedical Research (IIB Sant Pau), Spain 0
Bruce W. Carter VA Medical Center, Miami VA Healthcare System, United States of America (USA) 0
UCL Department of Molecular Neuroscience, United Kingdom (UK) 0
Fred Hutchinson Cancer Research Center (FHCRC), United States of America (USA) 0
Center for Translational and Computational Neuroimmunology, CU, United States of America (USA) 0
Faculty of Medicine, University of Iceland, Iceland 0
Department of Psychiatry and Psychotherapy, Uni Freiburg, Germany 0
Institute of Neurological Sciences (ISN), CNR, Italy 0
Department of Pathology and Laboratory Medicine, UCI, United States of America (USA) 0
Department of Psychiatry, Penn, United States of America (USA) 0
OHSU Department of Pathology, United States of America (USA) 0
NIH National Institute of Neurological Disorders and Stroke (NINDS), United States of America (USA) 0
Department of Psychiatry, Pitt, United States of America (USA) 0
School of Nursing, UW, United States of America (USA) 0
Department of Surgery, UT Southwestern Medical Center, United States of America (USA) 0
LUSAGE Laboratory, France 0
Department of Clinical Sciences, UT Southwestern Medical Center, United States of America (USA) 0
Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), United States of America (USA) 0
Cambridge Institute of Public Health (Cambridge IPH), University of Cambridge, United Kingdom (UK) 0
Institute for Social Medicine, Occupational Medicine and Public Health (ISAP), Leipzig University, Germany 0
USC Department of Pathology, United States of America (USA) 0
UC Davis Department of Pathology and Laboratory Medicine, United States of America (USA) 0
Department of Population Health Sciences, UoB, United Kingdom (UK) 0
Department of Pathology and Laboratory Medicine (BUMC), BU, United States of America (USA) 0
Alzheimer Disease Research Center (ADRC), Pitt, United States of America (USA) 0
Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, United States of America (USA) 0
Mayo Clinic Department of Laboratory Medicine and Pathology (DLMP), United States of America (USA) 0
NIH NIA Laboratory of Neurogenetics, United States of America (USA) 0
Medical University of Lodz (MUL), Poland 0
Department of Neurology, UW, United States of America (USA) 0
Department of Interdisciplinary of Medicine (DIM), UniBA, Italy 0
Department of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), UNIFI, Italy 0
Department of Neurology, CU Anschutz, United States of America (USA) 0
Department of Neurology, UM, United States of America (USA) 0
NYU Division of Pulmonary, Critical Care and Sleep Medicine, United States of America (USA) 0
A. I. Virtanen Institute for Molecular Sciences, UEF, Finland 0
UNC Department of Genetics, United States of America (USA) 0
Oxford Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), United Kingdom (UK) 0
Alzheimer's Disease and Memory Disorders Center, BCM, United States of America (USA) 0
Epidémiologie et Analyses en Santé Publique: Risques, Maladies Chroniques, Handicaps, France 0
Texas Tech University Health Sciences Center (TTUHSC), United States of America (USA) 0
Section of Computational Biomedicine, BU, United States of America (USA) 0
University of North Texas Health Science Center at Fort Worth (UNTHSC), United States of America (USA) 0
Institute for Ageing (NUIA), Newcastle University, United Kingdom (UK) 0
Department of Neurobiology and Behavior, UCI, United States of America (USA) 0
C. S. Kubik Laboratory for Neuropathology, MGH, United States of America (USA) 0
Geriatrics Research Education and Clinical Center (GRECC), VAPSHCS, United States of America (USA) 0
Lou Ruvo Center for Brain Health, Cleveland Clinic, United States of America (USA) 0
Department of Pathology, JHU, United States of America (USA) 0
Department of Pathology, U-M, United States of America (USA) 0
Cambridge Institute for Medical Research (CIMR), University of Cambridge, United Kingdom (UK) 0
Department of Psychiatry and Behavioral Sciences, JHU, United States of America (USA) 0
Laboratory of Genomic and Personalized Medicine in Cancer and Neurological Disorders, France 0
Centre National de Référence pour les Malades Alzheimer Jeunes (CNR-MAJ), France 0
Rouen University Hospital-Charles Nicolle (CHU de Rouen), France 0
Department of Neurology, WUSTL, United States of America (USA) 0
DZNE Site Bonn, Germany 0
Department of Neurology, U-M, United States of America (USA) 0
Michigan Alzheimer's Disease Center (MADC), U-M, United States of America (USA) 0
Wisconsin Alzheimer's Disease Research Center (ADRC), UW-Madison, United States of America (USA) 0
Karolinska University Hospital, Sweden 0
Nash Family Department of Neuroscience, ISMMS, United States of America (USA) 0
Karolinska Institute - Alzheimer’s Disease Research Center (KIADRC), KI, Sweden 0
Department of Genetics and Genomic Sciences, ISMMS, United States of America (USA) 0
Division of Neurogeriatrics, KI, Sweden 0
Department of Neurology, Pitt, United States of America (USA) 0
Department of Medical and Molecular Genetics, IUPUI, United States of America (USA) 0
Hospital La Colombière, CHRU de Montpellier, France 0
Neuropsychiatry: Epidemiological and Clinical Research, France 0
University of Montpellier, France 0
Life and Brain Center, Uni Bonn, Germany 0
Department of Genomics, Uni Bonn, Germany 0
Institute of Human Genetics, Uni Bonn, Germany 0
Department of Radiology and Imaging Sciences, IUPUI, United States of America (USA) 0
FERB Centro Eccellenza Alzheimer di Gazzaniga, Italy 0
NYU Alzheimer's Disease Center, United States of America (USA) 0
Division of Neuropsychiatry, BCM, United States of America (USA) 0
IRCCS Fondazione Don Carlo Gnocchi - ONLUS, Italy 0
Department of Medicine and Surgery (DiMeC), UNIPR, Italy 0
UK Department of Biostatistics, United States of America (USA) 0
Centri di Ricerca, Trasferimento e Alta Formazione (DENOTHE), UNIFI, Italy 0
Department of Internal Medicine, Erasmus MC, Netherlands 0
Netherlands Genomics Initiative (NGI), Netherlands 0
Human Genetics Center (HGC), UTHealth, United States of America (USA) 0
Rush Department of Internal Medicine, United States of America (USA) 0
Human Genome Sequencing Center (HGSC), BCM, United States of America (USA) 0
UCSF Memory and Aging Center, United States of America (USA) 0
Ken and Ruth Davee Department of Neurology, NU, United States of America (USA) 0
Netherlands Consortium for Healthy Ageing (NCHA), Netherlands 0
UCLA Department of Pathology and Laboratory Medicine, United States of America (USA) 0
USC Department of Psychiatry and Behavioral Sciences, United States of America (USA) 0
IRCCS Casa Sollievo della Sofferenza Hospital, Italy 0
Department of Biostatistics, Epidemiology and Informatics (DBEI), Penn, United States of America (USA) 0
Center for Clinical Epidemiology and Biostatistics (CCEB), Penn, United States of America (USA) 0
Department of Family Medicine, UW, United States of America (USA) 0
Department of Biostatistics, U-M, United States of America (USA) 0
Center of Public Health Sciences, University of Iceland, Iceland 0
DZNE Site Berlin, Germany 0
Galliera Hospital, Italy 0
Institute for Medical Informatics, Statistics and Documentation (IMI), Med Uni Graz, Austria 0
UK Department of Neuroscience, United States of America (USA) 0
Harvard Department of Epidemiology, United States of America (USA) 0
Department of Psychiatry, MGH, United States of America (USA) 0
Department of Human Genetics, Emory University, United States of America (USA) 0
Duke Department of Psychiatry and Behavioral Sciences, United States of America (USA) 0
Department of Psychiatry and Behavioral Sciences, NU, United States of America (USA) 0
Department of Pathology and Cell Biology, CU, United States of America (USA) 0
Institute of Primary Care and Public Health, Cardiff University, United Kingdom (UK) 0
University Hospital of Wales, United Kingdom (UK) 0
UK DRI at King’s College London (UK DRI KCL), United Kingdom (UK) 0
San Antonio Geriatric Research, Education and Clinical Center (GRECC), STVHCS, United States of America (USA) 0
QIMR Berghofer Genetic Epidemiology Laboratory, Australia 0
Department of Pathology, UC San Diego, United States of America (USA) 0
OHSU Department of Neurology, United States of America (USA) 0
Portland VA Medical Center (PVAMC), United States of America (USA) 0
Department of Genome Sciences, UW, United States of America (USA) 0
UK DRI at The University of Cambridge (UK DRI Cambridge), United Kingdom (UK) 0
Central Institute of Mental Health (CIMH), Germany 0
Medical Faculty Mannheim, Uni Heidelberg, Germany 0
Partners HealthCare Center for Personalized Genetic Medicine (PCPGM), United States of America (USA) 0
Institute for Stroke and Dementia Research (ISD), LMU, Germany 0
DZNE Site Munich, Germany 0
Division of Genetics, BWH, United States of America (USA) 0
UK Department of Epidemiology, United States of America (USA) 0
Department of Pathology, NU, United States of America (USA) 0
Alzheimer's Disease Research Center (ADRC), Emory University, United States of America (USA) 0
School of Life Sciences, UoN, United Kingdom (UK) 0
The University of Texas Health Science Center at San Antonio (UT Health San Antonio), United States of America (USA) 0
Bordeaux Population Health (BPH), France 0
School of Medicine, UoN, United Kingdom (UK) 0
Division of Medical Genetics, UW, United States of America (USA) 0
Department of Pathology and Laboratory Medicine, Emory University, United States of America (USA) 0
Rush Institute for Healthy Aging, United States of America (USA) 0
CHU de Bordeaux, France 0
Department of Neurology, Erasmus MC, Netherlands 0
Department of Radiology and Nuclear Medicine, Erasmus MC, Netherlands 0
Department of Genetics, WUSTL, United States of America (USA) 0
Severo Ochoa Centre for Molecular Biology (CBMSO), Spain 0
Ronald M. Loeb Center for Alzheimer’s Disease, ISMMS, United States of America (USA) 0
Rush Department of Behavioral Sciences, United States of America (USA) 0
Center for Applied Genomics (CAG), CHOP, United States of America (USA) 0
Perelman School of Medicine, Penn, United States of America (USA) 0
Department of Psychology, Pitt, United States of America (USA) 0
Department of Pediatrics, Penn, United States of America (USA) 0
Hospital La Paz Institute for Health Research (IdiPAZ), Spain 0
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases (Biggs Institute), UT Health San Antonio, United States of America (USA) 0
Department of Neurology, Ole Miss, United States of America (USA) 0
Department of Human Genetics, Pitt, United States of America (USA) 0
Division of Geriatrics and Gerontology, Ole Miss, United States of America (USA) 0
Institute of Memory and Alzheimer’s Disease (IM2A), AP-HP Pitié-Salpêtrière Hospital - Charles-Foix, France 0
Department of Medicine, Ole Miss, United States of America (USA) 0
Département de Neurologie, AP-HP Hôpitaux Universitaires La Pitié-Salpêtrière - Charles-Foix, France 0
Geriatric Research, Education and Clinical Center (GRECC), VAAAHS, United States of America (USA) 0
Rush Department of Pathology, United States of America (USA) 0
Banner Alzheimer's Institute (BAI), United States of America (USA) 0
Department of Medical Sciences, UA, Portugal 0
Arizona Alzheimer's Consortium (AAC), United States of America (USA) 0
Department of Psychiatry, Arizona, United States of America (USA) 0
Department of Health Services, UW, United States of America (USA) 0
Centre Hospitalier du Rouvray, France 0
Department of Psychiatry and Psychotherapy, University of Göttingen, Germany 0
DZNE Site Göttingen, Germany 0
Institute of Biomedicine of Aveiro (IBIMED), UA, Portugal 0
Madison VA Geriatrics Research Education and Clinical Center (GRECC), United States of America (USA) 0
KORA Biobank, United States of America (USA) 0
Joint Biobank Munich (JBM), Germany 0
LMU-HMGU Chair of Epidemiology, Germany 0
University of Wisconsin-Madison (UW-Madison), United States of America (USA) 0
Department of Biomedicine Basel, Switzerland 0
Centre for Clinical Brain Sciences (CCBS), The University of Edinburgh, United Kingdom (UK) 0
Department of Epidemiology, CU, United States of America (USA) 0
Department of Ophthalmology, BU, United States of America (USA) 0
Department of Epidemiology, BU, United States of America (USA) 0
Paris Institute of Translational Neuroscience (IHU-A-ICM), France 0
Pierre and Marie Curie University (UPMC) - Paris 6, France 0
GRC 21: Alzheimer Precision Medicine (APM), Sorbonne University, France 0
AXA Chair on Alzheimer's Disease, Sorbonne University, France 0

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