Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Journal: Nature Genetics

Published: 2019-02-18

DOI: 10.1038/s41588-018-0334-2

Affiliations: 249

Authors: 279

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Institutions FC
Wellcome Trust - MRC Institute of Metabolic Science (IMS), United Kingdom (UK) 0.03
Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), UCPH, Denmark 0.02
CAS Key Laboratory of Nutrition and Metabolism, SIBS CAS, China 0.02
Oxford Wellcome Trust Centre for Human Genetics, United Kingdom (UK) 0.02
National Institute for Health and Welfare (THL), Finland 0.02
Centre for Cancer Genetic Epidemiology (CCGE), University of Cambridge, United Kingdom (UK) 0.02
University of Exeter Medical School (UEMS), United Kingdom (UK) 0.02
William Harvey Research Institute (WHRI), QMUL, United Kingdom (UK) 0.02
MRC/BHF Cardiovascular Epidemiology Unit (CEU), University of Cambridge, United Kingdom (UK) 0.02
Department of Biostatistics, BU, United States of America (USA) 0.01
UCLA Translational Genomics and Population Sciences, United States of America (USA) 0.01
Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), United States of America (USA) 0.01
Department of Epidemiology, Erasmus MC, Netherlands 0.01
UNC Department of Epidemiology, United States of America (USA) 0.01
Montreal Heart Institute, UdeM, Canada 0.01
Charles Bronfman Institute for Personalized Medicine (IPM), ISMMS, United States of America (USA) 0.01
Department of Epidemiology, U-M, United States of America (USA) 0.01
deCODE Genetics, Inc., Iceland 0.01
UNC Department of Genetics, United States of America (USA) 0.01
MRC Institute of Genetics and Molecular Medicine (IGMM), United Kingdom (UK) 0.01
Department of Biostatistics, U-M, United States of America (USA) 0.01
Center for Statistical Genetics (CSG), U-M, United States of America (USA) 0.01
Department of Internal Medicine, Erasmus MC, Netherlands 0.01
Wellcome Trust Sanger Institute, United Kingdom (UK) 0.01
IRCCS Materno Infantile Burlo Garofolo, Italy 0.01
Department of Clinical Epidemiology, Leiden University, Netherlands 0.01
Department of Medicine, Surgery and Health Sciences, UNITS, Italy 0.01
Department of Medicine, UMB, United States of America (USA) 0.01
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), United Kingdom (UK) 0.01
Estonian Genome Center, UT, Estonia 0.01
Department of Epidemiology and Biostatistics (EBS), ICL, United Kingdom (UK) 0.01
Center for Diabetes Research, WFU, United States of America (USA) 0.01
Department of Nutrition and Dietetics, HUA, Greece 0.01
Division of Epidemiology and Community Health, UMN, United States of America (USA) 0.01
Department of Twin Research and Genetic Epidemiology, KCL, United Kingdom (UK) 0.01
Department of Biomedical Informatics (DBMI), VU, United States of America (USA) 0.01
NIH NHGRI Medical Genomics and Metabolic Genetics Branch, United States of America (USA) 0.01
Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), UTHealth, United States of America (USA) 0.01
Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University, Germany 0.01
Institute of Clinical Medicine, UEF, Finland 0.01
Department of Genetics, WUSTL, United States of America (USA) 0.01
Max Planck Institute of Immunobiology and Epigenetics (MPI-IE), Germany 0.01
Lehrstuhl für Genetische Epidemiologie, UR, Germany 0.01
Framingham Heart Study (FHS), United States of America (USA) 0.01
Division of Medical Genetics, UW, United States of America (USA) 0.01
Foundation for Research in Health Exercise and Nutrition (KULTU), Finland 0.01
NIHR Oxford Biomedical Research Centre (OxBRC), United Kingdom (UK) 0.01
Broad Institute of MIT and Harvard, United States of America (USA) 0.01
Harvard Medical School (HMS), United States of America (USA) 0.01
Research Centre for Prevention and Health (RCPH), Denmark 0.01
Department of Cardiovascular Sciences, University of Leicester, United Kingdom (UK) 0.01
Public Health Sciences Division (PHS), FHCRC, United States of America (USA) 0.01
Department of Medicine, UdeM, Canada 0.01
Department of Biostatistics, Epidemiology and Informatics (DBEI), Penn, United States of America (USA) 0.01
NIHR Leicester Cardiovascular Biomedical Research Unit (LCBRU), United Kingdom (UK) 0.01
NIHR Barts Cardiovascular Biomedical Research Unit (CVBRU), United Kingdom (UK) 0.01
Department of Biostatistics, University of Liverpool, United Kingdom (UK) 0.01
Science for Life Laboratory (SciLifeLab), Sweden 0.01
Lillebaelt Hospital, Denmark 0.01
Center for Non-Communicable Diseases (CNCD), Pakistan 0.01
Department of Nephrology, UR, Germany 0.01
Department of Computational Medicine and Bioinformatics (DCM&B), U-M, United States of America (USA) 0.01
Department of Internal Medicine, U-M, United States of America (USA) 0.01
MRC-PHE Centre for Environment and Health, United Kingdom (UK) 0.01
Swiss Institute of Bioinformatics (SIB), Switzerland 0
German Center for Diabetes Research (DZD), Germany 0
Institute of Genetic Epidemiology (IGE), HMGU, Germany 0
Department of Vascular Medicine, UvA, Netherlands 0
Center for Genomics and Personalized Medicine Research, WFU, United States of America (USA) 0
Department of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), UTHealth, United States of America (USA) 0
Human Genetics Center (HGC), UTHealth, United States of America (USA) 0
Icahn School of Medicine at Mount Sinai (ISMMS), MSHS, United States of America (USA) 0
Department of Epidemiology and Biostatistics, VU University Amsterdam, Netherlands 0
Faculté de Médecine, Université Toulouse III, France 0
UKCRC Centre of Excellence for Public Health (NI), United Kingdom (UK) 0
Faculty of Medicine, University of Iceland, Iceland 0
QIMR Berghofer Medical Research Institute, Australia 0
Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany 0
non-affiliated author contributions, Italy 0
Division of Biomedical Informatics and Personalized Medicine (BIPM), CU Anschutz, United States of America (USA) 0
Department of Public Health and Caring Sciences (IFV), UU, Sweden 0
School of Medicine and Pharmacology, UWA, Australia 0
Joseph J. Zilber School of Public Health, UWM, United States of America (USA) 0
Merck Research Laboratories (MRL) - Boston, United States of America (USA) 0
Uppsala University (UU), Sweden 0
School of Medicine and Public Health, UON, Australia 0
Echinos Medical Centre, Greece 0
Stanford Department of Biomedical Data Science, United States of America (USA) 0
Institute for Community Medicine (ICM), University of Greifswald, Germany 0
School of Kinesiology and Health Science, York University, Canada 0
Department of Family Medicine and Public Health (FMPH), UC San Diego, United States of America (USA) 0
Department of Biomedical Informatics and Medical Education, UW, United States of America (USA) 0
Risk Factors and Molecular Determinants of Aging-related Diseases (RID-AGE), France 0
Centre for Research in Epidemiology and Population Health (CESP), France 0
Department of Physiology and Biophysics, Ole Miss, United States of America (USA) 0
Faculty of Medicine, Leipzig University, Germany 0
Department of Epidemiology (EPI), DIfE, Germany 0
Finnish Cardiovascular Research Center-Tampere, UTA, Finland 0
Massachusetts General Hospital (MGH), United States of America (USA) 0
Fimlab Laboratories Ltd., Finland 0
GlaxoSmithKline R&D Collegeville, United States of America (USA) 0
Research Centre on Public Health (CESP), UNIMIB, Italy 0
Department of Molecular Epidemiology (MEP), DIfE, Germany 0
Institute of Cellular Medicine, Newcastle University, United Kingdom (UK) 0
USC Eye Institute, United States of America (USA) 0
Division of Public Health Sciences (PHS), WFU, United States of America (USA) 0
Medical Faculty Mannheim, Uni Heidelberg, Germany 0
UAB Division of Preventive Medicine (DOPM), United States of America (USA) 0
Merck & Co., Inc., United States of America (USA) 0
USC Department of Ophthalmology, United States of America (USA) 0
Anogia Medical Centre, Greece 0
Institute of Public Health and Clinical Nutrition, UEF, Finland 0
Stanford Division of Cardiovascular Medicine, United States of America (USA) 0
Center for Pediatric Research Leipzig (CPL), Leipzig University, Germany 0
Kuopio University Hospital (KUH), Finland 0
Radboud Institute for Health Sciences (RIHS), RU, Netherlands 0
Center for Basic and Translational Obesity Research, BCH, United States of America (USA) 0
NIHR Blood and Transplant Research Unit in Donor Health and Genomics, United Kingdom (UK) 0
Division of Endocrinology, BCH, United States of America (USA) 0
Department of Cardiology, LNWH, United Kingdom (UK) 0
Division of Preventive Medicine, BWH, United States of America (USA) 0
Centre for Global Health Research, The University of Edinburgh, United Kingdom (UK) 0
Institute of Biomedicine, UEF, Finland 0
Department of Computational Biology, UNIL, Switzerland 0
Department of Haematology, University of Cambridge, United Kingdom (UK) 0
Department of Obstetrics and Gynecology, VU, United States of America (USA) 0
K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norway 0
Institute for Medicine and Public Health, VU, United States of America (USA) 0
Department of Public Health and Nursing (ISM), NTNU, Norway 0
Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, United Kingdom (UK) 0
Harvard Department of Genetics, United States of America (USA) 0
Harvard Department of Medicine, United States of America (USA) 0
Division of Gastroenterology and Hepatology, U-M, United States of America (USA) 0
Department of Public Health and Primary Care (PHEG), Leiden University, Netherlands 0
University Hospitals of Strasbourg (HUS), France 0
Department of Epidemiology and Public Health, University of Strasbourg, France 0
University of Eastern Finland (UEF), Finland 0
Institute for Molecular Medicine Finland (FIMM), Finland 0
Uppsala Clinical Research Center (UCR), Sweden 0
UNC Carolina Center for Genome Sciences (CCGS), United States of America (USA) 0
University Institute of Social and Preventive Medicine (IUMSP), UNIL, Switzerland 0
Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (PACER-HD), KAU, Saudi Arabia 0
University of Glasgow, United Kingdom (UK) 0
GlaxoSmithKline R&D King of Prussia, United States of America (USA) 0
The University of Auckland, New Zealand 0
Auckland City Hospital (ACH), New Zealand 0
Department of Medical Sciences, UU, Sweden 0
Department of Epidemiology Research, SSI, Denmark 0
Steno Diabetes Center A/S, Denmark 0
Central Finland Central Hospital, Jyväskylä, Finland 0
LMU-HMGU Chair of Epidemiology, Germany 0
Generation Scotland (GS), United Kingdom (UK) 0
Ninewells Hospital and Medical School, United Kingdom (UK) 0
Omicsoft Corporation, United States of America (USA) 0
GlaxoSmithKline R&D Research Triangle Park, United States of America (USA) 0
Department of Epidemiology, UW, United States of America (USA) 0
Institute for Personalized Medicine (IPM), Penn State, United States of America (USA) 0
Oxford Big Data Institute (BDI), United Kingdom (UK) 0
Department of Public Health Sciences, Penn State, United States of America (USA) 0
Department of Genome Sciences, UW, United States of America (USA) 0
Faculty of Arts and Sciences (FAS), EMU, Cyprus 0
Department of Neurology, BU, United States of America (USA) 0
Institute of Regional Health Services Research, SDU, Denmark 0
Julius Center for Health Sciences and Primary Care, UU, Netherlands 0
UMC Section Genetics, Netherlands 0
Faculty of Pharmacy, UdeM, Canada 0
Klinik und Poliklinik für Innere Medizin B, Ernst-Moritz-Arndt-Universität Greifswald, Germany 0
DZHK Partner Site Greifswald, Germany 0
Department of Hygiene and Epidemiology, UOI, Greece 0
Institute of Clinical Physiology (IFC), CNR, Italy 0
Tri-Service General Hospital, Taiwan 0
School of Medicine, NDMC, Taiwan 0
Weis Center for Research, United States of America (USA) 0
Stanford Cardiovascular Institute (CVI), United States of America (USA) 0
Department of Clinical and Experimental Medicine, UNIPI, Italy 0
Department of Social Work, Tunghai University, Taiwan 0
Department of Medical Research, Taichung Veterans General Hospital, Taiwan 0
Department of Medicine, University of Cambridge, United Kingdom (UK) 0
BHF Cambridge Centre of Excellence (CRE), University of Cambridge, United Kingdom (UK) 0
Imperial College Healthcare NHS Trust, United Kingdom (UK) 0
School of Medicine, University of Split, Croatia 0
Department of Epidemiology, IUPUI, United States of America (USA) 0
Department of Anthropology, Sociology and History, USC, Philippines 0
USC-Office of Population Studies Foundation, Inc., Philippines 0
University of San Carlos (USC), Philippines 0
Menzies Health Institute Queensland, Griffith University, Australia 0
Department of Medicine, IUPUI, United States of America (USA) 0
UCL Institute of Cardiovascular Science (ICS), United Kingdom (UK) 0
Diabetes Translational Research Center (DTRC), IUPUI, United States of America (USA) 0
Department of Biochemistry, WFU, United States of America (USA) 0
Human Genome Sequencing Center (HGSC), BCM, United States of America (USA) 0
Department of Human Genetics, U-M, United States of America (USA) 0
School of Public Health (SPH), U-M, United States of America (USA) 0
McDonnell Genome Institute (MGI), WUSTL, United States of America (USA) 0
Center for the Genetics of Host Defense, UT Southwestern Medical Center, United States of America (USA) 0
Quantitative Biomedical Research Center (QBRC), UT Southwestern Medical Center, United States of America (USA) 0
Department of Clinical Sciences, UT Southwestern Medical Center, United States of America (USA) 0
The Mindich Child Health and Development Institute (MCHDI), ISMMS, United States of America (USA) 0
Department of Health Services, UW, United States of America (USA) 0
Department of Neurology, Erasmus MC, Netherlands 0
MRC Integrative Epidemiology Unit (IEU), UoB, United Kingdom (UK) 0
Kaiser Permanente Washington Health Research Institute (KPWHRI), United States of America (USA) 0
Department of Public Health, UCPH, Denmark 0
Department of Clinical Physiology and Nuclear Medicine, UTU, Finland 0
Turku University Hospital (TYKS), UTU, Finland 0
Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC), UTU, Finland 0
Faculty of Medicine (SUND), AAU, Denmark 0
Department of Radiology and Nuclear Medicine, Erasmus MC, Netherlands 0
Department of Clinical Physiology and Nuclear Medicine, UEF, Finland 0
HUNT Research Centre, NTNU, Norway 0
Department of Life Sciences, Brunel University London, United Kingdom (UK) 0
Verge Genomics, Inc., United States of America (USA) 0
National University Health System (NUHS), Singapore 0
Institute of Epidemiology II (EPI II), HMGU, Germany 0
Department of Public Health and Clinical Medicine, UMU, Sweden 0
Harvard Department of Nutrition, United States of America (USA) 0
Genetic and Molecular Epidemiology (GAME) Unit, LU, Sweden 0
Hospital Grosshadern, LMU, Germany 0
Research Unit of Molecular Epidemiology (AME), HMGU, Germany 0
Munich Heart Alliance (MHA), Germany 0
Saudi Diabetes Research Group, KAU, Saudi Arabia 0
Dasman Diabetes Institute (DDI), Kuwait 0
Frederiksberg Hospital, Denmark 0
Division of Epidemiology, VU, United States of America (USA) 0
Vanderbilt-Ingram Cancer Center (VICC), VU, United States of America (USA) 0
Center for Vascular Prevention, Danube University Krems, Austria 0
Bispebjerg University Hospital (BBH), Denmark 0
Centre for Brain Research (CBR), IISc, India 0
Department of Clinical Medicine, UCPH, Denmark 0
National Heart and Lung Institute (NHLI), ICL, United Kingdom (UK) 0
Hammersmith Hospital, Imperial College Healthcare NHS Trust, United Kingdom (UK) 0
Harvard Department of Pediatrics, United States of America (USA) 0
Division of Cardiovascular Medicine, BWH, United States of America (USA) 0
Lee Kong Chian School of Medicine, Singapore 0
Division of Genetics, BWH, United States of America (USA) 0

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