Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Journal: Nature Genetics

Published: 2019-01-14

DOI: 10.1038/s41588-018-0309-3

Affiliations: 268

Authors: 444

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Institutions FC
23andMe, Inc., United States of America (USA) 0.06
Estonian Genome Center, UT, Estonia 0.03
Institute for Molecular Bioscience (IMB), UQ, Australia 0.02
Department of Epidemiology, Erasmus MC, Netherlands 0.02
Department of Biological Psychology, VU University Amsterdam, Netherlands 0.02
Department of Genetics, RUG, Netherlands 0.02
Centre for Global Health Research, The University of Edinburgh, United Kingdom (UK) 0.02
MRC Integrative Epidemiology Unit (IEU), UoB, United Kingdom (UK) 0.02
Department of Medical Epidemiology and Biostatistics (MEB), KI, Sweden 0.02
Department of Complex Trait Genetics (CTG), VU University Amsterdam, Netherlands 0.02
Department of Psychology, UMN, United States of America (USA) 0.01
Queensland Brain Institute (QBI), UQ, Australia 0.01
University of Helsinki, Finland 0.01
MRC Institute of Genetics and Molecular Medicine (IGMM), United Kingdom (UK) 0.01
VU University Amsterdam, Netherlands 0.01
University Hospital of Lausanne (CHUV), UNIL, Switzerland 0.01
deCODE Genetics, Inc., Iceland 0.01
Institute for Community Medicine (ICM), University of Greifswald, Germany 0.01
Department of Medicine, Surgery and Health Sciences, UNITS, Italy 0.01
Erasmus University Rotterdam Institute for Behavior and Biology (EURIBEB), EUR, Netherlands 0.01
Sassari Site, CNR, Italy 0.01
Department of Internal Medicine, Erasmus MC, Netherlands 0.01
Computational Biology Program, OICR, Canada 0.01
Department of Genetics, WUSTL, United States of America (USA) 0.01
National Institute for Health and Welfare (THL), Finland 0.01
Harvard Department of Economics, United States of America (USA) 0.01
Department of Economics, UZH, Switzerland 0.01
Department of Epidemiology, U-M, United States of America (USA) 0.01
Department of Economics, VU Amsterdam, Netherlands 0.01
Department of Public Health, University of Helsinki, Finland 0.01
TUM-HMGU Institute of Human Genetics (IHG), Germany 0.01
Department of Public Health Sciences, UChicago, United States of America (USA) 0.01
Radboud University Medical Centre (Radboudumc), RU, Netherlands 0.01
NYU Department of Economics, United States of America (USA) 0.01
Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Germany 0.01
Department of Twin Research and Genetic Epidemiology, KCL, United Kingdom (UK) 0.01
School of Biological Sciences, Georgia Tech, United States of America (USA) 0.01
Singapore Immunology Network (SIgN), A*STAR, Singapore 0.01
NIH NIA Laboratory of Genetics and Genomics, United States of America (USA) 0.01
Department of Economics, U of T, Canada 0.01
Institute for Social and Economic Research (ISER), University of Essex, United Kingdom (UK) 0.01
Institute of Medical Computer Science, Biometry and Epidemiology (IMIBE), UDE, Germany 0.01
Institute of Behavioural Sciences (IBS), University of Helsinki, Finland 0.01
Western General Hospital, NHS Lothian, United Kingdom (UK) 0.01
Department of Epidemiology, RUG, Netherlands 0.01
Norwegian Institute of Public Health (NIPH), Norway 0.01
Department of Computer Science (CS), JHU, United States of America (USA) 0.01
Institute of Genetic Epidemiology (IGE), HMGU, Germany 0.01
Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), UCPH, Denmark 0.01
Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), The University of Edinburgh, United Kingdom (UK) 0.01
IRCCS Materno Infantile Burlo Garofolo, Italy 0.01
Department of Cardiology, RUG, Netherlands 0.01
German Socio-Economic Panel (SOEP), DIW Berlin, Germany 0
University Hospital Graz, Austria 0
Faculty of Health and Medicine, UON, Australia 0
Team Loyalty B.V., Netherlands 0
Department of Psychiatry, UC San Diego, United States of America (USA) 0
QIMR Berghofer Department of Genetics and Computational Biology, Australia 0
Cardiovascular Health Research Unit (CHRU), United States of America (USA) 0
University of Exeter Medical School (UEMS), United Kingdom (UK) 0
Department of Psychiatry, WUSTL, United States of America (USA) 0
Survey Research Center (SRC), U-M, United States of America (USA) 0
Department of Nutrition and Dietetics, HUA, Greece 0
Oulu Business School, Finland 0
Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Germany 0
Department of Epidemiology Research, SSI, Denmark 0
Center for Translational Bioethics and Healthcare Policy, GHS, United States of America (USA) 0
Department of Economics, SSE, Sweden 0
Department of Psychiatry and Behavior Neuroscience, UChicago, United States of America (USA) 0
Faculty of Medicine, University of Iceland, Iceland 0
Faculty of Medicine, Leipzig University, Germany 0
Department of Government, UU, Sweden 0
Center for Life Course Health Research (CLCHR), University of Oulu, Finland 0
Department of Cell Biology, Erasmus MC, Netherlands 0
Department of Experimental and Health Sciences (DCEXS), UPF, Spain 0
Lübeck Medical School, University of Lübeck, Germany 0
Rush Alzheimer’s Disease Center (RADC), United States of America (USA) 0
Department of Health Sciences (DISS), UNIMI, Italy 0
Social Impact, United States of America (USA) 0
Research Unit of Molecular Epidemiology (AME), HMGU, Germany 0
Institute of Clinical Sciences, GU, Sweden 0
Centre for Integrated Genomic Medical Research (CIGMR), UoM, United Kingdom (UK) 0
Department of Psychology, The University of Edinburgh, United Kingdom (UK) 0
Charité Berlin Aging Study II Research Group on Geriatrics, Germany 0
Folkhälsan Research Center, Finland 0
William Harvey Research Institute (WHRI), QMUL, United Kingdom (UK) 0
Hunter Medical Research Institute (HMRI), Australia 0
Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University, Germany 0
Department of Clinical Chemistry, UTA, Finland 0
Institute of Epidemiology II (EPI II), HMGU, Germany 0
Department of Neurology, Med Uni Graz, Austria 0
Fimlab Laboratories Ltd., Finland 0
Icelandic Heart Association (IHA), Iceland 0
Translational Research Institute (TRI), Australia 0
Department of Family Medicine and Public Health (FMPH), UC San Diego, United States of America (USA) 0
Max Planck Institute for Human Development (MPIB), Germany 0
UCL Great Ormond Street Institute of Child Health (ICH), United Kingdom (UK) 0
Harvard Department of Epidemiology, United States of America (USA) 0
Harvard Medical School (HMS), United States of America (USA) 0
USC Behavioral and Health Genomics Center, United States of America (USA) 0
Stanley Center for Psychiatric Research, Broad Institute, United States of America (USA) 0
Gentofte University Hospital, Denmark 0
Herlev University Hospital, Denmark 0
Copenhagen Studies on Asthma in Childhood (COPSAC), UCPH, Denmark 0
Analytic and Translational Genetics Unit (ATGU), MGH, United States of America (USA) 0
Medical Research Institute, University of Dundee, United Kingdom (UK) 0
Department of Economics, UMN, United States of America (USA) 0
NorthShore Department of Psychiatry and Behavioral Sciences, United States of America (USA) 0
Glenfield Hospital, United Kingdom (UK) 0
Department of Econometrics, EUR, Netherlands 0
Stanford Department of Psychiatry and Behavioral Sciences, United States of America (USA) 0
NIHR Leicester Cardiovascular Biomedical Research Unit (LCBRU), United Kingdom (UK) 0
Department of Cardiovascular Sciences, University of Leicester, United Kingdom (UK) 0
Faculty of Science and Medicine, UNIFR, Switzerland 0
Department of Psychology, UIUC, United States of America (USA) 0
Department of Healthcare Policy and Research (HPR), Cornell University, United States of America (USA) 0
NIHR Guy's and St Thomas' Biomedical Research Centre, United Kingdom (UK) 0
Department of Genomics of Common Disease, ICL, United Kingdom (UK) 0
Department of Economics, UC San Diego, United States of America (USA) 0
Institute of Epidemiology and Social Medicine, WWU, Germany 0
Oxford Saïd Business School, United Kingdom (UK) 0
Amsterdam Brain and Cognition (ABC), UvA, Netherlands 0
Warwick Medical School (WMS), United Kingdom (UK) 0
Institute of Molecular Genetics (IGM), CNR, Italy 0
Center for the Advancement of Value in Musculoskeletal Care, HSS, United States of America (USA) 0
Rush Department of Neurological Sciences, United States of America (USA) 0
NIH NIA Laboratory of Epidemiology and Population Science (LEPS), United States of America (USA) 0
Stuyvesant High School, United States of America (USA) 0
NIH National Institute on Aging (NIA), United States of America (USA) 0
NIH NCI Division of Cancer Epidemiology and Genetics (DCEG), United States of America (USA) 0
Institute of Applied Health Sciences, University of Aberdeen, United Kingdom (UK) 0
School of Medical Sciences, UoM, United Kingdom (UK) 0
GGZ inGeest, Netherlands 0
Department of Psychiatry, VU University Amsterdam, Netherlands 0
SURFsara, Netherlands 0
Department of Public Health, University of Split, Croatia 0
Harvard Department of Health Care Policy (HCP), United States of America (USA) 0
Heart Center Leipzig, Germany 0
College of Medicine, FSU, United States of America (USA) 0
Donders Centre for Neuroscience (DCN), Netherlands 0
Leiden University Medical Center (LUMC), Netherlands 0
QIMR Berghofer Genetic Epidemiology Laboratory, Australia 0
Department of Clinical Physiology, UTA, Finland 0
Tampere University Hospital (TAUH), Finland 0
Department of Economics, JGU, Germany 0
Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University, Germany 0
Interdisciplinary Centre for Clinical Research Leipzig (IKFZ Leipig), Leipzig University, Germany 0
Department of Clinical Genetics, VUmc, Netherlands 0
Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany 0
Department of Health Sciences, University of Leicester, United Kingdom (UK) 0
Garvan-Weizmann Centre for Cellular Genomics, Australia 0
Department of Clinical Physiology and Nuclear Medicine, UTU, Finland 0
Turku University Hospital (TYKS), UTU, Finland 0
Amsterdam School of Economics, UvA, Netherlands 0
UCL Genetics Institute (UGI), United Kingdom (UK) 0
Department of Psychology, Union College, United States of America (USA) 0
Department of Integrative Physiology, CU-Boulder, United States of America (USA) 0
New York Genome Center (NYGC), United States of America (USA) 0
Faculty of Economics, LMU, Germany 0
Institute of Genetic and Biomedical Research (IRGB), CNR, Italy 0
Montpellier Business School, France 0
University Medical Center Groningen (UMCG), RUG, Netherlands 0
Institute for Molecular Medicine Finland (FIMM), Finland 0
National Bureau of Economic Research (NBER), United States of America (USA) 0
USC Department of Economics, United States of America (USA) 0
Department of Applied Economics, EUR, Netherlands 0
German Institute for Economic Research (DIW Berlin), Germany 0
Max Planck Institute for Demographic Research (MPIDR), Germany 0
Oxford Nuffield Department of Population Health (NDPH), United Kingdom (UK) 0
UiO Department of Psychology, Norway 0
School of Public Health (SPH), ICL, United Kingdom (UK) 0
Institute of Biomedical and Neural Engineering (BNE), Reykjavik University, Iceland 0
QUT Institute of Health and Biomedical Innovation (IHBI), Australia 0
QIMR Berghofer Medical Research Institute, Australia 0
NYU Department of Sociology, United States of America (USA) 0
Charité Institute of Medical Genetics and Human Genetics, Germany 0
School of Medicine, University of Split, Croatia 0
Department of General Practice and Primary Health Care, University of Helsinki, Finland 0
Maastricht University (UM), Netherlands 0
Information Based Medicine, HMRI, Australia 0
Helios Hanseklinikum Stralsund, Germany 0
Institute for Medical Informatics, Biometry and Epidemiology (IBE), LMU, Germany 0
School of Policy Studies (SPS), Queen's University, Canada 0
Institute for Biomedical Technologies (ITB), CNR, Italy 0
Major of Economics, NYU Shanghai, China 0
Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven, Belgium 0
Clinic of Psychiatry and Psychotherapy, University of Greifswald, Germany 0
Research Center for Group Dynamics (RCGD), U-M, United States of America (USA) 0
School of Oral and Dental Sciences, UoB, United Kingdom (UK) 0
Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (PACER-HD), KAU, Saudi Arabia 0
Faculty of Pharmaceutical Sciences, University of Iceland, Iceland 0
Oxford Wellcome Trust Centre for Human Genetics, United Kingdom (UK) 0
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), United Kingdom (UK) 0
Thurgauer Wirtschaftsinstitut an der Universität Konstanz (TWI), Switzerland 0
UNC Department of Sociology, United States of America (USA) 0
Rush Department of Behavioral Sciences, United States of America (USA) 0
Peter Boris Centre for Addictions Research (PBCAR), Canada 0
Homewood Research Institute (HRI), Canada 0
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig University, Germany 0
Institute for Computing and Information Sciences (iCIS), RU, Netherlands 0
Department of Population Health Sciences, UoB, United Kingdom (UK) 0
Institute for Genomic Medicine (IGM), UC San Diego, United States of America (USA) 0
Department of Genetics and Genomic Sciences, ISMMS, United States of America (USA) 0
Department of Psychiatry, USU, United States of America (USA) 0
Center for the Study of Traumatic Stress (CSTS), USU, United States of America (USA) 0
Kaiser Permanente Washington Health Research Institute (KPWHRI), United States of America (USA) 0
Department of Medicine, UW, United States of America (USA) 0
Department of Economics, University of Konstanz, Germany 0
University of North Carolina Population Center (UNC CPC), United States of America (USA) 0
NYU School of Medicine, United States of America (USA) 0
Department of Epidemiology and Preventive Medicine, UR, Germany 0
Swiss Institute of Bioinformatics (SIB), Switzerland 0
Department of Medical Genetics (DGM), UNIL, Switzerland 0
School of Psychological Sciences, UoM, United Kingdom (UK) 0
Department of Gastroenterology and Hepatology, RUG, Netherlands 0
Department of Materials (D-MATL), ETH Zurich, Switzerland 0
Steno Diabetes Center A/S, Denmark 0
Program in Medical and Population Genetics, Broad Institute, United States of America (USA) 0
Psychiatric and Neurodevelopmental Genetics Unit (PNGU), MGH, United States of America (USA) 0
Centre for Genomic Regulation (CRG), BIST, Spain 0
Catalan Institution for Research and Advanced Studies (ICREA), Spain 0
South Australian Health and Medical Research Institute (SAHMRI), Australia 0
Durrer Center for Cardiovascular Research (Durrer Center), Netherlands 0
Centre for Population Health Research (CPHR), UniSA, Australia 0
Life and Brain Center, Uni Bonn, Germany 0
Department of Genomics, Uni Bonn, Germany 0
Institute of Human Genetics, Uni Bonn, Germany 0
Faculty of Biology, Medicine and Health (FBMH), UoM, United Kingdom (UK) 0
Salford Royal Hospital, United Kingdom (UK) 0
Manchester Institute for Collaborative Research on Ageing (MICRA), UoM, United Kingdom (UK) 0
Institute for Behavioral Genetics, CU-Boulder, United States of America (USA) 0
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Spain 0
Institute of Public Finance, LFU, Austria 0
Max Planck Institute for Research on Collective Goods, Germany 0
Pere Virgili Institute (IISPV), Spain 0
Institute of Behavioral Science (IBS), CU-Boulder, United States of America (USA) 0
Department of Sociology, CU-Boulder, United States of America (USA) 0
Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Spain 0
Pompeu Fabra University (UPF), Spain 0
Division of Experimental Genetics, Sidra Medical and Research Center, Qatar 0
Barcelona Institute for Global Health (ISGlobal), Spain 0
Faculty of Management, Economics and Social Sciences (WiSo), UoC, Germany 0
MRC-PHE Centre for Environment and Health, United Kingdom (UK) 0
Center for Life Course Epidemiology and Systems Medicine, University of Oulu, Finland 0
Oulu University Hospital (OUH), Finland 0
Institute for Medical Informatics, Statistics and Documentation (IMI), Med Uni Graz, Austria 0
Institute of Molecular Biology and Biochemistry (MBBC), Med Uni Graz, Austria 0
Department of Psychiatry, BWH, United States of America (USA) 0
Generation Scotland (GS), United Kingdom (UK) 0
Department of Neurology, BWH, United States of America (USA) 0
Institute of Preventive Medicine (IPM), Frederiksberg Hospital, Denmark 0
Bispebjerg University Hospital (BBH), Denmark 0
Biocenter Oulu, University of Oulu, Finland 0
Harvard Department of Sociology, United States of America (USA) 0
Department of Neurology, MGH, United States of America (USA) 0

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