Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Journal: Nature Genetics

Published: 2018-03-12

DOI: 10.1038/s41588-018-0058-3

Affiliations: 294

Authors: 425

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Institutions FC
deCODE Genetics, Iceland 0.02
School of Medicine / Graduate School of Medical Sciences / Faculty of Medical Sciences, Kyushu University, Japan 0.02
Population Health Research Institute (PHRI), MUMC, Canada 0.02
Bordeaux Population Health (BPH), France 0.02
Framingham Heart Study (FHS), United States of America (USA) 0.02
UC College of Medicine, United States of America (USA) 0.01
Center for Public Health Genomics (CPHG), UVA, United States of America (USA) 0.01
Department of Clinical Sciences - Malmö (DCSM), LU, Sweden 0.01
National Institute for Health and Welfare (THL), Finland 0.01
Department of Medicine, UMB, United States of America (USA) 0.01
Department of Biostatistics, UW, United States of America (USA) 0.01
Science for Life Laboratory (SciLifeLab), Sweden 0.01
Department of Neurology, MGH, United States of America (USA) 0.01
Department of Epidemiology, Erasmus MC, Netherlands 0.01
Department of Epidemiology, UW, United States of America (USA) 0.01
Cardiovascular Health Research Unit (CHRU), United States of America (USA) 0.01
MRC/BHF Cardiovascular Epidemiology Unit (CEU), University of Cambridge, United Kingdom (UK) 0.01
Program in Medical and Population Genetics, Broad Institute, United States of America (USA) 0.01
Institute of Neurodegenerative Diseases (IMN), France 0.01
Center for Public Health Sciences, NCC, Japan 0.01
Wellcome Trust - MRC Institute of Metabolic Science (IMS), United Kingdom (UK) 0.01
Department of Neurology, UM, United States of America (USA) 0.01
Public Health Sciences Division (PHS), FHCRC, United States of America (USA) 0.01
Institute for Community Medicine (ICM), University of Greifswald, Germany 0.01
Institute of Cardiovascular Research (ICR2UL), RHUL, United Kingdom (UK) 0.01
Iwate Tohoku Medical Megabank Organization (IMM), Japan 0.01
Tohoku Medical Megabank Organization (ToMMo), Tohoku University, Japan 0.01
School of Public Health (SPH), BU, United States of America (USA) 0.01
Department of Public Health Sciences, UVA, United States of America (USA) 0.01
HUCH Department of Neurology, Finland 0.01
Mútua Terrassa, Spain 0.01
Department of Clinical Neurosciences, University of Cambridge, United Kingdom (UK) 0.01
Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), UTHealth, United States of America (USA) 0.01
Department of Medical Epidemiology and Biostatistics (MEB), KI, Sweden 0.01
School of Medicine, Dentistry and Nursing, University of Glasgow, United Kingdom (UK) 0.01
Department of Biostatistics and Data Science (BDS), WFU, United States of America (USA) 0.01
Department of Neuroscience, Saint Francis Medical Center, United States of America (USA) 0.01
IRCCS Carlo Besta Neurological Institute, Italy 0.01
Jagiellonian University Medical College (JUMC), Poland 0.01
Hunter Medical Research Institute (HMRI), Australia 0.01
Hospital del Mar Medical Research Institute (IMIM), Spain 0.01
OU Department of Pediatrics, United States of America (USA) 0.01
Department of Clinical Sciences - Lund, LU, Sweden 0.01
Skåne University Hospital in Lund, SUS, Sweden 0.01
Harvard Medical School (HMS), United States of America (USA) 0.01
Division of Preventive Medicine, BWH, United States of America (USA) 0.01
RIKEN Laboratory for Statistical Analysis, Japan 0.01
Department of Statistical Genetics, Osaka University, Japan 0.01
J. Philip Kistler Stroke Research Center, MGH, United States of America (USA) 0.01
Department of Neurology, UVA, United States of America (USA) 0
RIKEN Center for Integrative Medical Sciences (IMS), Japan 0
UAB Department of Epidemiology, United States of America (USA) 0
Department of Physiology and Biophysics, Ole Miss, United States of America (USA) 0
Faculty of Medicine (FB11), JLU, Germany 0
Klinik und Poliklinik für Neurologie, Ernst-Moritz-Arndt-Universität Greifswald, Germany 0
Department of Neurology, Med Uni Graz, Austria 0
Department of Gene Diagnostics and Therapeutics, NCGM, Japan 0
Hero DMC Heart Institute (HDHI), DMCH, India 0
Department of Cardiology, Leiden University, Netherlands 0
Department of Pediatrics, Harbor-UCLA Medical Center, United States of America (USA) 0
Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), United States of America (USA) 0
Department of Medicine, CU Anschutz, United States of America (USA) 0
Department of Genetics, Penn, United States of America (USA) 0
Oxford Nuffield Department of Clinical Neurosciences (NDCN), United Kingdom (UK) 0
NIH NIA Intramural Research Program (IRP), United States of America (USA) 0
School of Medicine (BUSM), BU, United States of America (USA) 0
Centre for Brain Research (CBR), IISc, India 0
Centre for Clinical Brain Sciences (CCBS), The University of Edinburgh, United Kingdom (UK) 0
Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, United Kingdom (UK) 0
Troubles Cognitifs Dégénératifs et Vasculaires, France 0
Department of Pathology and Genetics, GU, Sweden 0
Sahlgrenska Academy, GU, Sweden 0
University Medicine Rostock, Germany 0
Faculty of Health, UTS, Australia 0
Oxford Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), United Kingdom (UK) 0
Mayo Clinic's Campus in Florida, United States of America (USA) 0
Department of Medicine (DOM), BWH, United States of America (USA) 0
Department of Epidemiology and Population Health, Einstein, United States of America (USA) 0
Department of Neurology, UMB, United States of America (USA) 0
Landspitali - The National University Hospital of Iceland, Iceland 0
Baltimore VA Medical Center, United States of America (USA) 0
Mayo Clinic Department of Neurology, United States of America (USA) 0
School of Life Sciences, University of Lincoln, United Kingdom (UK) 0
Brain Research Center, Canada 0
Department of Neurology and Neurosurgery, JHU, United States of America (USA) 0
UNC Department of Genetics, United States of America (USA) 0
Faculty of Medicine, University of Iceland, Iceland 0
Leeds General Infirmary, LTHT, United Kingdom (UK) 0
NIH NIA Laboratory of Epidemiology and Population Science (LEPS), United States of America (USA) 0
UAB School of Public Health, United States of America (USA) 0
Neurovascular Research Laboratory (LIN-BCN), VHIR ICS, Spain 0
Autonomous University of Barcelona (UAB), Spain 0
Department of Psychiatry, WUSTL, United States of America (USA) 0
UMC Department of Medical Genetics, Netherlands 0
Aichi Cancer Center Research Institute, Japan 0
Institute for Molecular Medicine Finland (FIMM), Finland 0
NIHR Blood and Transplant Research Unit in Donor Health and Genomics, United Kingdom (UK) 0
Cardiovascular Research Center (CVRC), MGH, United States of America (USA) 0
Department of Radiology and Nuclear Medicine, Erasmus MC, Netherlands 0
Department of Internal Medicine I, HUVH ICS, Spain 0
Department of Neurology, HUVH ICS, Spain 0
Icahn Institute for Genomics and Multiscale Biology, ISMMS, United States of America (USA) 0
Department of Genetics and Genomic Sciences, ISMMS, United States of America (USA) 0
Oxford Wellcome Trust Centre for Human Genetics, United Kingdom (UK) 0
Department of Neurology, WUSTL, United States of America (USA) 0
Department of Cardiology, RUG, Netherlands 0
NIHR Guy's and St Thomas' Biomedical Research Centre, United Kingdom (UK) 0
Department of Epidemiology, Tulane University, United States of America (USA) 0
Icelandic Heart Association (IHA), Iceland 0
Division of Health and Social Care Research, KCL, United Kingdom (UK) 0
Department of Internal Medicine, Erasmus MC, Netherlands 0
Institute of Biomedicine, GU, Sweden 0
Department of Epidemiology and Public Health (EPH), UMB, United States of America (USA) 0
MRC-PHE Centre for Environment and Health, United Kingdom (UK) 0
National Heart and Lung Institute (NHLI), ICL, United Kingdom (UK) 0
National University Health System (NUHS), Singapore 0
Institute of Cardiometabolism and Nutrition (ICAN), France 0
Research Unit on Cardiovascular, Metabolic and Nutritional Diseases, ICAN, France 0
Department of Human Genetics, McGill University, Canada 0
Institute of Neuroscience and Physiology, GU, Sweden 0
BioBank Japan Project, Japan 0
Department of Genetics, Microbiology and Statistics, UB, Spain 0
Oxford Centre for the Prevention of Stroke and Dementia (CPSD), United Kingdom (UK) 0
Robertson Centre for Biostatistics, University of Glasgow, United Kingdom (UK) 0
Faculty of Medicine, UAB, Spain 0
Azienda Ospedaliera di Perugia, Università degli Studi di Perugia, Italy 0
Heidelberg University Hospital, Uni Heidelberg, Germany 0
Department of Neurology, Erasmus MC, Netherlands 0
Centre for Research in Environmental Epidemiology (CREAL), Spain 0
Hospital Universitario, Mútua Terrassa, Spain 0
Montefiore Medical Center, Einstein, United States of America (USA) 0
Neuropsychiatry: Epidemiological and Clinical Research, France 0
UK College of Public Health, United States of America (USA) 0
DZNE Site Munich, Germany 0
Cluster of Excellence - Munich Cluster for Systems Neurology (SyNergy), LMU, Germany 0
Department of Neurosciences, University of Helsinki, Finland 0
Center for Genomic Medicine, Kyoto University, Japan 0
Human Genetics Center (HGC), UTHealth, United States of America (USA) 0
Department of Medical Sciences, UU, Sweden 0
Wake Forest School of Medicine (WFSM), WFU, United States of America (USA) 0
Department of Neurology, Pitt, United States of America (USA) 0
Laboratory of Clinical Genome Sequencing, UTokyo, Japan 0
Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases (Biggs Institute), UT Health San Antonio, United States of America (USA) 0
Department of Public Health and Caring Sciences (IFV), UU, Sweden 0
Department of Clinical and Experimental Sciences, UNIBS, Italy 0
IRCCS Department of Oncology, Italy 0
Department of Neurology, UW, United States of America (USA) 0
Department of Basic and Clinical Neuroscience, KCL, United Kingdom (UK) 0
Survey Research Center (SRC), U-M, United States of America (USA) 0
Centre for Medical Systems Biology (CMSB), Netherlands 0
Northern Institute for Cancer Research (NICR), Newcastle University, United Kingdom (UK) 0
IHA Research Institute, Iceland 0
Faculty of Health and Medicine, UON, Australia 0
Aflac Cancer and Blood Disorders Center, CHOA, United States of America (USA) 0
HRB Clinical Research Facility, NUI Galway, Ireland 0
Data Tecnica International, United States of America (USA) 0
NIH NIA Laboratory of Neurogenetics, United States of America (USA) 0
Memory Impairment and Neurodegenerative Dementia Center (MIND), Ole Miss, United States of America (USA) 0
Division of Geriatrics and Gerontology, Ole Miss, United States of America (USA) 0
Baltimore Geriatric Research, Education and Clinical Center, United States of America (USA) 0
MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, KCL, United Kingdom (UK) 0
Department of Biology, ECU, United States of America (USA) 0
Department of Medical and Molecular Genetics, KCL, United Kingdom (UK) 0
VIB-KU Leuven Center for Brain and Disease Research (CBD), Belgium 0
Research Group Experimental Neurology, KU Leuven, Belgium 0
Department of Pediatrics, Emory University, United States of America (USA) 0
Stanford Division of Cardiovascular Medicine, United States of America (USA) 0
Center for Public Health Genomics, WFU, United States of America (USA) 0
Center for Health Disparities (CHD), ECU, United States of America (USA) 0
College of Pharmacy, UF, United States of America (USA) 0
Division of Cardiovascular Medicine, UF, United States of America (USA) 0
Yale Department of Neurology, United States of America (USA) 0
Genetic Epidemiology Unit, Erasmus MC, Netherlands 0
Clinical and Translational Research Program, GW, United States of America (USA) 0
Centre Hospitalier Régional Universitaire de Lille (CHRU de Lille), France 0
Julius Center for Health Sciences and Primary Care, UU, Netherlands 0
UMC Laboratory of Experimental Cardiology, Netherlands 0
UMC Division of Heart and Lungs, Netherlands 0
Department of Allergy and Rheumatology, UTokyo, Japan 0
Department of Clinical Neuroscience, GU, Sweden 0
Sahlgrenska University Hospital (SU), GU, Sweden 0
Center for Genomic Medicine (CGM), MGH, United States of America (USA) 0
Department of Gerontology and Geriatrics, Leiden University, Netherlands 0
Department of Internal Medicine, Leiden University, Netherlands 0
Children's Research Institute (CRI), Children's National Health System, United States of America (USA) 0
Risk Factors and Molecular Determinants of Aging-related Diseases (RID-AGE), France 0
Institute of Genetic Epidemiology (IGE), HMGU, Germany 0
Laboratory of Statistical Immunology, Osaka University, Japan 0
Clinic of Neurology, UB, Switzerland 0
MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, United States of America (USA) 0
University Center for Medicine of Aging and Rehabilitation Basel, Felix Platter Hospital, Switzerland 0
Department of Medicine, Ole Miss, United States of America (USA) 0
Department of Pediatrics, Ole Miss, United States of America (USA) 0
John D. Bower School of Population Health, Ole Miss, United States of America (USA) 0
Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), WUSTL, United States of America (USA) 0
Department of Developmental Biology, WUSTL, United States of America (USA) 0
University Hospital Basel (USB), UB, Switzerland 0
Harvard PhD Program in Bioinformatics and Integrative Genomics (BIG), United States of America (USA) 0
University of Washington (UW), United States of America (USA) 0
UMC Utrecht Department of Neurology, Netherlands 0
Florey Institute of Neuroscience and Mental Health, Australia 0
The University of Melbourne (UniMelb), Australia 0
OU Department of Pharmaceutical Sciences, United States of America (USA) 0
Oklahoma Center for Neuroscience (OCNS), United States of America (USA) 0
UMC Utrecht Brain Center Rudolf Magnus, Netherlands 0
Department of Neurology, Austin Health, Australia 0
Fred Hutchinson Cancer Research Center (FHCRC), United States of America (USA) 0
Department of Biomedical Engineering (BME), WUSTL, United States of America (USA) 0
Department of Radiology, WUSTL, United States of America (USA) 0
Public Health Center, CHU de Bordeaux, France 0
Clinical Gene Networks AB (CGN), Sweden 0
Department of Pathophysiology, UT, Estonia 0
Institute of Cardiovascular and Medical Sciences (ICAMS), University of Glasgow, United Kingdom (UK) 0
Institute for Medical Informatics, Biometry and Epidemiology (IBE), LMU, Germany 0
Department of Epidemiology, Nagoya University, Japan 0
Centre Hospitalier Universitaire de Caen (CHU), UNICAEN, France 0
Caen University (UNICAEN), France 0
Department of Biomedical Engineering (BME), UVA, United States of America (USA) 0
Estonian Genome Center, UT, Estonia 0
Department of Biostatistics, University of Liverpool, United Kingdom (UK) 0
Vall d'Hebron Institute of Oncology (VHIO), HUVH ICS, Spain 0
DZHK Partner Site Greifswald, Germany 0
BHF Glasgow Cardiovascular Research Centre (BHF GCRC), University of Glasgow, United Kingdom (UK) 0
Klinik und Poliklinik für Innere Medizin B, Ernst-Moritz-Arndt-Universität Greifswald, Germany 0
NIH NHLBI Population Sciences Branch, United States of America (USA) 0
Beth Israel Deaconess Medical Center (BIDMC), United States of America (USA) 0
CHU de Bordeaux, France 0
Bordeaux Imaging Center (BIC), France 0
Atherosclerosis Research Unit, KI, Sweden 0
Karolinska Institute (KI), Sweden 0
Division of Emergency Medicine, WUSTL, United States of America (USA) 0
Broad Institute of MIT and Harvard, United States of America (USA) 0
Department of Epidemiology and Biostatistics (EBS), ICL, United Kingdom (UK) 0
OSU Center for Clinical and Translational Science (CCTS), United States of America (USA) 0
OSU Department of Internal Medicine, United States of America (USA) 0
Department of Health Services, UW, United States of America (USA) 0
Kaiser Permanente Washington Health Research Institute (KPWHRI), United States of America (USA) 0
Department of Cardiology, LNWH, United Kingdom (UK) 0
Wellcome Trust Sanger Institute, United Kingdom (UK) 0
BHF Cambridge Centre of Excellence (CRE), University of Cambridge, United Kingdom (UK) 0
Department of Medicine, University of Cambridge, United Kingdom (UK) 0
Vall d'Hebron Research Institute (VHIR), HUVH ICS, Spain 0
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Spain 0
Group Health Research Institute (GHRI), GHC, United States of America (USA) 0
Tartu University Hospital, UT, Estonia 0
Seattle Epidemiologic Research and Information Center (ERIC), United States of America (USA) 0
Munich Heart Alliance (MHA), Germany 0
Medizinische Klinik und Poliklinik I, LMU, Germany 0
Bærum Hospital, Vestre Viken Hospital Trust, Norway 0
Oxford Nuffield Department of Population Health (NDPH), United Kingdom (UK) 0
KI-AZ Integrated Cardio Metabolic Centre (ICMC), Sweden 0
Institute for Stroke and Dementia Research (ISD), LMU, Germany 0

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