Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Journal: Nature Genetics

Published: 2017-12-22

DOI: 10.1038/s41588-017-0011-x

Affiliations: 342

Authors: 401

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Institutions FC
Novo Nordisk Foundation Center for Basic Metabolic Research, UCPH, Denmark 0.02
Oxford Wellcome Trust Centre for Human Genetics, United Kingdom (UK) 0.02
CAS Key Laboratory of Nutrition and Metabolism, SIBS CAS, China 0.01
Centre for Cancer Genetic Epidemiology (CCGE), University of Cambridge, United Kingdom (UK) 0.01
National Institute for Health and Welfare (THL), Finland 0.01
University of Exeter Medical School (UEMS), United Kingdom (UK) 0.01
IRCCS Materno Infantile Burlo Garofolo, Italy 0.01
UNC Department of Epidemiology, United States of America (USA) 0.01
MRC/BHF Cardiovascular Epidemiology Unit (CEU), University of Cambridge, United Kingdom (UK) 0.01
William Harvey Research Institute (WHRI), QMUL, United Kingdom (UK) 0.01
Montreal Heart Institute, UdeM, Canada 0.01
University of Glasgow, United Kingdom (UK) 0.01
Department of Epidemiology, U-M, United States of America (USA) 0.01
Wellcome Trust - MRC Institute of Metabolic Science (IMS), United Kingdom (UK) 0.01
UNC Department of Genetics, United States of America (USA) 0.01
University Medical Center Utrecht (UMC Utrecht), Netherlands 0.01
Erasmus Medical Center (Erasmus MC), Netherlands 0.01
Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), United States of America (USA) 0.01
Radboud Institute for Health Sciences (RIHS), RU, Netherlands 0.01
UCLA Translational Genomics and Population Sciences, United States of America (USA) 0.01
QIMR Berghofer Medical Research Institute, Australia 0.01
MRC Epidemiology Unit, University of Cambridge, United Kingdom (UK) 0.01
Broad Institute of MIT and Harvard, United States of America (USA) 0.01
Wellcome Trust Sanger Institute, United Kingdom (UK) 0.01
Center for Statistical Genetics (CSG), U-M, United States of America (USA) 0.01
Department of Biostatistics, U-M, United States of America (USA) 0.01
Massachusetts General Hospital (MGH), United States of America (USA) 0.01
Charles Bronfman Institute for Personalized Medicine (IPM), ISMMS, United States of America (USA) 0.01
deCODE Genetics, Iceland 0.01
Department of Medicine, Surgery and Health Sciences, UNITS, Italy 0.01
Marshfield Clinic Research Foundation, United States of America (USA) 0.01
NIH NHGRI Medical Genomics and Metabolic Genetics Branch, United States of America (USA) 0.01
Department of Biostatistics, BU, United States of America (USA) 0.01
Public Health Sciences Division (PHS), FHCRC, United States of America (USA) 0.01
MRC Institute of Genetics and Molecular Medicine (IGMM), The University of Edinburgh, United Kingdom (UK) 0.01
Department of Public Health, UCPH, Denmark 0.01
Harvard Medical School (HMS), United States of America (USA) 0.01
Lillebaelt Hospital, Denmark 0.01
Department of Nephrology, UR, Germany 0.01
Department of Biostatistics, University of Liverpool, United Kingdom (UK) 0.01
Department of Clinical Epidemiology, Leiden University, Netherlands 0.01
Department of Medicine, UMB, United States of America (USA) 0.01
Centre for Global Health Research, The University of Edinburgh, United Kingdom (UK) 0.01
Department of Internal Medicine, Erasmus MC, Netherlands 0.01
Department of Epidemiology and Biostatistics (EBS), ICL, United Kingdom (UK) 0.01
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), United Kingdom (UK) 0.01
Department of Public Health, University of Helsinki, Finland 0.01
NIHR Oxford Biomedical Research Centre (OxBRC), United Kingdom (UK) 0.01
Center for Diabetes Research, WFU, United States of America (USA) 0.01
NIHR Blood and Transplant Research Unit in Donor Health and Genomics, United Kingdom (UK) 0.01
School of Women's and Infants' Health (SWIH), UWA, Australia 0
Leipzig Research Centre for Civilization Diseases (LIFE), Leipzig University, Germany 0
Department of Biomedical Informatics (DBMI), VU, United States of America (USA) 0
Institute of Clinical Medicine, UEF, Finland 0
Amsterdam Neuroscience, Netherlands 0
Division of Epidemiology and Community Health, UMN, United States of America (USA) 0
Department of Genetics, WUSTL, United States of America (USA) 0
Institute of Clinical Molecular Biology (IKMB), UKSH Kiel, Germany 0
Department of Twin Research and Genetic Epidemiology, KCL, United Kingdom (UK) 0
Division of Public Health Sciences (PHS), WFU, United States of America (USA) 0
Max Planck Institute of Immunobiology and Epigenetics (MPI-IE), Germany 0
Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), The University of Edinburgh, United Kingdom (UK) 0
Faculty of Medicine, Soton, United Kingdom (UK) 0
Faculty of Medicine, University of Iceland, Iceland 0
Lehrstuhl für Genetische Epidemiologie, UR, Germany 0
Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), UTHealth, United States of America (USA) 0
Department of Medicine, UW, United States of America (USA) 0
Gentofte University Hospital, Denmark 0
Herlev University Hospital, Denmark 0
Genetic and Molecular Epidemiology (GAME) Unit, LU, Sweden 0
Department of Public Health and Clinical Medicine, UMU, Sweden 0
Weis Center for Research, United States of America (USA) 0
Human Genetics Center (HGC), UTHealth, United States of America (USA) 0
Research Centre for Prevention and Health (RCPH), Denmark 0
Estonian Genome Center, UT, Estonia 0
NIHR Leicester Cardiovascular Biomedical Research Unit (LCBRU), United Kingdom (UK) 0
Kuopio University Hospital (KUH), Finland 0
Merck Research Laboratories (MRL) - Boston, United States of America (USA) 0
GlaxoSmithKline R&D King of Prussia, United States of America (USA) 0
Department of Medicine, UdeM, Canada 0
Survey Research Center (SRC), U-M, United States of America (USA) 0
Science for Life Laboratory (SciLifeLab), Sweden 0
K.G. Jebsen Center for Diabetes Research, Norway 0
Department of Nutrition and Dietetics, HUA, Greece 0
Department of Psychology, The University of Edinburgh, United Kingdom (UK) 0
Stanford Division of Cardiovascular Medicine, United States of America (USA) 0
Julius Center for Health Sciences and Primary Care, UU, Netherlands 0
Center for Non-Communicable Diseases (CNCD), Pakistan 0
Swiss Institute of Bioinformatics (SIB), Switzerland 0
Department of Cardiovascular Sciences, University of Leicester, United Kingdom (UK) 0
Department of Biostatistics, Epidemiology and Informatics (DBEI), Penn, United States of America (USA) 0
Department of Internal Medicine, U-M, United States of America (USA) 0
Department of Computational Medicine and Bioinformatics (DCM&B), U-M, United States of America (USA) 0
Department of Biochemistry, WFU, United States of America (USA) 0
German Center for Diabetes Research (DZD), Germany 0
UCLA Center for Neurobehavioral Genetics (CNG), United States of America (USA) 0
Institute of Public Health and Clinical Nutrition, UEF, Finland 0
Institute of Genetic Epidemiology (IGE), HMGU, Germany 0
Department of Vascular Medicine, UvA, Netherlands 0
Finnish Cardiovascular Research Center-Tampere, UTA, Finland 0
MRC-PHE Centre for Environment and Health, United Kingdom (UK) 0
Fimlab Laboratories Ltd., Finland 0
Center for Genomics and Personalized Medicine Research, WFU, United States of America (USA) 0
Program in Medical and Population Genetics, Broad Institute, United States of America (USA) 0
Donders Institute for Brain, Cognition and Behaviour, Netherlands 0
Foundation for Research in Health Exercise and Nutrition (KULTU), Finland 0
Institute of Biomedicine, UEF, Finland 0
Institute for Molecular Medicine Finland (FIMM), Finland 0
Faculty of Medicine and Life Sciences, UTA, Finland 0
Icahn School of Medicine at Mount Sinai (ISMMS), MSHS, United States of America (USA) 0
Ealing Hospital, LNWH, United Kingdom (UK) 0
Division of Cardiovascular Medicine, BWH, United States of America (USA) 0
Biological Sciences, Soton, United Kingdom (UK) 0
Department of Public Health and Caring Sciences (IFV), UU, Sweden 0
AREA Science Park, Italy 0
Faculty of Health, York University, Canada 0
Department of Clinical Biochemistry, Rigshospitalet, Denmark 0
Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany 0
University of North Carolina Population Center (UNC CPC), United States of America (USA) 0
Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (PACER-HD), KAU, Saudi Arabia 0
Institute for Community Medicine (ICM), University of Greifswald, Germany 0
Echinos Medical Centre, Greece 0
Duke Molecular Physiology Institute (DMPI), United States of America (USA) 0
Frederiksberg Hospital, Denmark 0
Center for Pediatric Research Leipzig (CPL), Leipzig University, Germany 0
Icelandic Heart Association (IHA), Iceland 0
NIH NIA Laboratory of Epidemiology and Population Science (LEPS), United States of America (USA) 0
Department of Family Medicine and Public Health (FMPH), UC San Diego, United States of America (USA) 0
Duke Social Science Research Institute (SSRI), United States of America (USA) 0
Institute of Cellular Medicine, Newcastle University, United Kingdom (UK) 0
Department of Psychiatry, WUSTL, United States of America (USA) 0
Haukeland University Hospital, Norway 0
Steno Diabetes Center A/S, Denmark 0
Department of Cardiology, Leiden University, Netherlands 0
Institute for Medicine and Public Health, VU, United States of America (USA) 0
UKCRC Centre of Excellence for Public Health (NI), United Kingdom (UK) 0
Ninewells Hospital and Medical School, United Kingdom (UK) 0
Department of Ophthalmology, Taichung Veterans General Hospital, Taiwan 0
Cardiovascular Epidemiology, UU, Sweden 0
Department of Biomedical Informatics and Medical Education, UW, United States of America (USA) 0
Warwick Division of Health Sciences, United Kingdom (UK) 0
Faculty of Medicine, Leipzig University, Germany 0
Department of Epidemiology (EPI), DIfE, Germany 0
USC Department of Preventive Medicine, United States of America (USA) 0
UAB Division of Preventive Medicine (DOPM), United States of America (USA) 0
Framingham Heart Study (FHS), United States of America (USA) 0
Department of Molecular Epidemiology (MEP), DIfE, Germany 0
Barts and The London School of Medicine and Dentistry (SMD), QMUL, United Kingdom (UK) 0
NIHR Barts Cardiovascular Biomedical Research Unit (CVBRU), United Kingdom (UK) 0
Vanderbilt Genetics Institute (VGI), VU, United States of America (USA) 0
School of Medicine and Pharmacology, UWA, Australia 0
Department of Medicine, BU, United States of America (USA) 0
Department of Computational Biology, UNIL, Switzerland 0
Risk Factors and Molecular Determinants of Aging-related Diseases (RID-AGE), France 0
Centre for Research in Epidemiology and Population Health (CESP), France 0
Faculté de Médecine, Université Toulouse III, France 0
University Hospital of Cologne, Germany 0
American Cancer Society (ACS), United States of America (USA) 0
Merck Research Laboratories (MRL), United States of America (USA) 0
Joseph J. Zilber School of Public Health, UWM, United States of America (USA) 0
Centre for Research in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Italy 0
Department of Psychiatry, Dalhousie University, Canada 0
MRC Integrative Epidemiology Unit (IEU), UoB, United Kingdom (UK) 0
Department of Internal Medicine, VU University Amsterdam, Netherlands 0
Department of Cardiology, Rigshospitalet, Denmark 0
South Ostrobothnia Health Care District (SO HCD), Finland 0
Department of Physiology and Biophysics, Ole Miss, United States of America (USA) 0
Anogia Medical Centre, Greece 0
Center for Basic and Translational Obesity Research, BCH, United States of America (USA) 0
Division of Endocrinology, BCH, United States of America (USA) 0
Division of Epidemiology, VU, United States of America (USA) 0
Center for Applied Genomics (CAG), CHOP, United States of America (USA) 0
Division of Human Genetics, CHOP, United States of America (USA) 0
UCL Institute of Cardiovascular Science (ICS), United Kingdom (UK) 0
Department of Ophthalmology, RU, Netherlands 0
UMC Division of Laboratory and Pharmacy, Netherlands 0
UMC Department of Psychiatry, Netherlands 0
Department of Haematology, University of Cambridge, United Kingdom (UK) 0
UMC Utrecht Brain Center Rudolf Magnus, Netherlands 0
Division of Molecular Biology and Human Genetics, SU, South Africa 0
Heart Hospital, TAUH, Finland 0
Harvard Department of Genetics, United States of America (USA) 0
NIHR Cambridge Biomedical Research Centre (Cambridge BRC), United Kingdom (UK) 0
University of Cambridge Metabolic Research Laboratories (MRL), IMS, United Kingdom (UK) 0
Addenbrooke's Hospital, United Kingdom (UK) 0
Munich Heart Alliance (MHA), Germany 0
Department of Clinical Physiology and Nuclear Medicine, UEF, Finland 0
Department of Clinical Physiology, TAUH, Finland 0
Department of Pediatrics, Penn, United States of America (USA) 0
Imperial College Healthcare NHS Trust, United Kingdom (UK) 0
Division of Gastroenterology, U-M, United States of America (USA) 0
MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, KCL, United Kingdom (UK) 0
QUT Institute of Health and Biomedical Innovation (IHBI), Australia 0
Data Tecnica International, United States of America (USA) 0
Department of Epidemiology and Public Health, University of Strasbourg, France 0
Oxford Nuffield Department of Obstetrics and Gynaecology (NDOG), United Kingdom (UK) 0
NIH National Institute on Aging (NIA), United States of America (USA) 0
NIHR Maudsley Biomedical Research Centre (BRC), United Kingdom (UK) 0
University Hospitals of Strasbourg (HUS), France 0
Institute for Molecular Bioscience (IMB), UQ, Australia 0
Department of Public Health and Primary Care (PHEG), Leiden University, Netherlands 0
Department of Molecular Cell Biology (MCB), Leiden University, Netherlands 0
Department of Public Health and Primary Care (DPHPC), University of Cambridge, United Kingdom (UK) 0
Institute of Regional Health Services Research, SDU, Denmark 0
K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norway 0
Department of Mathematical and Statistical Sciences, CU Anschutz, United States of America (USA) 0
Department of Epidemiology, Pitt, United States of America (USA) 0
Alzheimer Scotland Dementia Research Centre (ASDRC), The University of Edinburgh, United Kingdom (UK) 0
Department of Epidemiology, UW, United States of America (USA) 0
Omicsoft Corporation, United States of America (USA) 0
GlaxoSmithKline R&D Research Triangle Park, United States of America (USA) 0
College of Biomedical and Life Sciences, Cardiff University, United Kingdom (UK) 0
Netherlands Comprehensive Cancer Organisation (IKNL), Netherlands 0
Department of Gerontology and Geriatrics, Leiden University, Netherlands 0
Oxford Big Data Institute (BDI), United Kingdom (UK) 0
Department of Medicine, Pitt, United States of America (USA) 0
Human Genome Sequencing Center (HGSC), BCM, United States of America (USA) 0
UNC Carolina Center for Genome Sciences (CCGS), United States of America (USA) 0
Department of Biobank Research, UMU, Sweden 0
Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC), UTU, Finland 0
Department of Clinical Physiology and Nuclear Medicine, UTU, Finland 0
School of Medicine, University of Split, Croatia 0
Centre for Vision Research, Westmead Institute for Medical Research, Australia 0
Department of Epidemiology Research, SSI, Denmark 0
Department of Epidemiology and Biostatistics, VU University Amsterdam, Netherlands 0
Faculty of Arts and Sciences (FAS), EMU, Turkey 0
Department of Ophthalmology, USYD, Australia 0
Department of Public Health Sciences, Penn State, United States of America (USA) 0
UNC Department of Sociology, United States of America (USA) 0
Department of Neurology, BU, United States of America (USA) 0
DZNE Site Rostock/Greifswald, Germany 0
DZHK Partner Site Greifswald, Germany 0
Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Germany 0
The University of Auckland, New Zealand 0
LMU-HMGU Chair of Genetic Epidemiology, Germany 0
Interuniversity Cardiology Institute of the Netherlands (ICIN), Netherlands 0
Auckland City Hospital (ACH), New Zealand 0
National Institute of Public Health (NIPH), SDU, Denmark 0
UNC Department of Nutrition, United States of America (USA) 0
Center for Medical Genetics and Molecular Medicine (MGM), Haukeland University Hospital, Norway 0
Department of Epidemiology, IUPUI, United States of America (USA) 0
Department of Genome Sciences, UW, United States of America (USA) 0
Umeå University in Skellefteå, Sweden 0
Diabetes Translational Research Center (DTRC), IUPUI, United States of America (USA) 0
Department of Medical Sciences, UU, Sweden 0
Uppsala Clinical Research Center (UCR), Sweden 0
Harvard Department of Medicine, United States of America (USA) 0
University Medicine Greifswald, Germany 0
Department of Clinical and Experimental Medicine, UNIPI, Italy 0
USC-Office of Population Studies Foundation, Inc., Philippines 0
Central Finland Central Hospital, Jyväskylä, Finland 0
Institute of Clinical Physiology (IFC), CNR, Italy 0
Department of Health Sciences, University of Leicester, United Kingdom (UK) 0
Department of Hygiene and Epidemiology, UOI, Greece 0
Department of Epidemiology and Biostatistics, MSKCC, United States of America (USA) 0
University Institute of Social and Preventive Medicine (IUMSP), UNIL, Switzerland 0
Danish Diabetes Academy (DDA), Denmark 0
Institute for Personalized Medicine (IPM), Penn State, United States of America (USA) 0
USC Department of Ophthalmology, United States of America (USA) 0
Department of Anthropology, Sociology and History, USC, Philippines 0
Department of Public Health and Nursing (ISM), NTNU, Norway 0
UMC Section Genetics, Netherlands 0
Department of Public Health, AU, Denmark 0
The University of Queensland Diamantina Institute (UQDI), UQ, Australia 0
USC Eye Institute, United States of America (USA) 0
Division of Preventive Medicine, BWH, United States of America (USA) 0
Department of Clinical Sciences, UT Southwestern Medical Center, United States of America (USA) 0
Department of Human Genetics, U-M, United States of America (USA) 0
Department of Obstetrics and Gynecology, VU, United States of America (USA) 0
Quantitative Biomedical Research Center (QBRC), UT Southwestern Medical Center, United States of America (USA) 0
Center for the Genetics of Host Defense, UT Southwestern Medical Center, United States of America (USA) 0
The Mindich Child Health and Development Institute (MCHDI), ISMMS, United States of America (USA) 0
Kanazawa University (KU), Japan 0
Department of Psychiatry, SU, South Africa 0
McDonnell Genome Institute (MGI), WUSTL, United States of America (USA) 0
Durrer Center for Cardiogenetic Research, ICIN KNAW, Netherlands 0
Quantinuum Research, LLC, United States of America (USA) 0
Menzies Health Institute Queensland, Griffith University, Australia 0
UMC Laboratory of Clinical Chemistry and Haematology (LKCH), Netherlands 0
Division of Pharmacoepidemiology and Clinical Pharmacology, UU, Netherlands 0
Harvard Department of Nutrition, United States of America (USA) 0
Centre for Eye Research Australia (CERA), Australia 0
Lions Eye Institute (LEI), UWA, Australia 0
Menzies Institute for Medical Research, UTAS, Australia 0
Department of Neurology, Erasmus MC, Netherlands 0
Department of Radiology, Erasmus MC, Netherlands 0
National University Health System (NUHS), Singapore 0
Faculty of Medicine (SUND), AAU, Denmark 0
Kaiser Permanente Washington Health Research Institute (KPWHRI), United States of America (USA) 0
School of Medicine, NYMU, Taiwan 0
School of Medicine, NDMC, Taiwan 0
Department of Health Services, UW, United States of America (USA) 0
Department of Clinical Experimental Research, Rigshospitalet, Denmark 0
Department of Clinical Medicine, UCPH, Denmark 0
Hospital Grosshadern, LMU, Germany 0
Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan 0
Institute of Epidemiology II (EPI II), HMGU, Germany 0
NHS Blood and Transplant (NHSBT), United Kingdom (UK) 0
Dasman Diabetes Institute (DDI), Kuwait 0
Center for Vascular Prevention, Danube University Krems, Austria 0
Saudi Diabetes Research Group, KAU, Saudi Arabia 0
National Heart and Lung Institute (NHLI), ICL, United Kingdom (UK) 0
Division of Endocrinology and Diabetes, CHOP, United States of America (USA) 0
Vanderbilt-Ingram Cancer Center (VICC), VU, United States of America (USA) 0
Faculty of Medicine, University of Helsinki, Finland 0
Centre for Brain Research (CBR), IISc, India 0
The University of Texas Graduate School of Biomedical Sciences (GSBS), United States of America (USA) 0
The University of Texas MD Anderson Cancer Center, United States of America (USA) 0
Department of Medicine, University of Cambridge, United Kingdom (UK) 0
BHF Cambridge Centre of Excellence (CRE), University of Cambridge, United Kingdom (UK) 0
Harvard Department of Pediatrics, United States of America (USA) 0
Division of Genetics, BWH, United States of America (USA) 0

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