Whole-genome sequencing of patients with rare diseases in a national health system

Journal: Nature

Published: 2020-06-24

DOI: 10.1038/s41586-020-2434-2

Affiliations: 246

Authors: 511

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Institutions Share
NIHR BioResource, United Kingdom (UK) 0.09
Department of Haematology, University of Cambridge, United Kingdom (UK) 0.08
Guy's and St Thomas' NHS Foundation Trust, United Kingdom (UK) 0.04
Great Ormond Street Hospital for Children NHS Trust, United Kingdom (UK) 0.04
Department of Medicine, University of Cambridge, United Kingdom (UK) 0.03
Addenbrooke's Hospital, United Kingdom (UK) 0.02
Illumina Cambridge Ltd., United Kingdom (UK) 0.02
Oxford University Hospitals NHS Trust (OUH), United Kingdom (UK) 0.02
The Newcastle Upon Tyne Hospitals NHS Foundation Trust (NUTH), United Kingdom (UK) 0.02
UCL Great Ormond Street Institute of Child Health (ICH), United Kingdom (UK) 0.02
NIHR Oxford Biomedical Research Centre (OxBRC), United Kingdom (UK) 0.02
Department of Clinical Neurosciences, University of Cambridge, United Kingdom (UK) 0.01
Genomics England Ltd., United Kingdom (UK) 0.01
Congenica Ltd., United Kingdom (UK) 0.01
University of Cambridge, United Kingdom (UK) 0.01
Center for Molecular and Vascular Biology, KU Leuven, Belgium 0.01
European Bioinformatics Institute (EMBL-EBI), United Kingdom (UK) 0.01
UCL Medical School, United Kingdom (UK) 0.01
Manchester University NHS Foundation Trust (MFT), United Kingdom (UK) 0.01
Oxford Nuffield Department of Clinical Neurosciences (NDCN), United Kingdom (UK) 0.01
Department of Medicine (DOM), ICL, United Kingdom (UK) 0.01
Academic Department of Medical Genetics, University of Cambridge, United Kingdom (UK) 0.01
Genalice B.V., Netherlands 0.01
University Hospitals Birmingham NHS Foundation Trust (UHB), United Kingdom (UK) 0.01
Institute of Genetic Medicine (IGM), Newcastle University, United Kingdom (UK) 0.01
University College London Hospitals NHS Foundation Trust (UCLH), United Kingdom (UK) 0.01
Hammersmith Hospital, Imperial College Healthcare NHS Trust, United Kingdom (UK) 0.01
Barts Health NHS Trust, United Kingdom (UK) 0.01
MRC Biostatistics Unit (BSU), University of Cambridge, United Kingdom (UK) 0.01
Cambridge University Hospitals NHS Foundation Trust, United Kingdom (UK) 0.01
Oxford MRC Molecular Haematology Unit (MHU), United Kingdom (UK) 0.01
University Hospital Southampton NHS Foundation Trust, United Kingdom (UK) 0.01
Nottingham University Hospitals NHS Trust (NUH), United Kingdom (UK) 0.01
Wellcome Sanger Institute, United Kingdom (UK) 0.01
Translational and Clinical Research Institute, Newcastle University, United Kingdom (UK) 0.01
Royal Free London NHS Foundation Trust, United Kingdom (UK) 0.01
NIHR Cambridge Biomedical Research Centre (Cambridge BRC), United Kingdom (UK) 0.01
Department of Public Health and Primary Care (DPHPC), University of Cambridge, United Kingdom (UK) 0.01
Moorfields Eye Hospital NHS Foundation Trust, United Kingdom (UK) 0.01
Papworth Hospital NHS Foundation Trust, United Kingdom (UK) 0.01
King's College London (KCL), United Kingdom (UK) 0.01
Salford Royal NHS Foundation Trust, United Kingdom (UK) 0.01
Cambridge Institute of Therapeutic Immunology and Infectious Diseases (CITIID), University of Cambridge, United Kingdom (UK) 0.01
Sheffield Teaching Hospitals NHS Foundation Trust, United Kingdom (UK) 0.01
Oxford Division of Cardiovascular Medicine (CVM), United Kingdom (UK) 0.01
Birmingham Women's and Children's NHS Foundation Trust, United Kingdom (UK) 0.01
Faculty of Biology, Medicine and Health (FBMH), UoM, United Kingdom (UK) 0.01
Department of Women and Children’s Health, KCL, United Kingdom (UK) 0.01
UCL Institute of Ophthalmology (IoO), United Kingdom (UK) 0.01
CRUK Cambridge Centre, United Kingdom (UK) 0.01
National Heart and Lung Institute (NHLI), ICL, United Kingdom (UK) 0.01
University of Giessen and Marburg Lung Center (UGMLC), Germany 0
NHS Greater Glasgow and Clyde (NHSGGC), United Kingdom (UK) 0
Oxford Wellcome Trust Centre for Human Genetics, United Kingdom (UK) 0
Centre for Haematology, ICL, United Kingdom (UK) 0
NIHR Barts Biomedical Research Centre (BRC), United Kingdom (UK) 0
Royal Victoria Infirmary (RVI), NUTH, United Kingdom (UK) 0
Department of Surgery and Cancer, ICL, United Kingdom (UK) 0
NHS Blood and Transplant (NHSBT), United Kingdom (UK) 0
Department of Paediatrics, University of Cambridge, United Kingdom (UK) 0
University Hospitals Bristol NHS Foundation Trust (UHBristol), United Kingdom (UK) 0
IRCCS Policlinico San Matteo, Italy 0
University Hospitals of North Midlands NHS Trust (UHNM NHS Trust), United Kingdom (UK) 0
MRC Institute of Genetics and Molecular Medicine (IGMM), United Kingdom (UK) 0
Royal Liverpool and Broadgreen University Hospitals NHS Trust, United Kingdom (UK) 0
Bristol Medical School, UoB, United Kingdom (UK) 0
Royal Hallamshire Hospital, United Kingdom (UK) 0
University Hospital of Wales, United Kingdom (UK) 0
Royal United Hospital, Royal United Hospitals Bath NHS Foundation Trust, United Kingdom (UK) 0
East Kent Hospitals University NHS Foundation Trust, United Kingdom (UK) 0
St George's University Hospitals NHS Foundation Trust, United Kingdom (UK) 0
Amsterdam UMC, Netherlands 0
Bristol Renal, UoB, United Kingdom (UK) 0
Golden Jubilee National Hospital, NHSGGC, United Kingdom (UK) 0
VU University Medical Center (VUmc), Netherlands 0
Institute of Cardiometabolism and Nutrition (ICAN), France 0
Ludwig Boltzmann Institute Lung Vascular Research, Austria 0
NIHR Newcastle Biomedical Research Centre, United Kingdom (UK) 0
Royal Brompton and Harefield NHS Foundation Trust, United Kingdom (UK) 0
University College London (UCL), United Kingdom (UK) 0
Oxford MRC Weatherall Institute of Molecular Medicine (WIMM), United Kingdom (UK) 0
UCL Institute of Cardiovascular Science (ICS), United Kingdom (UK) 0
UCL Department of Molecular Neuroscience, United Kingdom (UK) 0
Hampshire Hospitals NHS Foundation Trust, United Kingdom (UK) 0
School of Cellular and Molecular Medicine, UoB, United Kingdom (UK) 0
Leicester Royal Infirmary, UHL, United Kingdom (UK) 0
MRC Mitochondrial Biology Unit (MBU), University of Cambridge, United Kingdom (UK) 0
John Radcliffe Hospital, United Kingdom (UK) 0
BHF Cambridge Centre of Excellence (CRE), University of Cambridge, United Kingdom (UK) 0
Glasgow Royal Infirmary (GRI), United Kingdom (UK) 0
Hopital Xavier Arnozan, France 0
Faculty of Medicine, UPSud, France 0
Division of Genetics and Molecular Medicine (GMM), KCL, United Kingdom (UK) 0
Sandwell and West Birmingham Hospitals NHS Trust (SWBH), United Kingdom (UK) 0
Bicêtre Hospital, France 0
Institute of Neuroscience and Psychology (INP), University of Glasgow, United Kingdom (UK) 0
Unit Pulmonary Hypertension: Pathophysiology and Novel Therapies, France 0
Department of Molecular and Clinical Medicine (MKM), GU, Sweden 0
Hull Royal Infirmary, Hull and East Yorkshire Hospitals NHS Trust, United Kingdom (UK) 0
Institute of Cancer and Genomic Sciences, UB, United Kingdom (UK) 0
Liverpool Women's NHS Foundation Trust, United Kingdom (UK) 0
Epsom and St Helier University Hospitals NHS Trust, United Kingdom (UK) 0
University Medicine Greifswald, Germany 0
St George's, University of London (SGUL), United Kingdom (UK) 0
Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, United Kingdom (UK) 0
University Hospital "Santa Maria della Misericordia", Italy 0
Frimley Park Hospital, Frimley Health NHS Foundation Trust, United Kingdom (UK) 0
NIHR Leicester Biomedical Research Centre, United Kingdom (UK) 0
Department of Internal Medicine, Med Uni Graz, Austria 0
King's College Hospital NHS Foundation Trust, United Kingdom (UK) 0
Northern Lincolnshire and Goole Hospitals NHS Foundation Trust, United Kingdom (UK) 0
Leeds Teaching Hospitals NHS Trust (LTHT), United Kingdom (UK) 0
Institute of Biomedical Research (B2), UB, United Kingdom (UK) 0
Division of Immunology and Inflammation, ICL, United Kingdom (UK) 0
Center for Precision Medicine and Genomics (CPMG), CU, United States of America (USA) 0
UK Renal Registry (UKRR), United Kingdom (UK) 0
JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (JDRF/Wellcome Trust DIL), United Kingdom (UK) 0
Institute of Infection and Immunity, Cardiff University, United Kingdom (UK) 0
MRC Clinical Sciences Centre (CSC), ICL, United Kingdom (UK) 0
University Hospital Tübingen (UKT), Uni Tübingen, Germany 0
Evelina London Children’s Hospital, Guy's and St Thomas' NHS Foundation Trust, United Kingdom (UK) 0
Chapel Allerton Hospital, United Kingdom (UK) 0
Hôpital Armand-Trousseau, France 0
Royal Devon and Exeter NHS Foundation Trust, United Kingdom (UK) 0
Ramón Sardá Mothers' and Children's Hospital, Argentina 0
Wellcome Trust Centre for Mitochondrial Research, Newcastle University, United Kingdom (UK) 0
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), United Kingdom (UK) 0
Imperial College Healthcare NHS Trust, United Kingdom (UK) 0
MRC London Institute of Medical Sciences (LMS), United Kingdom (UK) 0
MRC Toxicology Unit, University of Cambridge, United Kingdom (UK) 0
MRC Centre for Neuromuscular Diseases (London), United Kingdom (UK) 0
Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care (NMPC), KCL, United Kingdom (UK) 0
MRC Centre for Social, Genetic and Developmental Psychiatry (SGDP), KCL, United Kingdom (UK) 0
NIHR Maudsley Biomedical Research Centre (BRC), United Kingdom (UK) 0
UCL Institute of Immunity and Transplantation (IIT), United Kingdom (UK) 0
University of Leicester, United Kingdom (UK) 0
Hull York Medical School (HYMS), United Kingdom (UK) 0
Castle Hill Hospital, Hull and East Yorkshire Hospitals NHS Trust, United Kingdom (UK) 0
Chelsea and Westminster Hospital NHS Foundation Trust, United Kingdom (UK) 0
Faculty of Life Sciences and Medicine (LSM), KCL, United Kingdom (UK) 0
Oxford Department of Paediatrics, United Kingdom (UK) 0
Institute of Reproductive and Developmental Biology (IRDB), ICL, United Kingdom (UK) 0
School of Life Sciences, University of Lincoln, United Kingdom (UK) 0
Queen Elizabeth University Hospital Glasgow, United Kingdom (UK) 0
Department of Pediatrics, Penn, United States of America (USA) 0
Robinson Research Institute (RRI), Adelaide Uni, Australia 0
Salisbury NHS Foundation Trust, United Kingdom (UK) 0
Faculty of Health and Medical Sciences, UWA, Australia 0
Institute for Genomic Medicine (IGM), CU, United States of America (USA) 0
Department of Genetics and Development, CU, United States of America (USA) 0
PathWest Laboratory Medicine of Western Australia, Australia 0
Trinity College Dublin (TCD), Ireland 0
St. James's Hospital (SJH), TCD, Ireland 0
Great Ormond Street Hospital for Children (GOSH), United Kingdom (UK) 0
Women's and Children's Hospital (WCH), SA Health, Australia 0
Division of Hematology, CHOP, United States of America (USA) 0
Department of Allergy and Clinical Immunology, St James's University Hospital, United Kingdom (UK) 0
UCL Genetics Institute (UGI), United Kingdom (UK) 0
Dalhousie University, Canada 0
IWK Health Centre, Canada 0
Beth Israel Deaconess Medical Center (BIDMC), United States of America (USA) 0
Academic Medical Center (AMC), UvA, Netherlands 0
Sanquin Department of Blood Cell Research, Netherlands 0
Harvard Medical School (HMS), United States of America (USA) 0
UCL Arthritis Research UK Centre for Adolescent Rheumatology, United Kingdom (UK) 0
NIHR Great Ormond Street Biomedical Research Centre (GOSH BRC), United Kingdom (UK) 0
Newcastle University, United Kingdom (UK) 0
Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, United Kingdom (UK) 0
NIHR/Wellcome Trust Clinical Research Facility, MFT, United Kingdom (UK) 0
Department of Biotechnology, Osaka University, Japan 0
Chelsea and Westminster Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, United Kingdom (UK) 0
NIHR Leeds Biomedical Research Centre, United Kingdom (UK) 0
NIHR University College London Hospitals Biomedical Research Centre, United Kingdom (UK) 0
UCSF School of Medicine, United States of America (USA) 0
North Bristol NHS Trust, United Kingdom (UK) 0
St James's University Hospital, United Kingdom (UK) 0
Queen Mary University of London (QMUL), United Kingdom (UK) 0
John Walton Muscular Dystrophy Research Centre, United Kingdom (UK) 0
National Heart Research Institute Singapore (NHRIS), Singapore 0
Duke-National University of Singapore (Duke-NUS), Singapore 0
Lee Kong Chian School of Medicine, Singapore 0
Ealing Hospital, LNWH, United Kingdom (UK) 0
MRC-PHE Centre for Environment and Health, United Kingdom (UK) 0
Department of Epidemiology and Biostatistics (EBS), ICL, United Kingdom (UK) 0

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