The mutational constraint spectrum quantified from variation in 141,456 humans

Journal: Nature

Published: 2020-05-27

DOI: 10.1038/s41586-020-2308-7

Affiliations: 169

Authors: 176

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Institutions Share
Program in Medical and Population Genetics, Broad Institute, United States of America (USA) 0.12
Data Sciences Platform (DSP), Broad Institute, United States of America (USA) 0.11
Analytic and Translational Genetics Unit (ATGU), MGH, United States of America (USA) 0.07
Stanley Center for Psychiatric Research, Broad Institute, United States of America (USA) 0.02
Genomics Platform, Broad Institute, United States of America (USA) 0.02
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG), Cardiff University, United Kingdom (UK) 0.02
Institute for Molecular Medicine Finland (FIMM), Finland 0.02
Charles Bronfman Institute for Personalized Medicine (IPM), ISMMS, United States of America (USA) 0.01
Harvard Department of Medicine, United States of America (USA) 0.01
Center for Genomic Medicine (CGM), MGH, United States of America (USA) 0.01
NIHR Leicester Cardiovascular Biomedical Research Unit (LCBRU), United Kingdom (UK) 0.01
Saint Antoine Hospital, France 0.01
Department of Quantitative Health Sciences (QHS), Cleveland Clinic, United States of America (USA) 0.01
Center for Genome Science (CGS), KNIH, South Korea 0.01
National Institute for Health and Welfare (THL), Finland 0.01
Department of Public Health, University of Helsinki, Finland 0.01
National Institute of Medical Science and Nutrition Salvador Zubiran (INCMNSZ), Mexico 0.01
Department of Internal Medicine, SNU, South Korea 0.01
Department of Clinical Sciences - Malmö (DCSM), LU, Sweden 0.01
Department of Medicine and Therapeutics, CUHK, China 0.01
Human Genetics Center (HGC), UTHealth, United States of America (USA) 0.01
HUCH Department of Neurology, Finland 0.01
Institute of Biomedicine, UEF, Finland 0.01
Helsinki University Central Hospital (HUCH), Finland 0.01
Lund University Diabetes Centre (LUDC), LU, Sweden 0.01
Institute of Clinical Molecular Biology (IKMB), UKSH Kiel, Germany 0.01
Department of Gastroenterology and Hepatology, RUG, Netherlands 0.01
Institute for Genomic Medicine (IGM), CU, United States of America (USA) 0.01
Department of Physiology and Biophysics, Ole Miss, United States of America (USA) 0.01
Department of Genetics, Texas Biomed, United States of America (USA) 0.01
Department of Endocrinology, Metabolism and Diabetes, HUJI, Israel 0.01
Center for Population Health Research (CISP), INSP, Mexico 0.01
Shaare Zedek Medical Center (SZMC), Israel 0.01
Department of Twin Research and Genetic Epidemiology, KCL, United Kingdom (UK) 0.01
Skåne University Hospital (SUS), Sweden 0.01
Medical Research Center Oulu (MRC Oulu), Finland 0.01
ICR Division of Genetics and Epidemiology, United Kingdom (UK) 0.01
Department of Psychiatry and Behavioral Sciences, JHU, United States of America (USA) 0.01
USC Department of Psychiatry and Behavioral Sciences, United States of America (USA) 0.01
Ninewells Hospital and Medical School, United Kingdom (UK) 0.01
National Institute of Genomic Medicine (INMEGEN), Mexico 0.01
Oxford Radcliffe Department of Medicine (RDM), United Kingdom (UK) 0.01
Department of Health, THL, Finland 0.01
Atherogenomics Laboratory, uOttawa, Canada 0.01
Cedars-Sinai F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute (F. Widjaja Foundation IBIRI), United States of America (USA) 0.01
Fimlab Laboratories Ltd., Finland 0.01
Finnish Cardiovascular Research Center-Tampere, Tampere University, Finland 0.01
Colorado Department of Epidemiology, United States of America (USA) 0.01
Department of Pediatrics, Emory University, United States of America (USA) 0.01
Yale Section of Cardiovascular Medicine, United States of America (USA) 0.01
Institute of Clinical Medicine, UEF, Finland 0.01
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, United States of America (USA) 0.01
Department of Medicine, Ole Miss, United States of America (USA) 0.01
Peninsula College of Medicine and Dentistry (PCMD), United Kingdom (UK) 0.01
Harvard PhD Program in Bioinformatics and Integrative Genomics (BIG), United States of America (USA) 0.01
McLean Hospital, United States of America (USA) 0.01
Yale Department of Genetics, United States of America (USA) 0.01
Wellcome Trust Genome Campus, United Kingdom (UK) 0.01
Department of Pediatrics, UW, United States of America (USA) 0.01
NIH National Human Genome Research Institute (NHGRI), United States of America (USA) 0.01
University Hospitals Parma Medical Center, Italy 0.01
MRC London Institute of Medical Sciences (LMS), United Kingdom (UK) 0
National Heart and Lung Institute (NHLI), ICL, United Kingdom (UK) 0
Institute of Genomics, UT, Estonia 0
Framingham Heart Study (FHS), United States of America (USA) 0
Department of Medical Epidemiology and Biostatistics (MEB), KI, Sweden 0
Division of Preventive Medicine, BWH, United States of America (USA) 0
Estonian Genome Center, UT, Estonia 0
Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Spain 0
Hospital del Mar Medical Research Institute (IMIM), Spain 0
Cardiovascular Research Centre (CRC), Royal Brompton and Harefield NHS Foundation Trust, United Kingdom (UK) 0
National University Health System (NUHS), Singapore 0
Cardiac Arrhythmia Service, MGH, United States of America (USA) 0
Cardiovascular Research Center (CVRC), MGH, United States of America (USA) 0
Folkhälsan Research Center, Finland 0
Folkhälsan Institute of Genetics, Finland 0
Kuopio University Hospital (KUH), Finland 0
Infectious Disease and Microbiome Program, Broad Institute, United States of America (USA) 0
William Harvey Research Institute (WHRI), QMUL, United Kingdom (UK) 0
The Mindich Child Health and Development Institute (MCHDI), ISMMS, United States of America (USA) 0
Instituto de Investigaciones Biomédicas (IIB), UNAM, Mexico 0
Harvard Department of Genetics, United States of America (USA) 0
Department of Molecular Medicine and Biopharmaceutical Sciences, SNU, South Korea 0
Department of Neuroscience and Neurology, UEF, Finland 0
VA Tennessee Valley Healthcare System, United States of America (USA) 0
Barts Health NHS Trust, United Kingdom (UK) 0
Montreal Heart Institute, UdeM, Canada 0
Department of Medicine, UdeM, Canada 0
Department of Biomedical Informatics (DBMI), VU, United States of America (USA) 0
Department of Medicine, VU, United States of America (USA) 0
Institute for Genomic Medicine (IGM), UC San Diego, United States of America (USA) 0
TUM German Heart Centre Munich (DHM), Germany 0
Technical University of Munich (TUM), Germany 0
Department of Psychiatry, UC San Diego, United States of America (USA) 0
Division of Cardiovascular Medicine, VU, United States of America (USA) 0
Center for Computational and Integrative Biology (CCIB), MGH, United States of America (USA) 0
Department of Medicine, UIC, United States of America (USA) 0
Department of Pharmacology, UIC, United States of America (USA) 0
Department of Biostatistics, BU, United States of America (USA) 0
Department of Genetics and Development, CU, United States of America (USA) 0
Icahn School of Medicine at Mount Sinai (ISMMS), MSHS, United States of America (USA) 0
Center for Statistical Genetics (CSG), U-M, United States of America (USA) 0
Department of Psychiatry, University of Helsinki, Finland 0
Department of Biostatistics, U-M, United States of America (USA) 0
Department of Neurology, CU, United States of America (USA) 0
Faculty of Medicine, University of Helsinki, Finland 0
Department of Epidemiology and Biostatistics (EBS), ICL, United Kingdom (UK) 0
Imperial College Healthcare NHS Trust, United Kingdom (UK) 0
Department of Cardiology, LNWH, United Kingdom (UK) 0
Imperial College London (ICL), United Kingdom (UK) 0
Australian Centre for Population Genomics, Australia 0
NUS Department of Statistics and Applied Probability, Singapore 0
NUS Life Sciences Institute (LSI), Singapore 0
Duke-NUS Graduate Medical School Singapore, Singapore 0
NUS Department of Medicine, Singapore 0
Harvard Medical School (HMS), United States of America (USA) 0
Heart Center Lübeck, University of Lübeck, Germany 0
UNC Department of Psychiatry, United States of America (USA) 0
DZHK Partner Site Hamburg/Kiel/Lübeck, Germany 0
Institute for Cardiogenetics, University of Lübeck, Germany 0
UNC Department of Genetics, United States of America (USA) 0
Facultat de Medicina, UVic-UCC, Spain 0
Harvard Biological and Biomedical Sciences Progam (BBS), United States of America (USA) 0
Center for Non-Communicable Diseases (CNCD), Pakistan 0
Department of Human Biology, HU, Israel 0
Department of Medicine, Penn, United States of America (USA) 0
Department of Biostatistics, Epidemiology and Informatics (DBEI), Penn, United States of America (USA) 0
Center for Diabetes Research, WFU, United States of America (USA) 0
Division of Cardiovascular Medicine, BWH, United States of America (USA) 0
Department of Medicine, Einstein, United States of America (USA) 0
Department of Genetics, Einstein, United States of America (USA) 0
Department of Medicine, BU, United States of America (USA) 0
Hong Kong Institute of Diabetes and Obesity (HKIDO), CUHK, China 0
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), United Kingdom (UK) 0
Oxford Wellcome Trust Centre for Human Genetics, United Kingdom (UK) 0
NIHR Oxford Biomedical Research Centre (OxBRC), United Kingdom (UK) 0
Harvard Department of Neurology, United States of America (USA) 0
Division of General Internal Medicine, MGH, United States of America (USA) 0
Department of Epidemiology, BU, United States of America (USA) 0
Li Ka Shing Institute of Health Sciences, CUHK, China 0
Department of Biochemistry, WFU, United States of America (USA) 0
Center for Genomics and Personalized Medicine Research, WFU, United States of America (USA) 0
Vertex Pharmaceuticals Incorporated, United States of America (USA) 0
Division of Genetics and Genomics, BCH, United States of America (USA) 0
HUCH Abdominal Center, Finland 0
Cardiovascular Disease Initiative (CVDi), Broad Institute, United States of America (USA) 0
Department of Psychiatry, ISMMS, United States of America (USA) 0
Department of Genetics and Genomic Sciences, ISMMS, United States of America (USA) 0
Icahn Institute for Genomics and Multiscale Biology, ISMMS, United States of America (USA) 0
Harvard Department of Pediatrics, United States of America (USA) 0
Broad Metabolism Program (BMP), Broad Institute, United States of America (USA) 0
Massachusetts General Hospital (MGH), United States of America (USA) 0
University of New South Wales (UNSW Sydney), Australia 0
Diabetes Unit, MGH, United States of America (USA) 0
Cancer Area, Broad Institute, United States of America (USA) 0
Department of Pathology, MGH, United States of America (USA) 0
Cancer Center, MGH, United States of America (USA) 0

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