Complement genes contribute sex-biased vulnerability in diverse disorders

Journal: Nature

Published: 2020-05-11

DOI: 10.1038/s41586-020-2277-x

Affiliations: 282

Authors: 415

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Institutions Share
Wellcome Trust Genome Campus, United Kingdom (UK) 0.06
Lieber Institute for Brain Development (LIBD), United States of America (USA) 0.04
Stanley Center for Psychiatric Research, Broad Institute, United States of America (USA) 0.04
Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, United Kingdom (UK) 0.02
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG), Cardiff University, United Kingdom (UK) 0.02
VCU Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG), United States of America (USA) 0.02
Department of Psychiatry, TCD, Ireland 0.02
Institute of Psychiatry, Psychology and Neuroscience (IOPPN), KCL, United Kingdom (UK) 0.02
Department of Psychiatry, ISMMS, United States of America (USA) 0.02
UNC Department of Genetics, United States of America (USA) 0.02
Queensland Brain Institute (QBI), UQ, Australia 0.01
Harvard Department of Genetics, United States of America (USA) 0.01
Schizophrenia Research Institute (SRI), NeuRA, Australia 0.01
Department of Medical and Molecular Genetics, KCL, United Kingdom (UK) 0.01
Division of Psychiatry, The University of Edinburgh, United Kingdom (UK) 0.01
Department of Psychiatry, Psychotherapy and Psychosomatics, MLU, Germany 0.01
National Institute for Health and Welfare (THL), Finland 0.01
Department of Psychiatry, HKU, China 0.01
Analytic and Translational Genetics Unit (ATGU), MGH, United States of America (USA) 0.01
Clinical Neuroscience, MPI-EM, Germany 0.01
UCL Division of Psychiatry, United Kingdom (UK) 0.01
Department of Medical Epidemiology and Biostatistics (MEB), KI, Sweden 0.01
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark 0.01
Institute of Mental Health (IMH), Singapore 0.01
Program in Medical and Population Genetics, Broad Institute, United States of America (USA) 0.01
UCLA Center for Neurobehavioral Genetics (CNG), United States of America (USA) 0.01
Estonian Genome Center, UT, Estonia 0.01
deCODE Genetics, Inc., Iceland 0.01
Institute of Molecular Genetics (IMG), RAS, Russia 0.01
King's College London (KCL), United Kingdom (UK) 0.01
Pfizer Worldwide Research & Development (WRD), United States of America (USA) 0.01
Department of Psychiatry, UvA, Netherlands 0.01
Janssen Research & Development (J&J PRD), Raritan, United States of America (USA) 0.01
Pamela Sklar Division of Psychiatric Genomics, ISMMS, United States of America (USA) 0.01
Medical Faculty Mannheim, Uni Heidelberg, Germany 0.01
Department for Genetic Epidemiology in Psychiatry, CIMH, Germany 0.01
Norwegian Centre for Mental Disorders Research (NORMENT), Norway 0.01
Priority Research Centre for Brain and Mental Health Research (CBMHR), UON, Australia 0.01
UMC Utrecht Brain Center Rudolf Magnus, Netherlands 0.01
UMC Department of Psychiatry, Netherlands 0.01
Stanford Department of Psychiatry and Behavioral Sciences, United States of America (USA) 0.01
UCLA Department of Human Genetics, United States of America (USA) 0.01
Department of Psychiatry and Behavioral Sciences, JHU, United States of America (USA) 0.01
West China School of Medicine/West China Hospital of Sichuan University (WCSM/WCH), SCU, China 0
Vall d'Hebron Research Institute (VHIR), HUVH ICS, Spain 0
Department of Psychiatry, CU, United States of America (USA) 0
Department of Psychiatry, WUSTL, United States of America (USA) 0
Chaim Sheba Medical Center at Tel HaShomer, Israel 0
Department of Psychiatry, Fujita Health University, Japan 0
Faculty of Medicine, VU, Lithuania 0
Department of Psychiatry, CU Anschutz, United States of America (USA) 0
Division of Psychiatry, UMU, Sweden 0
Department of Genetics, RUG, Netherlands 0
Latvian Biomedical Research and Study Centre (BMC), Latvia 0
1st Department of Psychiatry, UOA, Greece 0
Roche Pharma Research and Early Development (Roche pRED), Switzerland 0
Department of Psychiatry and Behavioral Neuroscience, UChicago, United States of America (USA) 0
EURON, Netherlands 0
Department of Medical Genetics, Medical University of Sofia, Bulgaria 0
MRC Centre for Social, Genetic and Developmental Psychiatry (SGDP), KCL, United Kingdom (UK) 0
Institute of Neurology (CIN), MUW, Austria 0
Lilly Research Centre, United Kingdom (UK) 0
UCSF The Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, United States of America (USA) 0
SUNY Downstate Health Sciences University (SUNY Downstate), United States of America (USA) 0
Department of Psychiatry, RUG, Netherlands 0
Harvard Department of Psychiatry, United States of America (USA) 0
Centre for Psychiatry Research, KI, Sweden 0
Research Institute for Biological Psychiatry (IBP), Region Hovedstadens Psykiatriske Hospital, Denmark 0
USC Department of Psychiatry and Behavioral Sciences, United States of America (USA) 0
Department of Genomics, Uni Bonn, Germany 0
Life and Brain Center, Uni Bonn, Germany 0
Institute of Human Genetics, Uni Bonn, Germany 0
Psychiatric and Neurodevelopmental Genetics Unit (PNGU), MGH, United States of America (USA) 0
Department of Human Genetics, A*STAR, Singapore 0
NorthShore Department of Psychiatry and Behavioral Sciences, United States of America (USA) 0
Centre for Medical Research (CMR), UWA, Australia 0
Department of General Psychiatry at Medical Faculty Heidelberg, Uni Heidelberg, Germany 0
Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, United Kingdom (UK) 0
USC Zilkha Neurogenetic Institute (ZNI), United States of America (USA) 0
School of Biomedical Sciences and Pharmacy, UON, Australia 0
Department of Psychiatry and Psychotherapy, LMU, Germany 0
School of Psychiatry and Clinical Neurosciences, UWA, Australia 0
National Centre for Mental Health (NCMH), United Kingdom (UK) 0
UNC Department of Psychiatry, United States of America (USA) 0
Section Structural and functional Organisation of the Brain (INM-1), FZJ, Germany 0
Campbell Family Mental Health Research Institute, U of T, Canada 0
Centre for Integrative Sequencing (iSEQ), AU, Denmark 0
Department of Psychiatry, U of T, Canada 0
State Key Laboratory for Brain and Cognitive Sciences, HKU, China 0
Department of Psychiatry, MGH, United States of America (USA) 0
Oxford Department of Statistics, United Kingdom (UK) 0
Addenbrooke's Hospital, United Kingdom (UK) 0
Ninewells Hospital and Medical School, United Kingdom (UK) 0
School of Medicine, SGUL, United Kingdom (UK) 0
Department of Biology and Medical Genetics, CU, Czech Republic 0
Hadassah Medical Center, HUJI, Israel 0
Department of Biostatistics, JHU, United States of America (USA) 0
UCL Department of Molecular Neuroscience, United Kingdom (UK) 0
Instituto de Investigación Marqués de Valdecilla (IDIVAL), HUMV, Spain 0
The University of Queensland Diamantina Institute (UQDI), UQ, Australia 0
Princess Alexandra Hospital, Australia 0
University Hospital in Motol, Czech Republic 0
Peninsula College of Medicine and Dentistry (PCMD), United Kingdom (UK) 0
Faculty of Medicine, TSMU, Georgia 0
UiO Division of Mental Health and Addiction, Norway 0
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Spain 0
Queensland Centre for Mental Health Research (QCMHR), UQ, Australia 0
NIH NCI Division of Cancer Epidemiology and Genetics (DCEG), United States of America (USA) 0
Department of Psychiatry and Psychotherapy, FAU, Germany 0
Oxford Wellcome Trust Centre for Human Genetics, United Kingdom (UK) 0
School of Medicine (BUSM), University of Belgrade, Serbia 0
Berkshire Healthcare NHS Foundation Trust, United Kingdom (UK) 0
Centre for Public Health (CPH), QUB, United Kingdom (UK) 0
Department of Neurosciences, Biomedicine and Movement Sciences (DSNM), UNIVR, Italy 0
DETECT Early Intervention Service for Psychosis, Ireland 0
Department of Molecular and Cellular Therapeutics (MCT), RCSI, Ireland 0
Health Research Board, Ireland 0
Eli Lilly and Company, United States of America (USA) 0
Department of Psychiatry and Psychotherapy, FSU, Germany 0
Department of Genetics and Pathology, PMU, Poland 0
University College London (UCL), United Kingdom (UK) 0
Department of Psychiatry, RCSI, Ireland 0
Department of Genetics, HUJI, Israel 0
Faculty of Medicine, Medical University of Sofia, Bulgaria 0
VCU Department of Human and Molecular Genetics, United States of America (USA) 0
Landspitali - The National University Hospital of Iceland, Iceland 0
Institute of Medical Sciences (IMS), University of Aberdeen, United Kingdom (UK) 0
Discipline of Psychiatry, NUI Galway, Ireland 0
Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs (LGN), France 0
Department of Psychiatry and Psychotherapy, Uni Bonn, Germany 0
Department of Mental Health, JHU, United States of America (USA) 0
Oxford Department of Psychiatry, United Kingdom (UK) 0
Helse Stavanger University Hospital, Norway 0
Department of Psychology and Neuroscience, CU-Boulder, United States of America (USA) 0
Department of Clinical Biochemistry, Immunology and Genetics, SSI, Denmark 0
Department of Non-communicable Disease Epidemiology (NCDE), LSHTM, United Kingdom (UK) 0
Department of Psychiatry, UCC, Ireland 0
VA Boston Healthcare System, United States of America (USA) 0
VIB-UAntwerp Center for Molecular Neurology (CMN), Belgium 0
Instituto de Formación e Investigación Marqués de Valdecilla (IFIMAV), HUMV, Spain 0
Blue Note Biosciences, United States of America (USA) 0
Castle Peak Hospital, China 0
UNC Department of Computer Science, United States of America (USA) 0
Institute of Psychology (IP), CAS, China 0
Génétique du Cancer et des Maladies Neuropsychiatriques (GCMN), France 0
Department of Psychiatry and Psychotherapy, UR, Germany 0
UCSF Department of Psychiatry, United States of America (USA) 0
LSUHSC School of Nursing, LSU, United States of America (USA) 0
Department of Psychiatry, UI, United States of America (USA) 0
Szentágothai Research Centre, PTE, Hungary 0
Medical School, PTE, Hungary 0
State Mental Hospital Haar, Germany 0
Genentech, Inc., United States of America (USA) 0
Department of Biostatistics and Data Science (BDS), WFU, United States of America (USA) 0
UAB Division of Clinical Immunology and Rheumatology, United States of America (USA) 0
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Göttingen, Germany 0
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), United Kingdom (UK) 0
AP-HP Pitié-Salpêtrière Hospital - Charles-Foix, France 0
Illumina, Inc., United States of America (USA) 0
Mental Health Research Center, RAMS, Russia 0
Center for Neonatal Screening, SSI, Denmark 0
Friedman Brain Institute, ISMMS, United States of America (USA) 0
Department of Biomedicine, AU, Denmark 0
MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, United States of America (USA) 0
Icahn Institute for Genomics and Multiscale Biology, ISMMS, United States of America (USA) 0
Institute for Molecular Medicine Finland (FIMM), Finland 0
James J. Peters VA Medical Center, United States of America (USA) 0
Department of Genetics and Genomic Sciences, ISMMS, United States of America (USA) 0
Centre for Clinical Research in Neuropsychiatry (CCRN), Australia 0
Department of Biomedicine Basel, Switzerland 0
Center for Basic and Translational Obesity Research, BCH, United States of America (USA) 0
Division of Endocrinology, BCH, United States of America (USA) 0
Harry Perkins Institute of Medical Research (HPIMR), Australia 0
School of Psychology, NUI Galway, Ireland 0
UC Center for Autoimmune Genomics and Etiology (CAGE), United States of America (USA) 0
Department of Psychiatry, BIDMC, United States of America (USA) 0
Massachusetts Mental Health Center, United States of America (USA) 0
Cambridge Institute for Medical Research (CIMR), University of Cambridge, United Kingdom (UK) 0
Institute of Medical Science (IMS), U of T, Canada 0
Cincinnati VA Medical Center (VAMC), United States of America (USA) 0
The National Centre for Register-based Research, AU, Denmark 0
Centre for Genomic Sciences, HKU, China 0
Telethon Kids Institute, Australia 0
Centre for Child Health Research, UWA, Australia 0
Discipline of Biochemistry, NUI Galway, Ireland 0
Zucker Hillside Hospital, Northwell Health, United States of America (USA) 0
UC Department of Pediatrics, United States of America (USA) 0
Centre for Integrated Register-Based Research at Aarhus University (CIRRAU), AU, Denmark 0
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, United States of America (USA) 0
Feinstein Institute for Medical Research, Northwell Health, United States of America (USA) 0
Aarhus University Hospital, Denmark 0
Department of Psychiatry and Behavioral Sciences, Emory University, United States of America (USA) 0
Atlanta VA Medical Center, United States of America (USA) 0
Oulu University Hospital (OUH), Finland 0
NUS Saw Swee Hock School of Public Health (SSHPH), Singapore 0
Faculty of Medicine (FMed), University of Oulu, Finland 0
Faculty of Medicine, Sorbonne University, France 0
Faculty of Medicine "Carl Gustav Carus", TU Dresden, Germany 0
Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), The University of Edinburgh, United Kingdom (UK) 0
NIHR Moorfields Biomedical Research Centre (BRC), United Kingdom (UK) 0
The University of Western Australia (UWA), Australia 0
Duke-NUS Graduate Medical School Singapore, Singapore 0
Center for Statistical Genetics (CSG), U-M, United States of America (USA) 0
UCL Research Department of Epidemiology and Public Health (EPH), United Kingdom (UK) 0
Wolfson Institute of Preventive Medicine, QMUL, United Kingdom (UK) 0
Faculty of Epidemiology and Population Health (EPH), LSHTM, United Kingdom (UK) 0
Lawrence Berkeley National Laboratory (LBNL), United States of America (USA) 0
University of California, Berkeley (UC Berkeley), United States of America (USA) 0
Department of Psychiatry, University of Helsinki, Finland 0
Assistance Publique-Hôpitaux de Paris (AP-HP), France 0
Institute for Intelligent Systems and Robotics (ISIR), France 0
Harvard Department of Epidemiology, United States of America (USA) 0
Department of Human Genetics, UChicago, United States of America (USA) 0
Sørlandet Hospital HF, Norway 0
School of Psychology, UON, Australia 0
Division of Cardiovascular Medicine, BWH, United States of America (USA) 0
UCL Institute of Ophthalmology (IoO), United Kingdom (UK) 0
School of Psychiatry, UNSW Sydney, Australia 0
Department of Biostatistics, U-M, United States of America (USA) 0
UCL Institute of Cognitive Neuroscience (ICN), United Kingdom (UK) 0
Diakonhjemmet Hospital, Diakonhjemmet Foundation, Norway 0
University of Barcelona (UB), Spain 0
Fundació per la Docència i Recerca, MútuaTerrassa, Spain 0
Department of Clinical Medicine, UCPH, Denmark 0
Royal Brisbane and Women's Hospital (RBWH), Australia 0
Department of Functional Genomics (FGA), VUmc, Netherlands 0
Harvard Center for Brain Science (CBS), United States of America (USA) 0
Oslo University Hospital (OUS), Norway 0
Institute of Translational Medicine (ITM), University of Liverpool, United Kingdom (UK) 0
Max Planck Institute of Psychiatry, Germany 0
Cluster of Excellence - Munich Cluster for Systems Neurology (SyNergy), LMU, Germany 0
UiO Department of Medical Genetics (DMG), Norway 0
Melbourne Neuropsychiatry Centre (MNC), Australia 0
Department of Psychiatry and Psychotherapy, University of Göttingen, Germany 0
Hunter New England Local Health District, Australia 0
The University of Queensland (UQ), Australia 0
Melbourne Health, Australia 0
UMC Department of Medical Genetics, Netherlands 0
Priority Research Centre for Health Behaviour (CHB), UON, Australia 0
Department of Complex Trait Genetics (CTG), VUmc, Netherlands 0
School of Electrical Engineering and Computer Science, UON, Australia 0
Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, Netherlands 0
DTU Center for Biological Sequence Analysis (CBS), Denmark 0
University of Helsinki, Finland 0
Center for Human Genetic Research (CHGR), MGH, United States of America (USA) 0
Faculty of Mathematics and Natural Sciences, Uni Bonn, Germany 0
Biomedicum Helsinki, Finland 0
HUCH Unit of General Practice, Finland 0
Department of Psychiatry, Georgetown University, United States of America (USA) 0
VCU Department of Psychiatry, United States of America (USA) 0
Washington DC VA Medical Center, United States of America (USA) 0
Nash Family Department of Neuroscience, ISMMS, United States of America (USA) 0
Department of Neurology and Neurosurgery, JHU, United States of America (USA) 0
McKusick-Nathans Institute of Genetic Medicine, JHU, United States of America (USA) 0
Solomon H. Snyder Department of Neuroscience, JHU, United States of America (USA) 0
Howard Hughes Medical Institute (HHMI), United States of America (USA) 0
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