Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Journal: Nature

Published: 2020-05-06

DOI: 10.1038/s41586-020-2265-1

Affiliations: 307

Authors: 635

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NIHR BioResource, United Kingdom (UK) 0.07
Department of Haematology, University of Cambridge, United Kingdom (UK) 0.07
Great Ormond Street Hospital for Children (GOSH), United Kingdom (UK) 0.04
Department of Medicine, University of Cambridge, United Kingdom (UK) 0.04
Addenbrooke's Hospital, United Kingdom (UK) 0.03
Barts Health NHS Trust, United Kingdom (UK) 0.02
Department of Medicine (DOM), ICL, United Kingdom (UK) 0.02
Guy's and St Thomas' NHS Foundation Trust, United Kingdom (UK) 0.02
UCL Great Ormond Street Institute of Child Health (ICH), United Kingdom (UK) 0.02
University Hospitals Birmingham NHS Foundation Trust (UHB), United Kingdom (UK) 0.01
Oxford University Hospitals NHS Trust (OUH), United Kingdom (UK) 0.01
Royal Free London NHS Foundation Trust, United Kingdom (UK) 0.01
Cambridge University Hospitals NHS Foundation Trust, United Kingdom (UK) 0.01
The Newcastle Upon Tyne Hospitals NHS Foundation Trust (NUTH), United Kingdom (UK) 0.01
Royal Brompton and Harefield NHS Foundation Trust, United Kingdom (UK) 0.01
NHS Greater Glasgow and Clyde (NHSGGC), United Kingdom (UK) 0.01
Oxford Nuffield Department of Clinical Neurosciences (NDCN), United Kingdom (UK) 0.01
Cambridge Institute of Therapeutic Immunology and Infectious Diseases (CITIID), University of Cambridge, United Kingdom (UK) 0.01
Hammersmith Hospital, Imperial College Healthcare NHS Trust, United Kingdom (UK) 0.01
University Hospital Southampton NHS Foundation Trust, United Kingdom (UK) 0.01
Sheffield Teaching Hospitals NHS Foundation Trust, United Kingdom (UK) 0.01
King's College Hospital NHS Foundation Trust, United Kingdom (UK) 0.01
Papworth Hospital NHS Foundation Trust, United Kingdom (UK) 0.01
Department of Clinical Neurosciences, University of Cambridge, United Kingdom (UK) 0.01
University Hospital of Wales, United Kingdom (UK) 0.01
Salford Royal NHS Foundation Trust, United Kingdom (UK) 0.01
University College London Hospitals NHS Foundation Trust (UCLH), United Kingdom (UK) 0.01
VU University Medical Center (VUmc), Netherlands 0.01
Nottingham University Hospitals NHS Trust (NUH), United Kingdom (UK) 0.01
University of Cambridge, United Kingdom (UK) 0.01
NIHR Oxford Biomedical Research Centre (OxBRC), United Kingdom (UK) 0.01
NHS Blood and Transplant (NHSBT), United Kingdom (UK) 0.01
Cambridge Institute for Medical Research (CIMR), University of Cambridge, United Kingdom (UK) 0.01
UCL Centre for Nephrology, United Kingdom (UK) 0.01
King's College London (KCL), United Kingdom (UK) 0.01
National Heart and Lung Institute (NHLI), ICL, United Kingdom (UK) 0.01
Kennedy-Galton Centre (North West Thames Regional Genetics Service), LNWH, United Kingdom (UK) 0.01
Center for Molecular and Vascular Biology, KU Leuven, Belgium 0.01
Bristol Medical School, UoB, United Kingdom (UK) 0.01
Oxford MRC Molecular Haematology Unit (MHU), United Kingdom (UK) 0.01
Maastricht University Medical Center+ (Maastricht UMC+), Netherlands 0.01
Birmingham Children's Hospital, Birmingham Women's and Children's NHS Foundation Trust, United Kingdom (UK) 0.01
Institute of Cellular Medicine, Newcastle University, United Kingdom (UK) 0.01
West Midlands Regional Genetics Laboratory, Birmingham Women's and Children's NHS Foundation Trust, United Kingdom (UK) 0.01
Golden Jubilee National Hospital, NHSGGC, United Kingdom (UK) 0.01
UCL Institute of Immunity and Transplantation (IIT), United Kingdom (UK) 0.01
MRC Biostatistics Unit (BSU), University of Cambridge, United Kingdom (UK) 0.01
Royal Hallamshire Hospital, United Kingdom (UK) 0.01
Gartnavel General Hospital, United Kingdom (UK) 0.01
Moorfields Eye Hospital NHS Foundation Trust, United Kingdom (UK) 0.01
Institute of Genetic Medicine (IGM), Newcastle University, United Kingdom (UK) 0.01
Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, United Kingdom (UK) 0
University Hospitals of North Midlands NHS Trust (UHNM NHS Trust), United Kingdom (UK) 0
Leeds Teaching Hospitals NHS Trust (LTHT), United Kingdom (UK) 0
St George's University Hospitals NHS Foundation Trust, United Kingdom (UK) 0
Great Ormond Street Hospital for Children NHS Trust, United Kingdom (UK) 0
Wellcome Trust Genome Campus, United Kingdom (UK) 0
NIHR Cambridge Biomedical Research Centre (Cambridge BRC), United Kingdom (UK) 0
Department of Public Health and Primary Care (DPHPC), University of Cambridge, United Kingdom (UK) 0
Department of Women and Children’s Health, KCL, United Kingdom (UK) 0
Oxford Division of Cardiovascular Medicine (CVM), United Kingdom (UK) 0
University of Giessen and Marburg Lung Center (UGMLC), Germany 0
Centre for Haematology, ICL, United Kingdom (UK) 0
Churchill Hospital, United Kingdom (UK) 0
Royal Victoria Infirmary (RVI), NUTH, United Kingdom (UK) 0
University College London (UCL), United Kingdom (UK) 0
Manchester University NHS Foundation Trust (MFT), United Kingdom (UK) 0
Amsterdam UMC, Netherlands 0
School of Clinical Medicine, University of Cambridge, United Kingdom (UK) 0
National Hospital for Neurology and Neurosurgery (NHNN), UCLH, United Kingdom (UK) 0
UiO K.G. Jebsen Centre for Cancer Immunotherapy, Norway 0
Royal United Hospital, Royal United Hospitals Bath NHS Foundation Trust, United Kingdom (UK) 0
Queen Elizabeth University Hospital Glasgow, United Kingdom (UK) 0
Royal Liverpool and Broadgreen University Hospitals NHS Trust, United Kingdom (UK) 0
Kent and Canterbury Hospital, East Kent Hospitals University NHS Foundation Trust, United Kingdom (UK) 0
Institute of Cardiometabolism and Nutrition (ICAN), France 0
Sheffield Children's NHS Foundation Trust, United Kingdom (UK) 0
IRCCS Policlinico San Matteo, Italy 0
Freeman Hospital, United Kingdom (UK) 0
Royal Manchester Children's Hospital, MFT, United Kingdom (UK) 0
Queen Charlotte's and Chelsea Hospital, Imperial College Healthcare NHS Trust, United Kingdom (UK) 0
Institute of Neuroscience and Psychology (INP), University of Glasgow, United Kingdom (UK) 0
Ludwig Boltzmann Institute Lung Vascular Research, Austria 0
St Mary's Hospital, United Kingdom (UK) 0
Royal Devon and Exeter NHS Foundation Trust, United Kingdom (UK) 0
Leeds Children's Hospital, LTHT, United Kingdom (UK) 0
Hull and East Yorkshire Hospitals NHS Trust, United Kingdom (UK) 0
North East Thames Regional Genetics Service, GOSH, United Kingdom (UK) 0
NIHR Leeds Musculoskeletal Biomedical Research Unit (LMBRU), United Kingdom (UK) 0
Aberdeen Royal Infirmary, NHS Grampian, United Kingdom (UK) 0
Arthur Bloom Haemophilia Centre, University Hospital of Wales, United Kingdom (UK) 0
UCL Institute of Ophthalmology (IoO), United Kingdom (UK) 0
Clinical Genetics Service, Guy's and St Thomas' NHS Foundation Trust, United Kingdom (UK) 0
CRUK Cambridge Centre, United Kingdom (UK) 0
Sanquin Research, Netherlands 0
Royal Surrey County Hospital NHS Trust, United Kingdom (UK) 0
Hampshire Hospitals NHS Foundation Trust, United Kingdom (UK) 0
Lancashire Teaching Hospitals NHS Foundation Trust, United Kingdom (UK) 0
Frimley Park Hospital, Frimley Health NHS Foundation Trust, United Kingdom (UK) 0
Leicester Royal Infirmary, UHL, United Kingdom (UK) 0
Chelsea and Westminster Hospital NHS Foundation Trust, United Kingdom (UK) 0
JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (JDRF/Wellcome Trust DIL), United Kingdom (UK) 0
MRC Institute of Genetics and Molecular Medicine (IGMM), United Kingdom (UK) 0
UCL Department of Molecular Neuroscience, United Kingdom (UK) 0
Epsom and St Helier University Hospitals NHS Trust, United Kingdom (UK) 0
University Hospitals Bristol NHS Foundation Trust (UHBristol), United Kingdom (UK) 0
Oslo University Hospital (OUS), Norway 0
Cancer Research UK Cambridge Institute (CRUK-CI), University of Cambridge, United Kingdom (UK) 0
Faculty of Medicine, ICL, United Kingdom (UK) 0
Newcastle University, United Kingdom (UK) 0
Queen Mary University of London (QMUL), United Kingdom (UK) 0
Oxford Wellcome Trust Centre for Human Genetics, United Kingdom (UK) 0
MRC Mitochondrial Biology Unit (MBU), University of Cambridge, United Kingdom (UK) 0
Emma Children’s Hospital, UvA, Netherlands 0
Harvard Medical School (HMS), United States of America (USA) 0
Beth Israel Deaconess Medical Center (BIDMC), United States of America (USA) 0
Sandwell and West Birmingham Hospitals NHS Trust (SWBH), United Kingdom (UK) 0
Manchester Royal Eye Hospital, MFT, United Kingdom (UK) 0
Barnet Hospital, Royal Free London NHS Foundation Trust, United Kingdom (UK) 0
Leeds General Infirmary, LTHT, United Kingdom (UK) 0
Lister Hospital, East and North Herts NHS Trust, United Kingdom (UK) 0
Ninewells Hospital and Medical School, United Kingdom (UK) 0
Charité Institute of Medical Genetics and Human Genetics, Germany 0
Northwick Park Hospital, LNWH, United Kingdom (UK) 0
University Hospital Carl Gustav Carus Dresden, TU Dresden, Germany 0
Hopital Xavier Arnozan, France 0
Sunderland Royal Hospital, City Hospitals Sunderland NHS Foundation Trust, United Kingdom (UK) 0
Unit Pulmonary Hypertension: Pathophysiology and Novel Therapies, France 0
Bicêtre Hospital, France 0
Ramón Sardá Mothers' and Children's Hospital, Argentina 0
West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, United Kingdom (UK) 0
Texas Children's Hospital, BCM, United States of America (USA) 0
University Medicine Greifswald, Germany 0
Department of Medicine, University of Perugia, Italy 0
Department of Pediatrics, BCM, United States of America (USA) 0
Hôpital Saint-Louis, France 0
Faculty of Medicine, UPSud, France 0
Plymouth Hospitals NHS Trust, United Kingdom (UK) 0
Faculty of Health and Medical Sciences, UWA, Australia 0
Molecular and Clinical Sciences Research Institute, SGUL, United Kingdom (UK) 0
Liverpool Women's NHS Foundation Trust, United Kingdom (UK) 0
Royal Sussex County Hospital, BSUH, United Kingdom (UK) 0
Trinity College Dublin (TCD), Ireland 0
St. James's Hospital (SJH), TCD, Ireland 0
Glenfield Hospital, United Kingdom (UK) 0
Royal Devon and Exeter Hospital, United Kingdom (UK) 0
University Hospital of Würzburg (UKW), JMU, Germany 0
Canadian Center for Vaccinology (CCfV), Canada 0
Scunthorpe General Hospital, Northern Lincolnshire and Goole NHS Foundation Trust, United Kingdom (UK) 0
Aarhus University Hospital, Denmark 0
Institute of Cardiovascular Research (ICR2UL), RHUL, United Kingdom (UK) 0
Gloucestershire Royal Hospital (GRH), GHNHSFT, United Kingdom (UK) 0
Division of Genetics and Molecular Medicine (GMM), KCL, United Kingdom (UK) 0
American Friends of Kaplan Medical Center (AFKMC), HUJI, Israel 0
Colchester Hospital University NHS Foundation Trust, United Kingdom (UK) 0
Department of Molecular Medicine, Sapienza University of Rome, Italy 0
Department of Internal Medicine, Med Uni Graz, Austria 0
Blizard Institute, QMUL, United Kingdom (UK) 0
School of Cellular and Molecular Medicine, UoB, United Kingdom (UK) 0
Warrington and Halton Hospitals NHS Foundation Trust, United Kingdom (UK) 0
Department of Molecular Medicine, UNIPV, Italy 0
Ege University Hospital, Turkey 0
Princess Alexandra Hospital NHS Trust, United Kingdom (UK) 0
Birmingham Women's Hospital, Birmingham Women's and Children's NHS Foundation Trust, United Kingdom (UK) 0
Shaare Zedek Medical Center (SZMC), Israel 0
University Hospitals Coventry and Warwickshire NHS Trust, United Kingdom (UK) 0
Institute of Infection and Immunity, Cardiff University, United Kingdom (UK) 0
Royal Victoria Hospital (RVH), BHSCT, United Kingdom (UK) 0
University Hospital Tübingen (UKT), Uni Tübingen, Germany 0
Sahlgrenska Academy, GU, Sweden 0
Department of Infection, Immunity and Inflammation, University of Leicester, United Kingdom (UK) 0
Genomics England Ltd., United Kingdom (UK) 0
Evelina London Children’s Hospital, Guy's and St Thomas' NHS Foundation Trust, United Kingdom (UK) 0
Imperial College Healthcare NHS Trust, United Kingdom (UK) 0
Leeds Institute of Rheumatic and Musculoskeletal Medicine (LIRMM), University of Leeds, United Kingdom (UK) 0
School of the Biological Sciences, University of Cambridge, United Kingdom (UK) 0
St James's University Hospital, United Kingdom (UK) 0
NIHR Leeds Biomedical Research Centre, United Kingdom (UK) 0
Oxford MRC Weatherall Institute of Molecular Medicine (WIMM), United Kingdom (UK) 0
MRC London Institute of Medical Sciences (LMS), United Kingdom (UK) 0
Barts and The London School of Medicine and Dentistry (SMD), QMUL, United Kingdom (UK) 0
Eccles Institute of Human Genetics, Utah, United States of America (USA) 0
MRC Centre for Neuromuscular Diseases (London), United Kingdom (UK) 0
North Bristol NHS Trust, United Kingdom (UK) 0
Department of Cardiovascular Sciences, University of Leicester, United Kingdom (UK) 0
NIHR Leicester Biomedical Research Centre, United Kingdom (UK) 0
Faculty of Life Sciences and Medicine (LSM), KCL, United Kingdom (UK) 0
UCL Genetics Institute (UGI), United Kingdom (UK) 0
Imperial College London (ICL), United Kingdom (UK) 0
The Royal London Hospital, United Kingdom (UK) 0
Department of Internal Medicine, Utah, United States of America (USA) 0
Department of Surgery and Cancer, ICL, United Kingdom (UK) 0
Epsom Hospital, Epsom and St Helier University Hospitals NHS Trust, United Kingdom (UK) 0
Cardiff & Vale University Health Board, United Kingdom (UK) 0
Cardiff University, United Kingdom (UK) 0
Normal and Pathologic Haematopoïesis, France 0
Institute of Cardiovascular and Medical Sciences (ICAMS), University of Glasgow, United Kingdom (UK) 0
Faculty of Medicine, Soton, United Kingdom (UK) 0
University of Leicester, United Kingdom (UK) 0
MRC Centre for Social, Genetic and Developmental Psychiatry (SGDP), KCL, United Kingdom (UK) 0
NIHR Maudsley Biomedical Research Centre (BRC), United Kingdom (UK) 0
Norfolk and Norwich University Hospitals NHS Foundation Trust, United Kingdom (UK) 0
MRC Clinical Sciences Centre (CSC), ICL, United Kingdom (UK) 0
Chapel Allerton Hospital, United Kingdom (UK) 0
Yorkshire Regional Genetics Service (YRGS), LTHT, United Kingdom (UK) 0
Castle Hill Hospital, Hull and East Yorkshire Hospitals NHS Trust, United Kingdom (UK) 0
Hôpital Armand-Trousseau, France 0
UK Renal Registry (UKRR), United Kingdom (UK) 0
Salisbury NHS Foundation Trust, United Kingdom (UK) 0
Robinson Research Institute (RRI), Adelaide Uni, Australia 0
Great North Children's Hospital (GNCH), NUTH, United Kingdom (UK) 0
School of Life Sciences, University of Lincoln, United Kingdom (UK) 0
Division of Hematology, CHOP, United States of America (USA) 0
Department of Pediatrics, Penn, United States of America (USA) 0
Hull York Medical School (HYMS), United Kingdom (UK) 0
Women's and Children's Hospital (WCH), SA Health, Australia 0
John Walton Muscular Dystrophy Research Centre, United Kingdom (UK) 0
UCL/MRC Laboratory for Molecular Cell Biology (LMCB), United Kingdom (UK) 0
School of Biological Sciences (SBS), UoM, United Kingdom (UK) 0
School of Paediatrics and Child Health (SPACH), UWA, Australia 0
Genetic Services of Western Australia, Australia 0
Telethon Kids Institute, Australia 0
Institute of Clinical Molecular Biology (IKMB), UKSH Kiel, Germany 0
UiO Institute of Clinical Medicine (Klinmed), Norway 0
NIHR/Wellcome Trust Clinical Research Facility, MFT, United Kingdom (UK) 0
School of Mathematics and Statistics, University of St Andrews, United Kingdom (UK) 0
School of Medicine, University of St Andrews, United Kingdom (UK) 0
Chelsea and Westminster Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, United Kingdom (UK) 0
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), United Kingdom (UK) 0
NIH National Institute of Allergy and Infectious Diseases (NIAID), United States of America (USA) 0
Wellcome Trust Centre for Mitochondrial Research, Newcastle University, United Kingdom (UK) 0
BHF Cambridge Centre of Excellence (CRE), University of Cambridge, United Kingdom (UK) 0
Oxford Nuffield Department of Women's and Reproductive Health, United Kingdom (UK) 0
NIHR Moorfields Biomedical Research Centre (BRC), United Kingdom (UK) 0
Department of Biotechnology, Osaka University, Japan 0
UCSF School of Medicine, United States of America (USA) 0
Duke-NUS Cardiovascular and Metabolic Disorders (CVMD), Singapore 0
National Heart Research Institute Singapore (NHRIS), Singapore 0
MRC Epidemiology Unit, University of Cambridge, United Kingdom (UK) 0
Department of Epidemiology and Biostatistics (EBS), ICL, United Kingdom (UK) 0
Ealing Hospital, LNWH, United Kingdom (UK) 0
MRC-PHE Centre for Environment and Health, United Kingdom (UK) 0
Lee Kong Chian School of Medicine, Singapore 0

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