Structural basis of ligand recognition and self-activation of orphan GPR52

Journal: Nature

Published: 2020-02-19

DOI: 10.1038/s41586-020-2019-0

Affiliations: 14

Authors: 16

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Research Highlight

Structure sheds light on a protein receptor



The determination of the three-dimensional structure of a protein receptor implicated in psychiatric disorders will help efforts to develop drugs to treat those disorders.

Cells detect changes in their chemical environment via proteins on their surfaces known as receptors. G-protein-coupled receptors (GPCRs) are largest family of such receptors, with more than 800 of them known in humans. Many commercial drugs act by binding to GPCRs.

Now, a team led by researchers from ShanghaiTech University has determined for the first time the three-dimensional structure of GPR52, a GPCR that is highly expressed in the brain and that has been implicated in Huntington’s disease and other psychiatric disorders.

This structural knowledge is all the more valuable because GPR52 is an orphan GPCR, meaning that the natural occurring molecules that activate it by binding to it have yet to be identified.

Supported content

  1. Nature 579, 152–157 (2020) doi: 10.1038/s41586-020-2019-0
Institutions Share
iHuman Institute, ShanghaiTech, China 0.21
School of Life Science and Technology (SLST), ShanghaiTech, China 0.17
Institute of Biochemistry and Cell Biology (IBCB), SIBS CAS, China 0.09
University of Chinese Academy of Sciences (UCAS), China 0.09
Shanghai Ninth People's Hospital, SJTU, China 0.07
Shanghai Institute of Precision Medicine at Shanghai Ninth People's Hospital, SJTU, China 0.07
Institute of Molecular Enzymology, Soochow University, China 0.06
CAS Key Laboratory of Receptor Research (CASKLRR), SIMM CAS, China 0.05
National Center for Drug Screening, China 0.05
USC Department of Biological Sciences, United States of America (USA) 0.03
USC Bridge Institute, United States of America (USA) 0.03
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases at Xinhua Hospital, SJTU, China 0.02
MOE Key Laboratory of Cell Differentiation and Apoptosis, SJTU, China 0.02
CAS Center for Excellence in Molecular Cell Science, SIBS CAS, China 0.02