m6A facilitates hippocampus-dependent learning and memory through YTHDF1

Journal: Nature

Published: 2018-10-31

DOI: 10.1038/s41586-018-0666-1

Affiliations: 18

Authors: 22

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Research Highlight

Changes to RNA aid in learning and memory

© PM Images/Getty

© PM Images/Getty

With the help of a binding protein, a common chemical modification to RNA underpins the brain’s response to memory-inducing stimuli, according to a mouse study co-led by scientists at ShanghaiTech University.

The researchers used CRISPR gene-editing tools to create mice with and without YTHDF1—a protein that recognizes RNA transcripts with attached methyl tags and enhances the conversion of those RNA molecules into proteins.

Behaviourally, mice without YTHDF1 displayed deficits in spatial learning and contextual memory. And molecularly, the same animals showed impaired synaptic function in the brain region that controls those processes. The problems could be reversed, however, by reintroducing a working version of the gene that encodes YTHDF1 into the brain.

The findings reveal a biological process that could be manipulated to treat memory-related conditions such as post-traumatic stress disorder.

Supported content

  1. Nature 563, 249–253 (2018). doi: 10.1038/s41586-018-0666-1
Institutions FC
School of Life Science and Technology (SLST), ShanghaiTech, China 0.34
Department of Neurobiology, UChicago, United States of America (USA) 0.14
Department of Neuroscience, Penn, United States of America (USA) 0.09
Mahoney Institute for Neurosciences (MINS), Penn, United States of America (USA) 0.09
School of Life Sciences and Technology, Tongji University, China 0.05
Department of Biochemistry and Molecular Biology, UChicago, United States of America (USA) 0.03
Department of Chemistry, UChicago, United States of America (USA) 0.03
The University of Chicago (UChicago), United States of America (USA) 0.03
Institute for Biophysical Dynamics (IBD), UChicago, United States of America (USA) 0.03
Zhejiang University Laboratory Animal Center (ZJULAC), ZJU, China 0.02
MOE Key Laboratory of Brain Functional Genomics (IBFG), ECNU, China 0.02
Shanghai Key Laboratory of Brain Functional Genomics, ECNU, China 0.02
State Key Laboratory of Reproductive Medicine (SKLRM), NJMU, China 0.02
Department of Histology and Embryology, NJMU, China 0.02
Department of Cell and Developmental Biology, Penn, United States of America (USA) 0.02
Institute for Regenerative Medicine (IRM), Penn, United States of America (USA) 0.02
Department of Psychiatry, Penn, United States of America (USA) 0.01
Epigenetics Institute, Penn, United States of America (USA) 0.01

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