Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Journal:
Nature Communications
Published:
DOI:
10.1038/s41467-021-22491-8
Affiliations:
320
Authors:
565
Institutions Authors Share
Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), Spain
33.083333
33.083333
33.083333
33.083333
0.06
Barcelona Alzheimer Treatment and Research Center (ACE), Spain
27.500000
27.500000
27.500000
0.05
Universitat Internacional de Catalunya (UIC), Spain
27.500000
27.500000
27.500000
0.05
Institute of Biomedicine of Seville (IBiS), Spain
14.000000
14.000000
0.02
Amsterdam UMC, Netherlands
12.166667
12.166667
0.02
Cardiff University, United Kingdom (UK)
12.000000
12.000000
0.02
University Hospital Bonn (UKB), Uni Bonn, Germany
9.250000
0.02
Hospital Universitario Virgen de la Arrixaca, Spain
9.000000
0.02
University of Perugia, Italy
9.000000
0.02
University of Eastern Finland (UEF), Finland
8.583333
0.02
University of Buenos Aires (UBA), Argentina
8.000000
0.01
IRCCS Santa Lucia Foundation, Italy
7.500000
0.01
Karolinska Institute (KI), Sweden
7.250000
0.01
Aristotle University of Thessaloniki (AUTH), Greece
7.000000
0.01
University Hospital of Würzburg (UKW), JMU, Germany
7.000000
0.01
Hospital Universitario Nuestra Señora de Valme, Spain
6.500000
0.01
University of Málaga (UMA), Spain
6.000000
0.01
Agostino Gemelli University Polyclinic, Italy
6.000000
0.01
The French Alternative Energies and Atomic Energy Commission (CEA), France
6.000000
0.01
IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Italy
5.500000
0.01
Queen's University Belfast (QUB), United Kingdom (UK)
5.000000
0.01
Institute for Studies in Neuroscience and Complex Systems (ENyS CONICET-UNAJ), Argentina
5.000000
0.01
Risk Factors and Molecular Determinants of Aging-related Diseases (RID-AGE), France
5.000000
0.01
National Scientific and Technical Research Council (CONICET), Argentina
4.833333
0.01
University of Gothenburg (GU), Sweden
4.750000
0.01
University of Florence (UNIFI), Italy
4.500000
0.01
Andalusian Institute for Neuroscience (IANEC), Spain
4.500000
0.01
The University of Manchester (UoM), United Kingdom (UK)
4.500000
0.01
University of Oxford, United Kingdom (UK)
4.500000
0.01
August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Spain
4.500000
0.01
Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Spain
4.250000
0.01
DZNE Site Bonn, Germany
4.083333
0.01
Uppsala University (UU), Sweden
4.000000
0.01
Instituto de Investigación Marqués de Valdecilla (IDIVAL), HUMV, Spain
4.000000
0.01
University of Turin (UNITO), Italy
4.000000
0.01
IRCCS Fatebenefratelli di Brescia, Italy
4.000000
0.01
Centro Andaluz de Estudios Bioinformaticos (CAEBi), Spain
4.000000
0.01
Hospital La Paz Institute for Health Research (IdiPAZ), Spain
3.916667
0.01
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Spain
3.833333
0.01
Boston University (BU), United States of America (USA)
3.666667
0.01
National Institute for Health and Welfare (THL), Finland
3.583333
0.01
University Hospital of Munich (KUM), LMU, Germany
3.583333
0.01
Salford Royal Hospital, United Kingdom (UK)
3.500000
0.01
Hospital de la Santa Creu i Sant Pau, Spain
3.333333
0.01
Autonomous University of Barcelona (UAB), Spain
3.333333
0.01
Mútua Terrassa, Spain
3.000000
0.01
Dino Ferrari Centre, Italy
3.000000
0.01
Hospital Universitario de Gran Canaria Doctor Negrín, Spain
3.000000
0.01
IRCCS Carlo Besta Neurological Institute, Italy
3.000000
0.01
University of Antwerp (UA), Belgium
3.000000
0.01
University of Milano-Bicocca (UNIMIB), Italy
3.000000
0.01
TUM University Hospital Klinikum rechts der Isar (MRI), Germany
3.000000
0.01
Milan Center for Neuroscience, Italy
3.000000
0.01
Argentina Ministry of Health (MSAL), Argentina
3.000000
0.01
Hospital Universitario MútuaTerrassa, Spain
3.000000
0.01
La Fe University Hospital, Spain
3.000000
0.01
University of Brescia (UNIBS), Italy
3.000000
0.01
University of Pennsylvania (Penn), United States of America (USA)
3.000000
0.01
University Hospital in Halle (Saale) (UKH), MLU, Germany
3.000000
0.01
Fundación Centro Investigación Enfermedades Neurológicas (Fundación CIEN), Spain
3.000000
0.01
University Hospital Alexandrovska, Bulgaria
3.000000
0.01
Bangor University, United Kingdom (UK)
3.000000
0.01
UK DRI at Cardiff (UK DRI Cardiff), United Kingdom (UK)
3.000000
0.01
University of Cologne (UoC), Germany
2.583333
0.00
University of Cagliari (UNICA), Italy
2.500000
0.00
Genomic Medicine Group (GMX), Spain
2.500000
0.00
Rouen University Hospital-Charles Nicolle (CHU de Rouen), France
2.500000
0.00
Haugesund Hospital, Norway
2.500000
0.00
Hospital de Cabueñes, Spain
2.500000
0.00
University of Bonn (Uni Bonn), Germany
2.500000
0.00
Karolinska University Hospital, Sweden
2.500000
0.00
Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Spain
2.500000
0.00
Asturias Central University Hospital (HUCA), Spain
2.333333
0.00
The University of Texas Health Science Center at San Antonio (UT Health San Antonio), United States of America (USA)
2.250000
0.00
Reina Sofia Foundation, Spain
2.166667
0.00
Aging Research Center (ARC), Sweden
2.000000
0.00
Murdoch University, Australia
2.000000
0.00
Neurología Clinica, Argentina
2.000000
0.00
University of Bari Aldo Moro (UniBA), Italy
2.000000
0.00
Amsterdam Neuroscience, Netherlands
2.000000
0.00
IRCCS Casa Sollievo della Sofferenza Hospital, Italy
2.000000
0.00
University of Miami (UM), United States of America (USA)
2.000000
0.00
Rigshospitalet, Denmark
2.000000
0.00
International Clinical Research Center (FNUSA-ICRC), Czech Republic
2.000000
0.00
Harokopio University of Athens (HUA), Greece
2.000000
0.00
University of Lisbon (ULISBOA), Portugal
2.000000
0.00
DZNE Site Berlin, Germany
2.000000
0.00
University of Liverpool, United Kingdom (UK)
2.000000
0.00
University Hospital in Motol, Czech Republic
2.000000
0.00
Biomedical Research Institute of Lleida (IRBLleida), Spain
1.833333
0.00
Hospital de Santa Maria, Spain
1.833333
0.00
Free University of Brussels (VUB), Belgium
1.750000
0.00
AP-HP Hôpital Broca, France
1.750000
0.00
UCL, United Kingdom (UK)
1.750000
0.00
University of Bristol (UoB), United Kingdom (UK)
1.666667
0.00
Hospital Escuela Eva Perón, Argentina
1.666667
0.00
University of Zurich (UZH), Switzerland
1.666667
0.00
Biodonostia Health Research Institute (Biodonostia HRI), Spain
1.583333
0.00
DZNE Site Munich, Germany
1.583333
0.00
LUSAGE Laboratory, France
1.500000
0.00
Erasmus University Medical Center (Erasmus MC), Netherlands
1.500000
0.00
The University of Texas Health Science Center at Houston (UTHealth), United States of America (USA)
1.500000
0.00
Hospital Dr. Lucio Molas, Argentina
1.500000
0.00
Institute for Research and Innovation in Biomedicine (IRIB), France
1.500000
0.00
Fundacion Sinapsis, Argentina
1.500000
0.00
Hospital Universitari Son Espases, Spain
1.500000
0.00
Teaching Hospital of Cagliari, Italy
1.500000
0.00
Health Research Institute of San Carlos (IdISSC), Spain
1.500000
0.00
Flanders Institute for Biotechnology (VIB), Belgium
1.500000
0.00
Severo Ochoa Centre for Molecular Biology (CBMSO), Spain
1.416667
0.00
University of Copenhagen (UCPH), Denmark
1.333333
0.00
Oslo University Hospital (OUS), Norway
1.333333
0.00
University of the Basque Country (UPV/EHU), Spain
1.250000
0.00
Donostia University Hospital, Spain
1.083333
0.00
Greek Association of Alzheimer’s Disease and Related Disorders (Alzheimer Hellas), Greece
1.000000
0.00
University of Cambridge, United Kingdom (UK)
1.000000
0.00
The University of Newcastle (UON), Australia
1.000000
0.00
Essen University Hospital, Germany
1.000000
0.00
Charité - University Medicine Berlin, Germany
1.000000
0.00
University of Stirling, United Kingdom (UK)
1.000000
0.00
University Medical Center Hamburg-Eppendorf (UKE), UHH, Germany
1.000000
0.00
University of Exeter, United Kingdom (UK)
1.000000
0.00
Hospital Universitario de La Princesa, Spain
1.000000
0.00
Barcelonabeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Spain
1.000000
0.00
University of Parma (UNIPR), Italy
1.000000
0.00
Hospital Universitario Ramón y Cajal, Spain
1.000000
0.00
Danube Hospital Vienna, Austria
1.000000
0.00
Newcastle University, United Kingdom (UK)
1.000000
0.00
Biomedical Research Center of Navarre (Navarrabiomed), Spain
1.000000
0.00
Fundacion CITA Alzheimer, Spain
1.000000
0.00
The Newcastle Upon Tyne Hospitals NHS Foundation Trust (NUTH), United Kingdom (UK)
1.000000
0.00
Na Homolce Hospital, Czech Republic
1.000000
0.00
Azienda Socio Sanitaria Territoriale (ASST) degli Spedali Civili di Brescia, Italy
1.000000
0.00
Medical University of Sofia, Bulgaria
1.000000
0.00
UCL/MRC Prion Unit, United Kingdom (UK)
1.000000
0.00
Norwegian Centre for Mental Disorders Research (NORMENT), Norway
1.000000
0.00
Salford Royal NHS Foundation Trust, United Kingdom (UK)
1.000000
0.00
Leipzig University, Germany
1.000000
0.00
Fundacion Ayuda Enfermo Renal y Alta Complejidad (Faerac), Argentina
1.000000
0.00
European Network of Research Ethics and Research Integrity (ENERI) - Austria, Austria
1.000000
0.00
Hospital Clínico Universitario de Valencia, Spain
1.000000
0.00
San Gerardo Hospital, Italy
1.000000
0.00
Azienda Ospedaliero, UNIPR, Italy
1.000000
0.00
University of Thessaly (UTH), Greece
1.000000
0.00
Kuopio University Hospital (KUH), Finland
1.000000
0.00
University of Cyprus, Cyprus
1.000000
0.00
Jean Pierre Aubert Research Centre (JPARC), France
1.000000
0.00
Heidelberg University (Uni Heidelberg), Germany
1.000000
0.00
Baylor College of Medicine (BCM), United States of America (USA)
1.000000
0.00
A.O.U. Citta della Salute e della Scienza di Torino, Italy
1.000000
0.00
University of Southampton (Soton), United Kingdom (UK)
1.000000
0.00
Norwegian University of Science and Technology (NTNU), Norway
1.000000
0.00
University of California, Riverside (UCR), United States of America (USA)
1.000000
0.00
CHU de Bordeaux, France
1.000000
0.00
Bordeaux Population Health (BPH), France
1.000000
0.00
Catholic University of the Sacred Heart (UCSC), Italy
1.000000
0.00
IRCCS Fondazione Don Carlo Gnocchi - ONLUS, Italy
1.000000
0.00
Cardiovascular Health Research Unit (CHRU), United States of America (USA)
1.000000
0.00
St. Olavs Hospital (Trondheim University Hospital), NTNU, Norway
1.000000
0.00
Development of Innovative Strategies for a Transdisciplinary Approach to Alzheimer’s Disease (DISTALZ), France
1.000000
0.00
Swansea University, United Kingdom (UK)
1.000000
0.00
University Hospital of Erlangen, FAU, Germany
1.000000
0.00
Central Institute of Mental Health (CIMH), Germany
1.000000
0.00
The University of Nottingham (UoN), United Kingdom (UK)
1.000000
0.00
Case Western Reserve University (CWRU), United States of America (USA)
1.000000
0.00
University of Oulu, Finland
0.833333
0.00
Columbia University Irving Medical Center (CUIMC), CU, United States of America (USA)
0.833333
0.00
University Medical Center Göttingen (UMG), Germany
0.833333
0.00
UK DRI at UCL (UK DRI UCL), United Kingdom (UK)
0.750000
0.00
Sahlgrenska University Hospital (SU), GU, Sweden
0.750000
0.00
Columbia University in the City of New York (CU), United States of America (USA)
0.666667
0.00
Institute of Biomedicine of Valencia (IBV), CSIC, Spain
0.666667
0.00
Health Research Institute (IIS La Fe), Spain
0.666667
0.00
Cluster of Excellence - Munich Cluster for Systems Neurology (SyNergy), LMU, Germany
0.583333
0.00
University Medicine Rostock, Germany
0.500000
0.00
DZNE Site Magdeburg, Germany
0.500000
0.00
Helse Stavanger University Hospital, Norway
0.500000
0.00
King's College London (KCL), United Kingdom (UK)
0.500000
0.00
Eginition Hospital, Greece
0.500000
0.00
Universitair Ziekenhuis Brussel (UZ Brussel), Belgium
0.500000
0.00
DZNE Site Rostock/Greifswald, Germany
0.500000
0.00
Imperial College London (ICL), United Kingdom (UK)
0.500000
0.00
Helsinki University Central Hospital (HUCH), Finland
0.500000
0.00
Otto-von-Guericke University Magdeburg (OVGU), Germany
0.500000
0.00
University Hospitals Leuven (UZ Leuven), Belgium
0.500000
0.00
Fundación para la Formación e Investigación Sanitarias de la Región de Murcia (FFIS), Spain
0.500000
0.00
Catholic University of Leuven (KU Leuven), Belgium
0.500000
0.00
University of Milan (UNIMI), Italy
0.500000
0.00
University of Bergen (UIB), Norway
0.500000
0.00
Autonomous University of Madrid (UAM), Spain
0.500000
0.00
Institute of Health Carlos III (ISCIII), Spain
0.500000
0.00
DZNE Site Tübingen, Germany
0.500000
0.00
University of Tübingen (Uni Tübingen), Germany
0.500000
0.00
Neuroscience Research Australia (NeuRA), Australia
0.500000
0.00
University Hospital Basel (USB), UB, Switzerland
0.500000
0.00
VU Amsterdam, Netherlands
0.500000
0.00
Hospital Santojanni, Argentina
0.500000
0.00
USC Health Research Institute of Santiago de Compostela (IDIS), Spain
0.500000
0.00
Biomedical Research Networking Center on Rare Diseases (CIBERER), Spain
0.500000
0.00
Galician Foundation of Genomic Medicine (FPGMX), Spain
0.500000
0.00
University of New South Wales (UNSW Sydney), Australia
0.500000
0.00
Sorbonne University, France
0.500000
0.00
Jönköping University (JU), Sweden
0.500000
0.00
McLean Hospital, United States of America (USA)
0.500000
0.00
Careggi University Hospital (AOUC), UNIFI, Italy
0.500000
0.00
AP-HP Pitié-Salpêtrière Hospital, France
0.500000
0.00
Centre for Research in Epidemiology and Population Health (CESP), France
0.500000
0.00
Medical University of Vienna (MUW), Austria
0.500000
0.00
University of Oviedo (UniOvi), Spain
0.333333
0.00
La Paz University Hospital, UAM, Spain
0.333333
0.00
University of Aveiro (UA), Portugal
0.333333
0.00
Herlev University Hospital, Denmark
0.333333
0.00
Gentofte University Hospital, Denmark
0.333333
0.00
Delft University of Technology (TU Delft), Netherlands
0.333333
0.00
Framingham Heart Study (FHS), United States of America (USA)
0.333333
0.00
Psychiatric Hospital, UZH, Switzerland
0.333333
0.00
University of Oslo (UiO), Norway
0.333333
0.00
Siun Sote—the Joint Municipal Authority for North Karelia Social and Health Services, Finland
0.333333
0.00
Frenchay Hospital, United Kingdom (UK)
0.333333
0.00
Oulu City Hospital, Finland
0.333333
0.00
Oulu University Hospital (OUH), Finland
0.333333
0.00
DZNE Site Göttingen, Germany
0.333333
0.00
Norwegian National Advisory Unit on Ageing and Health (Ageing and Health), Norway
0.333333
0.00
Cluster of Excellence - Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), UoC, Germany
0.333333
0.00
Neuroscience Center Zurich (ZNZ), Switzerland
0.333333
0.00
University Hospital of Lausanne (CHUV), UNIL, Switzerland
0.333333
0.00
University Hospital Zurich (UHZ), Switzerland
0.333333
0.00
Stockholms Sjukhem, Sweden
0.250000
0.00
University Hospital, VUB, Belgium
0.250000
0.00
South Ostrobothnia Health Care District (SO HCD), Finland
0.250000
0.00
University of Helsinki, Finland
0.250000
0.00
Hôpital Paul-Brousse, France
0.250000
0.00