Haplotype-resolved genomes provide insights into structural variation and gene content in Angus and Brahman cattle

Journal: Nature Communications

Published: 2020-04-29

DOI: 10.1038/s41467-020-15848-y

Affiliations: 11

Authors: 22

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Research Highlight

Cattle chromosomes contrasted

© Photography by Mangiwau/Getty

© Photography by Mangiwau/Getty

Chromosome-level genome maps for the two main subspecies of cattle have revealed several genetic variants that differentiate the two breeds.

A University of Adelaide–led team sequenced the DNA of a calf born to a Brahman dam and an Angus bull. This allowed the researchers to create high-quality, chromosome-detailed assemblies of the genomes for each parental breed.

Not only did the method prove more accurate than other genome-mapping techniques, but it also enabled the researchers to directly compare structural and copy number variants found in each subspecies.

In this way, they showed that the Brahman cattle, bred for pest and drought environments, had additional copies of six genes with immune-related functions, as well as an extra copy of a gene involved in fat metabolism under environmental stress, compared to Angus cattle, which were bred for beef production.

Supported content

  1. Nature Communications 11, 2071 (2020). doi: 10.1038/s41467-020-15848-y
Institutions Share
Davies Research Centre, Adelaide Uni, Australia 0.23
NIH NHGRI Computational and Statistical Genomics Branch (CSGB), United States of America (USA) 0.14
BioNano Genomics, United States of America (USA) 0.14
Pacific Biosciences of California, Inc., United States of America (USA) 0.09
European Bioinformatics Institute (EMBL-EBI), United Kingdom (UK) 0.09
USDA-ARS Meat Animal Research Center, United States of America (USA) 0.09
USDA-ARS U.S. Dairy Forage Research Center, United States of America (USA) 0.05
USDA-ARS Animal Genomics and Improvement Laboratory (AGIL), United States of America (USA) 0.05
Phase Genomics, Inc., United States of America (USA) 0.05
NIH NLM National Center for Biotechnology Information (NCBI), United States of America (USA) 0.05
Center for Bioinformatics and Computational Biology (CBCB), UMCP, United States of America (USA) 0.05