Shared heritability and functional enrichment across six solid cancers

Journal: Nature Communications

Published: 2019-01-25

DOI: 10.1038/s41467-018-08054-4

Affiliations: 392

Authors: 333

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Institutions FC
Centre for Cancer Genetic Epidemiology (CCGE), University of Cambridge, United Kingdom (UK) 0.02
NIH NCI Division of Cancer Epidemiology and Genetics (DCEG), United States of America (USA) 0.02
USC Department of Preventive Medicine, United States of America (USA) 0.02
Department of Public Health and Primary Care (DPHPC), University of Cambridge, United Kingdom (UK) 0.02
WHO International Agency for Research on Cancer (IARC), France 0.02
Public Health Sciences Division (PHS), FHCRC, United States of America (USA) 0.02
Department of Cancer Epidemiology, MOFFITT, United States of America (USA) 0.02
Harvard Department of Epidemiology, United States of America (USA) 0.01
Department of Epidemiology, UW, United States of America (USA) 0.01
Department of Medical Epidemiology and Biostatistics (MEB), KI, Sweden 0.01
Department of Genetics and Pathology, PMU, Poland 0.01
Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, United States of America (USA) 0.01
ICR Division of Genetics and Epidemiology, United Kingdom (UK) 0.01
Centre for Epidemiology and Biostatistics, UniMelb, Australia 0.01
Mayo Clinic Department of Health Sciences Research (HSR), United States of America (USA) 0.01
Princess Margaret Cancer Centre, U of T, Canada 0.01
Epidemiology Research Program, ACS, United States of America (USA) 0.01
QIMR Berghofer Department of Genetics and Computational Biology, Australia 0.01
Mayo Clinic Department of Laboratory Medicine and Pathology (DLMP), United States of America (USA) 0.01
Harvard T.H. Chan School of Public Health, United States of America (USA) 0.01
Department of Clinical Sciences - Lund, LU, Sweden 0.01
Division of Cancer Epidemiology, DKFZ, Germany 0.01
Department of Gynaecology and Obstetrics, MHH, Germany 0.01
IRCCS Istituto Oncologico Veneto (IOV), Italy 0.01
National Institute of Occupational Health (STAMI), Norway 0.01
USC Department of Medicine (DOM), United States of America (USA) 0.01
Duke Department of Obstetrics and Gynecology, United States of America (USA) 0.01
Institute of Nuclear and Radiological Sciences and Technology, Energy and Safety (INRASTES), NCSR, Greece 0.01
USC Norris Comprehensive Cancer Center, United States of America (USA) 0.01
Health Innovation Manchester, United Kingdom (UK) 0.01
Program in Medical and Population Genetics, Broad Institute, United States of America (USA) 0.01
Biomedical Research Networking Center on Rare Diseases (CIBERER), Spain 0.01
Division of Molecular Genetics, DKFZ, Germany 0
Copenhagen University Hospital (CUH), Denmark 0
Bellvitge Biomedical Research Institute (IDIBELL), Spain 0
Department of Genetics and Fundamental Medicine, BashSU, Russia 0
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Spain 0
Galician Foundation of Genomic Medicine (FPGMX), Spain 0
Comprehensive Cancer Center Erlangen-EMN (CCC), FAU, Germany 0
Unit of Nutritional Epidemiology, KI, Sweden 0
Department of Oncology and Metabolism, The University of Sheffield, United Kingdom (UK) 0
NIH NIEHS Epidemiology Branch, United States of America (USA) 0
Epidemiology Program, FHCRC, United States of America (USA) 0
Channing Division of Network Medicine, BWH, United States of America (USA) 0
Department of Internal Medicine, Utah, United States of America (USA) 0
Oslo University Hospital (OUS), Norway 0
Division of Clinical Epidemiology and Aging Research, DKFZ, Germany 0
Cancer Epidemiology Centre (CEC), Cancer Council Victoria, Australia 0
N.N. Alexandrov National Cancer Centre of Belarus for Oncology and Medical Radiology, Belarus 0
Cancer Research UK Cambridge Institute (CRUK-CI), University of Cambridge, United Kingdom (UK) 0
Division of Epidemiology, VU, United States of America (USA) 0
Clalit National Israeli Cancer Control Center (NICCC), Israel 0
Carmel Medical Center, Israel 0
N. N. Petrov Research Institute of Oncology, Russia 0
NIH NIEHS Biostatistics and Computational Biology Branch, United States of America (USA) 0
UCLA Department of Pathology and Laboratory Medicine, United States of America (USA) 0
KU Department of Pathology and Laboratory Medicine, United States of America (USA) 0
WSU College of Pharmacy, United States of America (USA) 0
Department of Integrative Oncology, BCCRC, Canada 0
Maastricht University Medical Center+ (Maastricht UMC+), Netherlands 0
Centre Hospitalier Universitaire de Québec (CHUQ), UL, Canada 0
Maria Skłodowska Curie Memorial Cancer Centre and Institute of Oncology (MCMCC), Poland 0
Department of Medical Biosciences, UMU, Sweden 0
NIH NCI Clinical Genetics Branch (CGB), United States of America (USA) 0
Dalla Lana School of Public Health (DLSPH), U of T, Canada 0
Prosserman Centre for Health Research, U of T, Canada 0
Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, United States of America (USA) 0
Radboud Institute for Molecular Life Sciences (RIMLS), RU, Netherlands 0
Department of Preventive Medicine, SNU, South Korea 0
Centre for Research in Epidemiology and Population Health (CESP), France 0
Center for Genomic Medicine (CGM), MGH, United States of America (USA) 0
Department of Epidemiology, MD Anderson Cancer Center, United States of America (USA) 0
UNC Department of Otolaryngology/Head and Neck Surgery, United States of America (USA) 0
Clinical Cancer Genetics Community Research Network (CCGCRN), City of Hope, United States of America (USA) 0
Department of Surgery, BWH, United States of America (USA) 0
University Hospital Carl Gustav Carus Dresden, TU Dresden, Germany 0
Faculty of Medicine, MUN, Canada 0
Department of Cancer Epidemiology, UHH, Germany 0
Faculty of Medicine, Medical University of Sofia, Bulgaria 0
Department of Radiation Sciences, UMU, Sweden 0
Danish Cancer Society Research Center (DCRC), Denmark 0
Copenhagen Health Science Partners (CHSP), Denmark 0
Georgetown Lombardi Comprehensive Cancer Center, United States of America (USA) 0
OSU Department Cancer Biology and Genetics, United States of America (USA) 0
Department of Cancer Control Research, BCCRC, Canada 0
Department of Genetics and Genomic Sciences, ISMMS, United States of America (USA) 0
School of Oral and Dental Sciences, UoB, United Kingdom (UK) 0
IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy 0
deCODE Genetics, Inc., Iceland 0
Division of Genetics, UP, South Africa 0
Yale Department of Chronic Disease Epidemiology (CDE), United States of America (USA) 0
Oxford Nuffield Department of Population Health (NDPH), United Kingdom (UK) 0
Erasmus University Medical Center (Erasmus MC), Netherlands 0
Department of Basic Medical Sciences, UGent, Belgium 0
Beth Israel Deaconess Medical Center (BIDMC), United States of America (USA) 0
University General Hospital of Heraklion (PAGNI), Greece 0
Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, United Kingdom (UK) 0
Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL), Netherlands 0
University Hospital of Munich (KUM), LMU, Germany 0
Pediatric Epidemiology Center, USF, United States of America (USA) 0
SWOG Statistical Center, United States of America (USA) 0
School of Health and Related Research (ScHARR), The University of Sheffield, United Kingdom (UK) 0
Department of Epidemiology, CU, United States of America (USA) 0
Research Centre for Genetic Engineering and Biotechnology "Georgi D. Efremov" (ICGIB), MASA, Macedonia 0
Department of Gastroenterology, RU, Netherlands 0
Institute of Human Genetics, UHH, Germany 0
Department of Medicine, Penn, United States of America (USA) 0
Translational Research Program, FHCRC, United States of America (USA) 0
Department of Clinical Genetics, OUH SDU, Denmark 0
QIMR Berghofer Department of Population Health, Australia 0
Institute of Human Genetics, Ulm University, Germany 0
University of Hawai'i Cancer Center (UH Cancer Center), United States of America (USA) 0
TUM Department of Gynecology and Obstetrics, Germany 0
Biomedical Research Networking Center for Epidemiology and Public Health (CIBERESP), Spain 0
Department of Cancer Prevention and Control, RPCI, United States of America (USA) 0
NIHR Bristol Biomedical Research Centre (Bristol BRC), United Kingdom (UK) 0
Leuven Cancer Institute (LKI), UZ Leuven, Belgium 0
Department of Population Sciences, City of Hope, United States of America (USA) 0
Helsinki University Central Hospital (HUCH), Finland 0
Latvian Biomedical Research and Study Centre (BMC), Latvia 0
Cancer Genetics and Prevention (CGP), DFCI, United States of America (USA) 0
UCSF Helen Diller Family Comprehensive Cancer Center, United States of America (USA) 0
Department of Molecular Genetics, NIO, Hungary 0
Center for Clinical Cancer Genetics and Global Health, UChicago, United States of America (USA) 0
University of Surrey, United Kingdom (UK) 0
Department of Molecular Medicine and Surgery (MMK), KI, Sweden 0
Stanford Cancer Institute (SCI), United States of America (USA) 0
Center for Medical Genetics (CMGG), UGent, Belgium 0
UPMC Hillman Cancer Center (UPCI), United States of America (USA) 0
Department of Neurology, Dartmouth College, United States of America (USA) 0
Department of Biomedical Sciences, University of Westminster, United Kingdom (UK) 0
Cancer Sciences Academic Unit, Soton, United Kingdom (UK) 0
Vanderbilt Epidemiology Center (VEC), VU, United States of America (USA) 0
Dipartimento di Medicina di Laboratorio, UNIPI, Italy 0
Department of Epidemiology (EPI), UCI, United States of America (USA) 0
Fondazione Policlinico Universitario Agostino Gemelli, Italy 0
Biomedicum Helsinki, Finland 0
Catholic University of the Sacred Heart (UCSC), Italy 0
Manchester Centre for Genomic Medicine (MCGM), United Kingdom (UK) 0
Sir Peter MacCallum Department of Oncology, UniMelb, Australia 0
Vall d'Hebron Institute of Oncology (VHIO), HUVH ICS, Spain 0
Genetic Epidemiology Research Institute (GERI), UCI, United States of America (USA) 0
School of Public Health, UW, United States of America (USA) 0
Bristol Medical School: Population Health Sciences, UoB, United Kingdom (UK) 0
UK Markey Cancer Center, United States of America (USA) 0
Department of Biomedical Data Science (BMDS), Dartmouth College, United States of America (USA) 0
Department of Genetic Epidemiology, University of Göttingen, Germany 0
Department of Molecular and Clinical Cancer Medicine (DMCCM), University of Liverpool, United Kingdom (UK) 0
Human Cancer Genetics Programme, CNIO, Spain 0
ICR Breast Cancer Now Toby Robins Research Centre, United Kingdom (UK) 0
Department of Clinical Genetics, Temple University, United States of America (USA) 0
Department of Breast Medical Oncology, MD Anderson Cancer Center, United States of America (USA) 0
Comprehensive Cancer Center, UPR, United States of America (USA) 0
Department of Clinical Genetics, Erasmus MC, Netherlands 0
Laboratory of Molecular Endocrinology, KU Leuven, Belgium 0
Rutgers Cancer Institute of New Jersey (CINJ), RU, United States of America (USA) 0
Health Research Institute of San Carlos (IdISSC), Spain 0
Victorian Comprehensive Cancer Centre (VCCC), Australia 0
Department of Clinical Pathology, UniMelb, Australia 0
Huntsman Cancer Institute at the University of Utah (HCI), Utah, United States of America (USA) 0
Cedars-Sinai Department of Biomedical Sciences, United States of America (USA) 0
John Radcliffe Hospital, United Kingdom (UK) 0
Oxford Nuffield Department of Surgical Sciences (NDS), United Kingdom (UK) 0
Vanderbilt-Ingram Cancer Center (VICC), VU, United States of America (USA) 0
Ruth and Bruce Rappaport Faculty of Medicine, IIT, Israel 0
German Consortium of Translational Cancer Research (DKTK), Germany 0
Aarhus University Hospital, Denmark 0
Department of Medicine, MSKCC, United States of America (USA) 0
Cancer Biology and Genetics Program (CBG), MSKCC, United States of America (USA) 0
Center for Genomic Medicine, UCPH, Denmark 0
Department of Population Health Science and Policy, ISMMS, United States of America (USA) 0
Department of Urology, UW, United States of America (USA) 0
Landspitali - The National University Hospital of Iceland, Iceland 0
Department of Obstetrics and Gynecology, MUW, Austria 0
Department of Laboratory Medicine, LU, Sweden 0
Comprehensive Cancer Center Vienna (CCC), Austria 0
BioMedical Center (BMC), Iceland 0
QUT School of Biomedical Sciences (SBMS), Australia 0
Australian Prostate Cancer Research Centre - Queensland (APCRC - Q), Australia 0
Translational Research Institute (TRI), Australia 0
QUT Institute of Health and Biomedical Innovation (IHBI), Australia 0
School of Women's and Children's Health (SPHCM), UNSW, Australia 0
Department of Radiation Oncology, ISMMS, United States of America (USA) 0
UNC Department of Epidemiology, United States of America (USA) 0
UNC Lineberger Comprehensive Cancer Center, United States of America (USA) 0
Faculty of Health and Medical Sciences, UCPH, Denmark 0
OHSU Department of Obstetrics and Gynecology, United States of America (USA) 0
OHSU Knight Cancer Institute (KCI), United States of America (USA) 0
The Copenhagen General Population Study, Denmark 0
The Kinghorn Cancer Centre (TKCC), Australia 0
Örebro University Hospital, Sweden 0
HUCH Department of Oncology, Finland 0
Sackler Faculty of Medicine, TAU, Israel 0
Department of Clinical Medicine, AU, Denmark 0
Department of Surgical Sciences, UU, Sweden 0
Center for Public Health Genomics (CPHG), UVA, United States of America (USA) 0
Department of Public Health Sciences, UVA, United States of America (USA) 0
UCL Genetics Institute (UGI), United Kingdom (UK) 0
UCL Division of Psychiatry, United Kingdom (UK) 0
Fred Hutchinson Cancer Research Center (FHCRC), United States of America (USA) 0
Stanford Department of Health Research and Policy (HRP), United States of America (USA) 0
Stanford Department of Biomedical Data Science, United States of America (USA) 0
Department of Gastrointestinal Oncology, MOFFITT, United States of America (USA) 0
Cross Cancer Institute, Canada 0
University of Pittsburgh School of Medicine (UPSOM), United States of America (USA) 0
UPMC Magee-Womens Hospital, United States of America (USA) 0
UH Seidman Cancer Center, CWRU, United States of America (USA) 0
Department of Human Genetics, Pitt, United States of America (USA) 0
The Royal Marsden NHS Foundation Trust, United Kingdom (UK) 0
Department of Population and Quantitative Health Sciences, CWRU, United States of America (USA) 0
Margaret M. and Albert B. Alkek Department of Medicine, BCM, United States of America (USA) 0
Department of Thoracic Surgery, VU, United States of America (USA) 0
Department of Oncology, U of A, Canada 0
School of Clinical Sciences (SCS), Monash University, Australia 0
NIH NIEHS Epigenetics and Stem Cell Biology Laboratory (ESCBL), United States of America (USA) 0
Centre for Genetic Origins of Health and Disease (GOHaD), Australia 0
Sahlgrenska Cancer Center, GU, Sweden 0
Institute of Clinical Sciences, GU, Sweden 0
ICR Division of Breast Cancer Research, United Kingdom (UK) 0
Institute of Biosciences (IB), USP, Brazil 0
Queen's Cancer Research Institute (QCRI), Queen's University, Canada 0
Faculty of Medicine and Health Sciences, UniOvi, Spain 0
Department of Public Health Sciences, Queen's University, Canada 0
Fred A. Litwin Centre for Cancer Genetics, U of T, Canada 0
Genetics Service, IPO, Portugal 0
Abel Salazar Biomedical Sciences Institute (ICBAS), UP, Portugal 0
Obstetrics and Gynecology Epidemiology (OB/GYN) Center, BWH, United States of America (USA) 0
Haukeland University Hospital, Norway 0
Centre for Cancer Biomarkers (CCBIO), UIB, Norway 0
Institute of Human Genetics, Pontifical Xaverian University, Colombia 0
Department of Molecular Genetics, U of T, Canada 0
Faculty of Medicine of São José do Rio Preto (FAMERP), Brazil 0
Biomedical Research Institute of Girona (IDIBGI), Spain 0
Institute for Clinical and Translational Research (ICTR), BCM, United States of America (USA) 0
VIB-KU Leuven Center for Cancer Biology (CCB), Belgium 0
NYU Laura and Isaac Perlmutter Cancer Center, United States of America (USA) 0
Department of Human Genetics, Leiden University, Netherlands 0
UCLA Division of Hematology/Oncology, United States of America (USA) 0
VA Salt Lake City Health Care System, United States of America (USA) 0
Department of Biology, UNIPI, Italy 0
Department of Oncology, Stockholm South General Hospital, Sweden 0
Helios Dr. Horst Schmidt Kliniken Wiesbaden, Germany 0
Molecular Oncology Research Center (CPOM), Barretos Cancer Hospital, Brazil 0
Kliniken Essen-Mitte, Germany 0
Moores Cancer Center, UC San Diego, United States of America (USA) 0
Genomic Medicine Group (GMX), Spain 0
Department of Human Genetics, KU Leuven, Belgium 0
Barretos Cancer Hospital, Brazil 0
Swedish Medical Center, United States of America (USA) 0
Division of Gastroenterology, MGH, United States of America (USA) 0
University Cancer Center Hamburg (UCCH), UHH, Germany 0
Helmholtz Zentrum München - German Research Center for Environmental Health (HMGU), Germany 0
Institute of Cancer Research (ICR), United Kingdom (UK) 0
NorthShore Center for Medical Genetics, United States of America (USA) 0
Pritzker School of Medicine, UChicago, United States of America (USA) 0
Sheffield Institute for Nucleic Acids (SInFoNiA), The University of Sheffield, United Kingdom (UK) 0
Federal State Institute of Biochemistry and Genetics, RAS, Russia 0
Department of Public Health Sciences (DPHS), MUSC, United States of America (USA) 0
Hollings Cancer Center, MUSC, United States of America (USA) 0
Clinical and Translational Epidemiology Unit (CTEU), MGH, United States of America (USA) 0
Department of Pathology, Leiden University, Netherlands 0
Familial Cancer Centre, Australia 0
Department of Otolaryngology, Pitt, United States of America (USA) 0
Department of Surgery, MSKCC, United States of America (USA) 0
Faculty of Medicine, PMU, Poland 0
NRG Oncology Statistical and Data Management Center (SDMC), United States of America (USA) 0
Laboratory Medicine Program (LMP) at UHN, Canada 0
Department of Laboratory Medicine and Pathobiology (LMP), U of T, Canada 0
Warwick Division of Health Sciences, United Kingdom (UK) 0
School of Health Sciences (SHS), UoM, United Kingdom (UK) 0
UCLA Fielding School of Public Health (FSPH), United States of America (USA) 0
Department of Obstetrics and Gynecology, Uni Heidelberg, Germany 0
German Cancer Research Center in the Helmholtz Association (DKFZ), Germany 0
UCLA Jonsson Comprehensive Cancer Center (JCCC), United States of America (USA) 0
Suzanne Levy-Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Israel 0
USC Keck School of Medicine, United States of America (USA) 0
Women's Cancer Research Center (WCRC), United States of America (USA) 0
Roswell Park Cancer Institute (RPCI), United States of America (USA) 0
Department of Obstetrics, Gynecology and Reproductive Sciences, Pitt, United States of America (USA) 0
Department of Medicine, McGill University, Canada 0
Peter MacCallum Cancer Centre (Peter Mac), Australia 0
Stockholm South General Hospital, Sweden 0
Department of Clinical Science and Education, KI, Sweden 0
Royal Victoria Hospital (RVH), McGill University, Canada 0
Department of Dermatology, Utah, United States of America (USA) 0
Medical Faculty Heidelberg, Uni Heidelberg, Germany 0
TUM Institut für Medizinische Statistik und Epidemiologie (IMSE), Germany 0
Lunenfeld-Tanenbaum Research Institute (LTRI), U of T, Canada 0
Department of Molecular Oncology, BCCA, Canada 0
Institute of Environmental Medicine (IMM), KI, Sweden 0
Department of Human Genetics, McGill University, Canada 0
Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, Finland 0
Biocenter Oulu, University of Oulu, Finland 0
Gerald Bronfman Department of Oncology, McGill University, Canada 0
Ovarian Cancer Research Program (OVCARE), Canada 0
Academic Department of Medical Genetics, University of Cambridge, United Kingdom (UK) 0
Toronto General Hospital (TGH), U of T, Canada 0
Northern Finland Laboratory Centre (NordLab), Finland 0
Department of Electron Microscopy and Molecular Pathology, CING, Cyprus 0
Department of Obstetrics and Gynecology, VU, United States of America (USA) 0
Department of Epidemiology and Preventive Medicine (DEPM), Monash University, Australia 0
LMU-HMGU Chair of Epidemiology, Germany 0
Vanderbilt Genetics Institute (VGI), VU, United States of America (USA) 0
Department of Population Health Sciences (PHS), Utah, United States of America (USA) 0
Institute of Epidemiology II (EPI II), HMGU, Germany 0
UiO Department of Cancer Genetics, Norway 0
Department of Pathology and Laboratory Medicine, UBC, Canada 0
Translational Cancer Research Area, UEF, Finland 0
Translational Lung Research Center Heidelberg (TLRC), Germany 0
Division of Cancer Epigenomics, DKFZ, Germany 0
Cancer Cluster Salzburg (CCS), Austria 0
Swetland Center for Environmental Health, CWRU, United States of America (USA) 0
USC Health Research Institute of Santiago de Compostela (IDIS), Spain 0
GRC-UPMC SLA et Maladies du Motoneurone, France 0
Institute of Clinical Medicine, UEF, Finland 0
Centre for Research on Prostatic Diseases (CeRePP), France 0
Kuopio University Hospital (KUH), Finland 0
Department of Radiation Oncology, MHH, Germany 0
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (IKP), Germany 0
University of Tübingen (Uni Tübingen), Germany 0
Department of Clinical Neurosciences, University of Cambridge, United Kingdom (UK) 0
National Center for Tumor Diseases (NCT) Heidelberg, Germany 0
Mount Sinai Hospital (MSH), U of T, Canada 0
Unit for Cardiovascular Medicine, KI, Sweden 0
School of Medicine, CWRU, United States of America (USA) 0
Tenon Hospital, France 0
UiO Institute of Clinical Medicine (Klinmed), Norway 0
Department of Gynaecological Oncology, WSLHD, Australia 0
The University of Sydney (USYD), Australia 0
Centre for Cancer Research, Westmead Institute for Medical Research, Australia 0
Royal Melbourne Hospital (RMH), Australia 0
Collaborative Innovation Center for Cancer Personalized Medicine, NJMU, China 0
Department of Epidemiology, NJMU, China 0
Department of Biostatistics, NJMU, China 0
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, NJMU, China 0
Institute of Biomedicine, UTU, Finland 0
Pompeu Fabra University (UPF), Spain 0
Strangeways Research Laboratory, University of Cambridge, United Kingdom (UK) 0
Department of Oncology, University of Cambridge, United Kingdom (UK) 0
UCL Department of Applied Health Research (DAHR), United Kingdom (UK) 0
Hospital del Mar Medical Research Institute (IMIM), Spain 0
Centre for Research in Environmental Epidemiology (CREAL), ISGlobal, Spain 0
Prostate Cancer Research Center (PCRC), UTA, Finland 0
Institute of Biosciences and Medical Technology (BioMediTech), Tampere University, Finland 0
Turku University Hospital (TYKS), UTU, Finland 0
Department of Oncology, Addenbrooke's Hospital, United Kingdom (UK) 0

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