Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Journal: Nature Communications

Published: 2019-04-15

DOI: 10.1038/s41467-018-08053-5

Affiliations: 325

Authors: 312

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Institutions FC
Centre for Cancer Genetic Epidemiology (CCGE), University of Cambridge, United Kingdom (UK) 0.05
QIMR Berghofer Department of Genetics and Computational Biology, Australia 0.02
Department of Medical Epidemiology and Biostatistics (MEB), KI, Sweden 0.02
Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL), Netherlands 0.02
Centre for Epidemiology and Biostatistics, UniMelb, Australia 0.01
Center for Integrated Oncology Köln Bonn (CIO Köln Bonn), Germany 0.01
Center for Hereditary Breast and Ovarian Cancer, UoC, Germany 0.01
Copenhagen University Hospital (CUH), Denmark 0.01
Department of Genetics and Pathology, PMU, Poland 0.01
Netherlands Cancer Institute (NKI), Netherlands 0.01
Institute of Human Genetics, Leipzig University, Germany 0.01
American Cancer Society (ACS), United States of America (USA) 0.01
Department of Cancer Epidemiology, UHH, Germany 0.01
Division of Molecular Genetics, DKFZ, Germany 0.01
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Spain 0.01
Department of Gynaecology and Obstetrics, MHH, Germany 0.01
Charité Institute of Medical Genetics and Human Genetics, Germany 0.01
Department of Gynecology and Obstetrics, HHU, Germany 0.01
Health Innovation Manchester, United Kingdom (UK) 0.01
Department of Biomedical Sciences, University of Westminster, United Kingdom (UK) 0.01
Institute of Medical Genetics and Applied Genomics, Uni Tübingen, Germany 0.01
Huntsman Cancer Institute at the University of Utah (HCI), Utah, United States of America (USA) 0.01
TUM Department of Gynecology and Obstetrics, Germany 0.01
ICR Breast Cancer Now Toby Robins Research Centre, United Kingdom (UK) 0.01
Institute of Human Genetics, WWU, Germany 0.01
Department of Human Genetics, MHH, Germany 0.01
Department of Cancer Epidemiology, LU, Sweden 0.01
Faculty of Medicine, Soton, United Kingdom (UK) 0.01
Health Research Institute of San Carlos (IdISSC), Spain 0.01
Department of Obstetrics and Gynecology, LMU, Germany 0.01
IRCCS Istituto Oncologico Veneto (IOV), Italy 0.01
Division of Cancer Epidemiology, DKFZ, Germany 0.01
Department of Molecular Genetics, NIO, Hungary 0.01
Kolling Institute of Medical Research, USYD, Australia 0.01
Institute of Nuclear and Radiological Sciences and Technology, Energy and Safety (INRASTES), NCSR, Greece 0.01
Amsterdam UMC, Netherlands 0.01
Helsinki University Central Hospital (HUCH), Finland 0.01
UCLA Department of Obstetrics and Gynecology, United States of America (USA) 0.01
Clinical Cancer Genetics Community Research Network (CCGCRN), City of Hope, United States of America (USA) 0.01
NIH NCI Clinical Genetics Branch (CGB), United States of America (USA) 0.01
Research Centre for Genetic Engineering and Biotechnology "Georgi D. Efremov" (ICGIB), MASA, Macedonia 0.01
Centre Hospitalier Universitaire de Québec (CHUQ), UL, Canada 0.01
Human Cancer Genetics Programme, CNIO, Spain 0.01
Cancer Institute, Erasmus MC, Netherlands 0.01
Rotterdam Family Cancer Clinic, Erasmus MC, Netherlands 0.01
Center for Medical Genetics (CMGG), UGent, Belgium 0.01
Centre for Research in Epidemiology and Population Health (CESP), France 0.01
ICR Division of Genetics and Epidemiology, United Kingdom (UK) 0.01
NIH NCI Division of Cancer Epidemiology and Genetics (DCEG), United States of America (USA) 0.01
U.S. Department of Health and Human Services (HHS), United States of America (USA) 0.01
Suzanne Levy-Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Israel 0
Division of Epidemiology, VU, United States of America (USA) 0
Sloan Kettering Institute (SKI), MSKCC, United States of America (USA) 0
Genomic Medicine Group (GMX), Spain 0
Genetics Service, IPO, Portugal 0
Department of Clinical Genetics, Leiden University, Netherlands 0
Bellvitge Biomedical Research Institute (IDIBELL), Spain 0
Vanderbilt-Ingram Cancer Center (VICC), VU, United States of America (USA) 0
Vall d'Hebron Institute of Oncology (VHIO), HUVH ICS, Spain 0
HUCH Children's Hospital, Finland 0
Federal State Institute of Biochemistry and Genetics, RAS, Russia 0
Fred A. Litwin Centre for Cancer Genetics, U of T, Canada 0
Pathology West, WSLHD, Australia 0
Comprehensive Cancer Center Erlangen-EMN (CCC), FAU, Germany 0
Canberra Hospital (TCH), Australia 0
Department of Radiation Oncology, MHH, Germany 0
Division of Clinical Epidemiology and Aging Research, DKFZ, Germany 0
The University of Sydney (USYD), Australia 0
General University Hospital of Larissa, Greece 0
Department of Genetics, RUG, Netherlands 0
South East Scotland Genetic Service, NHS Lothian, United Kingdom (UK) 0
Hôpital Dupuytren, France 0
Clinical Genetics Group, KI, Sweden 0
KU Department of Internal Medicine, United States of America (USA) 0
Bergonié Cancer Institute, France 0
Department of Epidemiology, CU, United States of America (USA) 0
Centre Léon Bérard (CLB), France 0
Yale Department of Chronic Disease Epidemiology (CDE), United States of America (USA) 0
Department of Clinical Genetics, VUmc, Netherlands 0
IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy 0
UMC Department of Medical Genetics, Netherlands 0
Department of Pathology, Erasmus MC, Netherlands 0
IFOM - FIRC Institute of Molecular Oncology, Italy 0
Center for Clinical Cancer Genetics and Global Health, UChicago, United States of America (USA) 0
UCSF Cancer Genetics and Prevention Program at Mount Zion, United States of America (USA) 0
Latvian Biomedical Research and Study Centre (BMC), Latvia 0
Department of Population Sciences, City of Hope, United States of America (USA) 0
School of Science and Health (SSH), Western Sydney University, Australia 0
Basser Center for BRCA, Penn, United States of America (USA) 0
NRG Oncology Statistical and Data Management Center (SDMC), United States of America (USA) 0
MRC Clinical Trials Unit (CTU), United Kingdom (UK) 0
SydPath, St Vincent's Hospital Sydney, Australia 0
Department of Clinical Genetics, OUH SDU, Denmark 0
OSU Department Cancer Biology and Genetics, United States of America (USA) 0
West Midlands Regional Genetics Laboratory, Birmingham Women's and Children's NHS Foundation Trust, United Kingdom (UK) 0
Sheffield Children’s Hospital, Sheffield Children's NHS Foundation Trust, United Kingdom (UK) 0
Northern Ireland Regional Genetics Centre, Belfast City Hospital, United Kingdom (UK) 0
Alder Hey Children’s Hospital, Alder Hey Children's NHS Foundation Trust, United Kingdom (UK) 0
Guy's and St Thomas' NHS Foundation Trust, United Kingdom (UK) 0
All Wales Medical Genetics Service (AWMGS), University Hospital of Wales, United Kingdom (UK) 0
University General Hospital of Heraklion (PAGNI), Greece 0
North of Scotland Medical Genetic Service, NHS Grampian, United Kingdom (UK) 0
Princess Anne Hospital, University Hospital Southampton NHS Foundation Trust, United Kingdom (UK) 0
Nottingham University Hospitals NHS Trust (NUH), United Kingdom (UK) 0
Molecular and Clinical Sciences Research Institute, SGUL, United Kingdom (UK) 0
Churchill Hospital, United Kingdom (UK) 0
Department of Clinical Genetics, UHBristol, United Kingdom (UK) 0
South Glasgow University Hospitals NHS Trust, United Kingdom (UK) 0
Institute of Human Genetics, UKSH Kiel, Germany 0
Institute of Human Genetics, JMU, Germany 0
Institute of Human Genetics, Ulm University, Germany 0
Beth Israel Deaconess Medical Center (BIDMC), United States of America (USA) 0
Division of Genetics, UP, South Africa 0
Hôpital Arnaud de Villeneuve, CHRU de Montpellier, France 0
Hôpital Nord, CHU Saint Etienne, France 0
Faculty of Medicine, UR, Germany 0
Mayo Clinic Division of Epidemiology, United States of America (USA) 0
Department of Obstetrics and Gynaecology, Ulm University, Germany 0
Department of Clinical Genetics, Erasmus MC, Netherlands 0
IRCCS National Cancer Institute 'Centro di Riferimento Oncologico' (CRO Aviano), Italy 0
Royal Devon and Exeter Hospital, United Kingdom (UK) 0
Institute of Human Genetics, Uni Heidelberg, Germany 0
Fox Chase Cancer Center (FCCC), Temple University, United States of America (USA) 0
Faculty of Medicine "Carl Gustav Carus", TU Dresden, Germany 0
North East Thames Regional Genetics Service, GOSH, United Kingdom (UK) 0
University Hospitals of Leicester NHS Trust (UHL), United Kingdom (UK) 0
Kennedy-Galton Centre (North West Thames Regional Genetics Service), LNWH, United Kingdom (UK) 0
South West Thames Regional Genetics Service, United Kingdom (UK) 0
Crown Princess Mary Cancer Centre Westmead, WSLHD, Australia 0
Genetic Epidemiology Research Institute (GERI), UCI, United States of America (USA) 0
Vilnius University Hospital Santariskiu Klinikos (Santariškių Klinikos), VU, Lithuania 0
Research Group Genomic Epidemiology, DKFZ, Germany 0
Department of Obstetrics and Gynecology, MUW, Austria 0
Evangelische Kliniken Johanniter- und Waldkrankenhaus Bonn gGmbH, Germany 0
Stanford Cancer Institute (SCI), United States of America (USA) 0
Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig University, Germany 0
Galicia Sur Health Research Institute (IISGS), Spain 0
Department of Epidemiology (EPI), UCI, United States of America (USA) 0
Mayo Clinic Department of Laboratory Medicine and Pathology (DLMP), United States of America (USA) 0
USC Department of Preventive Medicine, United States of America (USA) 0
Department of Human Genetics, Leiden University, Netherlands 0
Georgetown Lombardi Comprehensive Cancer Center, United States of America (USA) 0
N. N. Petrov Research Institute of Oncology, Russia 0
School of Population and Global Health, UWA, Australia 0
Department of Neuroscience, The University of Sheffield, United Kingdom (UK) 0
Department of Clinical Genetics, Temple University, United States of America (USA) 0
Department of Breast Medical Oncology, MD Anderson Cancer Center, United States of America (USA) 0
Sir Peter MacCallum Department of Oncology, UniMelb, Australia 0
Comprehensive Cancer Center Vienna (CCC), Austria 0
Dipartimento di Medicina di Laboratorio, UNIPI, Italy 0
KU Department of Pathology and Laboratory Medicine, United States of America (USA) 0
Biomedical Research Networking Center on Rare Diseases (CIBERER), Spain 0
IRCCS Dipartimento Oncologia Medica, Italy 0
Dana-Farber Cancer Institute (DFCI), United States of America (USA) 0
Westmead Institute for Medical Research, Australia 0
Department of Clinical Science and Education, KI, Sweden 0
Stockholm South General Hospital, Sweden 0
Department of Oncology, Stockholm South General Hospital, Sweden 0
School of Clinical Sciences (SCS), Monash University, Australia 0
Aalborg University Hospital, Denmark 0
Cancer Epidemiology Centre (CEC), Cancer Council Victoria, Australia 0
Curie Institute, France 0
German Consortium of Translational Cancer Research (DKTK), Germany 0
Genetics and Biology of Cancers, France 0
Moores Cancer Center, UC San Diego, United States of America (USA) 0
Institute of Cancer Research (ICR), United Kingdom (UK) 0
Queen's Cancer Research Institute (QCRI), Queen's University, Canada 0
The Royal Marsden Hospital - London, The Royal Marsden NHS Foundation Trust, United Kingdom (UK) 0
Vall d'Hebron University Hospital (HUVH), ICS, Spain 0
Chapel Allerton Hospital, United Kingdom (UK) 0
Yorkshire Regional Genetics Service (YRGS), LTH, United Kingdom (UK) 0
Department of Internal Medicine, Utah, United States of America (USA) 0
Department of Pathology, Leiden University, Netherlands 0
UCLA Division of Hematology/Oncology, United States of America (USA) 0
UCLA Fielding School of Public Health (FSPH), United States of America (USA) 0
Sackler Faculty of Medicine, TAU, Israel 0
Sheffield Institute for Nucleic Acids (SInFoNiA), The University of Sheffield, United Kingdom (UK) 0
St George's, University of London (SGUL), United Kingdom (UK) 0
Research Division, Peter Mac, Australia 0
Institut Paoli-Calmettes (IPC), France 0
Faculty of Medicine, AMU, France 0
University of Lorraine (UL), France 0
Division of Oncology and Pathology, LU, Sweden 0
Skåne University Hospital in Lund, SUS, Sweden 0
Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), France 0
German Cancer Research Center in the Helmholtz Association (DKFZ), Germany 0
Women's Hospital, Uni Heidelberg, Germany 0
Department of Biology, UNIPI, Italy 0
University Hospital of Cologne, Germany 0
Department of Clinical Genetics, St George's Hospital, United Kingdom (UK) 0
Center for Molecular Medicine Cologne (CMMC), UoC, Germany 0
Institute of Clinical Molecular Biology (IKMB), UKSH Kiel, Germany 0
University Medical Center Schleswig-Holstein - Campus Kiel (UKSH Kiel), Germany 0
Chris O'Brien Lifehouse, Australia 0
Department of Pediatrics, CU, United States of America (USA) 0
Department of Medicine, CU, United States of America (USA) 0
Department of Pathology and Molecular Medicine, McMaster University, Canada 0
Department of Oncology and Metabolism, The University of Sheffield, United Kingdom (UK) 0
St. James's Hospital (SJH), TCD, Ireland 0
Academic Unit of Clinical and Molecular Oncology (AUCMO), TCD, Ireland 0
Juravinski Cancer Centre (JCC), HHS, Canada 0
UCLA Jonsson Comprehensive Cancer Center (JCCC), United States of America (USA) 0
Harvard Department of Surgery, United States of America (USA) 0
Division of Genetic Medicine, VU, United States of America (USA) 0
Department of Cancer Biology, DFCI, United States of America (USA) 0
Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, United Kingdom (UK) 0
Familial Cancer Centre, Australia 0
Division of Gastroenterology, Hepatology and Nutrition, Pitt, United States of America (USA) 0
UPMC Hillman Cancer Center (UPCI), United States of America (USA) 0
Department of Genetics and Fundamental Medicine, BashSU, Russia 0
Clinical Genetics Service, MSKCC, United States of America (USA) 0
Department of Molecular Genetics, U of T, Canada 0
VIB-KU Leuven Center for Cancer Biology (CCB), Belgium 0
University of Cambridge, United Kingdom (UK) 0
Westmead Breast Cancer Institute (BCI), Australia 0
Pritzker School of Medicine, UChicago, United States of America (USA) 0
Department of Human Genetics, KU Leuven, Belgium 0
Centre for Clinical Research (UQCCR), UQ, Australia 0
Laboratory Medicine Program (LMP) at UHN, Canada 0
Department of Laboratory Medicine and Pathobiology (LMP), U of T, Canada 0
School of Medicine (SOM), UQ, Australia 0
Hereditary Cancer Clinic, Prince of Wales Private Hospital, Australia 0
Department of Electron Microscopy and Molecular Pathology, CING, Cyprus 0
Department of Epidemiology, UW, United States of America (USA) 0
Public Health Sciences Division (PHS), FHCRC, United States of America (USA) 0
The Kinghorn Cancer Centre (TKCC), Australia 0
Pomeranian Medical University (PMU), Poland 0
King's College London (KCL), United Kingdom (UK) 0
Department of Clinical Pathology, UniMelb, Australia 0
BC Cancer Agency (BCCA), PHSA, Canada 0
Harvard Department of Epidemiology, United States of America (USA) 0
Harvard T.H. Chan School of Public Health, United States of America (USA) 0
Department of Public Health Sciences, Queen's University, Canada 0
BioMedical Center (BMC), Iceland 0
Landspitali - The National University Hospital of Iceland, Iceland 0
Department of Medicine, McGill University, Canada 0
Royal Victoria Hospital (RVH), McGill University, Canada 0
Department of Dermatology, Utah, United States of America (USA) 0
Institute of Human Genetics, Pontifical Xaverian University, Colombia 0
Pathology North, Australia 0
John Hunter Hospital, Australia 0
UPMC Magee-Womens Hospital, United States of America (USA) 0
Department of Medicine, Pitt, United States of America (USA) 0
NorthShore Center for Medical Genetics, United States of America (USA) 0
Abel Salazar Biomedical Sciences Institute (ICBAS), UP, Portugal 0
NIH NIEHS Epigenetics and Stem Cell Biology Laboratory (ESCBL), United States of America (USA) 0
NIH NIEHS Epidemiology Branch, United States of America (USA) 0
ICR Division of Breast Cancer Research, United Kingdom (UK) 0
Centre for Genetic Origins of Health and Disease (GOHaD), Australia 0
School of Population and Public Health (SPPH), UBC, Canada 0
Örebro University Hospital, Sweden 0
Laboratory of Cancer Genetics and Tumor Biology, University of Oulu, Finland 0
Australian Breast Cancer Tissue Bank (ABCTB), Australia 0
School of Medicine and Public Health, UON, Australia 0
ANZ Breast Cancer Trials Group Limited, Australia 0
Calvary Mater Newcastle, Australia 0
ANU Medical School, Australia 0
ACT Pathology, Australia 0
Clinical Pathology and Forensic Medicine, UEF, Finland 0
N.N. Alexandrov National Cancer Centre of Belarus for Oncology and Medical Radiology, Belarus 0
Department of Human Genetics, McGill University, Canada 0
Translational Cancer Research Area, UEF, Finland 0
Mines ParisTech, France 0
Bioinformatics and Computational Systems Biology of Cancer, France 0
Multidisciplinary Breast Center (MBC), UZ Leuven, Belgium 0
Department of Oncology, KU Leuven, Belgium 0
UiO Institute of Clinical Medicine (Klinmed), Norway 0
UiO Norwegian Radium Hospital, Norway 0
UiO Department of Cancer Genetics, Norway 0
Faculty of Medicine (SUND), AAU, Denmark 0
Clalit National Israeli Cancer Control Center (NICCC), Israel 0
Carmel Medical Center, Israel 0
Ruth and Bruce Rappaport Faculty of Medicine, IIT, Israel 0
Gerald Bronfman Department of Oncology, McGill University, Canada 0
Academic Department of Medical Genetics, University of Cambridge, United Kingdom (UK) 0
Department of Epidemiology and Preventive Medicine (DEPM), Monash University, Australia 0
Kuopio University Hospital (KUH), Finland 0
Institute of Genetic Medicine (IGM), Newcastle University, United Kingdom (UK) 0
International Centre for Life (ICFL), United Kingdom (UK) 0
The Newcastle Upon Tyne Hospitals NHS Foundation Trust (NUTH), United Kingdom (UK) 0
National Center for Tumor Diseases (NCT) Heidelberg, Germany 0
University of Tübingen (Uni Tübingen), Germany 0
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (IKP), Germany 0
Leuven Cancer Institute (LKI), UZ Leuven, Belgium 0
The Copenhagen General Population Study, Denmark 0
Cyprus School of Molecular Medicine (CSMM), CING, Cyprus 0
Faculty of Health and Medical Sciences, UCPH, Denmark 0
Cancer and Translational Medicine Research Unit, University of Oulu, Finland 0
Biocenter Oulu, University of Oulu, Finland 0
Northern Finland Laboratory Centre (NordLab), Finland 0

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