Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

Journal: Nature Communications

Published: 2018-08-22

DOI: 10.1038/s41467-018-05772-7

Affiliations: 12

Authors: 20

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Research Highlight

New immune system structures found

© Westend61/Getty

© Westend61/Getty

The discovery of a previously unknown structure in the immune system could help scientists to develop more-effective vaccines.

Vaccines work by priming the immune system so that when it encounters a pathogen in the future, it ‘remembers’ it and can quickly produce antibodies to fight it. Cells known as memory B cells are responsible for this memory effect, but scientists did not know where or how they are reactivated.

Now, by taking videos using a three-dimensional microscopy technique, a team that included University of New South Wales researchers has discovered that memory B cells are found in thin, flat structures on the lymph nodes of mice. These structures appeared only when the immune system was activated to fight an infection that it had been previously exposed to. The researchers also found similar structures in the lymph nodes of human patients. The activated memory B cells turned into infection-fighting plasma cells.

This knowledge will help improve vaccine efficacy.

Supported content

  1. Nature Communications 9, 3372 (2018). doi: 10.1038/s41467-018-05772-7
Institutions Share
Immunology Division, Garvan Institute of Medical Research, Australia 0.35
St Vincent's Clinical School (STVCS), UNSW Sydney, Australia 0.17
St Vincent's Hospital Sydney, Australia 0.15
The Kirby Institute, UNSW Sydney, Australia 0.13
UNSW Node of EMBL Australia in Single Molecule Science, Australia 0.05
Bone Biology Division, Garvan Institute of Medical Research, Australia 0.04
School of Biotechnology and Biomolecular Sciences (BABS), UNSW Sydney, Australia 0.04
School of Medical Sciences (SoMS), UNSW Sydney, Australia 0.03
Charles Perkins Centre (CPC), USYD, Australia 0.03
School of Life and Environmental Sciences (SoLES), USYD, Australia 0.03