Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors

Journal: Nature Communications

Published: 2018-05-23

DOI: 10.1038/s41467-018-04324-3

Affiliations: 10

Authors: 33

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Research Highlight

The smell of fear

© David Malan/Getty

© David Malan/Getty

A ‘smell sensor’ in mice triggers fear of foxes, snakes and other predators. This suggests aversion to threatening stimuli is genetically hardwired in mice — and perhaps in humans as well.

A team co-led by investigators from the University of Tsukuba exposed mice to a chemical mutagen and then looked for offspring with diminished fear responses to two predatory cues: a potent derivative of a fox odorant and shed snake skin.

They found that mice with a mutant version of Trpa1, a protein receptor involved in relaying chemosensory signals to the brain, could still smell the scents but were no longer intuitively afraid of them.

By studying core fear pathways like this one in mice, the researchers hope to better understand the genetic basis of human anxiety disorders and other conditions linked to emotional processing.

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  1. Nature Communications 9, 2041 (2018). doi: 10.1038/s41467-018-04324-3
Institutions Share
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Japan 0.46
Department of Biochemistry, UT Southwestern Medical Center, United States of America (USA) 0.13
Center for the Genetics of Host Defense, UT Southwestern Medical Center, United States of America (USA) 0.13
Department of Surgery, KMU, Japan 0.12
Department of Neuroscience, UT Southwestern Medical Center, United States of America (USA) 0.07
National Institute of Biological Sciences, Beijing (NIBS), China 0.04
Department of Internal Medicine, UT Southwestern Medical Center, United States of America (USA) 0.03
Faculty of Medicine, Toho University, Japan 0.02
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (LS-TARA Center), University of Tsukuba, Japan 0.02
Institute of Multidisciplinary Biomedical Research, Tsinghua, China 0.01