A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses

Journal: Nature Communications

Published: 2018-03-26

DOI: 10.1038/s41467-018-03662-6

Affiliations: 9

Authors: 16

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Research Highlight

Combined chikungunya and Zika vaccine shows effectiveness in mice

© Joao Paulo Burini/Moment/Getty

© Joao Paulo Burini/Moment/Getty

One vaccine could be used to protect against two leading mosquito-borne viruses — chikungunya and Zika — according to a study in mice.

Chikungunya infection causes joint pain and swelling, while Zika virus infection in pregnant women has been linked to severe birth defects in newborns. A team that included scientists from the University of South Australia modified vaccine technology based on the vaccine used to eradicate smallpox by incorporating structural proteins from both the chikungunya and Zika viruses.

The researchers tested the vaccine in mice genetically engineered to be more susceptible to viral infection and in unmodified mice. They found that a single shot of the vaccine was able to protect against infection by both viruses and also prevented the Zika virus from being transmitted from mother to fetus through the placenta.

Supported content

  1. Nature Communications 9, 1230 (2018). doi: 10.1038/s41467-018-03662-6
Institutions FC
QIMR Berghofer Medical Research Institute, Australia 0.34
School of Chemistry and Molecular Biosciences (SCMB), UQ, Australia 0.16
Sansom Institute for Health Research, UniSA, Australia 0.13
School of Pharmacy and Medical Sciences, UniSA, Australia 0.13
Australian Infectious Diseases Research Centre (AID), Australia 0.09
Sementis, Australia 0.06
Department of Virology I, NIID, Japan 0.03
Robinson Research Institute (RRI), Adelaide Uni, Australia 0.03
Adelaide Medical School, Adelaide Uni, Australia 0.03

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