Orexin modulates behavioral fear expression through the locus coeruleus

Journal: Nature Communications

Published: 2017-11-20

DOI: 10.1038/s41467-017-01782-z

Affiliations: 7

Authors: 8

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Research Highlight

Learning to fight, flee or freeze

© mrs/Moment/Getty

© mrs/Moment/Getty

Behaviour that braces us for looming danger is triggered by the brain cells responsible for arousal and reward.

Animals anticipate impending threats by recalling similar unpleasant experiences, and react accordingly. A team including researchers from the University of Tsukuba conditioned mice to fear a loud noise by following it with an electric shock to the foot. After a while, the loud noise made the mice freeze in fear. Studying the mice’s brain activity during the scary sound, the team found that orexin neurons, brain cells that respond to emotional cues, were activated. This triggered a reaction in noradrenergic neurons — brain cells that mobilize the body for action. Blocking this circuit made the mice freeze less, but stimulating it made them freeze more, even when a slightly different sound was played.

This brain circuit could help explain why traumatic experiences can make people fearful of similar yet safe situations.

Supported content

  1. Nature Communications 8, 1606 (2017). doi: 10.1038/s41467-017-01782-z
Institutions FC
Department of Cellular Neurobiology, Niigata University, Japan 0.25
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Japan 0.23
Graduate School of Medical Sciences, KU, Japan 0.19
RIKEN Laboratory for Circuit and Behavioral Physiology, Japan 0.13
Department of General Zoology and Neurobiology, RUB, Germany 0.13
Faculty of Medicine, University of Tsukuba, Japan 0.04
Life Science Center of Tsukuba Advanced Research Alliance (LS-TARA Center), University of Tsukuba, Japan 0.04

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