Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Journal: Molecular Psychiatry

Published: 2019-11-11

DOI: 10.1038/s41380-019-0558-2

Affiliations: 413

Authors: 504

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Institutions Share
MRC Centre for Social, Genetic and Developmental Psychiatry (SGDP), KCL, United Kingdom (UK) 0.03
Stanley Center for Psychiatric Research, Broad Institute, United States of America (USA) 0.02
Department for Genetic Epidemiology in Psychiatry, CIMH, Germany 0.02
Medical Faculty Mannheim, Uni Heidelberg, Germany 0.02
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Denmark 0.02
Department of Medical Epidemiology and Biostatistics (MEB), KI, Sweden 0.02
Institute of Human Genetics, Uni Bonn, Germany 0.02
QIMR Berghofer Department of Genetics and Computational Biology, Australia 0.02
Institute for Molecular Bioscience (IMB), UQ, Australia 0.02
Department of Psychiatry and Behavioral Sciences, JHU, United States of America (USA) 0.02
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG), Cardiff University, United Kingdom (UK) 0.02
EMGO+ Institute for Health and Care Research (EMGO+), VU University Amsterdam, Netherlands 0.02
Division of Psychiatry, The University of Edinburgh, United Kingdom (UK) 0.01
deCODE Genetics, Inc., Iceland 0.01
Institute of Biomedical Research in Malaga (IBIMA), Spain 0.01
Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, United Kingdom (UK) 0.01
Department of Psychiatry, ISMMS, United States of America (USA) 0.01
Queensland Brain Institute (QBI), UQ, Australia 0.01
Department of Psychiatry, UC San Diego, United States of America (USA) 0.01
Estonian Genome Center, UT, Estonia 0.01
Charité Department of Psychiatry and Psychotherapy, Germany 0.01
Department of Psychiatry, Dalhousie University, Canada 0.01
Department of Psychiatry, U-M, United States of America (USA) 0.01
Centre for Integrative Sequencing (iSEQ), AU, Denmark 0.01
School of Allied Health and Community, University of Worcester, United Kingdom (UK) 0.01
VCU Department of Psychiatry, United States of America (USA) 0.01
Department of Psychiatry, WUSTL, United States of America (USA) 0.01
The National Centre for Register-based Research, AU, Denmark 0.01
Department of Genetics and Genomic Sciences, ISMMS, United States of America (USA) 0.01
Institute of Psychiatric Phenomics and Genomics (IPPG), LMU, Germany 0.01
Department of Psychiatry and Psychotherapy, WWU, Germany 0.01
GGZ inGeest, Netherlands 0.01
Max Planck Institute of Psychiatry, Germany 0.01
Department of Psychiatry, VUmc, Netherlands 0.01
UCLA Center for Neurobehavioral Genetics (CNG), United States of America (USA) 0.01
Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Germany 0.01
Analytic and Translational Genetics Unit (ATGU), MGH, United States of America (USA) 0.01
Department of Biomedicine Basel, Switzerland 0.01
MRC Institute of Genetics and Molecular Medicine (IGMM), United Kingdom (UK) 0.01
Kaiser Permanente Division of Research, United States of America (USA) 0.01
Department of Psychiatry and Psychotherapy, TU Dresden, Germany 0.01
Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), The University of Edinburgh, United Kingdom (UK) 0.01
UCL Division of Psychiatry, United Kingdom (UK) 0.01
Institute of Epidemiology and Social Medicine, WWU, Germany 0.01
Faculty of Medicine, University of Iceland, Iceland 0.01
Center for Molecular Medicine (CMM), KI, Sweden 0.01
Department of Biomedicine, AU, Denmark 0.01
School of Psychiatry, UNSW Sydney, Australia 0
Center for Neonatal Screening, SSI, Denmark 0
NIHR Maudsley Biomedical Research Centre (BRC), United Kingdom (UK) 0
UCLA Department of Human Genetics, United States of America (USA) 0
Department of Psychiatry, TCD, Ireland 0
Department for Congenital Disorders, SSI, Denmark 0
Research Group of Human Genomics, Department of Biomedicine Basel, Switzerland 0
College of Medicine (COM), SUNY Downstate, United States of America (USA) 0
UiO Division of Mental Health and Addiction, Norway 0
Centre for Addiction and Mental Health (CAMH), U of T, Canada 0
Program in Medical and Population Genetics, Broad Institute, United States of America (USA) 0
Institute of Medical Genetics and Pathology, UB, Switzerland 0
Department of Psychiatry and Psychotherapy, Uni Bonn, Germany 0
Division of Psychiatry, UMU, Sweden 0
Psychiatric Genetics Unit, PUMS, Poland 0
Department of Psychiatry, Psychosomatics and Psychotherapy, GU, Germany 0
Department of Psychiatry and Behavioral Sciences, Howard University, United States of America (USA) 0
Discipline of Psychiatry, Adelaide Uni, Australia 0
Howard University Hospital (HUH), United States of America (USA) 0
Barcelona Institute for Global Health (ISGlobal), Spain 0
HudsonAlpha Genome Sequencing Center (HGSC), HudsonAlpha Institute for Biotechnology, United States of America (USA) 0
Janssen Research and Development, LLC (J&J PRD), United States of America (USA) 0
Roche Pharma Research and Early Development (Roche pRED), Switzerland 0
Institute for Community Medicine (ICM), University of Greifswald, Germany 0
USC Department of Psychiatry and Behavioral Sciences, United States of America (USA) 0
Molecular and Behavioral Neuroscience Institute (MBNI), U-M, United States of America (USA) 0
Amsterdam Neuroscience, Netherlands 0
Oxford Wellcome Trust Centre for Human Genetics, United Kingdom (UK) 0
Stanford Department of Psychiatry and Behavioral Sciences, United States of America (USA) 0
University Hospital of Puerto Real, Spain 0
VCU Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG), United States of America (USA) 0
Mayo Clinic Department of Health Sciences Research (HSR), United States of America (USA) 0
Clinic of Psychiatry and Psychotherapy, University of Greifswald, Germany 0
Department of Psychiatry, UNIL, Switzerland 0
Pfizer R&D Groton, CT, United States of America (USA) 0
Pfizer R&D Cambridge, MA, United States of America (USA) 0
Mental Health Centre Sct. Hans, Region Hovedstadens Psykiatriske Hospital, Denmark 0
Norwegian Centre for Mental Disorders Research (NORMENT), Norway 0
Department of Genomics, Uni Bonn, Germany 0
Life and Brain Center, Uni Bonn, Germany 0
Neuroscience Research Australia (NeuRA), Australia 0
Section Structural and functional Organisation of the Brain (INM-1), FZJ, Germany 0
Department of Psychiatry, McGill University, Canada 0
UMC Department of Psychiatry, Netherlands 0
Department of Epidemiology, Erasmus MC, Netherlands 0
Biomedical Research Networking Center for Mental Health Network (CIBERSAM), Spain 0
Department of Psychiatry (UPK), UB, Switzerland 0
Research Institute for Biological Psychiatry (IBP), Region Hovedstadens Psykiatriske Hospital, Denmark 0
Department of Biostatistics, U-M, United States of America (USA) 0
Department of Psychiatry, CU, United States of America (USA) 0
Center for Statistical Genetics (CSG), U-M, United States of America (USA) 0
Department of Psychiatry and Behavioral Neuroscience, UChicago, United States of America (USA) 0
St. Olavs Hospital (Trondheim University Hospital), NTNU, Norway 0
Department of Psychiatry, MGH, United States of America (USA) 0
Department of Statistics, UBC, Canada 0
Altrecht, Netherlands 0
Psychiatric and Neurodevelopmental Genetics Unit (PNGU), MGH, United States of America (USA) 0
Trinity College Institute of Neuroscience (TCIN), TCD, Ireland 0
Region Hovedstadens Psykiatriske Hospital, Denmark 0
Department of Psychiatric Research and Development, Diakonhjemmet Foundation, Norway 0
Centre for Integrated Register-Based Research at Aarhus University (CIRRAU), AU, Denmark 0
Department of Cognitive Science, UC San Diego, United States of America (USA) 0
Department of Molecular Medicine and Surgery (MMK), KI, Sweden 0
Department of Clinical Neuroscience (CNS), KI, Sweden 0
NIH NIMH Human Genetics Branch, United States of America (USA) 0
Vall d'Hebron Research Institute (VHIR), HUVH ICS, Spain 0
Department of Psychiatry, HUVH ICS, Spain 0
Department of Psychiatry, U of T, Canada 0
Department of Neurosciences, UC San Diego, United States of America (USA) 0
Vanderbilt University Medical Center (VUMC), United States of America (USA) 0
Psychiatrische Zentrum Nordbaden (PZN), Germany 0
Neurogenomics Division, TGen, United States of America (USA) 0
PsyQ, Netherlands 0
Rush University Medical Center, United States of America (USA) 0
Scripps Research, United States of America (USA) 0
Federal Institute for Drugs and Medical Devices (BfArM), Germany 0
Institute of Medical Sciences (IMS), University of Aberdeen, United Kingdom (UK) 0
Centre for Integrative Biology (CIBIO), UNITN, Italy 0
Neuroscience and Mental Health Research Institute, Cardiff University, United Kingdom (UK) 0
Institute of Psychiatry, Psychology and Neuroscience (IOPPN), KCL, United Kingdom (UK) 0
Department of Cancer Epidemiology and Prevention, MCMCC, Poland 0
Department of Biochemistry and Molecular Biology, IUPUI, United States of America (USA) 0
Department of Psychiatry, IUPUI, United States of America (USA) 0
UNC Department of Psychiatry, United States of America (USA) 0
Department of Biomedical and Neuromotor Sciences (DIBINEM), UNIBO, Italy 0
Duke Center for Genomic and Computational Biology (GCB), United States of America (USA) 0
Aarhus University Hospital, Denmark 0
Institute of Molecular and Cell Biology (IMCB), UT, Estonia 0
Lindner Center of HOPE, United States of America (USA) 0
Graduate School, UBC, Canada 0
Department of Mental Health, JHU, United States of America (USA) 0
Biometric Psychiatric Genetics and Developmental Psychopathology Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Romania 0
School of Medical Sciences (SoMS), UNSW Sydney, Australia 0
Mayo Clinic Department of Psychiatry and Psychology, United States of America (USA) 0
Hospital Universitario Reina Sofía, Spain 0
Department of Psychiatry, Penn, United States of America (USA) 0
Brain and Mind Centre, USYD, Australia 0
Department of Functional Genomics, University of Greifswald, Germany 0
McKusick-Nathans Institute of Genetic Medicine, JHU, United States of America (USA) 0
Oxford Department of Statistics, United Kingdom (UK) 0
Department of Psychiatry, UIC, United States of America (USA) 0
Solidus Biosciences, Inc., United States of America (USA) 0
Kaiser Permanente Northern California, United States of America (USA) 0
Department of Psychiatry, RUG, Netherlands 0
NIH NCI Division of Cancer Epidemiology and Genetics (DCEG), United States of America (USA) 0
TUM Department of Neurology, Germany 0
Cluster of Excellence - Munich Cluster for Systems Neurology (SyNergy), LMU, Germany 0
College of Medicine and Dentistry, JCU, Australia 0
Department of Psychiatry, UI, United States of America (USA) 0
Department of Medical and Molecular Genetics, IUPUI, United States of America (USA) 0
Institute of Health and Wellbeing, University of Glasgow, United Kingdom (UK) 0
College of Biomedical and Life Sciences, Cardiff University, United Kingdom (UK) 0
VIB-UAntwerp Center for Molecular Neurology (CMN), Belgium 0
Department of Psychology, Uni Tübingen, Germany 0
USC Department of Translational Genomics, United States of America (USA) 0
University of Iowa Hospitals and Clinics, United States of America (USA) 0
UCSF Department of Psychiatry, United States of America (USA) 0
Department of Clinical Neurosciences, University of Cambridge, United Kingdom (UK) 0
Department of Psychiatry and Human Behavior, UCI, United States of America (USA) 0
Department of Psychiatry, Cornell University, United States of America (USA) 0
Rush Department of Psychiatry, United States of America (USA) 0
Royal Berkshire Hospital, Royal Berkshire NHS Foundation Trust, United Kingdom (UK) 0
IRCCS Department of Neuroscience, Italy 0
Department of Internal Medicine, Erasmus MC, Netherlands 0
Division of Biostatistics, UMN, United States of America (USA) 0
Kaiser Permanente Washington, United States of America (USA) 0
Department of Psychiatry, BWH, United States of America (USA) 0
Department of Psychiatry, Leiden University, Netherlands 0
Unidad de Gestión Clínica del Dispositivo de Cuidados Críticos y Urgencias del Distrito Sanitario Málaga-Coín-Guadalhorce, Spain 0
Mental Health Services, NHSGGC, United Kingdom (UK) 0
Hospital Punta de Europa, Spain 0
Department of Psychiatry and Psychotherapy, UoC, Germany 0
East London NHS Foundation Trust (ELFT), United Kingdom (UK) 0
WHO International Agency for Research on Cancer (IARC), France 0
Institute for Neurology (Edinger Institute), GU, Germany 0
Hospital de Jerez de la Frontera, Spain 0
University Clinical Center Sarajevo (UKCS), Bosnia and Herzegovina 0
QUT Institute of Health and Biomedical Innovation (IHBI), Australia 0
Humus Inc., Iceland 0
Harvard Department of Psychiatry, United States of America (USA) 0
Hospital Universitario de Jaén, Spain 0
Department of Human Genetics, U-M, United States of America (USA) 0
McGill University Health Centre (MUHC), Canada 0
Faculty of Medicine, UPEC, France 0
Assistance Publique-Hôpitaux de Paris (AP-HP), France 0
Department of Medical and Molecular Genetics, KCL, United Kingdom (UK) 0
Department of Psychiatry and Psychotherapy, University of Göttingen, Germany 0
Centre for Psychiatry Research, KI, Sweden 0
Harvard Department of Genetics, United States of America (USA) 0
University of Liverpool, United Kingdom (UK) 0
UNC Department of Genetics, United States of America (USA) 0
Division of Endocrinology, BCH, United States of America (USA) 0
Department of Clinical Medicine, UCPH, Denmark 0
Swiss Institute of Bioinformatics (SIB), Switzerland 0
Institute of Genetic Medicine (IGM), Newcastle University, United Kingdom (UK) 0
Department of Complex Trait Genetics (CTG), VUmc, Netherlands 0
Department of Medical Genetics, UBC, Canada 0
Department of Clinical Genetics, VUmc, Netherlands 0
Department of Psychiatry and Behavioral Sciences, Emory University, United States of America (USA) 0
European Bioinformatics Institute (EMBL-EBI), United Kingdom (UK) 0
DZHK Partner Site Greifswald, Germany 0
Sanger Institute Human Genetics, United Kingdom (UK) 0
University Institute of Social and Preventive Medicine (IUMSP), UNIL, Switzerland 0
Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany 0
Department of Psychiatry and Psychotherapy, LMU, Germany 0
Centre for Advanced Imaging (CAI), UQ, Australia 0
MIT Department of Mathematics, United States of America (USA) 0
Harvard Department of Epidemiology, United States of America (USA) 0
Duke Division of Medical Genetics, United States of America (USA) 0
Department of Psychiatry, Dokuz Eylül University, Turkey 0
QUT School of Psychology and Counselling, Australia 0
Department of Biochemistry and Molecular Biology II, UGR, Spain 0
August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Spain 0
Department of Cell Biology, SUNY Downstate, United States of America (USA) 0
Dalla Lana School of Public Health (DLSPH), U of T, Canada 0
Princess Margaret Cancer Centre, U of T, Canada 0
The Federico Olóriz Neuroscience Institute, UGR, Spain 0
Biomedical Research Center (CIBM), UGR, Spain 0
Massachusetts General Hospital (MGH), United States of America (USA) 0
Department of Neurobiology, Care Sciences and Society (NVS), KI, Sweden 0
Faculty of Natural Sciences, NTNU, Norway 0
Institut Mondor de Recherche Biomédicale (IMRB), France 0
Biomarkers of Relapse and Therapeutic Response in Addictions and Mood Disorders Team, France 0
Center for Multimodal Imaging and Genetics, UC San Diego, United States of America (USA) 0
Bioinformatics Research Centre (BiRC), AU, Denmark 0
UiO Department of Neurology, Norway 0
Department of Psychiatry and Forensic Medicine, UAB, Spain 0
Department of Computational Medicine and Bioinformatics (DCM&B), U-M, United States of America (USA) 0
Department of Psychiatry, Psychosomatics and Psychotherapy, JMU, Germany 0
Centre for Human Genetics, Uni Marburg, Germany 0
National Institute of Mental Health (NIMH), Czech Republic 0
VA San Diego Healthcare System, United States of America (USA) 0
Faculty of Health, University of Paris, France 0
School of Psychology, UQ, Australia 0
Namsos Hospital, Norway 0
Montreal Neurological Institute and Hospital (MNI), McGill University, Canada 0
Department of Neurology and Neurosurgery, McGill University, Canada 0
Faculty of Medicine and Dentistry, UIB, Norway 0
Division of Psychiatry, Haukeland University Hospital, Norway 0
Department of Human Genetics, Pitt, United States of America (USA) 0
Department of Psychiatry, Pitt, United States of America (USA) 0
Department of Mental Health (IPH), NTNU, Norway 0
Division of Epidemiology, NYSPI, United States of America (USA) 0
Institute of Neuroscience and Physiology, GU, Sweden 0
Department of Human Genetics, UChicago, United States of America (USA) 0
VU University Medical Center (VUmc), Netherlands 0
Harvard Department of Biomedical Informatics (DBMI), United States of America (USA) 0
Center for Basic and Translational Obesity Research, BCH, United States of America (USA) 0
UiO Institute of Clinical Medicine (Klinmed), Norway 0
Department of Psychiatry, UniMelb, Australia 0
Florey Department of Neuroscience and Mental Health, UniMelb, Australia 0
Amsterdam Public Health Research Institute (APH), Netherlands 0
Department of Psychiatry and Psychotherapy, Uni Freiburg, Germany 0
Translational Neuropsychiatry Unit, AU, Denmark 0
Child and Youth Mental Health Service (CYMHS), CHQ, Australia 0
Center for Basics in NeuroModulation (NeuroModulBasics), Uni Freiburg, Germany 0
Faculty of Medicine, Uni Freiburg, Germany 0
Copenhagen University Hospital (CUH), Denmark 0
Institute of Translational Medicine (ITM), University of Liverpool, United Kingdom (UK) 0
Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC, Netherlands 0
Department of Psychiatry, Erasmus MC, Netherlands 0
Department of Medicine (DOM), BWH, United States of America (USA) 0
School of Biomedical and Healthcare Sciences, University of Plymouth, United Kingdom (UK) 0
Oslo University Hospital (OUS), Norway 0
Institute for Genomic Health (IGH), SUNY Downstate, United States of America (USA) 0
Centre for Children's Health Research (CHRC), UQ, Australia 0
National Institute for Health and Medical Research (INSERM), France 0
Nash Family Department of Neuroscience, ISMMS, United States of America (USA) 0
Peninsula Dental School, University of Plymouth, United Kingdom (UK) 0
Peninsula Medical School, University of Plymouth, United Kingdom (UK) 0
Boston Children's Hospital (BCH), United States of America (USA) 0
Centre for Neuroimaging and Cognitive Genomics (NICOG), NUI Galway, Ireland 0
UiO Department of Medical Genetics (DMG), Norway 0
UiO K.G. Jebsen Centre for Psychosis Research, Norway 0
Centre for Affective Disorders, KCL, United Kingdom (UK) 0
Department of Radiology, UC San Diego, United States of America (USA) 0
Institute of Medical Science (IMS), U of T, Canada 0
Campbell Family Mental Health Research Institute, U of T, Canada 0
Diakonhjemmet Sykehus AS, Norway 0
Paris Bipolar and TRD Expert Centres, Fondation Fondamental, France 0
Child and Adolescent Psychiatry Program, CPF, Sweden 0
Department of Neurology, Rigshospitalet, Denmark 0
Center of Mental Health (ZEP), JMU, Germany 0
NIH NIMH Division of Intramural Research Programs (DIRP), United States of America (USA) 0
Danish Headache Center, UCPH, Denmark 0

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