Rare and low-frequency coding variants alter human adult height

Journal: Nature

Published: 2017-02-01

DOI: 10.1038/nature21039

Affiliations: 316

Authors: 372

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Institutions FC WFC
Novo Nordisk Foundation Center for Basic Metabolic Research, UCPH, Denmark 0.02 0.02
Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), United States of America (USA) 0.02 0.02
Wellcome Trust - MRC Institute of Metabolic Science (IMS), United Kingdom (UK) 0.02 0.02
Oxford Wellcome Trust Centre for Human Genetics, United Kingdom (UK) 0.02 0.02
Centre for Cancer Genetic Epidemiology (CCGE), University of Cambridge, United Kingdom (UK) 0.02 0.02
National Institute for Health and Welfare (THL), Finland 0.02 0.02
William Harvey Research Institute (WHRI), QMUL, United Kingdom (UK) 0.01 0.01
Department of Epidemiology, U-M, United States of America (USA) 0.01 0.01
UNC Department of Epidemiology, United States of America (USA) 0.01 0.01
University of Exeter Medical School (UEMS), United Kingdom (UK) 0.01 0.01
Cardiovascular Epidemiology Unit (CEU), University of Cambridge, United Kingdom (UK) 0.01 0.01
Radboud University Medical Centre (Radboudumc), RU, Netherlands 0.01 0.01
University of Glasgow, United Kingdom (UK) 0.01 0.01
Massachusetts General Hospital (MGH), United States of America (USA) 0.01 0.01
Department of Medicine, Surgery and Health Sciences, UNITS, Italy 0.01 0.01
UNC Department of Genetics, United States of America (USA) 0.01 0.01
Montreal Heart Institute, UdeM, Canada 0.01 0.01
Faculty of Health and Medical Sciences, UCPH, Denmark 0.01 0.01
QIMR Berghofer Medical Research Institute, Australia 0.01 0.01
University Medical Center Utrecht (UMC Utrecht), Netherlands 0.01 0.01
Center for Statistical Genetics (CSG), U-M, United States of America (USA) 0.01 0.01
Department of Biostatistics, U-M, United States of America (USA) 0.01 0.01
University of Chinese Academy of Sciences (UCAS), Shanghai, China 0.01 0.01
Herlev University Hospital, UCPH, Denmark 0.01 0.01
Marshfield Clinic Research Foundation, United States of America (USA) 0.01 0.01
CAS Key Laboratory of Nutrition and Metabolism, SIBS CAS, China 0.01 0.01
MRC Institute of Genetics and Molecular Medicine (IGMM), The University of Edinburgh, United Kingdom (UK) 0.01 0.01
IRCCS Materno Infantile Burlo Garofolo, Italy 0.01 0.01
deCODE Genetics, Iceland 0.01 0.01
Department of Epidemiology, Erasmus MC, Netherlands 0.01 0.01
Wellcome Trust Genome Campus, United Kingdom (UK) 0.01 0.01
University Hospital of Regensburg (UKR), Germany 0.01 0.01
Centre for Global Health Research, The University of Edinburgh, United Kingdom (UK) 0.01 0.01
Department of Internal Medicine, Erasmus MC, Netherlands 0.01 0.01
Department of Psychology, The University of Edinburgh, United Kingdom (UK) 0.01 0.01
Department of Clinical Epidemiology, Leiden University, Netherlands 0.01 0.01
Department of Medicine, UMB, United States of America (USA) 0.01 0.01
Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), United Kingdom (UK) 0.01 0.01
Department of Epidemiology and Biostatistics (EBS), ICL, United Kingdom (UK) 0.01 0.01
Tampere University Hospital (TAUH), Finland 0.01 0.01
Broad Institute of MIT and Harvard, United States of America (USA) 0.01 0.01
Program in Medical and Population Genetics, Broad Institute, United States of America (USA) 0.01 0.01
Center for Diabetes Research, WFU, United States of America (USA) 0.01 0.01
Harvard Medical School (HMS), United States of America (USA) 0.01 0.01
Charles Bronfman Institute for Personalized Medicine (IPM), ISMMS, United States of America (USA) 0.01 0.01
Public Health Sciences Division (PHS), FHCRC, United States of America (USA) 0.01 0.01
Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE), The University of Edinburgh, United Kingdom (UK) 0.01 0.01
Department of Nutrition and Dietetics, HUA, Greece 0.01 0.01
Department of Twin Research and Genetic Epidemiology, KCL, United Kingdom (UK) 0.01 0.01
Faculty of Medicine, University of Iceland, Iceland 0.01 0.01
Foundation for Research in Health Exercise and Nutrition (KULTU), Finland 0.01 0.01
Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NKI-AVL), Netherlands 0.01 0.01
Lehrstuhl für Genetische Epidemiologie, UR, Germany 0.01 0.01
NIH NHGRI Medical Genomics and Metabolic Genetics Branch, United States of America (USA) 0.01 0.01
Institute of Clinical Medicine, UEF, Finland 0.01 0.01
Division of Experimental Genetics, Sidra Medical and Research Center, Qatar 0.01 0.01
Integrated Research and Treatment Center (IFB) Adiposity Diseases, Leipzig University, Germany 0.01 0.01
Swiss Institute of Bioinformatics (SIB), Switzerland 0.01 0.01
Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (IMM), UTHealth, United States of America (USA) 0.01 0.01
Division of Epidemiology and Community Health, UMN, United States of America (USA) 0.01 0.01
School of Women's and Infants' Health (SWIH), UWA, Australia 0.01 0.01
Department of Ophthalmology, RU, Netherlands 0.01 0.01
Department of Molecular Biology and Genetics, (MBG), AU, Denmark 0.01 0.01
NIHR Oxford Biomedical Research Centre (OxBRC), United Kingdom (UK) 0 0
Department of Public Health and Clinical Medicine, UMU, Sweden 0 0
Institute of Genetic Epidemiology (IGE), HMGU, Germany 0 0
Weis Center for Research, United States of America (USA) 0 0
Department of Medicine, UW, United States of America (USA) 0 0
Department of Clinical Sciences, LU, Sweden 0 0
Research Centre for Prevention and Health (RCPH), Denmark 0 0
Estonian Genome Center, UT, Estonia 0 0
Department of Internal Medicine, U-M, United States of America (USA) 0 0
NIHR Barts Cardiovascular Biomedical Research Unit (CVBRU), United Kingdom (UK) 0 0
Lillebaelt Hospital, Denmark 0 0
Department of Computational Medicine and Bioinformatics (DCM&B), U-M, United States of America (USA) 0 0
Science for Life Laboratory (SciLifeLab), Sweden 0 0
Department of Medicine, UdeM, Canada 0 0
Human Genetics Center (HGC), UTHealth, United States of America (USA) 0 0
Stanford Division of Cardiovascular Medicine, United States of America (USA) 0 0
UNC Department of Nutrition, United States of America (USA) 0 0
Center for Non-Communicable Diseases (CNCD), Pakistan 0 0
Department of Biostatistics, University of Liverpool, United Kingdom (UK) 0 0
Department of Biostatistics and Epidemiology (DBE), Penn, United States of America (USA) 0 0
Fimlab Laboratories Ltd., Finland 0 0
German Center for Diabetes Research (DZD), Germany 0 0
Department of Vascular Medicine, UvA, Netherlands 0 0
Department of Clinical Chemistry, UTA, Finland 0 0
Department of Public Health, University of Helsinki, Finland 0 0
UCLA Center for Neurobehavioral Genetics (CNG), United States of America (USA) 0 0
Lions Eye Institute (LEI), UWA, Australia 0 0
Department of Epidemiology and Biostatistics, VU University Amsterdam, Netherlands 0 0
Julius Center for Health Sciences and Primary Care, UU, Netherlands 0 0
NIHR Blood and Transplant Research Unit in Donor Health and Genomics, United Kingdom (UK) 0 0
Institute for Molecular Medicine Finland (FIMM), Finland 0 0
Center for Genomics and Personalized Medicine Research, WFU, United States of America (USA) 0 0
Ealing Hospital, LNWH, United Kingdom (UK) 0 0
Icahn School of Medicine at Mount Sinai (ISMMS), MSHS, United States of America (USA) 0 0
MRC Integrative Epidemiology Unit (IEU), UoB, United Kingdom (UK) 0 0
Faculty of Medicine (FMed), University of Oulu, Finland 0 0
Department of Public Health and General Practice, NTNU, Norway 0 0
K.G. Jebsen Center for Diabetes Research, Norway 0 0
NIH NIA Laboratory of Epidemiology and Population Science (LEPS), United States of America (USA) 0 0
Frederiksberg Hospital, UCPH, Denmark 0 0
UAB Division of Preventive Medicine (DOPM), United States of America (USA) 0 0
Department of Cardiology, Leiden University, Netherlands 0 0
Merck Research Laboratories (MRL) - Boston, United States of America (USA) 0 0
Faculty of Medicine, MUN, Canada 0 0
Department of Physiology and Biophysics, Ole Miss, United States of America (USA) 0 0
Department of Biostatistics, BU, United States of America (USA) 0 0
Institute of Cellular Medicine, Newcastle University, United Kingdom (UK) 0 0
Merck Research Laboratories (MRL), United States of America (USA) 0 0
Amsterdam Brain and Cognition (ABC), UvA, Netherlands 0 0
Department of Psychiatry, Dalhousie University, Canada 0 0
Anogia Medical Centre, Greece 0 0
Universitätsklinikum Leipzig, Germany 0 0
Institute for Community Medicine (ICM), University of Greifswald, Germany 0 0
Duke University, United States of America (USA) 0 0
Ninewells Hospital and Medical School, United Kingdom (UK) 0 0
Department of Clinical Physiology, TAUH, Finland 0 0
NIH NIA Laboratory of Neurogenetics, United States of America (USA) 0 0
Department of Molecular Epidemiology (MEP), DIfE, Germany 0 0
Department of Psychiatry, WUSTL, United States of America (USA) 0 0
Warwick Division of Health Sciences, United Kingdom (UK) 0 0
Division of Public Health Sciences (PHS), WFU, United States of America (USA) 0 0
Uppsala University (UU), Sweden 0 0
Department of Medicine, BU, United States of America (USA) 0 0
Service de Génétique Médicale, CHU de Nantes, France 0 0
University Medicine Greifswald, Germany 0 0
UKCRC Centre of Excellence for Public Health (NI), United Kingdom (UK) 0 0
Echinos Medical Centre, Greece 0 0
Icelandic Heart Association (IHA), Iceland 0 0
Department of Clinical Science (K2), UIB, Norway 0 0
University of North Carolina Population Center (UNC CPC), United States of America (USA) 0 0
Centre for Control of Chronic Diseases (CCCD), Bangladesh 0 0
University Institute of Social and Preventive Medicine (IUMSP), UNIL, Switzerland 0 0
Department of Computational Biology, UNIL, Switzerland 0 0
Department of Public Health and Caring Sciences (IFV), UU, Sweden 0 0
Glenfield Hospital, United Kingdom (UK) 0 0
NIHR Leicester Cardiovascular Biomedical Research Unit (LCBRU), United Kingdom (UK) 0 0
UMC Division of Surgical Specialties, Netherlands 0 0
Department of Family Medicine and Public Health (FMPH), UC San Diego, United States of America (USA) 0 0
Survey Research Center (SRC), U-M, United States of America (USA) 0 0
Risk Factors and Molecular Determinants of Aging-related Diseases (RID-AGE), France 0 0
Department of Human Genetics, RU, Netherlands 0 0
Joseph J. Zilber School of Public Health, UWM, United States of America (USA) 0 0
Centre for Research in Epidemiology and Population Health (CESP), France 0 0
Department of Cardiology, UCPH, Denmark 0 0
Faculty of Medicine, Leipzig University, Germany 0 0
Department of Epidemiology (EPI), DIfE, Germany 0 0
MRC-PHE Centre for Environment and Health, United Kingdom (UK) 0 0
Department of Cardiovascular Sciences, University of Leicester, United Kingdom (UK) 0 0
Department of Genetics, WUSTL, United States of America (USA) 0 0
Division of Statistical Genomics, WUSTL, United States of America (USA) 0 0
Faculté de Médecine, Université Toulouse III, France 0 0
Department of Clinical Biochemistry, UCPH, Denmark 0 0
Division of Endocrinology, BCH, United States of America (USA) 0 0
Center for Basic and Translational Obesity Research, BCH, United States of America (USA) 0 0
Division of Epidemiology, VU, United States of America (USA) 0 0
Department of Haematology, University of Cambridge, United Kingdom (UK) 0 0
USC Department of Ophthalmology, United States of America (USA) 0 0
USC Eye Institute, United States of America (USA) 0 0
UMC Utrecht Brain Center Rudolf Magnus, Netherlands 0 0
Framingham Heart Study (FHS), United States of America (USA) 0 0
Division of Molecular Biology and Human Genetics, SU, South Africa 0 0
UMC Department of Psychiatry, Netherlands 0 0
Harvard Department of Genetics, United States of America (USA) 0 0
Vanderbilt Epidemiology Center (VEC), VU, United States of America (USA) 0 0
Division of Preventive Medicine, BWH, United States of America (USA) 0 0
Division of Gastroenterology, U-M, United States of America (USA) 0 0
Haukeland University Hospital, Norway 0 0
Institute for Medicine and Public Health, VU, United States of America (USA) 0 0
Vanderbilt Genetics Institute (VGI), VU, United States of America (USA) 0 0
Harvard Department of Medicine, United States of America (USA) 0 0
Imperial College Healthcare NHS Trust, United Kingdom (UK) 0 0
UNC Carolina Center for Genome Sciences (CCGS), United States of America (USA) 0 0
Sydney Medical School (SMS), USYD, Australia 0 0
Department of Public Health and Primary Care (PHEG), Leiden University, Netherlands 0 0
Centre for Vision Research, Westmead Institute for Medical Research, Australia 0 0
Department of Neurology, BU, United States of America (USA) 0 0
Department of Epidemiology Research, SSI, Denmark 0 0
DZHK Partner Site Greifswald, Germany 0 0
Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany 0 0
University Hospitals of Strasbourg (HUS), France 0 0
Oxford Big Data Institute (BDI), United Kingdom (UK) 0 0
Department of Epidemiology and Public Health, University of Strasbourg, France 0 0
Indiana University Richard M. Fairbanks School of Public Health, United States of America (USA) 0 0
School of Medicine, University of Split, Croatia 0 0
GlaxoSmithKline USA, United States of America (USA) 0 0
Department of Obstetrics and Gynecology, VU, United States of America (USA) 0 0
The University of Texas Graduate School of Biomedical Sciences (GSBS), United States of America (USA) 0 0
Danish Diabetes Academy, Denmark 0 0
Department of Public Health, AU, Denmark 0 0
Department of Gerontology and Geriatrics, Leiden University, Netherlands 0 0
College of Biomedical and Life Sciences, Cardiff University, United Kingdom (UK) 0 0
Alzheimer Scotland Dementia Research Centre (ASDRC), The University of Edinburgh, United Kingdom (UK) 0 0
Oxford Nuffield Department of Medicine (NDM), United Kingdom (UK) 0 0
Department of Clinical Physiology and Nuclear Medicine, UTU, Finland 0 0
Department of Biobank Research, UMU, Sweden 0 0
Department of Epidemiology, UW, United States of America (USA) 0 0
Department of Medicine, IUPUI, United States of America (USA) 0 0
Netherlands Comprehensive Cancer Organisation (IKNL), Netherlands 0 0
Department of Public Health Sciences, Penn State, United States of America (USA) 0 0
Kuopio University Hospital (KUH), Finland 0 0
Institute for Personalized Medicine (IPM), Penn State, United States of America (USA) 0 0
Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC), UTU, Finland 0 0
Human Genome Sequencing Center (HGSC), BCM, United States of America (USA) 0 0
Institute of Regional Health Services Research, SDU, Denmark 0 0
MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, KCL, United Kingdom (UK) 0 0
Umeå University in Skellefteå, Sweden 0 0
UMC Division of Laboratory and Pharmacy, Netherlands 0 0
Division of Pharmacoepidemiology and Clinical Pharmacology, UU, Netherlands 0 0
Interuniversity Cardiology Institute of the Netherlands (ICIN), Netherlands 0 0
UCL Centre for Cardiovascular Genetics (CVG), United Kingdom (UK) 0 0
Department of Epidemiology and Biostatistics, MSKCC, United States of America (USA) 0 0
Steno Diabetes Center A/S, Denmark 0 0
National Institute of Public Health (NIPH), SDU, Denmark 0 0
Department of Genome Sciences, UW, United States of America (USA) 0 0
HUNT Research Centre, NTNU, Norway 0 0
The University of Queensland Diamantina Institute (UQDI), UQ, Australia 0 0
Department of Hygiene and Epidemiology, UOI, Greece 0 0
K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norway 0 0
Institute of Clinical Physiology (IFC), CNR, Italy 0 0
Department of Clinical and Experimental Medicine, UNIPI, Italy 0 0
Centre for Research in EPIdemiology and Preventive MEDicine (EPIMED), University of Insubria, Italy 0 0
Dipartimento di Medicina Clinica e Sperimentale (DMCS), Università degli Studi dell'Insubria, Italy 0 0
Duke Biodemography of Aging Research Unit (BARU), United States of America (USA) 0 0
UNC Department of Sociology, United States of America (USA) 0 0
Faculty of Pharmacy, UdeM, Canada 0 0
Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders (PACER-HD), KAU, Saudi Arabia 0 0
Institute of Biomedicine, UEF, Finland 0 0
Department of Biostatistical Sciences, WFU, United States of America (USA) 0 0
Center for Public Health Genomics, WFU, United States of America (USA) 0 0
NIHR Maudsley Biomedical Research Centre (BRC), United Kingdom (UK) 0 0
Department of Clinical Sciences, UT Southwestern Medical Center, United States of America (USA) 0 0
Department of Radiology, Erasmus MC, Netherlands 0 0
Department of Neurology, Erasmus MC, Netherlands 0 0
Menzies Institute for Medical Research, UTAS, Australia 0 0
Centre for Eye Research Australia (CERA), Australia 0 0
Group Health Research Institute (GHRI), GHC, United States of America (USA) 0 0
Menzies Health Institute Queensland, Australia 0 0
USC Department of Preventive Medicine, United States of America (USA) 0 0
Center for the Genetics of Host Defense, UT Southwestern Medical Center, United States of America (USA) 0 0
Department of Human Genetics, U-M, United States of America (USA) 0 0
Department of Health Services, UW, United States of America (USA) 0 0
Department of Experimental Medicine, UCPH, Denmark 0 0
Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan 0 0
School of Medicine, NYMU, Taiwan 0 0
Harvard Department of Nutrition, United States of America (USA) 0 0
Department of Biochemistry, WFU, United States of America (USA) 0 0
The Mindich Child Health and Development Institute (MCHDI), ISMMS, United States of America (USA) 0 0
Quantitative Biomedical Research Center (QBRC), UT Southwestern Medical Center, United States of America (USA) 0 0
University of Aalborg (AAU), Denmark 0 0
Center for Medical Genetics and Molecular Medicine (MGM), Haukeland University Hospital, Norway 0 0
UMC Utrecht Center for Molecular Medicine, Netherlands 0 0
Munich Heart Alliance (MHA), Germany 0 0
UCL Institute of Cardiovascular Science (ICS), United Kingdom (UK) 0 0
Research Unit of Molecular Epidemiology (AME), HMGU, Germany 0 0
Institute of Epidemiology II (EPI II), HMGU, Germany 0 0
National University of Singapore (NUS), Singapore 0 0
College of Medicine, CSMU, Taiwan 0 0
Medizinische Klinik und Poliklinik I, LMU, Germany 0 0
Department of Psychiatry, SU, South Africa 0 0
McDonnell Genome Institute (MGI), WUSTL, United States of America (USA) 0 0
Department of Molecular Cell Biology (MCB), Leiden University, Netherlands 0 0
UMC Department of Medical Genetics, Netherlands 0 0
Department of Clinical Genetics, VUmc, Netherlands 0 0
Neuroscience Campus Amsterdam (NCA), VU University Amsterdam, Netherlands 0 0
Department of Molecular Epidemiology, Leiden University, Netherlands 0 0
Department of Complex Trait Genetics (CTG), VU University Amsterdam, Netherlands 0 0
Durrer Center for Cardiovascular Research (Durrer Center), Netherlands 0 0
Hammersmith Hospital, Imperial College Healthcare NHS Trust, United Kingdom (UK) 0 0
Generation Scotland (GS), United Kingdom (UK) 0 0
Centre for Genomic and Experimental Medicine (CGEM), United Kingdom (UK) 0 0
Institute of Medical Sciences (IMS), University of Aberdeen, United Kingdom (UK) 0 0
Kosterlitz Centre for Therapeutics (KCT), University of Aberdeen, United Kingdom (UK) 0 0
Saudi Diabetes Research Group, KAU, Saudi Arabia 0 0
National Heart and Lung Institute (NHLI), ICL, United Kingdom (UK) 0 0
Center for Vascular Prevention, Danube University Krems, Austria 0 0
Dasman Diabetes Institute (DDI), Kuwait 0 0
Division of Cardiovascular Medicine, BWH, United States of America (USA) 0 0
Vanderbilt-Ingram Cancer Center (VICC), VU, United States of America (USA) 0 0
Department of Medicine, University of Cambridge, United Kingdom (UK) 0 0
BHF Cambridge Centre of Excellence (CRE), University of Cambridge, United Kingdom (UK) 0 0
Harvard Department of Pediatrics, United States of America (USA) 0 0
Division of Genetics, BWH, United States of America (USA) 0 0

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