Identification Of An Atypical Monocyte And Committed Progenitor Involved In Fibrosis

Journal: Nature

Published: 2016-12-21

DOI: 10.1038/nature20611

Affiliations: 7

Authors: 12

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Research Highlight

Odd blood cells implicated in fibrosis

 © JUAN GARTNER/Science Photo Library/Getty

© JUAN GARTNER/Science Photo Library/Getty

A newly discovered subset of white blood cells seem to be a lynchpin in the development of the scarring disease fibrosis, researchers have found.

Fibrosis is the thickening of scar tissue during the body’s reparative process and can have serious consequences on organs such as the liver and lungs. Although researchers know that activation of the immune system is involved in the disease, there are few effective therapies.

Studying the disease in mice, scientists from the Chugai Pharmaceutical Co., Ltd and elsewhere identified an unusual subset of white blood cells that they have called SatM (segregated nucleus atypical monocytes) as being critical for fibrosis to occur.

Mice without this cell type were significantly more resistant to fibrosis, the researchers found. Introducing SatM cells into these mice increased their susceptibility to the disease.

The researchers note these results suggest it may now be possible to develop novel, more specific therapeutic targets for fibrosis with fewer side-effects.

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  1. Nature 541,96–101 (2017). doi: 10.1038/nature20611
Institutions FC
Laboratory of Host Defense, Osaka University, Japan 0.24
Department of Host Defense, Osaka University, Japan 0.24
Chugai Pharmaceutical Co., Ltd., Japan 0.19
Laboratory of Biofunctional Imaging, Osaka University, Japan 0.17
Research Center for Ultra-High Voltage Electron Microscopy (UHVEM), Osaka University, Japan 0.08
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University, Japan 0.08

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