Forward-genetics analysis of sleep in randomly mutagenized mice

Journal: Nature

Published: 2016-11-02

DOI: 10.1038/nature20142

Affiliations: 14

Authors: 37

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Research Highlight

Lethargic lab mice and the science of slumber

© Paul Chang/EyeEm/Getty

© Paul Chang/EyeEm/Getty

A team led by a researcher from the University of Tsukuba have identified two mouse genes that may have a role in regulating sleep. Most people spend a third of their life asleep and yet we remain in the dark about the genetics behind our nocturnal needs.

In order to shed light on this fundamental question, the researchers observed the sleeping habits of 8,000 mice that carried a range of random genetic mutations hoping to spot unusual slumbering behaviour that could be linked to individual genes.

One group, nicknamed Sleepy, went into deep sleep for almost a third longer than average mice and were more sensitive to sleep deprivation. A second, dubbed Dreamless, spent 44 per cent less time in the lighter rapid-eye-movement (REM) sleeping state which is associated with dreaming in humans. These effects were linked to mutations in the multifunctional Sik3 gene, and Nalcn, a gene that may control neuron excitability, respectively.

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  1. Nature 539,378-383 (2016). doi: 10.1038/nature20142
Institutions Share
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Japan 0.57
Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan 0.08
Laboratory Animal Resource Center, University of Tsukuba, Japan 0.08
RIKEN BioResource Research Center (BRC), Japan 0.08
Department of Animal Model Development, Niigata University, Japan 0.05
Laboratory of Research Advancement, NCGG, Japan 0.03
Department of Neuroscience, UT Southwestern Medical Center, United States of America (USA) 0.02
Department of Molecular Genetics, UT Southwestern Medical Center, United States of America (USA) 0.02
The University of Texas Southwestern Medical Center (UT Southwestern Medical Center), United States of America (USA) 0.02
Graduate School of Medicine, Toho University, Japan 0.01
The Jackson Laboratory (JAX), United States of America (USA) 0.01
Department of Biochemistry, UT Southwestern Medical Center, United States of America (USA) 0.01
Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (LS-TARA Center), University of Tsukuba, Japan 0.01