TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling

Journal: Nature

Published: 2016-10-19

DOI: 10.1038/nature20095

Affiliations: 9

Authors: 12

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Research Highlight

Switching on that gut feeling

© Stocktrek Images/Getty

© Stocktrek Images/Getty

A DNA switch responsible for a critical stage in embryo development – folding a ball of cells inward to form the beginning of the gut cavity — has been uncovered by a study published in Nature.

A team of Chinese and US scientists, including researchers from ShanghaiTech University, genetically engineered mice that lacked a family of TET enzymes that can remove methyl groups from DNA, which control how the DNA is read.

The engineered and control mice both developed normally up until the seventh day when the control mice began to form a ‘gastrula’ – three layers of germ cells folded to form the beginning of the gut. Mouse embryos lacking TET enzymes were both smaller and their cells failed to migrate correctly to form tissues and organs.

The scientists concluded that TET enzymes genetically control the formation of the gut in mice and carried out further experiments to show they signal two growth factors called Lefty and Nodal to kick-start gut development.

Supported content

  1. Nature 538, 528–532 (2016). doi: 10.1038/nature20095
Institutions FC
State Key Laboratory of Molecular Biology (SLMB), IBCB SIBS CAS, China 0.13
CAS Center for Excellence in Molecular Cell Science, SIBS CAS, China 0.13
Shanghai Key Laboratory of Molecular Andrology (SLMA), IBCB SIBS CAS, China 0.13
Biodynamics Optical Imaging Center (BIOPIC), PKU, China 0.13
School of Life Sciences, PKU, China 0.13
School of Life Science and Technology (SLST), ShanghaiTech, China 0.10
MOE Key Laboratory of Cell Proliferation and Differentiation, PKU, China 0.08
Department of Biological Sciences, Pitt, United States of America (USA) 0.08
Department of Genetics, UW-Madison, United States of America (USA) 0.08

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