Landscape of somatic mutations in 560 breast cancer whole-genome sequences

Journal: Nature

Published: 2016-05-02

DOI: 10.1038/nature17676

Affiliations: 50

Authors: 88

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Research Highlight

Detailed genetic picture of breast cancer revealed

© SEBASTIAN KAULITZKI/Science Photo Library

© SEBASTIAN KAULITZKI/Science Photo Library

An international team has uncovered the most detailed evidence yet that the genetic profiles of breast cancers are highly specific to each patient. This finding represents a step towards bespoke cancer treatment based on an individual’s cancer genome.

In a study published in Nature, researchers analysed the whole genomes of 560 breast tumours, identifying 93 mutated cancer genes that were implicated in the genesis of breast cancer, including five previously unknown genes. They also found that the tumors of women carrying the BRCA1 or BRCA2 genes were genetically distinct from each other and from other breast cancers.

The study’s authors note that this information could one day help direct doctors to the most effective treatment for cancer sufferers.

"In the future, we'd like to be able to profile individual cancer genomes so that we can identify the treatment most likely to be successful for a woman or man diagnosed with breast cancer. It is a step closer to personalized healthcare for cancer," said lead author Serena Nik-Zainal from the Wellcome Trust Sanger Institute in a statement.

The multi-centre team included researchers from The University of Texas MD Anderson Cancer Center.

  1. Nature 2016; 534, 47–54. doi: 10.1038/nature17676
Institutions FC WFC
Wellcome Trust Sanger Institute, United Kingdom (UK) 0.30 0.30
Cancer (, Netherlands 0.06 0.06
The Netherlands Cancer Institute (NKI), Netherlands 0.03 0.03
Department of Clinical Sciences - Lund, LU, Sweden 0.03 0.03
Center for Oncological Research (CORE), UA, Belgium 0.03 0.03
Academic Medical Center (AMC), UvA, Netherlands 0.02 0.02
Institute Jules Bordet, ULB, Belgium 0.02 0.02
Asan Medical Center (AMC), South Korea 0.02 0.02
Faculty of Medicine, University of Iceland, Iceland 0.02 0.02
College of Medicine, HYU, South Korea 0.02 0.02
UiO K.G. Jebsen Centre for Breast Cancer Research, Norway 0.02 0.02
Morgan Welch Inflammatory Breast Cancer Clinic, MD Anderson Cancer Center, United States of America (USA) 0.02 0.02
Faculty of Science, RU, Netherlands 0.02 0.02
UiO Institute for Cancer Research, Norway 0.02 0.02
Department of Pathology, BWH, United States of America (USA) 0.02 0.02
Ninewells Hospital and Medical School, United Kingdom (UK) 0.02 0.02
Synergie Lyon Cancer, France 0.02 0.02
Dana-Farber Cancer Institute (DFCI), United States of America (USA) 0.02 0.02
Faculty of Medicine and Biomedical Sciences (MBS), UQ, Australia 0.02 0.02
Centre Léon Bérard (CLB), France 0.01 0.01
IRCCS National Cancer Institute (INT) Bari, Italy 0.01 0.01
Institut Régional du Cancer de Montpellier (ICM), France 0.01 0.01
Wellcome Trust Genome Campus, United Kingdom (UK) 0.01 0.01
Department of Genetics and Developmental Biology, France 0.01 0.01
Radboud University Medical Centre (Radboudumc), RU, Netherlands 0.01 0.01
Gachon University Gil Medical Center, South Korea 0.01 0.01
Cancer Research UK Cambridge Institute (CRUK-CI), University of Cambridge, United Kingdom (UK) 0.01 0.01
Clinical Sciences Centre, CLB, France 0.01 0.01
GZA Ziekenhuizen, Belgium 0.01 0.01
Memorial Sloan Kettering Cancer Center (MSKCC), United States of America (USA) 0.01 0.01
Department of Biomedical Engineering (BME), HYU, South Korea 0.01 0.01
French National Cancer Institute (INCa), France 0.01 0.01
Host-Graft-Tumor Interaction, Cell and Gene Engineering, France 0.01 0.01
European Bioinformatics Institute (EMBL-EBI), United Kingdom (UK) 0.01 0.01
INRIA Grenoble - Rhône-Alpes Research Centre, France 0.01 0.01
Singapore General Hospital (SGH), Singapore 0.01 0.01
Department of Genomic Medicine, MD Anderson Cancer Center, United States of America (USA) 0.01 0.01
Department of Surgical Oncology, MD Anderson Cancer Center, United States of America (USA) 0.01 0.01
National Cancer Centre Singapore (NCCS), Singapore 0.01 0.01
Biomedical Sciences Group, KU Leuven, Belgium 0.01 0.01
Department of Clinical Science (K2), UIB, Norway 0.01 0.01
Haukeland University Hospital, Norway 0.01 0.01
Cambridge University Hospitals NHS Foundation Trust, United Kingdom (UK) 0.01 0.01
UiO Faculty of Mathematics and Natural Sciences, Norway 0.01 0.01
Faculty of Life Sciences and Medicine (LSM), KCL, United Kingdom (UK) 0.01 0.01
ICR Breast Cancer Now Research Centre, United Kingdom (UK) 0.01 0.01
Pathology Queensland, Australia 0 0
Theoretical Biology and Biophysics (T-6), LANL, United States of America (USA) 0 0
Center for Nonlinear Studies (CNLS), LANL, United States of America (USA) 0 0
Royal Brisbane and Women's Hospital (RBWH), Australia 0 0